Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367647
D. Milenkovic, J. M. Markovic, Z. Marković
Cyanidin, as one important plant pigment, was theoretically (at M05-2X/6-311+G(d, p) level of theory) investigated for its ability to scavenge potentially, highly damaging hydroxyl radical. The applied method successfully reproduces the bond dissociation enthalpy (BDE), the ionization potential (IP) and proton affinity (PA). The HAT mechanism is most favorable reaction pathway for antioxidative action of cyanidin in the gas phase. On the other hand, the SPLET mechanism is most favorable reaction pathway for antioxidative action of cyanidin in the aqueous phase. Mechanistic investigations of antioxidative action of cyanidin in reaction with the hydroxyl radical confirmed that HAT is the dominant reaction pathway in the gas phase, and that the 4' position is most reactive.
{"title":"DFT investigation of the reaction of cyanidin with hydroxyl radical","authors":"D. Milenkovic, J. M. Markovic, Z. Marković","doi":"10.1109/BIBE.2015.7367647","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367647","url":null,"abstract":"Cyanidin, as one important plant pigment, was theoretically (at M05-2X/6-311+G(d, p) level of theory) investigated for its ability to scavenge potentially, highly damaging hydroxyl radical. The applied method successfully reproduces the bond dissociation enthalpy (BDE), the ionization potential (IP) and proton affinity (PA). The HAT mechanism is most favorable reaction pathway for antioxidative action of cyanidin in the gas phase. On the other hand, the SPLET mechanism is most favorable reaction pathway for antioxidative action of cyanidin in the aqueous phase. Mechanistic investigations of antioxidative action of cyanidin in reaction with the hydroxyl radical confirmed that HAT is the dominant reaction pathway in the gas phase, and that the 4' position is most reactive.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114776919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367632
Djordje Antonijević, K. Zelic, M. Djuric
Calcium silicate cements (CSC) present numerous properties that favor its use in dentistry. The purpose of this study was to investigate how the addition of soy extract affects porosity and wettability of the CSC. Soy was added to commercially available CSC named Portland cement (Italcementi, Spa Bergamo, Italy) at 10 weight % Pure Portland cement was used as a control material. Particle cement size was determined using scanning electron microscopy (TESCAN Mira3 XMU, USA Inc). Porosity of the cement was measured using micro computed tomography (μCT) (Skyscan 1172, Bruker, Belgium) at 10 μm isotropic resolution. Wettability of the cements was tested using contact angle analyzer and Endomethasone (Saint Maur, Cedex, France). Scanning electron microscopy has shown that Portland cement is composed of spherical and rods like particles ranging in size from 1 μm to 10 μm. The μCT analysis revealed that the addition of soy leads to an increased cement's porosity. Both open and closed porosity values were higher in Portland cement with soy addition than in pure Portland cement. More than 70% of pores were in the range of 20-57 μm in both investigated groups. The addition of soy resulted in lower contact angles of Endomethasone on the cement surface, suggesting that this cement formulation possesses superior wettability. It can be deduced that soy is a promising candidate for Portland cement adhesive properties improvements.
{"title":"Novel calcium silicate based dental material with the addition of biologically active soy compound","authors":"Djordje Antonijević, K. Zelic, M. Djuric","doi":"10.1109/BIBE.2015.7367632","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367632","url":null,"abstract":"Calcium silicate cements (CSC) present numerous properties that favor its use in dentistry. The purpose of this study was to investigate how the addition of soy extract affects porosity and wettability of the CSC. Soy was added to commercially available CSC named Portland cement (Italcementi, Spa Bergamo, Italy) at 10 weight % Pure Portland cement was used as a control material. Particle cement size was determined using scanning electron microscopy (TESCAN Mira3 XMU, USA Inc). Porosity of the cement was measured using micro computed tomography (μCT) (Skyscan 1172, Bruker, Belgium) at 10 μm isotropic resolution. Wettability of the cements was tested using contact angle analyzer and Endomethasone (Saint Maur, Cedex, France). Scanning electron microscopy has shown that Portland cement is composed of spherical and rods like particles ranging in size from 1 μm to 10 μm. The μCT analysis revealed that the addition of soy leads to an increased cement's porosity. Both open and closed porosity values were higher in Portland cement with soy addition than in pure Portland cement. More than 70% of pores were in the range of 20-57 μm in both investigated groups. The addition of soy resulted in lower contact angles of Endomethasone on the cement surface, suggesting that this cement formulation possesses superior wettability. It can be deduced that soy is a promising candidate for Portland cement adhesive properties improvements.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114692642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367669
A. Cvetkovic, D. Milasinovic, N. Filipovic, D. Canovic
This paper presents computer analysis of how geometry of reconstructed gastrointestinal tract can influence outcome of Billroth II gastric resection. We performed three-dimensional computer simulation in order to predict duodenal stump blowout. For creation of initial three dimensional FE models of preoperative gastroduodenal region we used data from Multi Slice Computer Tomography (MSCT). Using the initial model we performed virtual gastric surgery. All post operational models were examined separately in order to find correlation between post operational geometry and pressure in duodenal stump. Data acquired by methodology presented in this study can be valuable to surgeons for prediction of suture dehiscence after gastric surgery.
