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2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)最新文献

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Distinguishing Parkinson's disease from other syndromes causing tremor using automatic analysis of writing and drawing tasks 用书写和绘画任务的自动分析来区分帕金森病和其他引起震颤的综合征
A. Tolonen, L. Cluitmans, E. Smits, M. Gils, N. Maurits, R. Zietsma
An easily performed and objective test of patients fine motor skills would be valuable in the diagnosis of Parkinson's disease (PD). In this study we present a set of automatic methods for quantifying the motor symptoms of PD and show that these automatically extracted features can be used to distinguish PD from other movement disorders causing tremor, namely essential tremor (ET), functional tremor (FT) and enhanced physiological tremor (EPT). The classification accuracies (mean of sensitivity and specificity) for separating PD from the other tremor syndromes were 82.0 % for ET, 69.8 % for FT and 72.2 % for EPT.
一种简便、客观的患者精细运动技能测试对帕金森病(PD)的诊断有重要价值。在这项研究中,我们提出了一套用于量化PD运动症状的自动方法,并表明这些自动提取的特征可以用于区分PD与其他引起震颤的运动障碍,即原发性震颤(ET),功能性震颤(FT)和增强型生动性震颤(EPT)。将PD与其他震颤综合征区分开来的分类准确率(敏感性和特异性的平均值)ET为82.0%,FT为69.8%,EPT为72.2%。
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引用次数: 8
Prediction models for estimation of survival rate and relapse for breast cancer patients 估计乳腺癌患者生存率和复发率的预测模型
B. Cirkovic, A. Cvetkovic, S. Ninkovic, N. Filipovic
In this paper, we described the practical application of data mining methods for estimation of survival rate and disease relapse for breast cancer patients. A comparative study of prominent machine learning models was carried out and according to the achieved results we concluded that the classifiers obviously learn some of the concepts of breast cancer survivability and recurrence. These algorithms were successfully applied to a novel breast cancer data set of the Clinical Center of Kragujevac. The Naive Bayes classifier is selected as a model for prognosis of cancer survivability on the basis of the 5 years survival rate, while the Artificial Neural Network has achieved the best performance in prognosis of cancer recurrence. Selection of twenty attributes that are the most related to success of prognosis on survivability can give new insights into the set of prognostic factors which need to be observed by medical experts.
在本文中,我们描述了数据挖掘方法在估计乳腺癌患者生存率和疾病复发率方面的实际应用。我们对著名的机器学习模型进行了比较研究,根据取得的结果,我们得出结论,分类器显然学习了乳腺癌存活率和复发率的一些概念。这些算法成功地应用于Kragujevac临床中心的一个新的乳腺癌数据集。在5年生存率的基础上,选择朴素贝叶斯分类器作为癌症生存能力的预后模型,而人工神经网络在癌症复发预后方面取得了最好的效果。选择20个与生存能力预后最相关的属性,可以为医学专家需要观察的预后因素集提供新的见解。
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引用次数: 22
A fall detection algorithm for indoor video sequences captured by fish-eye camera 鱼眼摄像机捕捉室内视频序列的跌倒检测算法
K. Delibasis, Ilias Maglogiannis
In this paper we present an algorithm that can discriminate between standing and fallen silhouettes in video sequences acquired by a fish-eye camera, in order to detect falls in an indoor environment. The proposed algorithm exploits the model of image formation that is based on the spherical projection to derive the orientation in the image of elongated vertical structures. The algorithm does not require the camera to be calibrated. The only requirement is that the optical axis of the camera being parallel to the vertical axis. Initial results show that fall detection can be performed with high accuracy, whereas, the algorithm itself is very efficient, allowing real time implementation.
