Pub Date : 1900-01-01DOI: 10.25179/tjem.2018-63374
B. Bolayır, Damla Okay, M. Akturk, M. Akın, A. Poyraz, A. Sel, B. Yilmaz, A. Altinova, F. Törüner, N. Çakır
{"title":"Adrenocorticotropic Hormon-Secreting Pheochromocytoma: A Rare Cause of Cushing’s Syndrome","authors":"B. Bolayır, Damla Okay, M. Akturk, M. Akın, A. Poyraz, A. Sel, B. Yilmaz, A. Altinova, F. Törüner, N. Çakır","doi":"10.25179/tjem.2018-63374","DOIUrl":"https://doi.org/10.25179/tjem.2018-63374","url":null,"abstract":"","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115872216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2021-83764
S. Kisioglu, V. Bayraktar, Damla Tüfekçi, Yasemin EMUR GÜNAY, M. Kocak, I. Nuhoglu, H. Coskun, S. Karakullukçu, H. Önder Ersöz
{"title":"Efficacy and Side Effect Profile of Empagliflozin and Dapagliflozin in Combination Therapy: A Real-World Experience","authors":"S. Kisioglu, V. Bayraktar, Damla Tüfekçi, Yasemin EMUR GÜNAY, M. Kocak, I. Nuhoglu, H. Coskun, S. Karakullukçu, H. Önder Ersöz","doi":"10.25179/tjem.2021-83764","DOIUrl":"https://doi.org/10.25179/tjem.2021-83764","url":null,"abstract":"","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120959710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2021-84943
Burak Özbaş, Ö. Canöz, Z. Güven, İzzet Ökçesiz, H. Dursun, A. Selçuklu, H. Yilmaz, Z. Karaca, K. Ünlühızarcı
Division of Endocrinology and Metabolism, Erciyes University Faculty of Medicine, Kayseri, TURKIYE *Department of Pathology, Erciyes University Faculty of Medicine, Kayseri, TURKIYE **Division of Hematology, Erciyes University Faculty of Medicine, Kayseri, TURKIYE ***Department of Radiology, Erciyes University Faculty of Medicine, Kayseri, TURKIYE ****Department of Neurosurgery, Erciyes University Faculty of Medicine, Kayseri, TURKIYE *****Department of Internal Medicine, Erciyes University Faculty of Medicine, Kayseri, TURKIYE Case Report Turk J Endocrinol Metab. 2022;26:55-60
{"title":"Pituitary Gland as a Rare Primary Localization of Lymphoma","authors":"Burak Özbaş, Ö. Canöz, Z. Güven, İzzet Ökçesiz, H. Dursun, A. Selçuklu, H. Yilmaz, Z. Karaca, K. Ünlühızarcı","doi":"10.25179/tjem.2021-84943","DOIUrl":"https://doi.org/10.25179/tjem.2021-84943","url":null,"abstract":"Division of Endocrinology and Metabolism, Erciyes University Faculty of Medicine, Kayseri, TURKIYE *Department of Pathology, Erciyes University Faculty of Medicine, Kayseri, TURKIYE **Division of Hematology, Erciyes University Faculty of Medicine, Kayseri, TURKIYE ***Department of Radiology, Erciyes University Faculty of Medicine, Kayseri, TURKIYE ****Department of Neurosurgery, Erciyes University Faculty of Medicine, Kayseri, TURKIYE *****Department of Internal Medicine, Erciyes University Faculty of Medicine, Kayseri, TURKIYE Case Report Turk J Endocrinol Metab. 2022;26:55-60","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120966696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2019-70735
Ö. Topaloğlu, B. Evren, S. Yoloğlu, Ş. Şahin, I. Sahin
{"title":"The Frequency of Vitamin D Deficiency in Obese Patients on Bariatric Surgery Wait List: Is there any Association with Co-existence of Prediabetes or Diabetes?","authors":"Ö. Topaloğlu, B. Evren, S. Yoloğlu, Ş. Şahin, I. Sahin","doi":"10.25179/tjem.2019-70735","DOIUrl":"https://doi.org/10.25179/tjem.2019-70735","url":null,"abstract":"","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124786117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2019-66735
M. Şahin, A. Oguz, D. Tuzun, C. Ülgen, Semiha Çalkaya, O. Gungor, F. Yazar, K. Gul
{"title":"Therapeutic Plasmapheresis in Amiodarone-Induced Thyrotoxicosis Resistant to Medical Therapy","authors":"M. Şahin, A. Oguz, D. Tuzun, C. Ülgen, Semiha Çalkaya, O. Gungor, F. Yazar, K. Gul","doi":"10.25179/tjem.2019-66735","DOIUrl":"https://doi.org/10.25179/tjem.2019-66735","url":null,"abstract":"","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128454630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2019-71318
H. Düğer, M. Çalapkulu, B. Uçan, E. Çakal, M. Özbek, D. Yılmazer, K. Doğan, M. Sencar
