{"title":"Accompanying Infections in Hospitalized Children with Neurological Disease","authors":"Turgay Çokyaman, T. Kasap, Taylan Çelik","doi":"10.4274/jcp.2022.81084","DOIUrl":"https://doi.org/10.4274/jcp.2022.81084","url":null,"abstract":"","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45257072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Tunçer, F. Varol, Ş. Coşkun, B. Güzel, Şirin Güven, H. Çam
Introduction: Coronavirus 2 (SARS-CoV-2) has infected people of all ages all across the world, with children accounting for 1.7 percent of cases. Despite the fact that over 90% of children with COVID-19 had asymptomatic, mild, or moderate disease, new worries about hyperinflammatory states or Kawasaki-like disease have surfaced. Materials and Methods: We would like to present 17 patients with different patterns of myocardial involvement. They were selected from our database of 214 patients (19 newborns) hospitalized for SARS-CoV-2 infection treatment in our pediatrics clinic from March 2020 to October 2020. Selection criteria involved cardiac involvement in terms of positive laboratory findings (elevated troponin I) electrocardiographic and echocardiographic findings.
{"title":"Patterns of Myocardial Involvement During COVID-19 Pandemic; From Newborn to Adolescents","authors":"T. Tunçer, F. Varol, Ş. Coşkun, B. Güzel, Şirin Güven, H. Çam","doi":"10.4274/jcp.2021.83798","DOIUrl":"https://doi.org/10.4274/jcp.2021.83798","url":null,"abstract":"Introduction: Coronavirus 2 (SARS-CoV-2) has infected people of all ages all across the world, with children accounting for 1.7 percent of cases. Despite the fact that over 90% of children with COVID-19 had asymptomatic, mild, or moderate disease, new worries about hyperinflammatory states or Kawasaki-like disease have surfaced. Materials and Methods: We would like to present 17 patients with different patterns of myocardial involvement. They were selected from our database of 214 patients (19 newborns) hospitalized for SARS-CoV-2 infection treatment in our pediatrics clinic from March 2020 to October 2020. Selection criteria involved cardiac involvement in terms of positive laboratory findings (elevated troponin I) electrocardiographic and echocardiographic findings.","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46087597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hasan Durmuş, Yavuzalp Solak, Erhan Kaya, Halil Canbolat
Introduction: Obesity is an increasingly common health problem not only in adults but also in children all over the world. Obesity rates in Turkey vary between 4.5% and 15.9% according to regions. Regular and adequate sleep is important for maintaining a healthy life as well as for physical, cognitive and emotional development. The aim of the study is to determine the level of sleep problems in primary school children, their causes and their relationship with obesity. Materials and Methods: The study is descriptive. The sleep disorder scale in children, which was developed by Bruni to evaluate the sleep disorder of the children and whose Turkish validity was verified by Akçay, was answered by the parents of children of primary school age with questions containing the socioAnah tar ke li me ler Uyku bozukluğu, obezite, adölesan, uyku
肥胖症是一个越来越普遍的健康问题，不仅在成人，而且在世界各地的儿童。土耳其的肥胖率根据地区不同在4.5%到15.9%之间。规律和充足的睡眠对于维持健康的生活以及身体、认知和情感发展都很重要。这项研究的目的是确定小学生睡眠问题的程度、原因以及与肥胖的关系。材料与方法:本研究为描述性研究。儿童睡眠障碍量表由Bruni开发，用于评估儿童的睡眠障碍，其土耳其语效度由akay验证，由小学年龄儿童的父母回答包含社会anah tarke li me ler Uyku bozukluğu, obezite, adölesan, Uyku的问题
{"title":"Prevalence of Sleep Disorders in Primary School Children and its Relationship with Obesity","authors":"Hasan Durmuş, Yavuzalp Solak, Erhan Kaya, Halil Canbolat","doi":"10.4274/jcp.2021.38980","DOIUrl":"https://doi.org/10.4274/jcp.2021.38980","url":null,"abstract":"Introduction: Obesity is an increasingly common health problem not only in adults but also in children all over the world. Obesity rates in Turkey vary between 4.5% and 15.9% according to regions. Regular and adequate sleep is important for maintaining a healthy life as well as for physical, cognitive and emotional development. The aim of the study is to determine the level of sleep problems in primary school children, their causes and their relationship with obesity. Materials and Methods: The study is descriptive. The sleep disorder scale in children, which was developed by Bruni to evaluate the sleep disorder of the children and whose