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Evidence-Based Medicine or Patient-Directed Treatment? 循证医学还是患者导向治疗?
Pub Date : 2019-09-01 DOI: 10.25179/tjem.2019-71177
K. Yderstræde, S. Bonnema
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引用次数: 0
Importance of Magnetic Resonance Imaging in Pituitary Stalk Interruption Syndrome 磁共振成像在垂体柄中断综合征中的重要性
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2018-61562
E. Gurkan, Y. Anık, Mine Filiz Çömlekçioğlu, O. Akyay, B. Çetinarslan
Department of Endocrinology and Metabolism, Mustafa Kemal University of Faculty of Medicine, Hatay, Turkey *Department of Radiology, Kocaeli University of Faculty of Medicine, Kocaeli, Turkey **Department of Pediatric Endocrinology, Medical Faculty of Kocaeli University, Kocaeli, Turkey ***Department of Endocrinology and Metabolism, M. Akif Inan of Faculty of Medicine Training and Research Hospital, Şanlıurfa, Turkey ****Department of Endocrinology and Metabolism, Kocaeli University of Faculty of Medicine, Kocaeli, Turkey Original Article Turk J Endocrinol Metab
土耳其哈塔伊穆斯塔法·凯末尔大学医学院内分泌与代谢科*土耳其科恰埃利大学医学院放射科**土耳其科恰埃利科恰埃利医学院儿科内分泌科**土耳其科恰埃利培训与研究医院内分泌与代谢科Şanlıurfa土耳其****内分泌与代谢科科恰埃利大学医学院,科恰埃利,土耳其
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引用次数: 0
Ekzokrin Pankreas Yetmezliği: Diyabetin Göz Ardı Edilen Bir Komplikasyonu mudur?
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2019-71117
Mustafa Altay
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引用次数: 0
Disease Activity is Associated with Depression and Anxiety in Cushing's Syndrome During COVID-19 Pandemic COVID-19大流行期间库欣综合征患者的疾病活动与抑郁和焦虑相关
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2021-82526
H. Pişkinpaşa, S. Turgut, Özlem Karaarslan, E. Bozkur, A. Esen, N. Pamuk, İ. Cakir, M. Mert, S. Çiftçi Doğanşen
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引用次数: 0
Correlates of Recurrence-Free Survival in Papillary Thyroid Carcinoma: A Cohort Study in an Iranian Population 甲状腺乳头状癌无复发生存的相关因素:伊朗人群的队列研究
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2021-82672
Bahareh Shateri Amiri, M. Hemmatabadi, S. Rabizadeh, Hamideh Hasannejad, A. Esteghamati, M. Nakhjavani
Objective: Papillary thyroid carcinoma (PTC) is considered differentiated and has a good prognosis; however, the patient's survival differs from clinicopathological risk factors. This study is meant to assess factors predicting recurrence-free survival. Material and Methods: In this longitudinal study, we examined a cohort of 208 patients with PTC from 1977 to 2020. Patients who underwent total thyroidectomy entered the study. Thyroidectomy was considered the primary event, while the endpoint of the study was recurrence-free survival. A multivariate and univariate Cox regression test was used to identify independent risk factors in recurrence-free survival. Results: The 5-year recurrence-free survival was 90.5% [95% confidence interval (CI): 84.7-96.46]. Multiple regression models displayed that gender [p=0.01 hazard ratio (HR): 2.21, 95% CI 1.20-4.05] and tumor size (p=0.02 HR: 1.93, 95% CI 1.10-3.38) were the most significant factors influencing recurrence-free survival. The median recurrence-free survival among our patients was 12 years. According to the Kaplan-Meier tests, 5 and 10-year recurrencefree survival was 90.5% (95% CI: 84.7-96.46) and 51.7% (95% CI: 41.26-62.26), respectively. The median recurrence-free survival of the tumor was 24 years in tumors <1 cm and ten years in tumors in the range of 1-3.99 cm and ≥4 cm (p=0.02). Conclusion: The 5-year recurrence-free survival was 90.5% longer in women and those with tumors less than 1 cm. Tumor size and gender may affect the risk of recurrence/persistent disease.