{"title":"Coexistence of Primary Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid and Papillary Thyroid Microcarcinoma in a Background of Hashimoto’s Thyroiditis","authors":"H. Düğer, M. Çalapkulu, B. Uçan, E. Çakal, M. Özbek, D. Yılmazer, K. Doğan, M. Sencar","doi":"10.25179/tjem.2019-71318","DOIUrl":"https://doi.org/10.25179/tjem.2019-71318","url":null,"abstract":"","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126353976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2021-83912
S. Saha, Sujata Saha
Introduction Type 1 diabetes mellitus (T1DM) is primarily a childhood-onset hyperglycemic autoimmune condition resulting from the death of pancreatic beta cells. It’s triggered by genetic predisposition (human leukocyte antigen alleles such as DQ and DR) or viruses or environmental toxins, and other unknown factors (1,2). These patients are at risk of hyperglycemic complications such as diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic ketoacidosis, and As the efficacy and safety of empagliflozin remain poorly studied in Type 1 diabetes mellitus (T1DM) patients, this narrative-systematic review aims to review it. The randomized controlled trials studying the above across different empagliflozin dosages and placebo got searched in PubMed, Embase, and Scopus databases. The database searches yielded 5 eligible trials reporting data of about 1,870 T1DM patients from 45 countries. The empagliflozin dosages tested in these trials were 2.5, 10, and 25 mg. The trials collectively showed a low or unclear risk of bias (Cochrane tool used). The existing double-blinded randomized controlled trials mainly suggest a dose-dependent decrease in glycated hemoglobin, body weight, and total weekly insulin requirement in empagliflozin-treated T1DM patients. Ketoacidosis, urinary tract infection, and study discontinuation due to side effects were rare adverse effects of empagliflozin. Genital infection predominantly occurred among recipients of 10 or 25 mg empagliflozin.
{"title":"Efficacy and Safety of Empagliflozin in Type 1 Diabetes Mellitus Patients: A Systematic Review","authors":"S. Saha, Sujata Saha","doi":"10.25179/tjem.2021-83912","DOIUrl":"https://doi.org/10.25179/tjem.2021-83912","url":null,"abstract":"Introduction Type 1 diabetes mellitus (T1DM) is primarily a childhood-onset hyperglycemic autoimmune condition resulting from the death of pancreatic beta cells. It’s triggered by genetic predisposition (human leukocyte antigen alleles such as DQ and DR) or viruses or environmental toxins, and other unknown factors (1,2). These patients are at risk of hyperglycemic complications such as diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic ketoacidosis, and As the efficacy and safety of empagliflozin remain poorly studied in Type 1 diabetes mellitus (T1DM) patients, this narrative-systematic review aims to review it. The randomized controlled trials studying the above across different empagliflozin dosages and placebo got searched in PubMed, Embase, and Scopus databases. The database searches yielded 5 eligible trials reporting data of about 1,870 T1DM patients from 45 countries. The empagliflozin dosages tested in these trials were 2.5, 10, and 25 mg. The trials collectively showed a low or unclear risk of bias (Cochrane tool used). The existing double-blinded randomized controlled trials mainly suggest a dose-dependent decrease in glycated hemoglobin, body weight, and total weekly insulin requirement in empagliflozin-treated T1DM patients. Ketoacidosis, urinary tract infection, and study discontinuation due to side effects were rare adverse effects of empagliflozin. Genital infection predominantly occurred among recipients of 10 or 25 mg empagliflozin.","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125320490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2021-84279
Mustafa Ünübol, Zehra Erdemir, Gokhan Colak, M. Ünsal, Engin Güney