Turkish validity was verified by Akçay, was answered by the parents of children of primary school age with questions containing the socioAnah tar ke li me ler Uyku bozukluğu, obezite, adölesan, uyku","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45000697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dental Health Status and Affecting Factors of Preschool Children: A Pilot Study","authors":"Çiğdem Elbek Çubukçu","doi":"10.4274/jcp.2021.48243","DOIUrl":"https://doi.org/10.4274/jcp.2021.48243","url":null,"abstract":"","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47403485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Yücel, Adviye Çakıl Sağlık, Özge Sürmeli Onay, Z. Özdemir, Özcan Bör, A. Tekin
Introduction: While neonatal thromboembolism is uncommon, it is frequently seen in newborn infants with central catheters who are monitored in the neonatal intensive care unit. There is several case reports on rare thromboembolic events that occur during the intrauterine period. Case Report: Our patient was a term twin infant who was diagnosed with intrauterine onset right ulnar artery thromboembolism shortly after birth. The baby was given low molecular weight heparin treatment, but limb-sparing amputation was required during follow-up. The analysis of thrombophilic genetic mutations of the infant revealed heterozygous MHTFR677C> T and FII20210G> A mutations. Conclusion: On the basis of heterozygous mutations, twin pregnancy has been assessed as a significant risk factor. We believe that the case presented with the literature will help clinicians gain more experience. Anah tar ke li me ler Yenidoğan, arteriyel tromboemboli, intrauterin tromboemboli, ikiz
简介:虽然新生儿血栓栓塞不常见，但在新生儿重症监护病房监测中心导尿管的新生儿中经常出现。有几个病例报告罕见的血栓栓塞事件发生在宫内期间。病例报告:我们的病人是一个足月双胞胎婴儿谁被诊断为宫内发作右尺动脉血栓栓塞出生后不久。给予婴儿低分子肝素治疗，但在随访期间需要截肢。婴儿的亲血栓性基因突变分析显示MHTFR677C> T和FII20210G> A杂合突变。结论:在杂合突变的基础上，双胎妊娠已被评估为一个重要的危险因素。我们相信，与文献提出的情况下，将有助于临床医生获得更多的经验。Anah会像li - me - ler Yenidoğan，动脉血栓栓塞，宫内血栓栓塞，kiz
{"title":"Intrauterine Onset Ulnar Artery Thromboembolism: A Case Report","authors":"M. Yücel, Adviye Çakıl Sağlık, Özge Sürmeli Onay, Z. Özdemir, Özcan Bör, A. Tekin","doi":"10.4274/jcp.2021.02438","DOIUrl":"https://doi.org/10.4274/jcp.2021.02438","url":null,"abstract":"Introduction: While neonatal thromboembolism is uncommon, it is frequently seen in newborn infants with central catheters who are monitored in the neonatal intensive care unit. There is several case reports on rare thromboembolic events that occur during the intrauterine period. Case Report: Our patient was a term twin infant who was diagnosed with intrauterine onset right ulnar artery thromboembolism shortly after birth. The baby was given low molecular weight heparin treatment, but limb-sparing amputation was required during follow-up. The analysis of thrombophilic genetic mutations of the infant revealed heterozygous MHTFR677C> T and FII20210G> A mutations. Conclusion: On the basis of heterozygous mutations, twin pregnancy has been assessed as a significant risk factor. We believe that the case presented with the literature will help clinicians gain more experience. Anah tar ke li me ler Yenidoğan, arteriyel tromboemboli, intrauterin tromboemboli, ikiz","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44563703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emel Hatun Aytaç Kaplan, Aydilek Dağdeviren Çakır, I. Esen, E. Akbaş, Eda Çelebi Bitkin, N. Akyürek, B. Özcabı, S. Kılınç, B. Kırel, D. Okdemir, O. Evliyaoğlu, M. Keskin
Introduction: Ultrasonography and fine needle aspiration biopsy are reliable diagnostic methods used to predict malignancy in thyroid nodules. They are useful in identifying patients for therapy or preventing unnecessary surgery. Materials and Methods: The aim of this study was to compare clinical and ultrasonographic findings with fine needle aspiration biopsy and histopathological examination results in children with thyroid nodules. Retrospective study. This multicentre study included pediatric patients with thyroid nodules, followed up between July 2002 and November 2019 in nine Turkish Pediatric Endocrinology Units. Clinical, ultrasonographic, cytological and histopathological findings (malignant or benign) were analyzed retrospectively. Fine needle aspiration biopsy findings were classified according to American Thyroid Association criteria. Results: A total of 203 children were included, of whom 82.3% (n=167) were