在本文中,我们提出了一种算法,可以在鱼眼摄像机获取的视频序列中区分站立和跌倒的轮廓,以检测室内环境中的跌倒。该算法利用基于球面投影的图像生成模型,推导出细长垂直结构在图像中的方位。该算法不需要对相机进行校准。唯一的要求是,相机的光轴平行于垂直轴。初步结果表明,该算法能够以较高的精度进行跌落检测,并且算法本身非常高效,可以实时实现。
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引用次数: 5
An unsupervised methodology for the detection of epileptic seizures in long-term EEG signals 一种在长期脑电图信号中检测癫痫发作的无监督方法
Kostas M. Tsiouris, S. Konitsiotis, S. Markoula, D. Koutsouris, A. Sakellarios, D. Fotiadis
An unsupervised methodology for the detection of Epileptic seizures in EEG recordings is proposed. The time-frequency content of the EEG signals is extracted using the Short Time Fourier Transform. The analysis focuses on the EEG energy distribution among the well-established delta, theta and alpha rhythms (2-13 Hz), as energy variations in these frequency bands are widely associated with seizure activity. Relying on seizure rhythmicity, the classification is performed by isolating the segments where each rhythm is more clearly and dominantly expressed over the others. For the first time, an unsupervised methodology is evaluated using more than 978 hours of EEG recordings from a public database. The results show that the proposed methodology achieves high seizure detection sensitivity with significantly reduced human intervention.
提出了一种用于脑电图记录中癫痫发作检测的无监督方法。利用短时傅里叶变换提取脑电信号的时频内容。分析的重点是确定的δ、θ和α节律(2-13 Hz)之间的脑电图能量分布,因为这些频段的能量变化与癫痫发作活动广泛相关。根据发作节律性,通过分离每个节律比其他节律表达得更清楚、更占优势的片段来进行分类。首次使用来自公共数据库的超过978小时的脑电图记录来评估无监督方法。结果表明,该方法在显著减少人为干预的情况下实现了较高的癫痫检测灵敏度。
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引用次数: 8
EMBalance data repository modeling and clinical application EMBalance数据库建模及临床应用
Amal Anwer, Marios Prasinos, D. Bamiou, Nora Macdonald, M. Pavlou, T. Exarchos, G. Spanoudakis, L. Luxon
Dizziness is a common symptom for both benign and life-threatening disorders with subtle distinguishing features. This poses a clinical challenge for physicians dealing with patients suffering from dizziness and vertigo and managing them within primary care. The objective of the EMBalance project is to present a decision support system to assist general practitioners in the diagnosis and management of vestibular disorders. In this work we review the modeling techniques integrated with clinical data to produce a multi-scale, patient-specific balance model that is incorporated in the DSS based on data mining techniques. To understand this we have outlined both technical and clinical aspects to the project. Further we discuss how we intend to test this product in a multicentred, double blind, parallel group randomized controlled trial and the impact we expect the DSS to have both clinically and technologically.
头晕是良性和危及生命的疾病的常见症状,具有微妙的特征。这对治疗头晕和眩晕患者并在初级保健中对其进行管理的医生提出了临床挑战。EMBalance计划的目标是提供一个决策支持系统,以协助全科医生诊断和管理前庭疾病。在这项工作中,我们回顾了与临床数据集成的建模技术,以产生基于数据挖掘技术的DSS中包含的多尺度,患者特定的平衡模型。为了理解这一点,我们概述了项目的技术和临床方面。我们进一步讨论了我们打算如何在多中心、双盲、平行组随机对照试验中测试该产品,以及我们期望DSS在临床和技术上产生的影响。
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引用次数: 1
Study of electron transfer mechanism of gallic acid 没食子酸电子传递机理的研究
Jelena R. Dorovic, D. Milenkovic, Z. Marković
Free radical scavenging of gallic acid was studied through electron transfer mechanism (ET) in water and pentylethanoate solutions. Examination was performed using density functional theory (DFT) and Marcus theory. Three particular free radicals were selected for analysis of mechanistic pathway of the second step of sequential proton loss electron transfer (SPLET). Based on the thermochemical and kinetic data, it is presumed which hydroxyl group of gallic acid is more suitable for reaction through mentioned antioxidant mechanism. Obtained results are in line with our previous reports.
