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Open Approaches to Radical Nephrectomies: A Case Report of Bilateral T3b Renal Cell Carcinoma Clinical Summary 开放入路根治性肾切除术:双侧T3b肾细胞癌1例临床总结
IF 0.3 Pub Date : 2023-08-01 DOI: 10.4274/jus.galenos.2023.2022.0072
P. Kim, J. Kovacic, A. R. Shepherd, M. Winter*, A. Dhar
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引用次数: 0
Prevalence of Poor Sleep Quality and Its Determinants Among Men Suffering from Erectile Dysfunction 男性勃起功能障碍患者睡眠质量差的患病率及其影响因素
IF 0.3 Pub Date : 2023-08-01 DOI: 10.4274/jus.galenos.2022.2022.0073
Ahmet Cihan, I. Kazaz, M. Duran, Ö. Yildirim, A. Başer, Ü. Gül, E. Hasırcı, Y. Kızılkan, T. Turunc, H. Cam, B. Şahin, Kadir Akkuş
Objective: Recent findings implicate a higher prevalence of erectile dysfunction (ED) among men with sleep disorders. We investigated sleep quality among men with ED and reveal possible interrelations in a reverse manner. Materials and Methods: A prospective study was conducted at 12 different andrology outpatient clinics among men with complaints of insufficient erections. The subjective quality of sleep was measured using the Pittsburgh Sleep Quality Inventory. Erectile function and its dimensions were measured using the International Index of Erectile Function (IIEF) questionnaire. The age-adjusted Charlson comorbidity index and Beck Depression Inventory were used to evaluate interrelations with comorbid disease severity and depression of the subjects consecutively in the study. Results: Among 431 eligible men, the median age of the participants and their erectile function scores in the IIEF were 51 [interquartile range (IQR)=43-59] and 16 (IQR=11-19), respectively. Poor sleep was observed in 192 of 431 (44.5%) subjects. Multivariable analysis revealed that younger age [odds ratio (OR)=0.95, p=0.01], lower body mass (OR=0.86, p=0.01), lower serum high-density lipoprotein cholesterol (OR=0.95, p=0.02), and higher severity of depression (OR=2.1, p=0.0001) were predictors of poor sleep quality among men with ED. Conclusion: Nearly half of the men with ED also suffer from poor sleep. Younger age, lean body mass, and severe depression were the main predictors of poor sleep quality among ED sufferers.
目的:最近的研究结果表明,患有睡眠障碍的男性勃起功能障碍(ED)的患病率较高。我们调查了ED男性的睡眠质量,并以相反的方式揭示了可能的相互关系。材料和方法:一项前瞻性研究在12家不同的男科门诊进行,调查对象为勃起不足的男性。主观睡眠质量采用匹兹堡睡眠质量量表进行测量。使用国际勃起功能指数(IIEF)问卷测量勃起功能及其尺寸。年龄调整后的Charlson共病指数和Beck抑郁量表用于评估研究中受试者的共病严重程度和抑郁之间的相互关系。结果:在431名符合条件的男性中,参与者的中位年龄和他们在IIEF中的勃起功能得分分别为51[四分位间距(IQR)=43-59]和16(IQR=11-19)。431名受试者中有192名(44.5%)睡眠不良。多因素分析显示,年龄较小[比值比(OR)=0.95,p=0.01]、体重较低(OR=0.86,p=0.01)、血清高密度脂蛋白胆固醇较低(OR=0.95,p=0.02)和抑郁症严重程度较高(OR=2.1,p=0.0001)是ED男性睡眠质量差的预测因素。在ED患者中,年龄较小、体重较瘦和严重抑郁是睡眠质量差的主要预测因素。
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引用次数: 0
Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia- Reperfusion Injury in Rats 吡格列酮减轻大鼠睾丸扭转/束缚诱导的缺血再灌注损伤
IF 0.3 Pub Date : 2023-06-05 DOI: 10.4274/jus.galenos.2022.2022.0047
İrfan Yıldırım Şentürk, M. Değer, M. A. Aydın, S. Madendere, Oktay Kaya, E. Taştekin, T. Aktoz
167-172. Abstract Objective: This study demonstrated the protective effects of pioglitazone (Pio) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury. Materials and Methods: A total of 48 male rats were randomly divided into six experimental groups of eight rats each; Control group, I/R group, Pio 3 mg/kg group, I/R treated with Pio 3 mg/kg group, Pio 6 mg/kg group, and I/R treated with Pio 6 mg/kg group. Testicular torsion was induced by twisting the left testis 720 °C in a clockwise direction (I/R groups). Both ischemia and reperfusion periods were 4 h. Single-dose 3 mg/kg Pio or 6 mg/kg Pio was administered orally two hours before reperfusion (Pio groups). Left orchiectomy was performed at the end of the protocol. Results: In the I/R within-group analysis for mean seminiferous tubule diameter and epithelial lengths, a statistically significant difference was found only in the Pio 6 group (p=0.005; p=0.005). But Pio treatment failed to improve the levels of malondialdehyde and glutathione. Also, it did not cause any change in the non-I/R groups. Conclusion: Considering the findings of Pio, it may be used in emergencies such as torsion and other chronic diseases.