female. Mean±standard deviation age was 14.06±2.26 (range 3.7-19) years. Cytological diagnoses were: non–diagnostic or unsatisfactory 1.9%; benign 59.6%; atypia or follicular lesion of undetermined significance, suspicious for follicular neoplasm in 2.4%; suspicious for malignancy 12.8%; and malignant in 1.9%. Surgery was performed in 59 (29.1%) patients. In total 33 (16.3%) patients were diagnosed with malignancy. In patients with benign fine needle aspiration biopsy results, malignancy was detected in 17.6% when they underwent surgery. Malignancy was present in 44.4% of the patients with cytologically determined atypia or follicular lesion of undetermined significance. The diagnostic accuracy of fine needle aspiration biopsy was 79%. Conclusion: This study is first multicentre study investigating thyroid nodules in children and adolescents in Turkey. In this population fine needle aspiration
{"title":"Evaluation of Thyroid Nodules in Children and Adolescents: Multicenter Study in Turkey","authors":"Emel Hatun Aytaç Kaplan, Aydilek Dağdeviren Çakır, I. Esen, E. Akbaş, Eda Çelebi Bitkin, N. Akyürek, B. Özcabı, S. Kılınç, B. Kırel, D. Okdemir, O. Evliyaoğlu, M. Keskin","doi":"10.4274/jcp.2021.43926","DOIUrl":"https://doi.org/10.4274/jcp.2021.43926","url":null,"abstract":"Introduction: Ultrasonography and fine needle aspiration biopsy are reliable diagnostic methods used to predict malignancy in thyroid nodules. They are useful in identifying patients for therapy or preventing unnecessary surgery. Materials and Methods: The aim of this study was to compare clinical and ultrasonographic findings with fine needle aspiration biopsy and histopathological examination results in children with thyroid nodules. Retrospective study. This multicentre study included pediatric patients with thyroid nodules, followed up between July 2002 and November 2019 in nine Turkish Pediatric Endocrinology Units. Clinical, ultrasonographic, cytological and histopathological findings (malignant or benign) were analyzed retrospectively. Fine needle aspiration biopsy findings were classified according to American Thyroid Association criteria. Results: A total of 203 children were included, of whom 82.3% (n=167) were female. Mean±standard deviation age was 14.06±2.26 (range 3.7-19) years. Cytological diagnoses were: non–diagnostic or unsatisfactory 1.9%; benign 59.6%; atypia or follicular lesion of undetermined significance, suspicious for follicular neoplasm in 2.4%; suspicious for malignancy 12.8%; and malignant in 1.9%. Surgery was performed in 59 (29.1%) patients. In total 33 (16.3%) patients were diagnosed with malignancy. In patients with benign fine needle aspiration biopsy results, malignancy was detected in 17.6% when they underwent surgery. Malignancy was present in 44.4% of the patients with cytologically determined atypia or follicular lesion of undetermined significance. The diagnostic accuracy of fine needle aspiration biopsy was 79%. Conclusion: This study is first multicentre study investigating thyroid nodules in children and adolescents in Turkey. In this population fine needle aspiration","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41335683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pınar Şimşek Onat, Duygu Demirtaş, Hayriye Hızarcıoğlu Gülşen, E. Gümüş, İ. S. Saltık Temizel, H. Özen, H. Demir, E. Parlak
Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is a procedure that uses endoscopy and fluroscopy together to provide diagnosis and treatment in pancreatic and biliary tract diseases. Materials and Methods: The data of 46 pediatric patients who underwent ERCP between November 2017 April 2020 at Hacettepe University Gastroenterology Endoscopy Unit were retrospectively analyzed. Results: A total of 77 (1-5) ERCP procedures were performed in 46 patients (29 Anah tar ke li me ler ERCP, kronik pankreatit, koledok kisti, koledok taşı
简介：内镜逆行胰胆管造影（ERCP）是一种将内镜和荧光镜结合起来对胰胆管疾病进行诊断和治疗的方法。材料和方法：回顾性分析2017年11月至2020年4月在哈塞特佩大学胃肠道内镜科接受ERCP的46名儿科患者的数据。结果：46名患者共进行了77（1-5）次ERCP手术（29名Anah tar ke li me ler ERCP、kronik pankreatit、koledok kisti、koledak taşı
