Pub Date : 2022-11-22DOI: 10.4274/imj.galenos.2022.83357
Y. Karagöz, H. Bulut, Özdeş Mahmutoğlu, D. Aksoy, A. Mahmutoğlu
{"title":"Contribution of Apparent Diffusion Coefficient Histogram Analysis Findings in Differential Diagnosis of Parotid Gland Masses","authors":"Y. Karagöz, H. Bulut, Özdeş Mahmutoğlu, D. Aksoy, A. Mahmutoğlu","doi":"10.4274/imj.galenos.2022.83357","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.83357","url":null,"abstract":"","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46811668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.54077
A. Aykaç, Hüseyin Şah, A. Kükner, S. Sayıner, A. Sehirli
hepatorenal damage was reversed with CTS treatment in the renal and hepatic tissues (p<0.05). Overall, CIS-induced increases in apoptotic parameters, Bcl-2/Bax ratio and caspase-3 expression, were reversed by CTS treatment (p<0.05). Conclusion: It was determined that CTS, a biopolymer, may have a protective effect by preventing hepatorenal damage caused by CIS. ABSTRACT
{"title":"Effects of Chitosan on Cisplatin-Induced Hepatorenal Toxicity in an Animal Model","authors":"A. Aykaç, Hüseyin Şah, A. Kükner, S. Sayıner, A. Sehirli","doi":"10.4274/imj.galenos.2022.54077","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.54077","url":null,"abstract":"hepatorenal damage was reversed with CTS treatment in the renal and hepatic tissues (p<0.05). Overall, CIS-induced increases in apoptotic parameters, Bcl-2/Bax ratio and caspase-3 expression, were reversed by CTS treatment (p<0.05). Conclusion: It was determined that CTS, a biopolymer, may have a protective effect by preventing hepatorenal damage caused by CIS. ABSTRACT","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45998391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.62362
Nihal Seden Boyoğlu, Ö. Yiğit, Okan Övünç, S. Bilici, A. V. Sünter
Introduction: Fine-needle aspiration cytology is useful for the diagnosis and management of thyroid nodules. However, false negatives for malignancy may occur and affect treatment success. In this study, we investigated carcinoma size itself as another possible reason for false-negative results. Methods: We retrospectively reviewed patient charts who had undergone total thyroidectomy and complementary thyroidectomy. A total of 613 cases were investigated. Patients who had a final histopathological diagnosis of thyroid carcinoma were included, and 138 cases were eligible for the study. Patients were categorized into three groups according to their fine-needle aspiration biopsy reports: Benign cytology and atypical cells of undetermined significance (group 1), cytology suspicious for a follicular/Hurthle cell neoplasm (group 2), and suspicious or positive for malignancy (group 3). Results: Group 1 consisted of 55 patients with a mean tumor/nodule size ratio of 0.5236. Group 2 consisted of 21 patients with a mean tumor/nodule size ratio of 0.76. Group 3 consisted of 62 patients with a mean tumor/nodule size ratio of 0.848. There were no differences between the groups in terms of nodule size measured by ultrasonography (p=0.209), but the diameter of the carcinoma focus within the nodule was significantly smaller in false-negative cases (p<0.001). There were no statistically significant differences between the groups in terms of multicentricity (p=0.197). Conclusion: The size of malignant tumors may be more important than nodule size in explaining false negativity. ABSTRACT
{"title":"Tumor/Nodule Size Ratio: A Possible Reason for False-Negative Thyroid Cytology","authors":"Nihal Seden Boyoğlu, Ö. Yiğit, Okan Övünç, S. Bilici, A. V. Sünter","doi":"10.4274/imj.galenos.2022.62362","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.62362","url":null,"abstract":"Introduction: Fine-needle aspiration cytology is useful for the diagnosis and management of thyroid nodules. However, false negatives for malignancy may occur and affect treatment success. In this study, we investigated carcinoma size itself as another possible reason for false-negative results. Methods: We retrospectively reviewed patient charts who had undergone total thyroidectomy and complementary thyroidectomy. A total of 613 cases were investigated. Patients who had a final histopathological diagnosis of thyroid carcinoma were included, and 138 cases were eligible for the study. Patients were categorized into three groups according to their fine-needle aspiration biopsy reports: Benign cytology and atypical cells of undetermined significance (group 1), cytology suspicious for a follicular/Hurthle cell neoplasm (group 2), and suspicious or positive for malignancy (group 3). Results: Group 1 consisted of 55 patients with a mean tumor/nodule size ratio of 0.5236. Group 2 