目的:甲状腺乳头状癌(PTC)被认为是分化的,预后良好;然而,患者的生存不同于临床病理危险因素。本研究旨在评估预测无复发生存期的因素。材料和方法:在这项纵向研究中,我们检查了1977年至2020年期间208例PTC患者的队列。接受甲状腺全切除术的患者进入研究。甲状腺切除术被认为是主要事件,而研究的终点是无复发生存期。采用多因素和单因素Cox回归检验确定无复发生存的独立危险因素。结果:5年无复发生存率为90.5%[95%可信区间(CI): 84.7-96.46]。多元回归模型显示,性别[p=0.01危险比(HR): 2.21, 95% CI 1.20 ~ 4.05]和肿瘤大小(p=0.02 HR: 1.93, 95% CI 1.10 ~ 3.38)是影响无复发生存的最显著因素。我们的患者中位无复发生存期为12年。根据Kaplan-Meier检验,5年和10年无复发生存率分别为90.5% (95% CI: 84.7-96.46)和51.7% (95% CI: 41.26-62.26)。肿瘤<1 cm的中位无复发生存期为24年,1-3.99 cm和≥4 cm的中位无复发生存期为10年(p=0.02)。结论:女性及肿瘤小于1 cm者5年无复发生存期延长90.5%。肿瘤大小和性别可能影响复发/持续性疾病的风险。
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引用次数: 1
Evaluation of the Relationship Between Jaw Involvement and Systemic Involvement in Type 1 Gaucher Disease 1型戈谢病颌骨受累与全身受累关系的评价
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2021-82213
Firdevs Aşantoğrol, H. Dursun, E. M. Canger, F. Bayram
Objective: This study aimed to assess osteopenia and trabeculation loss in the jaws of patients diagnosed with Type 1 Gaucher disease (GD) using cone-beam computed tomography (CBCT) images, unlike the routine computed tomography, and evaluate the correlation of jaw involvement with systemic involvement of GD. Material and Methods: A total of 16 patients, five males and 11 females, who were followed up with the diagnosis of Type I GD were included in the study group. Moreover, 16 age-and sex-matched healthy individuals in the study group were included in the control group. The records of patients at the time of diagnosis were obtained, and the presence of generalized osteopenia of jaws was investigated in the CBCT images, which were taken for maxillofacial examinations. Results: In comparison, the incidence of generalized osteopenia of jaws was significantly higher in the study group than in the control group (p=0.001). In addition, six out of seven patients with hepatomegaly and seven of 11 splenomegaly/operated patients had generalized osteopenia. However, no statistically significant relationship was observed between the presence of hepatomegaly/splenomegaly and generalized osteopenia. In addition, no significant difference was observed among bone involvement, hematological parameters, and jaw involvement in patients with Type 1 GD (p>0.05). Conclusion: Trabecular bone loss and osteopenia increased in Type 1 GD; therefore, patients with Type 1 GD should be evaluated periodically in terms of jaw involvement along with other parameters.
目的:本研究旨在通过锥形束计算机断层扫描(CBCT)评估诊断为1型戈谢病(GD)患者颌骨骨质减少和小梁丢失,与常规计算机断层扫描不同,并评估颌骨受累与GD全身受累的相关性。材料与方法:研究对象为经诊断为1型GD随访的16例患者,男5例,女11例。此外,研究组中16名年龄和性别匹配的健康个体被纳入对照组。获得患者诊断时的记录,并在颌面部检查时拍摄的CBCT图像中调查颌骨广泛性骨质减少的存在。结果:与对照组相比,研究组颌骨广泛性骨质减少的发生率明显高于对照组(p=0.001)。此外,7例肝肿大患者中有6例,11例脾肿大/手术患者中有7例出现广泛性骨质减少。然而,肝肿大/脾肿大与广泛性骨质减少之间没有统计学意义的关系。1型GD患者的骨受累、血液学指标、颌骨受累差异无统计学意义(p>0.05)。结论:1型GD患者骨小梁丢失和骨质减少增加;因此,1型GD患者应定期评估颌骨受累情况及其他参数。
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引用次数: 0
Toxic Multi Goiter and Struma ovarii Coexistence: Report of a Rare Case 中毒性多发性甲状腺肿与卵巢甲状腺肿共存:罕见病例报告
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2021-81052
Sahar Karimpour Reyhan, Roya Shirzad, N. Shirzad, Farid Azmoudeh-Ardalan, M. Hemmatabadi
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引用次数: 0
Effect of Gibberellic Acid on the Levels of Tumor Necrosis Factor-α, Interleukin-4 and Interleukin-10 in Rats 赤霉素酸对大鼠肿瘤坏死因子-α、白细胞介素-4、白细胞介素-10水平的影响
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2019-65107
H. A. Öztürk, N. Erin, M. Balci
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引用次数: 3
An Asymptomatic Primary Hyperparathyroidism Case Due to a Mediastinum Localized Ectopic Giant Parathyroid Adenoma 纵隔局部异位巨大甲状旁腺瘤致原发性无症状甲状旁腺功能亢进1例
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2019-70987
S. Hepşen, I. Unsal, B. Uçan, Derya Çayır, P. Akhanlı, E. Sencar, Kubilay İnan, D. Sakız, E. Çakal
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引用次数: 0
Congenital Adrenal Hyperplasia as a Cause of Secondary Hypertension in Adults: Three Cases 先天性肾上腺增生是成人继发性高血压的病因:3例
Pub Date : 1900-01-01 DOI: 10.25179/tjem.2019-65085
I. Anaforoglu, E. Algun, K. Ersoy
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引用次数: 0
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The Turkish Journal of Endocrinology and Metabolism
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