摘要目的:本研究证明吡格列酮(Pio)对睾丸扭转/扭转诱导的缺血再灌注(I/R)损伤的保护作用。材料与方法:将48只雄性大鼠随机分为6个实验组,每组8只;对照组、I/R组、Pio 3 mg/kg组、Pio3 mg/kg组I/R、Pio6 mg/kg组和Pio6 g/kg组I/R。通过顺时针方向将左侧睾丸扭转720°C来诱导睾丸扭转(I/R组)。缺血和再灌注时间均为4小时。再灌注前2小时口服单剂量3 mg/kg Pio或6 mg/kg Pio(Pio组)。方案结束时进行左睾丸切除术。结果:在平均曲精小管直径和上皮长度的I/R组内分析中,只有Pio 6组有统计学意义(p=0.005;p=0.005)。但Pio治疗未能改善丙二醛和谷胱甘肽的水平。此外,它没有引起非I/R组的任何变化。结论:考虑到Pio的发现,它可能用于紧急情况,如扭转和其他慢性疾病。
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引用次数: 0
Protective Effects of Ellagic Acid on Testicular Ischemia-Reperfusion Injury in Rats 鞣花酸对大鼠睾丸缺血再灌注损伤的保护作用
IF 0.3 Pub Date : 2023-06-05 DOI: 10.4274/jus.galenos.2022.2022.0049
Ç. Şekerci, Hasan Rıza Aydın, A. Livaoglu, Ertuğrul Yiğit, T. Toprak, M. Ramazanoğlu, Ahmet Özgür Güçtaş, Raziye Ergün, S. Kartal, Hüseyin Kocagül, O. Değer
ischemia-reperfusion
缺血再灌注
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引用次数: 0
Evolution of the Percutaneous Nephrolithotomy: A Holistic Investigation of Global Outputs with Bibliometric Analysis 经皮肾镜取石术的发展:用文献计量学分析对全球产出进行全面调查
IF 0.3 Pub Date : 2023-06-05 DOI: 10.4274/jus.galenos.2022.2022.0057
Engin Kölükçü, B. Parlaktaş, Şahin Kılıç, E. Demir
Objective: This bibliometric study identifies the studies, institutions and journals with the highest impact by analyzing the articles published about percutaneous nephrolithotomy (PCNL) and further to establish trend topics and to holistically summarize and interpret collaboration among countries. Materials and Methods: Studies published about PCNL between 1975-2020 were downloaded from the Web of Science (WoS) database. They were analyzed using bibliometric and statistical methods. Spearman’s correlation coefficient was used for correlation analysis. Non-linear regression analysis was used to estimate the number of publications in the coming years. Results: A total of 4170 publications were found and 1936 (46.4%) of these publications were articles. We observed that the articles on PCNL have gradually increased in an exponential trend. Top 5 countries having contributed most to the literature ranked as Turkiye (n=376), USA (n=332), China (n=323), India (n=210) and Iran (n=123). Top 3 most active institutions were ranked as Guangzhou Medical University (n=63), University of Health Sciences Turkiye, İstanbul Haseki Training and Research Hospital (n=52) and Başkent University (n=32). Conclusion: In our study, we observed that there has been an increase in the number of PCNL-related publications over the course of time. Besides, we determined that recent publications, mainly focused on the success and reliability of PCNL. In this context, there has been a steady increase in the number of studies on the use of Guy’s scoring system for preoperative selection of eligible patients and surgical approaches such as mini PCNL, prone position.
