Jun Pyo Kim, Hye-ryeon Jang, Hee Jin Kim, D. Na, S. Seo
The amnestic form of mild cognitive impairment (aMCI) is understood to be a prodromal state of Alzheimer’s disease dementia. As recent studies and clinical trials have started to focus on the early detection of and intervention for Alzheimer’s disease, aMCI has become an important area of study. Due to the heterogeneous clinical course of aMCI, it is often more challenging for a clinician to predict the prognosis of aMCI patients than of those with Alzheimer’s disease dementia patients. Therefore, the ability to predict the clinical course of an aMCI patient based on the patient’s clinical data is crucial in both clinical and research settings. In the current study, we present our findings on the structural and prognostic differences between aMCI and Alzheimer’s disease dementia according to neuropsychological test results. Additionally, we introduce a neuropsychological test-based risk prediction model of the conversion to dementia.
{"title":"Neuropsychological test-based risk prediction of conversion to dementia in amnestic mild cognitive impairment patients: a personal view","authors":"Jun Pyo Kim, Hye-ryeon Jang, Hee Jin Kim, D. Na, S. Seo","doi":"10.23838/PFM.2018.00065","DOIUrl":"https://doi.org/10.23838/PFM.2018.00065","url":null,"abstract":"The amnestic form of mild cognitive impairment (aMCI) is understood to be a prodromal state of Alzheimer’s disease dementia. As recent studies and clinical trials have started to focus on the early detection of and intervention for Alzheimer’s disease, aMCI has become an important area of study. Due to the heterogeneous clinical course of aMCI, it is often more challenging for a clinician to predict the prognosis of aMCI patients than of those with Alzheimer’s disease dementia patients. Therefore, the ability to predict the clinical course of an aMCI patient based on the patient’s clinical data is crucial in both clinical and research settings. In the current study, we present our findings on the structural and prognostic differences between aMCI and Alzheimer’s disease dementia according to neuropsychological test results. Additionally, we introduce a neuropsychological test-based risk prediction model of the conversion to dementia.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68884400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prospects of deep learning for medical imaging","authors":"Jonghoon Kim, Jisu Hong, Hyunjin Park","doi":"10.23838/PFM.2018.00030","DOIUrl":"https://doi.org/10.23838/PFM.2018.00030","url":null,"abstract":"","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45222642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oncogenic gene fusions have been identified in many cancers, and many serve as druggable targets for therapy. Fibroblast growth factor receptor (FGFR) gene aberration is known to be associated with tumor progression and resistance to anticancer therapy. Here we report the first case of malignant melanoma harboring a FGFR3-TACC3 (transforming acidic coiled-coil containing protein 3) fusion, which appears to be a promising potential therapeutic target.
{"title":"FGFR3-TACC3: A novel gene fusion in malignant melanoma","authors":"J. Lee, Jeeyun Lee, S. Hong, K. Jang, Su Jin Lee","doi":"10.23838/PFM.2018.00044","DOIUrl":"https://doi.org/10.23838/PFM.2018.00044","url":null,"abstract":"Oncogenic gene fusions have been identified in many cancers, and many serve as druggable targets for therapy. Fibroblast growth factor receptor (FGFR) gene aberration is known to be associated with tumor progression and resistance to anticancer therapy. Here we report the first case of malignant melanoma harboring a FGFR3-TACC3 (transforming acidic coiled-coil containing protein 3) fusion, which appears to be a promising potential therapeutic target.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47828105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell-based therapy is a promising approach for treating acute stroke patients as well as those with fixed neurological deficits, and therefore, the number of stem cell trials conducted on stroke patients is increasing. However, more studies are needed to conclude the efficacy of stem cell therapy because while several studies showed a beneficial effect, there was significant bias in subsequent studies. Meanwhile, there have been recent advances in stroke treatment such as endovascular therapy for acute ischemic stroke and catheter-based closing of a patent foramen ovale in cryptogenic stroke. Clinical trials of the latter two interventional therapies have very similar histories of consistent success after repeated failures. In this review, the factors related to the success of these interventional therapies are discussed and applied to stem cell therapy for stroke patients. Through continued efforts, there is hope for success in stem cell therapy for stroke patients.
{"title":"Stem cell therapy for stroke: lessons learned from recent successful randomized trials of\u0000interventional therapy for stroke","authors":"O. Bang","doi":"10.23838/PFM.2018.00058","DOIUrl":"https://doi.org/10.23838/PFM.2018.00058","url":null,"abstract":"Cell-based therapy is a promising approach for treating acute stroke patients as well as those with fixed neurological deficits, and therefore, the number of stem cell trials conducted on stroke patients is increasing. However, more studies are needed to conclude the efficacy of stem cell therapy because while several studies showed a beneficial effect, there was significant bias in subsequent studies. Meanwhile, there have been recent advances in stroke treatment such as endovascular therapy for acute ischemic stroke and catheter-based closing of a patent foramen ovale in cryptogenic stroke. Clinical trials of the latter two interventional therapies have very similar histories of consistent success after repeated failures. In this review, the factors related to the success of these interventional therapies are discussed and applied to stem cell therapy for stroke patients. Through continued efforts, there is hope for success in stem cell therapy for stroke patients.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42259393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pulmonary sclerosing pneumocytoma is a rare, benign lung tumor commonly seen in women in the fifth decade of life. It usually manifests as a solitary, well-circumscribed juxtapleural nodule or mass with intense, homogeneous enhancement on computed tomography scans. Herein, we report a case of sclerosing pneumocytoma presenting as main nodule with satellite nodules, mimicking tuberculosis.
{"title":"Pulmonary sclerosing pneumocytoma with multiple satellite nodules mimicking tuberculosis","authors":"Min A Lee, Tae Jung Kim, Joungho Han, K. Lee","doi":"10.23838/PFM.2018.00051","DOIUrl":"https://doi.org/10.23838/PFM.2018.00051","url":null,"abstract":"Pulmonary sclerosing pneumocytoma is a rare, benign lung tumor commonly seen in women in the fifth decade of life. It usually manifests as a solitary, well-circumscribed juxtapleural nodule or mass with intense, homogeneous enhancement on computed tomography scans. Herein, we report a case of sclerosing pneumocytoma presenting as main nodule with satellite nodules, mimicking tuberculosis.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43735091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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