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Towards Prediction of Radiation Pneumonitis Arising from Lung Cancer Patients Using Machine Learning Approaches 使用机器学习方法预测肺癌患者引起的放射性肺炎
Pub Date : 2017-09-27 DOI: 10.5166/JROI-1-1-5
J. Oh, A. Apte, R. Al-Lozi, J. Bradley, I. E. El Naqa
Radiation pneumonitis (RP) is a potentially fatal side effect arising in lung cancer patients who receive radiotherapy as part of their treatment. For the modeling of RP outcomes data, several predictive models based on traditional statistical methods and machine learning techniques have been reported. However, no guidance to variation in performance has been provided to date. In this study, we explore several machine learning algorithms for classification of RP data. The performance of these classification algorithms is investigated in conjunction with several feature selection strategies and the impact of the feature selection strategy on performance is further evaluated. The extracted features include patients demographic, clinical and pathological variables, treatment techniques, and dose-volume metrics. In conjunction, we have been developing an in-house Matlab-based open source software tool, called DREES, customized for modeling and exploring dose response in radiation oncology. This software has been upgraded with a popular classification algorithm called support vector machine (SVM), which seems to provide improved performance in our exploration analysis and has strong potential to strengthen the ability of radiotherapy modelers in analyzing radiotherapy outcomes data.
放射性肺炎(RP)是在接受放射治疗的肺癌患者中产生的潜在致命副作用。对于RP结果数据的建模,已经报道了几种基于传统统计方法和机器学习技术的预测模型。但是,迄今为止还没有提供关于业绩变化的指导。在本研究中,我们探索了几种用于RP数据分类的机器学习算法。结合几种特征选择策略研究了这些分类算法的性能,并进一步评估了特征选择策略对性能的影响。提取的特征包括患者人口统计学、临床和病理变量、治疗技术和剂量-体积指标。同时,我们一直在开发一个内部基于matlab的开源软件工具,称为DREES,为放射肿瘤学的建模和探索剂量反应定制。该软件已经升级了一种流行的分类算法,称为支持向量机(SVM),它似乎在我们的探索分析中提供了更好的性能,并且具有很强的潜力来增强放疗建模者分析放疗结果数据的能力。
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引用次数: 1
Fully Automatic Danger Zone Determination for SBRT in NSCLC NSCLC中SBRT的全自动危险区测定
Pub Date : 2015-02-25 DOI: 10.3933/JROI-7-1-26
T. Fechter, J. Dolz, A. Chirindel, Matthias Schlachter, M. Carles, S. Adebahr, M. Mix, U. Nestle
Lung cancer is the major cause of cancer death worldwide. The most common form of lung cancer is non-small cell lung cancer(NSCLC). Stereotactic body radiation therapy (SBRT) has emerged as a good alternative to surgery in patients with peripheralstage I NSCLC, demonstrating favorable tumor control and low toxicity. Due to spatial relationship to several critical organs atrisk, SBRT of centrally located lesions is associated with more severe toxicity and requires modification in dose application andfractionation, which is currently evaluated in clinical trials. Therefore a classification of lung tumors into central or peripheralis required. In this work we present a novel, highly versatile, mulitmodality tool for tumor classification which requires no userinteraction. Furthermore the tool can automatically segment the trachea, proximal bronchial tree, mediastinum, gross target volumeand internal target volume. The proposed work is evaluated on 19 cases with different image modalities assessing segmentationquality as well as classification accuracy. Experiments showed a good segmentation quality and a classification accuracy of 95 %.These results suggest the use of the proposed tool for clinical trials to assist clinicians in their work and to fasten up the workflowin NSCLC patients treatment.