目的:本文献计量研究通过分析发表的关于经皮肾镜取石术(PCNL)的文章,确定影响最大的研究、机构和期刊,并进一步确定趋势主题,全面总结和解释各国之间的合作。材料和方法:1975-2020年间发表的关于PCNL的研究从Web of Science(WoS)数据库下载。采用文献计量学和统计学方法对它们进行了分析。采用Spearman相关系数进行相关分析。使用非线性回归分析来估计未来几年的出版物数量。结果:共发现4170篇出版物,其中1936篇(46.4%)为文章。我们观察到,关于PCNL的文章呈指数趋势逐渐增加。对文献贡献最大的前五个国家分别是土耳其(n=376)、美国(n=332)、中国(n=323)、印度(n=210)和伊朗(n=123)。排名前三的最活跃机构是广州医科大学(n=63)、土耳其卫生科学大学、伊斯坦布尔哈塞克培训研究医院(n=52)和塔什干大学(n=32)。结论:在我们的研究中,我们观察到PCNL相关出版物的数量随着时间的推移而增加。此外,我们确定,最近的出版物,主要集中在PCNL的成功和可靠性。在这种情况下,使用Guy评分系统在术前选择符合条件的患者和手术方法(如迷你PCNL、俯卧位)方面的研究数量稳步增加。
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引用次数: 0
Correlation of the Proximal Urethra Diameter in Voiding Cystourethrography with the Severity of the Disease, Vesicoureteral Reflux and the Uroflowmetry Parameters in Children with Voiding Dysfunction 儿童排尿功能障碍膀胱尿道造影中近端尿道直径与疾病严重程度、膀胱输尿管反流及尿流测量参数的相关性
IF 0.3 Pub Date : 2023-06-05 DOI: 10.4274/jus.galenos.2022.2022.0024
I. Akarken, H. Tarhan, S. Karakus, N. Cengiz, H. Şahin
was no correlation between the uroflowmetry parameters, post-voiding residual urine volume and proximal urethra diameter. Abstract Objective: Voiding dysfunction is a commonly encountered problem in children. If a patient has a history of urinary tract infection (UTI) and presents with fever, voiding cystourethrography (VCUG) is frequently used. Proximal urethra dilatation in VCUG was determined to be an indication of voiding dysfunction. Studies in literature have been the ones assessing the correlation between the presence of proximal urethra dilatation and voiding dysfunction. In our study, however, we analyzed the relationship between the proximal urethra diameter determined in VCUG of children with voiding dysfunction, the severity of the disease, the presence of reflux, and uroflowmetry parameters. Materials and Methods: Of the 522 VCUG-received patients 96 between the ages of 6-8 with voiding dysfunction concomitant with febrile UTI were evaluated. Dysfunctional voiding incontinence scoring (DVIS), uroflowmetry parameters, post-void residual measurements (PVR), proximal urethra diameter noted in VCUG, and presence of reflux in the patients were analysed. Results: The mean age was 7.2±0.66. The average proximal urethra diameter was 7.6±1.8 mm. Regarding the diameter, the patients were divided into two groups: Group 1 (7.6 mm and below) and group 2 (above 7.6 mm). DVIS was higher but vesicoureteral reflux (VUR) was lower in group 2 (p=0.017, p=0.008; respectively). For uroflowmetry parameters and PVR, no significant differences were noted. Conclusion: In the group with the high-proximal urethra diameter, DVIS was observed to be high. However, a negative correlation was determined between high-proximal urethra diameter and VUR.
尿流量测定参数、排尿后残余尿量和近端尿道直径之间没有相关性。摘要目的:排尿功能障碍是儿童常见的问题。如果患者有尿路感染史并伴有发烧,则经常使用排尿膀胱尿道造影术(VCUG)。VCUG中的近端尿道扩张被确定为排尿功能障碍的指征。文献中的研究评估了近端尿道扩张与排尿功能障碍之间的相关性。然而,在我们的研究中,我们分析了有排尿功能障碍的儿童的VCUG中确定的近端尿道直径、疾病的严重程度、反流的存在和尿流量测量参数之间的关系。材料和方法:在522名接受VCUG治疗的患者中,评估了96名年龄在6-8岁之间的排尿功能障碍伴发热性尿路感染的患者。分析功能性排尿失禁评分(DVIS)、尿流量测定参数、排尿后残余测量(PVR)、VCUG中记录的近端尿道直径以及患者是否存在反流。结果:平均年龄7.2±0.66岁。近端尿道的平均直径为7.6±1.8mm。关于直径,患者被分为两组:第一组(7.6 mm及以下)和第二组(7.6毫米以上)。第2组DVIS较高,但膀胱输尿管反流(VUR)较低(分别为p=0.017和p=0.008)。尿流量测定参数和PVR没有显著差异。结论:在尿道近端直径较大的组中,DVIS较高。然而,高近端尿道直径和VUR之间存在负相关。
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引用次数: 0
Risk Factors for Complications in Simple Nephrectomy: 17-Year Results from Single Institution 单纯性肾切除术并发症的危险因素:来自单一机构的17年结果
IF 0.3 Pub Date : 2023-06-05 DOI: 10.4274/jus.galenos.2022.2022.0038
M. Artykov, H. B. Haberal, Ö. F. Bahadır, A. Güdeloğlu, B. Akdogan, F. Aki, C. Bilen, S. Yazıcı