利用电子转移机制(ET)研究了没食子酸在水和戊乙醇酸溶液中的自由基清除作用。采用密度泛函理论(DFT)和马库斯理论进行检验。选择了3种特殊的自由基,分析了顺序质子损失电子转移(SPLET)第二步的机理途径。根据热化学和动力学数据,推测没食子酸的哪个羟基更适合通过上述抗氧化机理进行反应。所得结果与我们以前的报告一致。
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引用次数: 1
Extending inner-ear anatomical concepts in the Foundational Model of Anatomy (FMA) ontology 在解剖学基础模型(FMA)本体中扩展内耳解剖概念
Yasar Khan, Muntazir Mehdi, Alokkumar Jha, Saleem Raza, André Freitas, Marggie Jones, Ratnesh Sahay
The inner ear is physically inaccessible in living humans, which leads to unique difficulties in studying its normal function and pathology as in other human organs. Recently, biosimulation model has gained a significant attention to understand the exact causative factors that give rise to impairment in human organs. However, to build a biosimulation model for human organ concepts and their topological relationships from multiple and semantically overlapping domains such as biology, anatomy, geometrical, mathematical, physical models are required. In this paper, we focus on modelling the inner-ear macro anatomical concepts and their topological relationships. We extended the Foundational Model of Anatomy (FMA) ontology to cover micro-level version of human inner-ear anatomy where connection between simulating tissues, liquids, soft tissues and connecting adjacent (e.g. hair cells, perilymph) parts studied in detail, included and implemented.
人类的内耳在物理上是不可接近的,这导致了研究其正常功能和病理的独特困难,就像研究其他人体器官一样。近年来,生物模拟模型得到了广泛的关注,以了解引起人体器官损伤的确切病因。然而,建立人体器官概念及其拓扑关系的生物仿真模型需要从多个和语义重叠的领域,如生物学,解剖学,几何,数学,物理模型。本文主要对内耳宏观解剖概念及其拓扑关系进行建模。我们扩展了解剖学基础模型(FMA)本体,以涵盖人类内耳解剖学的微观版本,其中模拟组织,液体,软组织和连接邻近(例如毛细胞,淋巴管周围)部分之间的连接进行了详细的研究,包括和实现。
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引用次数: 0
Introducing weighted approaches to study network brain dynamics from EEG epilepsy measurements: The EigenBrain algorithm 引入加权方法研究脑电图癫痫测量的网络脑动力学:特征脑算法
Nantia D. Iakovidou, Manolis Christodoulakis, E. Papathanasiou, S. Papacostas, G. Mitsis
It is fairly established that dynamic recordings of functional activity maps can naturally and efficiently be represented by functional connectivity networks. In this article we study weighted and fully-connected brain networks, created from electroencephalographic (EEG) measurements that concern patients with focal and generalized epilepsy. We introduce a totally new methodology that has never been utilized before and that investigates weighted and fully-connected networks, which includes eigen-decomposition analysis, feature extraction and quantitative comparisons among entire graph datasets. Our goal is to establish epileptic seizure detection/prediction rules, by identifying repetitive EEG activity in patients before and after each seizure onset. In the present paper we treat each brain network as a weighted and full adjacency matrix, without cutting, binarizing or ignoring any values. In this way, it is the first time that the full structure of the connectivity weighing profile is exploited. Also apart from graph theory approaches, mathematical models such as eigen-decomposition analysis are used in our research, in order to study and analyze brain networks. Finally, we present and discuss the results and conclusions of our new method, which are in line with earlier EEG epilepsy findings and demonstrate a standard EEG behavior in both the postictal and preictal period.