{"title":"Endoscopic Retrograd Colangiopancreatography in Children: A Single Center Experience","authors":"Pınar Şimşek Onat, Duygu Demirtaş, Hayriye Hızarcıoğlu Gülşen, E. Gümüş, İ. S. Saltık Temizel, H. Özen, H. Demir, E. Parlak","doi":"10.4274/jcp.2021.94803","DOIUrl":"https://doi.org/10.4274/jcp.2021.94803","url":null,"abstract":"Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is a procedure that uses endoscopy and fluroscopy together to provide diagnosis and treatment in pancreatic and biliary tract diseases. Materials and Methods: The data of 46 pediatric patients who underwent ERCP between November 2017 April 2020 at Hacettepe University Gastroenterology Endoscopy Unit were retrospectively analyzed. Results: A total of 77 (1-5) ERCP procedures were performed in 46 patients (29 Anah tar ke li me ler ERCP, kronik pankreatit, koledok kisti, koledok taşı","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44653680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Karakök, D. Akdemir, S. Yalçın, Hacer Seniz Özusta, G. Utine, Ö. Doğan, P. Ö. Şimşek Kiper, Gizem Ürel Demir
Introduction: The aim of this study is to compare neurocognitive and psychosocial characteristics in adolescents with Turner Syndrome (TS) and age-matched adolescents with short stature (SS) and normal karyotypes. Materials and Methods: Seven patients with TS and 7 patients with SS and normal karyotypes were included in the study. Their comorbid psychopathologies, cognitive functioning, quality of life, self-esteem, emphatic tendencies, mentalizing abilities and coping strategies were investigated. Results: Although the adolescents with SS had higher levels of anxiety and conduct problems, there were no significant differences between the TS and SS groups in terms of comorbid psychopathologies, social cognition skills, quality of life, self-esteem and coping strategies. However, the cognitive functioning of adolescents with TS was found to be lower than both of the adolescents with SS and community samples. Conclusions: According to this preliminary study, anxiety/conduct problems and cognitive functioning of patients with TS should be evaluated in order to prevent subsequent negative outcomes.
{"title":"Psychometric and Psychosocial Evaluation of Adolescents with Turner Syndrome in a Multidisiplinary Approach: A Preliminary Study","authors":"B. Karakök, D. Akdemir, S. Yalçın, Hacer Seniz Özusta, G. Utine, Ö. Doğan, P. Ö. Şimşek Kiper, Gizem Ürel Demir","doi":"10.4274/jcp.2021.04864","DOIUrl":"https://doi.org/10.4274/jcp.2021.04864","url":null,"abstract":"Introduction: The aim of this study is to compare neurocognitive and psychosocial characteristics in adolescents with Turner Syndrome (TS) and age-matched adolescents with short stature (SS) and normal karyotypes. Materials and Methods: Seven patients with TS and 7 patients with SS and normal karyotypes were included in the study. Their comorbid psychopathologies, cognitive functioning, quality of life, self-esteem, emphatic tendencies, mentalizing abilities and coping strategies were investigated. Results: Although the adolescents with SS had higher levels of anxiety and conduct problems, there were no significant differences between the TS and SS groups in terms of comorbid psychopathologies, social cognition skills, quality of life, self-esteem and coping strategies. However, the cognitive functioning of adolescents with TS was found to be lower than both of the adolescents with SS and community samples. Conclusions: According to this preliminary study, anxiety/conduct problems and cognitive functioning of patients with TS should be evaluated in order to prevent subsequent negative outcomes.","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43730373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Binnaz Çelik, M. Dogan, Doğan Bahadır İnan, S. Sunkak, E. Saatçi, F. Tubaş
Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a newly described pathogen that is usually transmitted by droplets between person to person. Although the clinical spectrum of COVID-19 ranges from asymptomatic disease to the development of severe acute respiratory distress, children are generally milder than adults. It was aimed to compare the clinical and laboratory values of symptomatic and asymptomatic children followed up with a diagnosis of COVID-19 in this study. Materials and Methods: The records of children with nasopharyngeal swab SARS-CoV-2 Reverse Transcriptase-Polymerase Chain Reaction test positive were analyzed retrospectively. Children with symptoms such as fever, cough, shortness of breath, diarrhea and/or vomiting were accepted as symptomatic, and children with positive SARS-CoV-2 PCR in a nasopharyngeal swab taken only due to contact history and have no symptoms were considered asymptomatic.