Objective: To determine which preoperative patient characteristics are predictive of intraoperative complications (IOC) and postoperative complications (POC) in patients undergoing nephrectomy for non-oncological diseases. Materials and Methods: Demographics, pre-operative characteristics, the surgical technique and perioperative outcomes of 295 adult patients who had underwent simple nephrectomy between 2002 and 2019 in a single reference institution were analyzed retrospectively. Univariate and multivariable statistical analyses were performed to determine the factors affecting POC (Clavien-Dindo score ≥1) and IOC. All statistical analyses were performed using the Statistical Package for the Social Sciences v. 24.0 (SPSS Inc., Chicago, IL, USA) software for Windows. Results: The mean age of the patients was 44.84±15.51 years, with a female-to-male ratio of 154/141. The statistically significant factors associated with IOC in the multivariable analysis were male gender, higher American Society of Anesthesiologists (ASA) score and urgent surgical intervention (p=0.002, p=0.001, p=0.021, respectively). In multivariable analysis, preoperative anemia, emergency surgery and open surgery were found to be statistically significant and associated with POC (p<0.001, p=0.004, and p=0.049, respectively). Conclusion: Improved surgical outcomes can be achieved through treatment adapted to individual preoperative characteristics such as ASA score, pre-operative hemoglobin level and male gender. An elective laparoscopic approach should be used whenever possible.
目的:探讨非肿瘤性疾病行肾切除术患者术前哪些特征可预测术中并发症(IOC)和术后并发症(POC)。材料与方法:回顾性分析2002年至2019年在单一参考机构行单纯肾切除术的295例成人患者的人口统计学、术前特征、手术技术和围手术期结局。通过单因素和多因素统计分析,确定影响POC (Clavien-Dindo评分≥1)和IOC的因素。所有统计分析均使用statistical Package for the Social Sciences v. 24.0 (SPSS Inc., Chicago, IL, USA) Windows软件进行。结果:患者平均年龄44.84±15.51岁,男女比例为154/141。在多变量分析中,与IOC相关的有统计学意义的因素是男性、较高的美国麻醉学会(ASA)评分和紧急手术干预(p=0.002, p=0.001, p=0.021)。在多变量分析中,术前贫血、急诊手术和开放手术与POC有统计学意义(p<0.001, p=0.004, p=0.049)。结论:针对ASA评分、术前血红蛋白水平、男性性别等个体术前特征进行治疗,可改善手术效果。只要可能,应选择腹腔镜入路。
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引用次数: 0
Is A One-Question Visual Analog Scale A Screening Tool That Can Be Used to Assess Female Sexual Dysfunction Before Implementing A Female Sexual Function Index? 在实施女性性功能指数之前,一个问题视觉模拟量表是一种可以用来评估女性性功能障碍的筛查工具吗?
IF 0.3 Pub Date : 2023-06-05 DOI: 10.4274/jus.galenos.2022.2022.0056
M. Koparal, E. C. Bulut, S. Çetin, M. Onaran, I. Sen
Objective: To validate the use of a single-question visual analog scale assessing sexual dysfunction as a screening tool before implementing the female sexual function index (FSFI). Materials and Methods: The study included 141 sexually active women over 18 years of age who were diagnosed with OAB or UI. A female sexual function-visual analog scale (FSF-VAS) was defined and developed as a one-question form in which participants were asked to mark their sexual function on a 10 cm visual analog scale. The cut-off values for the FSF-VAS in predicting FSD were determined by receiver operating characteristic curve analysis and Youden’s index. Results: A positive, moderately strong correlation was found between the FSFI score and FSF-VAS (rs=0.741). We found a cut-off value for FSF-VAS as 5.95 for in predicting both FSFI score of <25 [area under the curve (AUC) (confidence interval (CI) 95%): 0.886 (0.827-0.945)] and FSFI score of <26.55 [AUC (CI 95%): 0.893 (0.834-0.952)]. FSF-VAS value was below 5.95 in 82 of 141 (58.1%) patients who participated in the study. Conclusion: Using the FSFI for only those with a FSF-VAS score of 5.95 or lower will reduce the clinician’s Workload save time, and also spare patients from the embarrassment caused by the questions in the FSFI.