consisted of 21 patients with a mean tumor/nodule size ratio of 0.76. Group 3 consisted of 62 patients with a mean tumor/nodule size ratio of 0.848. There were no differences between the groups in terms of nodule size measured by ultrasonography (p=0.209), but the diameter of the carcinoma focus within the nodule was significantly smaller in false-negative cases (p<0.001). There were no statistically significant differences between the groups in terms of multicentricity (p=0.197). Conclusion: The size of malignant tumors may be more important than nodule size in explaining false negativity. ABSTRACT","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45443299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.69077
D. Çakan, Semih Uşaklıoğlu
values for the 3 rd and 6 th months were significantly lower than the median of baseline values (p<0.05). Additionally, the median of nasal MCT values for the 6 th month was significantly lower than the median of nasal MCT values for the 3 rd month (p=0.0003, p<0.05). The medians of PNIFsD values for the 3 rd and 6 th months were significantly higher than the median of baseline values (p<0.05). Additionally, the median of the 6 th -month values was significantly higher than the median of the 3 rd -month values (p=0.023, p<0.05). There was no significant difference in terms of PNIFwD evaluations (p=0.06, p>0.05). Conclusion: The results of this study showed that smoking cessation improves nasal MCC and airflow. ABSTRACT
{"title":"Effects of Smoking Cessation on Peak Nasal Inspiratory Flow and Nasal Mucociliary Clearance","authors":"D. Çakan, Semih Uşaklıoğlu","doi":"10.4274/imj.galenos.2022.69077","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.69077","url":null,"abstract":"values for the 3 rd and 6 th months were significantly lower than the median of baseline values (p<0.05). Additionally, the median of nasal MCT values for the 6 th month was significantly lower than the median of nasal MCT values for the 3 rd month (p=0.0003, p<0.05). The medians of PNIFsD values for the 3 rd and 6 th months were significantly higher than the median of baseline values (p<0.05). Additionally, the median of the 6 th -month values was significantly higher than the median of the 3 rd -month values (p=0.023, p<0.05). There was no significant difference in terms of PNIFwD evaluations (p=0.06, p>0.05). Conclusion: The results of this study showed that smoking cessation improves nasal MCC and airflow. ABSTRACT","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43162021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.62443
S. Akbulut, F. Yağın, C. Colak
Introduction: Despite significant advances in breast cancer (BC) management, the prognosis for most patients with distant metastasis remains poor. We predicted distant metastasis in BC patients with artificial intelligence (AI) methods based on genomic biomarkers. Methods: The dataset used in the study included 97 patients with BC, of whom 46 (47%) developed distant metastases, and 51 (53%) did not develop distant metastases, and the expression level of 24,481 genes of these patients. An approach combining Boruta + LASSO methods was applied to identify biomarker genes associated with BC distant metastasis. Mann-Whitney U test was used to examine the difference between groups in terms of gene expression levels in statistical analyses, and Cohen d effect sizes and odds ratios were calculated. AdaBoost and XGBoost algorithms, which are tree-based methods, were used for BC distant metastasis prediction, and the results were compared by evaluating comprehensive performance criteria. Results: After Boruta + LASSO methods, 14 biomarker candidate genes were identified. These predictive genes were PIB5PA, SSX2, OR1F1, ALDH4A1, FGF18, WISP1, PRAME, CEGP1, AL080059, NMU, ATP5E, SMARCE1, FGD6, and SLC37A1 . In effect size results; in particular, show that the AL080059 (Cohen’s D: 1.318) gene is clinically predictive of BC Metastasis. The accuracy, F1-score, positive predictive value, sensitivity, and area under the ROC Curve (AUC) values obtained with the AdaBoost algorithm for BC metastasis prediction was 95%, 96.3%, 100%, 92.6%, and 98.8%, respectively. The model created with the XGBoost algorithm, on the other hand, obtained 90%, 92.9%, 92.9%, 92.9%, 97.6% accuracy, F1-score, positive predictive value, sensitivity, and AUC values, respectively. Conclusion: Identifying genes that successfully predict BC distant metastasis with AI methods in the study may be decisive for future therapeutic targets and help clinicians better adapt adjuvant chemotherapy to their patients. Additionally, the AdaBoost prediction model created can discriminate patients at risk of BC distant metastases.