肺癌是全世界癌症死亡的主要原因。最常见的肺癌类型是非小细胞肺癌(NSCLC)。立体定向体放射治疗(SBRT)已成为外周I期非小细胞肺癌患者手术治疗的良好选择,显示出良好的肿瘤控制和低毒性。由于与几个有危险的关键器官的空间关系,中心位置病变的SBRT与更严重的毒性相关,需要改变剂量应用和分离方法,目前正在临床试验中进行评估。因此,需要将肺肿瘤分为中枢性和外周性。在这项工作中,我们提出了一种新的、高度通用的、多模态的肿瘤分类工具,它不需要用户交互。此外,该工具还可以自动分割气管、近端支气管树、纵隔、总靶容积和内靶容积。在19个不同图像模式的案例中对所提出的工作进行了评估,评估了分割质量和分类精度。实验结果表明,该方法分割质量好,分类准确率达95%。这些结果表明,在临床试验中使用拟议的工具来协助临床医生的工作,并加快非小细胞肺癌患者治疗的工作流程。
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引用次数: 2
PROsaiq: A Smart Device-Based and EMR-Integrated System for Patient-Reported Outcome Measurement in Routine Cancer Care PROsaiq:一种基于智能设备和emr集成的系统,用于常规癌症治疗中患者报告的结果测量
Pub Date : 2014-06-19 DOI: 10.5166/JROI-6-1-24
T. Schuler, Andrew Miller
The PROsaiq prototype, which is based on the use of smart devices, was developed to show the technical feasibility of a lean, low-cost ePRO system that integrated with the oncology information system MOSAIQ to provide the potential for benefits in routine patient care, and improved data for clinical research. The system was built with Free & Open Source Software and trialled for a limited number of assessments. The report describes the components used, the decisions made and the hurdles met during the project. An on-line demonstration system is available to showcase PROsaiqs functionality.
PROsaiq原型是基于智能设备的使用,旨在展示精益、低成本的ePRO系统的技术可行性,该系统与肿瘤信息系统MOSAIQ集成,为常规患者护理提供潜在的好处,并为临床研究提供改进的数据。该系统是用免费和开源软件构建的,并进行了有限数量的测试。该报告描述了项目中使用的组件、做出的决策和遇到的障碍。一个在线演示系统可以展示PROsaiqs的功能。
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引用次数: 11
RadOnc: An R Package for Analysis of Dose-Volume Histogram and Three-Dimensional Structural Data RadOnc:用于剂量-体积直方图和三维结构数据分析的R包
Pub Date : 2014-06-19 DOI: 10.3933/JROI-6-1-25
Reid F Thompson
Purpose/Objectives: Dose volume histogram (DVH) data are generally analyzed within the context of a treatment planning system (TPS) on a per-patient basis, with evaluation of single-plan or comparative dose distributions. However, TPS software generally cannot perform simultaneous comparative dosimetry among a cohort of patients. The same limitations apply to parallel analyses of three-dimensional structures and other clinical data. Materials/Methods: We developed a suite of tools ("RadOnc" package) using R statistical software to better compare pooled DVH data and empower analysis of structure data and clinical correlates. Representative patient data were identified among previously analyzed adult (n=13) and pediatric (n=1) cohorts and these data were used to demonstrate the performance and functionality of the RadOnc package. Results: The RadOnc package facilitates DVH data import from the TPS and includes automated methods for DVH visualization, dosimetric parameter extraction, statistical comparison among multiple DVHs, basic three-dimensional structural processing, and visualization tools to enable customizable production of publication-quality images. Conclusions: The RadOnc package provides a potent clinical research tool with the ability to integrate robust statistical software and dosimetric data from cohorts of patients. It is made freely available to the community for their current use and remains under active development.
目的/目的:剂量体积直方图(DVH)数据通常在治疗计划系统(TPS)的背景下以每位患者为基础进行分析,评估单一计划或比较剂量分布。然而,TPS软件通常不能在一组患者中同时进行比较剂量测定。同样的局限性也适用于三维结构和其他临床数据的平行分析。材料/方法:我们使用R统计软件开发了一套工具(“RadOnc”包),以更好地比较汇集的DVH数据,并增强结构数据和临床相关性的分析能力。在先前分析的成人(n=13)和儿科(n=1)队列中确定具有代表性的患者数据,并使用这些数据来证明RadOnc包的性能和功能。RadOnc软件包有助于从TPS导入DVH数据,包括DVH可视化的自动化方法、剂量学参数提取、多个DVH之间的统计比较、基本的三维结构处理和可视化工具,以实现可定制的出版质量图像的生产。结论:RadOnc包提供了一个强大的临床研究工具,能够整合强大的统计软件和来自患者队列的剂量学数据。它目前免费提供给社区使用,并仍在积极发展中。
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引用次数: 18
Operations Research Methods for Optimization in Radiation Oncology 放射肿瘤学最优化的运筹学方法
Pub Date : 2014-02-16 DOI: 10.3933/JROI-6-1-21
M. Ehrgott, A. Holder
Operations Research has a successful tradition of applying mathematical analysis to a wide range of applications, and problems in Medical Physics have been popular over the last couple of decades. The original application was in the optimal design of the uence map for a radiotherapy treatment, a problem that has continued to receive attention. However, Operations Research has been applied to other clinical problems like patient scheduling, vault design, and image alignment. The overriding theme of this article is to present how techniques in Operations Research apply to clinical problems, which we accomplish in three parts. First, we present the perspective from which an operations researcher addresses a clinical problem. Second, we succinctly introduce the underlying methods that are used to optimize a system, and third, we demonstrate how modern software facilitates problem design. Our discussion is supported by several publications to foster continued study. With numerous clinical, medical, and managerial decisions associated with a clinic, operations research has a promising future at improving how radiotherapy treatments are designed and delivered.