目的:验证在实施女性性功能指数(FSFI)之前,将评估性功能障碍的单问题视觉模拟量表作为筛查工具的使用。材料和方法:该研究包括141名18岁以上的性活跃女性,她们被诊断为OAB或UI。女性性功能视觉模拟量表(FSF-VAS)被定义和开发为一个问题表,参与者被要求在10厘米的视觉模拟量上标记自己的性功能。FSF-VAS预测FSD的临界值通过受试者工作特性曲线分析和Youden指数确定。结果:A阳性,FSFI评分和FSF-VAS之间存在中等强度的相关性(rs=0.741)。我们发现FSF-VAS的临界值为5.95,用于预测FSFI评分<25[曲线下面积(AUC)(置信区间(CI)95%):0.886(0.827-0.945)]和FSFI评分<26.55[AUC(CI 95%):0.993(0.834-0.952)]。141名参与本研究的患者中,有82名(58.1%)的FSF-VAS值低于5.95学习结论:仅对FSF-VAS评分为5.95或更低的患者使用FSFI将减少临床医生的工作量,节省时间,并使患者免于因FSFI中的问题而引起的尴尬。
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引用次数: 0
A Guideline-Oriented Ontological Decision Support System for Diagnosis and Treatment of Urinary Incontinence (UrInO-DSS): A System Framework 面向指南的尿失禁诊断和治疗本体论决策支持系统(UrInO-DSS):一个系统框架
IF 0.3 Pub Date : 2023-06-05 DOI: 10.4274/jus.galenos.2022.2022.0045
Fatemeh Sadeghi-Ghyassi, Shahla Damanabi, Leila R. Kalankesh, S. V. D. Velde, M. Feizi-Derakhshi, S. Hajebrahimi
Objective: To design an ontology-based clinical decision support system based on a clinical guideline for urinary incontinence. Materials and Methods: The study will be conducted in four phases: Updating the adapted clinical guideline for urinary incontinence for Iranian clinicians; Developing an ontology based on the adapted guideline; Developing a guideline-oriented ontological decision support system for urinary incontinence; and evaluating both the ontology and the decision support system. The GRADE-Adolopment methodology will be used for updating the adapted guideline. The researcher will deploy Protégé 5.5.0 ontology editor for developing the ontology. The rules will be extracted from the adapted guideline for urinary incontinence, and the rule language will be Semantic Web Rule Language. Ontology consistency will be evaluated with Pellet reasoner. The system will be evaluated and analyzed by the GUIDES checklist. Results: The results of the study will be published and disseminated in peer-reviewed journals. Conclusion: UrInO-DSS will offer a tool to support clinicians in providing personalized treatment for patients who suffer from urinary incontinence. It can also help the residents and medical students to learn how to diagnose and manage urinary incontinence in the best way. The system can be implemented as an international decision support system for the diagnosis and management of urinary incontinence.
目的:设计一个基于本体论的尿失禁临床决策支持系统。材料和方法:该研究将分四个阶段进行:更新伊朗临床医生尿失禁的适应临床指南;根据修改后的准则开发一个本体;开发一个指南导向的尿失禁本体论决策支持系统;以及评估本体和决策支持系统。GRADE发展方法将用于更新调整后的指南。研究人员将部署Protégé5.5.0本体编辑器来开发本体。规则将从尿失禁的调整指南中提取,规则语言将是语义网络规则语言。本体一致性将通过Pellet推理器进行评估。该系统将通过GUIDES检查表进行评估和分析。结果:研究结果将在同行评审期刊上发表和传播。结论:UrInO DSS将为临床医生提供一种工具,为尿失禁患者提供个性化治疗。它还可以帮助住院医师和医学生学习如何以最佳方式诊断和管理尿失禁。该系统可以作为用于尿失禁诊断和管理的国际决策支持系统来实现。
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引用次数: 0
Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study 钬激光前列腺摘除术(HoLEP)治疗需要抗凝剂/血小板的患者的安全性和有效性:回顾性研究
IF 0.3 Pub Date : 2023-06-05 DOI: 10.4274/jus.galenos.2022.2022.0062
M. Yılmaz, O. Açıkgöz, H. C. Aybal, K. Yıldız, E. Gazel, L. Tunc
in
在……里面
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引用次数: 0
期刊
Journal of Urological Surgery
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