功能活动图的动态记录可以自然而有效地用功能连接网络表示。在本文中,我们研究加权和全连接的大脑网络,由脑电图(EEG)测量创建,涉及局灶性和全面性癫痫患者。我们介绍了一种全新的方法,以前从未使用过,并调查加权和全连接的网络,其中包括特征分解分析,特征提取和整个图数据集之间的定量比较。我们的目标是通过识别患者每次癫痫发作前后的重复脑电图活动,建立癫痫发作检测/预测规则。在本文中,我们将每个脑网络视为一个加权的和完全邻接矩阵,没有切割,二值化或忽略任何值。通过这种方式,这是第一次利用连通性称重剖面的完整结构。除了图论方法外,我们的研究还使用了特征分解分析等数学模型来研究和分析大脑网络。最后,我们提出并讨论了我们的新方法的结果和结论,这些结果和结论与早期的脑电图癫痫发现一致,并且在癫痫发作前后都表现出标准的脑电图行为。
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引用次数: 1
Security of mobile health (mHealth) systems 移动医疗系统的安全性
F. Zubaydi, Ayat Saleh, F. Aloul, A. Sagahyroon
mHealth is a growing field that enables individuals to monitor their health status and facilitates the sharing of medical records with physicians and between hospitals anytime and anywhere. Unfortunately, smartphones and mHealth applications are still vulnerable to a wide range of security threats due to their portability and weaknesses in management and design. Nevertheless, mHealth users are becoming more aware of the security and privacy issues related to their personal healthcare information. This survey discusses the security and privacy issues in current mHealth systems and their impact. We also discuss the latest threats, attacks and proposed countermeasures that could support secure sensitive mHealth systems. Finally, we conclude with a brief summary of open security problems that still need to be addressed in the mHealth field.
移动医疗是一个不断发展的领域,它使个人能够监测自己的健康状况,并促进与医生和医院之间随时随地的医疗记录共享。不幸的是,智能手机和移动健康应用程序仍然容易受到广泛的安全威胁,由于他们的便携性和弱点的管理和设计。尽管如此,移动医疗用户越来越意识到与个人医疗信息相关的安全和隐私问题。本调查讨论了当前移动医疗系统的安全和隐私问题及其影响。我们还讨论了最新的威胁,攻击和建议的对策,可以支持安全敏感的移动医疗系统。最后,我们简要总结了移动医疗领域仍需解决的开放式安全问题。
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引用次数: 50
Influence of monotonous work and body sensory vibration stimulus on physiological responses 单调工作和身体感觉振动刺激对生理反应的影响
Kento Konishi, H. Hagiwara
The objective of this study was to monitor changes in physiological indexes of alpha attenuation coefficient (AAC), high-frequency component (HF) and oxygenated hemoglobin (oxyHb) as objective parameters and Roken Arousal Scale (RAS) as a subjective parameter in experimental participants performing simple tasks related to motor skills, as necessary for safe driving. The oxyHb signal was monitored from the frontal association and somatosensory areas using near-infrared spectroscopy (NIRS), which can measure changes in brain hemodynamics during tasks noninvasively and without constraint. Experimental results showed oxyHb and AAC increased, while HF and tracking error decreased when experimental participants were exposed to body sensory vibrations. From these findings, we suggest that body sensory vibration stimuli are valid for monotonous work. In conclusion, we showed the usability of body sensory vibration stimuli for monotonous work such as UniMove, with influences on the autonomic and central nervous systems.
本研究的目的是监测实验参与者在执行与安全驾驶相关的简单运动技能任务时α衰减系数(AAC)、高频分量(HF)和氧合血红蛋白(oxyHb)作为客观参数和Roken觉醒量表(RAS)作为主观参数的生理指标的变化。使用近红外光谱(NIRS)从额叶关联区和体感区监测氧血红蛋白信号,该技术可以无创、无约束地测量任务期间脑血流动力学的变化。实验结果表明,当实验参与者暴露于身体感官振动时,氧血红蛋白和AAC增加,而HF和跟踪误差减少。从这些发现,我们认为身体感官振动刺激是有效的单调的工作。总之,我们展示了身体感觉振动刺激对单调工作(如UniMove)的可用性,以及对自主神经系统和中枢神经系统的影响。
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引用次数: 1
期刊
2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)
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