{"title":"Prediction of Breast Cancer Distant Metastasis by Artificial Intelligence Methods from an Epidemiological Perspective","authors":"S. Akbulut, F. Yağın, C. Colak","doi":"10.4274/imj.galenos.2022.62443","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.62443","url":null,"abstract":"Introduction: Despite significant advances in breast cancer (BC) management, the prognosis for most patients with distant metastasis remains poor. We predicted distant metastasis in BC patients with artificial intelligence (AI) methods based on genomic biomarkers. Methods: The dataset used in the study included 97 patients with BC, of whom 46 (47%) developed distant metastases, and 51 (53%) did not develop distant metastases, and the expression level of 24,481 genes of these patients. An approach combining Boruta + LASSO methods was applied to identify biomarker genes associated with BC distant metastasis. Mann-Whitney U test was used to examine the difference between groups in terms of gene expression levels in statistical analyses, and Cohen d effect sizes and odds ratios were calculated. AdaBoost and XGBoost algorithms, which are tree-based methods, were used for BC distant metastasis prediction, and the results were compared by evaluating comprehensive performance criteria. Results: After Boruta + LASSO methods, 14 biomarker candidate genes were identified. These predictive genes were PIB5PA, SSX2, OR1F1, ALDH4A1, FGF18, WISP1, PRAME, CEGP1, AL080059, NMU, ATP5E, SMARCE1, FGD6, and SLC37A1 . In effect size results; in particular, show that the AL080059 (Cohen’s D: 1.318) gene is clinically predictive of BC Metastasis. The accuracy, F1-score, positive predictive value, sensitivity, and area under the ROC Curve (AUC) values obtained with the AdaBoost algorithm for BC metastasis prediction was 95%, 96.3%, 100%, 92.6%, and 98.8%, respectively. The model created with the XGBoost algorithm, on the other hand, obtained 90%, 92.9%, 92.9%, 92.9%, 97.6% accuracy, F1-score, positive predictive value, sensitivity, and AUC values, respectively. Conclusion: Identifying genes that successfully predict BC distant metastasis with AI methods in the study may be decisive for future therapeutic targets and help clinicians better adapt adjuvant chemotherapy to their patients. Additionally, the AdaBoost prediction model created can discriminate patients at risk of BC distant metastases.","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41733446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.01212
S. Erdoğdu
observed that the deviation in the nasal septum showed improvement in 32 babies. In conclusion, no statistically significant difference was found between neonatal nasal septum deviation and maternal age, gender (p>0.05). However, a statistically significant difference was found between neonatal nasal septum deviation in the form of birth, the number of births, pregnancy duration, weight, head circumference (p<0.05). Conclusion: It is necessary to have an early diagnosis and intervention for nasal septal deviations in newborn babies. To prevent nasal obstruction and permanent impairment, all newborn babies must be examined by an ENT specialist immediately after birth. ABSTRACT
{"title":"Septal Deviation in Newborns: A Prospective Study and Literature Review","authors":"S. Erdoğdu","doi":"10.4274/imj.galenos.2022.01212","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.01212","url":null,"abstract":"observed that the deviation in the nasal septum showed improvement in 32 babies. In conclusion, no statistically significant difference was found between neonatal nasal septum deviation and maternal age, gender (p>0.05). However, a statistically significant difference was found between neonatal nasal septum deviation in the form of birth, the number of births, pregnancy duration, weight, head circumference (p<0.05). Conclusion: It is necessary to have an early diagnosis and intervention for nasal septal deviations in newborn babies. To prevent nasal obstruction and permanent impairment, all newborn babies must be examined by an ENT specialist immediately after birth. ABSTRACT","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43691922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.73444
Pınar Kundi, N. Bozan, M. Berkoz, H. Çankaya
isolation from Results: be statistically significant. For the -262 C/T polymorphism of the CAT gene; was concluded with 95% confidence that the presence of the T-allele increased the susceptibility to allergic rhinitis 27,064 times. This increase was found to be statistically significant. For Ala16Val polymorphism of the Mn-SOD gene; was concluded with 95% confidence that the presence of the Ala allele increased the susceptibility to allergic rhinitis 25,791 times. This increase was found to be statistically significant. Conclusion: A significant relationship was found between allergic rhinitis and the genotypes and the frequencies of alleles in the polymorphisms of the MnSOD and CAT genes. However, no significant relationship was found between allergic rhinitis and the polymorphisms of the GPx-1 gene. not only allows the Th2 cells in its own colon to proliferate, but also begins secreting its own characteristic cytokines such as interleukin-3 (IL-3), IL-4, IL-5, IL-13, and granulocyte macrophage colony-stimulating factor (GM-CSF) (6,7). IL-4 and IL-13 stimulate B-lymphocytes in circulation and cause their transformation into plasma cells. These plasma cells secrete allergen-specific IgE to which they are