Subacute thyroiditis (SAT) is granulomatous thyroiditis of the thyroid gland that usually occurs after a viral infection. Coronavirus disease-2019 (COVID-19) infection has led to a pandemic that has affected the whole world since late 2019. The virus has been reported to cause different extrapulmonary clinical symptoms. Few cases in the literature have reported SAT after COVID-19 viral infection. In this article, 2 cases were diagnosed, where SAT was presented after COVID-19 infection. Using these cases, we aimed to emphasize that patients who present with pain and tenderness in the anterior neck region after COVID-19 infection may develop SAT, whose diagnosis can be missed. Subakut tiroidit (SAT), genellikle bir viral enfeksiyondan sonra ortaya çıkan tiroid bezinin granülomatöz bir tiroiditidir. Koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonu, 2019 yılının sonundan beri tüm dünyayı etkileyen bir pandemiye yol açmıştır. Ekstrapulmoner birçok farklı klinik tabloya yol açtığı bildirilmiştir. COVID-19 viral enfeksiyonu sonrasında SAT bildirilen olgular literatürde az sayıdadır. Bu yazıda, COVID-19 enfeksiyonu sonrası SAT tanısı olan 2 olgu sunuldu. Bu olgular ile birlikte COVID-19 enfeksiyonu sonrası özellikle ön boyun bölgesinde ağrı ve hassasiyet gelişen olgularda atlanabilen bir tanı olarak SAT gelişebileceğini vurgulamak istemekteyiz.
亚急性甲状腺炎(SAT)是甲状腺肉芽肿性甲状腺炎,通常发生在病毒感染后。自2019年底以来,冠状病毒病-2019 (COVID-19)感染导致了一场影响全球的大流行。据报道,该病毒可引起不同的肺外临床症状。文献中很少有病例报道COVID-19病毒感染后出现SAT。在本文中,2例确诊病例在COVID-19感染后出现SAT。通过这些病例,我们旨在强调COVID-19感染后颈部前区出现疼痛和压痛的患者可能会发展为SAT,其诊断可能会被遗漏。Subakut tiroidit (SAT),类鸟病毒enfeksiyondan sonra ortaya çıkan类鸟嘌呤granülomatöz类鸟嘌呤。koronavir s hastalığı-2019[冠状病毒病-2019 (COVID-19)] enfeksiyonu, 2019 yılının sonundan beri t m dnyayyi etkileyen b流行病]açmıştır。Ekstrapulmoner birok farklikklinik tabloya yol açtığı bildirilmitir。COVID-19病毒enfeksiyonu sonrasında SAT bildiilen分子文献 sayıdadır。但是yazıda, COVID-19 enfeksiyonu sonrasyi SAT tanısı olan 2 olgu sunuldu。但是,像COVID-19一样的流感病毒enfeksiyonu sonrasyi özellikle ön boyun bölgesinde ağrı ve hassasiyet gelien olgularda atlanabilen bir tanir olarak SAT gelişebileceğini vurgulamak istemekteyz。
{"title":"Subacute Thyroiditis Associated with COVID-19 Infection: Two Case Reports","authors":"Mustafa Ünübol, Zehra Erdemir, Gokhan Colak, M. Ünsal, Engin Güney","doi":"10.25179/tjem.2021-84279","DOIUrl":"https://doi.org/10.25179/tjem.2021-84279","url":null,"abstract":"Subacute thyroiditis (SAT) is granulomatous thyroiditis of the thyroid gland that usually occurs after a viral infection. Coronavirus disease-2019 (COVID-19) infection has led to a pandemic that has affected the whole world since late 2019. The virus has been reported to cause different extrapulmonary clinical symptoms. Few cases in the literature have reported SAT after COVID-19 viral infection. In this article, 2 cases were diagnosed, where SAT was presented after COVID-19 infection. Using these cases, we aimed to emphasize that patients who present with pain and tenderness in the anterior neck region after COVID-19 infection may develop SAT, whose diagnosis can be missed. Subakut tiroidit (SAT), genellikle bir viral enfeksiyondan sonra ortaya çıkan tiroid bezinin granülomatöz bir tiroiditidir. Koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonu, 2019 yılının sonundan beri tüm dünyayı etkileyen bir pandemiye yol açmıştır. Ekstrapulmoner birçok farklı klinik tabloya yol açtığı bildirilmiştir. COVID-19 viral enfeksiyonu sonrasında SAT bildirilen olgular literatürde az sayıdadır. Bu yazıda, COVID-19 enfeksiyonu sonrası SAT tanısı olan 2 olgu sunuldu. Bu olgular ile birlikte COVID-19 enfeksiyonu sonrası özellikle ön boyun bölgesinde ağrı ve hassasiyet gelişen olgularda atlanabilen bir tanı olarak SAT gelişebileceğini vurgulamak istemekteyiz.","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114902589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2020-75230
Suleyman Emre Kocyigit, M. Şahin, Y. Houshyar, F. Günay, D. Çorapçıoğlu