{"title":"Role of computer analysis in prediction of surgical outcome after Billroth II gastric resection","authors":"A. Cvetkovic, D. Milasinovic, N. Filipovic, D. Canovic","doi":"10.1109/BIBE.2015.7367669","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367669","url":null,"abstract":"This paper presents computer analysis of how geometry of reconstructed gastrointestinal tract can influence outcome of Billroth II gastric resection. We performed three-dimensional computer simulation in order to predict duodenal stump blowout. For creation of initial three dimensional FE models of preoperative gastroduodenal region we used data from Multi Slice Computer Tomography (MSCT). Using the initial model we performed virtual gastric surgery. All post operational models were examined separately in order to find correlation between post operational geometry and pressure in duodenal stump. Data acquired by methodology presented in this study can be valuable to surgeons for prediction of suture dehiscence after gastric surgery.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125296991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367640
Batuhan Bardak, Mehmet Tan
Prediction of influenza outbreaks is of utmost importance for health practitioners, officers and people. After the increasing usage of internet, it became easier and more valuable to fetch and process internet search query data. There are two significant platforms that people widely use, Google and Wikipedia. In both platforms, access logs are available which means that we can see how often any query/article was searched. Google has its own web service for monitoring and forecasting influenza-illness which is called the Google Flu Trends. It provides estimates of influenza activity for some countries. The second alternative is Wikipedia access logs which provide the number of visits for the articles on Wikipedia. There are papers which work with these platforms separately. In this paper, we propose a new technique to use these two sources together to improve the prediction of influenza outbreaks. We achieved promising results for both nowcasting and forecasting with linear regression models.
{"title":"Prediction of influenza outbreaks by integrating Wikipedia article access logs and Google flu trend data","authors":"Batuhan Bardak, Mehmet Tan","doi":"10.1109/BIBE.2015.7367640","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367640","url":null,"abstract":"Prediction of influenza outbreaks is of utmost importance for health practitioners, officers and people. After the increasing usage of internet, it became easier and more valuable to fetch and process internet search query data. There are two significant platforms that people widely use, Google and Wikipedia. In both platforms, access logs are available which means that we can see how often any query/article was searched. Google has its own web service for monitoring and forecasting influenza-illness which is called the Google Flu Trends. It provides estimates of influenza activity for some countries. The second alternative is Wikipedia access logs which provide the number of visits for the articles on Wikipedia. There are papers which work with these platforms separately. In this paper, we propose a new technique to use these two sources together to improve the prediction of influenza outbreaks. We achieved promising results for both nowcasting and forecasting with linear regression models.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127025424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367659
S. Jeremic, Ana D. Amic, Z. Marković
Alizarin is anthraquinone with moderate antioxidative capacity. In this work mechanisms of antioxidative activity of alizarin with hydroperoxy and methylperoxy radicals are investigated. All calculations are carried out using B3LYP-D2 method and 6-311+G(d, p) basis set. It is affirmed based on several parameters that hydroxyl group at position 2 is predominant for antiradical activity. PCET mechanism is estimated as favorable mechanism for scavenging activity of alizarin with two selected radicals.
{"title":"Mechanisms of scavenging reactions of alizarin with hydroperoxyl and methylperoxyl radicals","authors":"S. Jeremic, Ana D. Amic, Z. Marković","doi":"10.1109/BIBE.2015.7367659","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367659","url":null,"abstract":"Alizarin is anthraquinone with moderate antioxidative capacity. In this work mechanisms of antioxidative activity of alizarin with hydroperoxy and methylperoxy radicals are investigated. All calculations are carried out using B3LYP-D2 method and 6-311+G(d, p) basis set. It is affirmed based on several parameters that hydroxyl group at position 2 is predominant for antiradical activity. PCET mechanism is estimated as favorable mechanism for scavenging activity of alizarin with two selected radicals.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"228 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128017417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367630
G. Potamias, Kleanthi Lakiotaki, Evgenia Kartsaki, A. Kanterakis, T. Katsila, G. Patrinos
We present ePGA (electronic Pharmacogenomics Assistant), a web-based system that offers two main services to the engaged pharmacogenomic biomedical communities namely, explore - a service to search and browse through established pharmacogenomic gene-drug associations, and translate - a service to infer metabolizing phenotypes from individual genotype profiles. Furthermore, we present our work on utilizing a machine-learning methodology (decision-tree induction) in order to induce generalized pharmacogenomic translation models from known haplotype-tables that are able to infer the metabolizer status of individuals from their genotype profiles. Preliminary results are highly predictive, and highlight the potential of the whole approach. The whole work falls into the rising field of Pharmacogenomic Informatics.