sensitized. These specific IgE antibodies bind to high affinity IgE receptors on circulating basophils and mast cells in tissues. IgE-bound mast cells that increase because of continuous allergen exposure pass into the epithelium and are degranulated by recognizing mucosal allergens (8). The products of this degranulation are Ready to Act mediators such as histamine, tryptase, chymase, quinogenase, heparin and other enzymes. Additionally, mast cells secrete new inflammatory mediators such as PGD 2 , tumor necrosis factor-alpha, sulfidopeptidyl leukotrienes LTC 4 , LTD 4 , and LTE 4 . These mediators lead to increased permeability and mucosal edema. These events occur within 1-2 minutes of allergen exposure and are called early phase allergic response (6). Late phase reactions occur because of infiltration with mast cells, basophils, neutrophils, eosinophils and mononuclear cells
{"title":"Correlation Between GSH-Px Pro198Leu, CAT-262C/T, MnSOD Ala16Val Gene Polymorphisms and Allergic Rhinitis","authors":"Pınar Kundi, N. Bozan, M. Berkoz, H. Çankaya","doi":"10.4274/imj.galenos.2022.73444","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.73444","url":null,"abstract":"isolation from Results: be statistically significant. For the -262 C/T polymorphism of the CAT gene; was concluded with 95% confidence that the presence of the T-allele increased the susceptibility to allergic rhinitis 27,064 times. This increase was found to be statistically significant. For Ala16Val polymorphism of the Mn-SOD gene; was concluded with 95% confidence that the presence of the Ala allele increased the susceptibility to allergic rhinitis 25,791 times. This increase was found to be statistically significant. Conclusion: A significant relationship was found between allergic rhinitis and the genotypes and the frequencies of alleles in the polymorphisms of the MnSOD and CAT genes. However, no significant relationship was found between allergic rhinitis and the polymorphisms of the GPx-1 gene. not only allows the Th2 cells in its own colon to proliferate, but also begins secreting its own characteristic cytokines such as interleukin-3 (IL-3), IL-4, IL-5, IL-13, and granulocyte macrophage colony-stimulating factor (GM-CSF) (6,7). IL-4 and IL-13 stimulate B-lymphocytes in circulation and cause their transformation into plasma cells. These plasma cells secrete allergen-specific IgE to which they are sensitized. These specific IgE antibodies bind to high affinity IgE receptors on circulating basophils and mast cells in tissues. IgE-bound mast cells that increase because of continuous allergen exposure pass into the epithelium and are degranulated by recognizing mucosal allergens (8). The products of this degranulation are Ready to Act mediators such as histamine, tryptase, chymase, quinogenase, heparin and other enzymes. Additionally, mast cells secrete new inflammatory mediators such as PGD 2 , tumor necrosis factor-alpha, sulfidopeptidyl leukotrienes LTC 4 , LTD 4 , and LTE 4 . These mediators lead to increased permeability and mucosal edema. These events occur within 1-2 minutes of allergen exposure and are called early phase allergic response (6). Late phase reactions occur because of infiltration with mast cells, basophils, neutrophils, eosinophils and mononuclear cells","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49270461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.44520
Tuğba Eyigürbüz, Z. Yıldırım, E. Korkut, Ece Akalın Akkaş, Mehmet Turgut Adatepe, N. Kale
Introduction: In this study, we documented the demographic, etiological, clinical and radiological features of our patients with primary hemifacial spasm (HFS). We also wanted to emphasize that there may be an association between idiopathic intracranial hypertension (IIH) and HFS. Methods: Fifty-five patients diagnosed with HFS (28 women) who were followed up in the Movement Disorders Outpatient Clinics of the Department of Neurology University of Health Sciences Turkey, Istanbul Bagolar Training and Research Hospital between January 2017 and January 2022 were included in this study. Demographic, clinical, and radiological findings were retrospectively reviewed. Depending on radiological findings, patients were divided into three groups: a) Normal findings, b) Incidental findings that did not appear to be related to clinical findings, and c) vascular abnormalities at the level of the brainstem. Results: Only 23 patients had no atherosclerotic risk factors. While magnetic resonance imaging of the brain was normal in 23 patients, 19 patients had ischemic white matter changes, 5 patients had partial empty sella, 7 patients had dolichoectatic basilar artery, and 1 patient had a compression of the anterior segment of the left superior cerebellar artery to the 7th cranial nerve. Based on the history and clinical findings, lumbar puncture was performed in 4 patients, and 3 of them were diagnosed with idiopathic IIH with HIS, and they were treated with acetazolamide. fifty-one patients were treated with botulinum toxin injections only. Conclusion: Vascular compression is often noted on imaging of patients with primary HIS, but as in our case series, an empty sella finding in patients with chronic headache may be a sign of IIH and should not be overlooked. Also, HFS may be an uncommon presentation of IIH, and symptoms of HFS may improve with treatment of IIH. Additionally, the presence and history of Coronavirus disease-2019 infection should be questioned in newly admitted cases.