{"title":"Demographic and Laboratory Findings of Symptomatic and Asymptomatic COVID-19 in Children","authors":"Binnaz Çelik, M. Dogan, Doğan Bahadır İnan, S. Sunkak, E. Saatçi, F. Tubaş","doi":"10.4274/jcp.2021.47640","DOIUrl":"https://doi.org/10.4274/jcp.2021.47640","url":null,"abstract":"Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a newly described pathogen that is usually transmitted by droplets between person to person. Although the clinical spectrum of COVID-19 ranges from asymptomatic disease to the development of severe acute respiratory distress, children are generally milder than adults. It was aimed to compare the clinical and laboratory values of symptomatic and asymptomatic children followed up with a diagnosis of COVID-19 in this study. Materials and Methods: The records of children with nasopharyngeal swab SARS-CoV-2 Reverse Transcriptase-Polymerase Chain Reaction test positive were analyzed retrospectively. Children with symptoms such as fever, cough, shortness of breath, diarrhea and/or vomiting were accepted as symptomatic, and children with positive SARS-CoV-2 PCR in a nasopharyngeal swab taken only due to contact history and have no symptoms were considered asymptomatic.","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42871651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine problem with complex diagnosis in adolescents. Therefore, it is important to identify reliable biomarkers that can be used in the diagnosis of PCOS in adolescents. To investigate the diagnostic value of anti-Müllerian hormone (AMH) and inhibin-A (INH-A) and insulin-like peptide-3 (INSL3) in adolescents with PCOS, and to explain the relationship between these hormones and the clinical / laboratory findings of hyperandrogenism. Materials and Methods: Fifty-five girls aged 15-20 years who were diagnosed with PCOS were included in the present study. The control group consisted of healthy adolescents who had regular menstrual cycles for at least two years and were compatible with the study group according to age and body mass index (BMI). The hormonal profile was assessed in the PCOS and control group. Transabdominal pelvic ultrasonography was performed only in the PCOS group. Results: AMH and INH-A levels were found to be significantly higher in the PCOS group than control group. While the INSL3 did not correlate with anthropometric or laboratory parameters, AMH level showed a positive correlation with the WC SDS, waist / hip ratio, FAI, LH, fT and INH-A. Moreover, INH-A level showed a positive correlation with WC SDS, LH, LH / FSH ratio, SHBG and AMH. In receiver-operating characteristic analysis, the cut-off value for AMH for the diagnosis of PCOS in adolescents was 5.8 ng / mL that for INH-A was 9.3 pg/mL (the specificity and sensitivity were 86% and 70% and 66% and 82% respectively). When AMH and INH-A were used in combination, the specificity and sensitivity were 74% and 88%, respectively. Conclusion: INH-A and AMH can be used as new biomarkers for the diagnosis of PCOS in adolescents, while INSL3 has no diagnostic value in this regard.
{"title":"Analysis of New Biomarkers for the Diagnosis of Polycystic Ovary Syndrome in Adolescents","authors":"Selma Tunç, B. Özkan","doi":"10.4274/jcp.2021.22599","DOIUrl":"https://doi.org/10.4274/jcp.2021.22599","url":null,"abstract":"Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine problem with complex diagnosis in adolescents. Therefore, it is important to identify reliable biomarkers that can be used in the diagnosis of PCOS in adolescents. To investigate the diagnostic value of anti-Müllerian hormone (AMH) and inhibin-A (INH-A) and insulin-like peptide-3 (INSL3) in adolescents with PCOS, and to explain the relationship between these hormones and the clinical / laboratory findings of hyperandrogenism. Materials and Methods: Fifty-five girls aged 15-20 years who were diagnosed with PCOS were included in the present study. The control group consisted of healthy adolescents who had regular menstrual cycles for at least two years and were compatible with the study group according to age and body mass index (BMI). The hormonal profile was assessed in the PCOS and control group. Transabdominal pelvic ultrasonography was performed only in the PCOS group. Results: AMH and INH-A levels were found to be significantly higher in the PCOS group than control group. While the INSL3 did not correlate with anthropometric or laboratory parameters, AMH level showed a positive correlation with the WC SDS, waist / hip ratio, FAI, LH, fT and INH-A. Moreover, INH-A level showed a positive correlation with WC SDS, LH, LH / FSH ratio, SHBG and AMH. In receiver-operating characteristic analysis, the cut-off value for AMH for the diagnosis of PCOS in adolescents was 5.8 ng / mL that for INH-A was 9.3 pg/mL (the specificity and sensitivity were 86% and 70% and 66% and 82% respectively). When AMH and INH-A were used in combination, the specificity and sensitivity were 74% and 88%, respectively. Conclusion: INH-A and AMH can be used as new biomarkers for the diagnosis of PCOS in adolescents, while INSL3 has no diagnostic value in this regard.","PeriodicalId":41880,"journal":{"name":"Guncel Pediatri-Journal of Current Pediatrics","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45369748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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