运筹学有一个成功的传统,将数学分析应用到广泛的应用中,在过去的几十年里,医学物理学中的问题已经很受欢迎。最初的应用是在放射治疗的序列图的优化设计中,这个问题一直受到关注。然而,运筹学已经应用于其他临床问题,如病人调度、保险库设计和图像对齐。本文最重要的主题是介绍运筹学中的技术如何应用于临床问题,我们将分三部分完成。首先,我们提出的观点,从一个操作研究员解决临床问题。其次,我们简要介绍了用于优化系统的基本方法,第三,我们演示了现代软件如何促进问题设计。我们的讨论得到了一些出版物的支持,以促进继续研究。由于与诊所相关的临床、医疗和管理决策众多,运筹学在改进放射治疗的设计和交付方面具有广阔的前景。
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引用次数: 10
Relational database of treatment planning system information 治疗计划系统信息的关系数据库
Pub Date : 2013-01-24 DOI: 10.3933/JROI-5-1-15
M. Kantor, G. Starkschall, P. Balter
The purpose of the present work was to develop a relational database and associated applications to facilitate retrospective review of data present in radiation treatment plans. The data source was a commercial radiation treatment planning system (Pinnacle3, Philips Medical Systems, Milpitas CA), which is specifically characterized by an open data storage format and internal scripting capability. The database is an open-source, relational database (PostgreSQL, PostgreSQL Global Development Group, http://www.postgresql.org). The data is presented through a web interface in addition to being fully query-accessible using standard tools. A database schema was created to organize the large collection of parameters used to generate treatment plans as well as the parameters that characterized these plans. The system was implemented through a combination of the treatment planning systems internal scripting language and externally executed code. Data is exported in a way that is transparent to the user, through integration into an existing and routinely-used process. The system has been transparently incorporated into our radiation treatment planning workflow. The website-based database interface has allowed users with minimal training to extract information from the database.
本工作的目的是开发一个关系数据库和相关的应用程序,以促进对放射治疗计划中现有数据的回顾性审查。数据源是一个商业放射治疗计划系统(Pinnacle3, Philips Medical Systems, Milpitas CA),其具体特点是开放的数据存储格式和内部脚本功能。该数据库是一个开源的关系数据库(PostgreSQL, PostgreSQL Global Development Group, http://www.postgresql.org)。除了使用标准工具完全可以查询之外,数据还通过web界面呈现。创建了一个数据库模式来组织用于生成治疗计划的大量参数集合以及表征这些计划的参数。该系统通过治疗计划系统内部脚本语言和外部执行代码的组合来实现。通过集成到现有的和常规使用的流程中,以一种对用户透明的方式导出数据。该系统已透明地纳入我们的放射治疗计划工作流程。基于网站的数据库接口允许用户以最少的训练从数据库中提取信息。
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引用次数: 2
A Radiation Oncology Based Electronic Health Record in an Integrated Radiation Oncology Network 综合放射肿瘤学网络中基于放射肿瘤学的电子健康记录
Pub Date : 2011-04-29 DOI: 10.3933/JROI-3-1-16
A. Colonias, D. Parda, S. Karlovits, R. Fuhrer, M. Trombetta, S. Strickland, Marc Luick, R. Billy, E. Werts
Purpose: The goal of this ongoing project is to develop and integrate a comprehensive electronic health record (EHR) throughout a multi-facility radiation oncology network to facilitate more efficient workflow and improve overall patient care and safety. Methodology: We required that the EHR provide pre-defined record and verify capability for radiation treatment while still providing a robust clinical health record. In 1996, we began to integrate the Local Area Network Treatment Information System (LANTIS®) across the West Penn Allegheny Radiation Oncology Network (currently including 9 sites). By 2001, we began modifying and expanding the assessment components