{"title":"Neuroimaging Findings in Hemifacial Spasm: A Single-Center Experience","authors":"Tuğba Eyigürbüz, Z. Yıldırım, E. Korkut, Ece Akalın Akkaş, Mehmet Turgut Adatepe, N. Kale","doi":"10.4274/imj.galenos.2022.44520","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.44520","url":null,"abstract":"Introduction: In this study, we documented the demographic, etiological, clinical and radiological features of our patients with primary hemifacial spasm (HFS). We also wanted to emphasize that there may be an association between idiopathic intracranial hypertension (IIH) and HFS. Methods: Fifty-five patients diagnosed with HFS (28 women) who were followed up in the Movement Disorders Outpatient Clinics of the Department of Neurology University of Health Sciences Turkey, Istanbul Bagolar Training and Research Hospital between January 2017 and January 2022 were included in this study. Demographic, clinical, and radiological findings were retrospectively reviewed. Depending on radiological findings, patients were divided into three groups: a) Normal findings, b) Incidental findings that did not appear to be related to clinical findings, and c) vascular abnormalities at the level of the brainstem. Results: Only 23 patients had no atherosclerotic risk factors. While magnetic resonance imaging of the brain was normal in 23 patients, 19 patients had ischemic white matter changes, 5 patients had partial empty sella, 7 patients had dolichoectatic basilar artery, and 1 patient had a compression of the anterior segment of the left superior cerebellar artery to the 7th cranial nerve. Based on the history and clinical findings, lumbar puncture was performed in 4 patients, and 3 of them were diagnosed with idiopathic IIH with HIS, and they were treated with acetazolamide. fifty-one patients were treated with botulinum toxin injections only. Conclusion: Vascular compression is often noted on imaging of patients with primary HIS, but as in our case series, an empty sella finding in patients with chronic headache may be a sign of IIH and should not be overlooked. Also, HFS may be an uncommon presentation of IIH, and symptoms of HFS may improve with treatment of IIH. Additionally, the presence and history of Coronavirus disease-2019 infection should be questioned in newly admitted cases.","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46699119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.84748
S. Ertaş, K. Yakın
oocyte follicle the in vitro maturation, natural cycle, natural cycle preimplantation genetic testicular sperm for fertilization oocyte of oocytes the intracytoplasmic The The counts of total and oocytes and 7.3±4.5, respectively. A mean count of 2.38 embryos was transferred in 10118 cycles. The group 3 patients had a considerably higher live birth ratio compared to the group 1 and 2. Conclusion: We propose oocyte maturity rate and the count of M-II oocytes as two diagnostic criteria for the case definition of asynchronous follicle growth. Based on our findings, stimulation cycles ending with low oocyte maturity rate (≤50%) and ≤3 M-II oocytes would be considered asynchronous follicle development. Patients with low oocyte maturity rate and asynchronous follicle development should be counseled and informed regarding potential poor prognosis of the treatment. ABSTRACT live birth. In the prediction of live birth; the area under the ROC curve was 0.684 [95% confidence interval (CI): 0.671-0.697] for the count of mature oocytes and 0.653 (95% CI: 0.639-0.666) for the entire count of retrieved oocytes. These results showed that the count of M-II oocytes was better predictive of live birth than the entire count of harvested oocytes (p=0.0007).