{"title":"Enabling pharmacogenomic services: Informatics and computational discovery aspects","authors":"G. Potamias, Kleanthi Lakiotaki, Evgenia Kartsaki, A. Kanterakis, T. Katsila, G. Patrinos","doi":"10.1109/BIBE.2015.7367630","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367630","url":null,"abstract":"We present ePGA (electronic Pharmacogenomics Assistant), a web-based system that offers two main services to the engaged pharmacogenomic biomedical communities namely, explore - a service to search and browse through established pharmacogenomic gene-drug associations, and translate - a service to infer metabolizing phenotypes from individual genotype profiles. Furthermore, we present our work on utilizing a machine-learning methodology (decision-tree induction) in order to induce generalized pharmacogenomic translation models from known haplotype-tables that are able to infer the metabolizer status of individuals from their genotype profiles. Preliminary results are highly predictive, and highlight the potential of the whole approach. The whole work falls into the rising field of Pharmacogenomic Informatics.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122764630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367663
I. Milankovic, A. Peulić, A. Ysasi, W. Wagner, A. Pabst, M. Ackermann, Jan Houdek, S. Föhst, S. Mentzer, M. Konerding, N. Filipovic, A. Tsuda
Image filtering is one of the most common and important tasks in image processing applications. In this paper, image processing using a mean filtering algorithm combined with thresholding and binarization algorithms for the 3D visualization and analysis of murine lungs is explained. These algorithms are then mapped on the Maxler's MAX2336B Dataflow Engine (DFE) to significantly increase calculation speed. Several different DFE configurations were tested and each yielded different performance characteristics. Optimal algorithm calculation speed was up to 30 fold baseline calculation speed.
{"title":"Acceleration of image filtering algorithms for 3D visualization of murine lungs using dataflow engines","authors":"I. Milankovic, A. Peulić, A. Ysasi, W. Wagner, A. Pabst, M. Ackermann, Jan Houdek, S. Föhst, S. Mentzer, M. Konerding, N. Filipovic, A. Tsuda","doi":"10.1109/BIBE.2015.7367663","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367663","url":null,"abstract":"Image filtering is one of the most common and important tasks in image processing applications. In this paper, image processing using a mean filtering algorithm combined with thresholding and binarization algorithms for the 3D visualization and analysis of murine lungs is explained. These algorithms are then mapped on the Maxler's MAX2336B Dataflow Engine (DFE) to significantly increase calculation speed. Several different DFE configurations were tested and each yielded different performance characteristics. Optimal algorithm calculation speed was up to 30 fold baseline calculation speed.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131029047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367648
Milos D. Radovic, V. Isailović, I. Šaveljić, Z. Milosevic, D. Nikolić, T. Exarchos, D. Fotiadis, O. Parodi, N. Filipovic
Atherosclerosis is a medical condition becoming the number one cause of death worldwide. For this reason, any developement that may help physicians in early diagnostic and selection of the most appropriate treatment strategy is of great importance. In this paper we describe three-dimensional computer model of plaque formation and development for human coronary artery. In order to validate proposed model we used ten specific patients from CT study belonging to one of the following groups: (1) de-novo group - patients with new formed plaques, (2) old-lesions group - patients with plaques with progression and (3) control group - patients with plaques without progression. Plaque volume progression is fitted by using two time points for baseline and follow up. Results obtained within this study indicate high potential of this model to be used in clinical practice, thus assisting physicians by providing them valuable information about future disease progression.