{"title":"Effects of Isotretinoin Treatment on Levels of Hormones Involved in the Etiopathogenesis of Acne","authors":"Suleyman Emre Kocyigit, M. Şahin, Y. Houshyar, F. Günay, D. Çorapçıoğlu","doi":"10.25179/tjem.2020-75230","DOIUrl":"https://doi.org/10.25179/tjem.2020-75230","url":null,"abstract":"","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121854694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.25179/tjem.2021-84450
Havva Sezer, D. Yazıcı
Introduction Therapeutic options for obesity have trended toward bariatric surgeries in recent decades. Bariatric surgery involves different procedures that can be restrictive, malabsorptive, or a combination of both. Malabsorptive procedures lead to weight loss by intestinal segment bypass that reduces food absorption. Restrictive procedures lead to weight loss by restricting food intake (1). Restrictive procedures include laparoscopic sleeve gastrectomy (LSG), laparoscopic adjustable gastric banding (LAGB), and vertical band gastroplasty. Malabsorptive procedures inBariatric surgery is the most effective therapeutic option for long-term weight loss among patients with morbid obesity. Nutrition after bariatric surgery is a very specialized condition. The most severe complications that can develop after bariatric surgery are nutritional deficiencies and the diseases related to them, such as anemia and osteoporosis. Screening associated with nutritional deficiencies should be performed preoperatively to optimize the postoperative outcomes and the nutritional status of patients. Bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion with duodenal switch (BPD-DS) reduce nutrient absorption. Moreover, bariatric surgery can exacerbate preexisting nutritional deficiencies. Patients who have undergone bariatric surgery should be followed up for common micronutrient deficiencies and protein-calorie malnutrition. There are gaps in the postoperative follow-up of these patients. This review aimed to focus on the postoperative nutritional strategies and nutritional complications in patients who have undergone bariatric surgery.
{"title":"Postoperative Nutrition and Nutritional Complications in Patients with Bariatric Surgery: An Update","authors":"Havva Sezer, D. Yazıcı","doi":"10.25179/tjem.2021-84450","DOIUrl":"https://doi.org/10.25179/tjem.2021-84450","url":null,"abstract":"Introduction Therapeutic options for obesity have trended toward bariatric surgeries in recent decades. Bariatric surgery involves different procedures that can be restrictive, malabsorptive, or a combination of both. Malabsorptive procedures lead to weight loss by intestinal segment bypass that reduces food absorption. Restrictive procedures lead to weight loss by restricting food intake (1). Restrictive procedures include laparoscopic sleeve gastrectomy (LSG), laparoscopic adjustable gastric banding (LAGB), and vertical band gastroplasty. Malabsorptive procedures inBariatric surgery is the most effective therapeutic option for long-term weight loss among patients with morbid obesity. Nutrition after bariatric surgery is a very specialized condition. The most severe complications that can develop after bariatric surgery are nutritional deficiencies and the diseases related to them, such as anemia and osteoporosis. Screening associated with nutritional deficiencies should be performed preoperatively to optimize the postoperative outcomes and the nutritional status of patients. Bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion with duodenal switch (BPD-DS) reduce nutrient absorption. Moreover, bariatric surgery can exacerbate preexisting nutritional deficiencies. Patients who have undergone bariatric surgery should be followed up for common micronutrient deficiencies and protein-calorie malnutrition. There are gaps in the postoperative follow-up of these patients. This review aimed to focus on the postoperative nutritional strategies and nutritional complications in patients who have undergone bariatric surgery.","PeriodicalId":425605,"journal":{"name":"The Turkish Journal of Endocrinology and Metabolism","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134405461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}