{"title":"Low Oocyte Maturity Rate and Asynchronous Follicle Development: Other Unnoticed Groups in the Bologna Criteria for Poor Responders?","authors":"S. Ertaş, K. Yakın","doi":"10.4274/imj.galenos.2022.84748","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.84748","url":null,"abstract":"oocyte follicle the in vitro maturation, natural cycle, natural cycle preimplantation genetic testicular sperm for fertilization oocyte of oocytes the intracytoplasmic The The counts of total and oocytes and 7.3±4.5, respectively. A mean count of 2.38 embryos was transferred in 10118 cycles. The group 3 patients had a considerably higher live birth ratio compared to the group 1 and 2. Conclusion: We propose oocyte maturity rate and the count of M-II oocytes as two diagnostic criteria for the case definition of asynchronous follicle growth. Based on our findings, stimulation cycles ending with low oocyte maturity rate (≤50%) and ≤3 M-II oocytes would be considered asynchronous follicle development. Patients with low oocyte maturity rate and asynchronous follicle development should be counseled and informed regarding potential poor prognosis of the treatment. ABSTRACT live birth. In the prediction of live birth; the area under the ROC curve was 0.684 [95% confidence interval (CI): 0.671-0.697] for the count of mature oocytes and 0.653 (95% CI: 0.639-0.666) for the entire count of retrieved oocytes. These results showed that the count of M-II oocytes was better predictive of live birth than the entire count of harvested oocytes (p=0.0007).","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46751138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.4274/imj.galenos.2022.44788
Y. Hacıoğlu, M. E. Pişkinpaşa, P. Kılıçkaya, M. Niyazoğlu, Burcu Hacıoğlu, E. Hatipoğlu
Acromegaly is a chronic multisystemic disease that causes cardiac dysfunction due to an increased levels of growth hormone. We evaluated the association of GDF-15 with diastolic dysfunction in acromegaly. Methods: Fifty-four patients with acromegaly [active (n=24), inactive (n=30)] and 34 healthy controls were included in the study. The acromegaly group (AG) and control group (CG) were compared for their blood pressures, metabolic parameters, GDF-15 levels, and echocardiographic findings. The correlation analysis was performed between the GDF-15 and the parameters that may be associated with it in the AG. Results: GDF-15 was significantly higher in AG than in the CG (p<0.001). GDF-15 was positively correlated with body mass index (r=0.4, p=0.008) and negatively correlated with fasting blood glucose (r=-0.4, p=0.004). GDF-15 was also positively correlated with diastolic blood pressure (DBP) (r=0.4, p=0.002). Among echocardiographic findings, end-diastolic volume (EDV), and stroke volume (SV) were negatively correlated with GDF-15 levels (r=-0.4, p=0.003, and r=-0.4, p=0.03, respectively). Conclusion: GDF-15 was detected to be significantly increased in patients with acromegaly. This increment was associated with subtle changes in DBP, EDV, and SV. Therefore, GDF-15 may play a role in diastolic impairment at the cardiac involvement in acromegaly.
{"title":"Increased Serum Growth Differentiation Factor 15 Levels may be Associated with Diastolic Dysfunction in Acromegaly","authors":"Y. Hacıoğlu, M. E. Pişkinpaşa, P. Kılıçkaya, M. Niyazoğlu, Burcu Hacıoğlu, E. Hatipoğlu","doi":"10.4274/imj.galenos.2022.44788","DOIUrl":"https://doi.org/10.4274/imj.galenos.2022.44788","url":null,"abstract":"Acromegaly is a chronic multisystemic disease that causes cardiac dysfunction due to an increased levels of growth hormone. We evaluated the association of GDF-15 with diastolic dysfunction in acromegaly. Methods: Fifty-four patients with acromegaly [active (n=24), inactive (n=30)] and 34 healthy controls were included in the study. The acromegaly group (AG) and control group (CG) were compared for their blood pressures, metabolic parameters, GDF-15 levels, and echocardiographic findings. The correlation analysis was performed between the GDF-15 and the parameters that may be associated with it in the AG. Results: GDF-15 was significantly higher in AG than in the CG (p<0.001). GDF-15 was positively correlated with body mass index (r=0.4, p=0.008) and negatively correlated with fasting blood glucose (r=-0.4, p=0.004). GDF-15 was also positively correlated with diastolic blood pressure (DBP) (r=0.4, p=0.002). Among echocardiographic findings, end-diastolic volume (EDV), and stroke volume (SV) were negatively correlated with GDF-15 levels (r=-0.4, p=0.003, and r=-0.4, p=0.03, respectively). Conclusion: GDF-15 was detected to be significantly increased in patients with acromegaly. This increment was associated with subtle changes in DBP, EDV, and SV. Therefore, GDF-15 may play a role in diastolic impairment at the cardiac involvement in acromegaly.","PeriodicalId":42584,"journal":{"name":"Istanbul Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46095821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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