{"title":"Computational modeling of plaque progression in coronary arteries","authors":"Milos D. Radovic, V. Isailović, I. Šaveljić, Z. Milosevic, D. Nikolić, T. Exarchos, D. Fotiadis, O. Parodi, N. Filipovic","doi":"10.1109/BIBE.2015.7367648","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367648","url":null,"abstract":"Atherosclerosis is a medical condition becoming the number one cause of death worldwide. For this reason, any developement that may help physicians in early diagnostic and selection of the most appropriate treatment strategy is of great importance. In this paper we describe three-dimensional computer model of plaque formation and development for human coronary artery. In order to validate proposed model we used ten specific patients from CT study belonging to one of the following groups: (1) de-novo group - patients with new formed plaques, (2) old-lesions group - patients with plaques with progression and (3) control group - patients with plaques without progression. Plaque volume progression is fitted by using two time points for baseline and follow up. Results obtained within this study indicate high potential of this model to be used in clinical practice, thus assisting physicians by providing them valuable information about future disease progression.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133621887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367665
Ana D. Amic, J. M. Markovic, S. Jeremic, Ivana Gadanski, B. Lučić, D. Amic
3-Hydroxyphenylacetic acid (3-HPA) is one of the colon microbial metabolites of flavonoids produced in high concentrations (~300 μM). In this work potency of direct inactivating of selected set of free radicals by 3-HPA was computationally investigated. All calculations were carried out using M05-2X functional with 6-311++G(d, p) basis set coupled with the SMD solvation model. Thermodynamics of three free radical scavenging mechanisms were studied considering electronic properties of 3-HPA and scavenged free radicals. On the basis of obtained results it can be safety predicted that 3-HPA is able to at least in situ effectively scavenge free radicals of different nature, thus contributing to protection from diseases mediated by oxidative stress.
{"title":"Free radical scavenging potency of 3-hydroxyphenylacetic acid: A DFT study","authors":"Ana D. Amic, J. M. Markovic, S. Jeremic, Ivana Gadanski, B. Lučić, D. Amic","doi":"10.1109/BIBE.2015.7367665","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367665","url":null,"abstract":"3-Hydroxyphenylacetic acid (3-HPA) is one of the colon microbial metabolites of flavonoids produced in high concentrations (~300 μM). In this work potency of direct inactivating of selected set of free radicals by 3-HPA was computationally investigated. All calculations were carried out using M05-2X functional with 6-311++G(d, p) basis set coupled with the SMD solvation model. Thermodynamics of three free radical scavenging mechanisms were studied considering electronic properties of 3-HPA and scavenged free radicals. On the basis of obtained results it can be safety predicted that 3-HPA is able to at least in situ effectively scavenge free radicals of different nature, thus contributing to protection from diseases mediated by oxidative stress.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132319012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-11-02DOI: 10.1109/BIBE.2015.7367700
Subrata Acharya, Reza Sarraf
Drug traffickers are active and always looking for new ways to mix drugs to avoid their detection and identification. One example is black cocaine, which is a mixture of cocaine base and cocaine hydrochloride and other additional substances. It is challenging for investigators to accurately identify the test for investigative purposes without conducting an on-site evaluation. Presumptive drug test is the preliminary on-site test, conducted by a crime scene investigative officer to detect the presence of a substance by changing color with a chemical reagent. The current approach is manual and relies heavily on the expertise of the officer conducting the test and is limited by their physical ability and other environmental factors. This research aims at developing a novel web-based solution to perform automated presumptive drug tests. The reporting and attestation and reporting are also fully automated. The solution includes real-time interactions between the on-site and the off-site investigative teams. The practical application of this approach is in the field of crime scene investigation both on-site and in the off-site laboratories. The application has been evaluated successfully with two nationally recognized forensic laboratories. Furthermore, a stand-alone hardware/software co-design approach (for security and privacy reasons) is being incorporated as am automated tool in the mobile vehicles of the investigative team.
{"title":"An automated approach to conduct effective on-site presumptive drug tests","authors":"Subrata Acharya, Reza Sarraf","doi":"10.1109/BIBE.2015.7367700","DOIUrl":"https://doi.org/10.1109/BIBE.2015.7367700","url":null,"abstract":"Drug traffickers are active and always looking for new ways to mix drugs to avoid their detection and identification. One example is black cocaine, which is a mixture of cocaine base and cocaine hydrochloride and other additional substances. It is challenging for investigators to accurately identify the test for investigative purposes without conducting an on-site evaluation. Presumptive drug test is the preliminary on-site test, conducted by a crime scene investigative officer to detect the presence of a substance by changing color with a chemical reagent. The current approach is manual and relies heavily on the expertise of the officer conducting the test and is limited by their physical ability and other environmental factors. This research aims at developing a novel web-based solution to perform automated presumptive drug tests. The reporting and attestation and reporting are also fully automated. The solution includes real-time interactions between the on-site and the off-site investigative teams. The practical application of this approach is in the field of crime scene investigation both on-site and in the off-site laboratories. The application has been evaluated successfully with two nationally recognized forensic laboratories. Furthermore, a stand-alone hardware/software co-design approach (for security and privacy reasons) is being incorporated as am automated tool in the mobile vehicles of the investigative team.","PeriodicalId":422807,"journal":{"name":"2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114122347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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