and creating user-defined templates and have developed a comprehensive electronic health record across our network. Results: In addition to access to the technical record and verify information and imaging obtained for image-guided therapy, we designed and customized 6 modules according to our networks needs to facilitate information acquisition, tracking, and analysis as follows: 1) Demographics/scheduling; 2) Charge codes; 3) Transcription/clinical documents; 4) Clinical/technical assessments; 5) Physician orders 6) Quality assurance pathways. Each module was developed to acquire specific technical/clinical data prospectively in an efficient manner by various staff within the department in a format that facilitates data queries for outcomes/statistical analyses and promotes standardized quality guidelines resulting in a more efficient workflow and improved patient safety and care. Conclusions: Development of a comprehensive EHR across a radiation oncology network is feasible and can be customized to promote clinical/technical standards, facilitate outcomes studies, and improve communication and peer review. The EHR has improved patient care and network integration across a multi-facility radiation oncology system and has markedly reduced the flow and storage of paper across the network.
目的:这个正在进行的项目的目标是在多设施放射肿瘤学网络中开发和集成一个全面的电子健康记录(EHR),以促进更有效的工作流程,并改善整体患者护理和安全性。方法:我们要求EHR在提供可靠的临床健康记录的同时,为放射治疗提供预定义的记录和验证能力。1996年,我们开始整合整个西宾夕法尼亚大学阿勒格尼放射肿瘤学网络的局域网治疗信息系统(LANTIS®)(目前包括9个站点)。到2001年,我们开始修改和扩展评估组件,创建用户定义模板,并在我们的网络中开发了一个全面的电子健康记录。结果:除了获取影像引导治疗的技术记录、验证信息和影像外,我们还根据网络需求设计定制了6个模块,便于信息获取、跟踪和分析,具体如下:1)人口统计/调度;2)收费代码;3)转录/临床文件;4)临床/技术评估;5)医嘱6)质量保证途径。每个模块的开发都是为了让科室内的不同工作人员以有效的方式获取特定的技术/临床数据,其格式便于查询数据以进行结果/统计分析,并促进标准化的质量准则,从而提高工作流程的效率,改善患者的安全和护理。结论:在放射肿瘤学网络中开发一个全面的电子病历是可行的,并且可以定制以提高临床/技术标准,促进结果研究,并改善沟通和同行评审。电子病历改善了患者护理和跨多设施放射肿瘤学系统的网络整合,并显著减少了网络中的纸张流动和存储。
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引用次数: 4
Determination of the source dwell position of an afterloading device with a detector array 带检测器阵列的后加载装置源驻留位置的测定
Pub Date : 2011-02-11 DOI: 10.5166/JROI-3-2-18
F. Breithuth, J. Schiefer, M. Arn, S. Peters, W. Seelentag
It was the aim to develop and test a measurement technique for the source position of an afterloading system using an electronic two-dimensional detector array (2D array). A "GammaMed plus IX" high dose rate afterloading device (Varian Medical Systems, Palo Alto, USA), and a Seven29 2D detector array (PTW Freiburg GmbH, Freiburg, Germany) have been used. A hollow needle has been connected to the afterloading device. Its outer diameter is 3.0 mm and its length about 220mm. A 14 mm thick Perspex slab was fixed in a reproducible position on the 2D array. Above the 14th detector row, a groove was cut in the slab which accommodates the hollow needle in a fixed position relative to the 2D array. In order to define the position of the source, the signals of the detectors in the 14th detector row have been evaluated. A theoretical curve depending on the source position and strength, has been fitted to the acquired detector signals. It has been shown that the reproducibility of the measurement technique - including the reproducibility of the source placement - was within 0.15mm. This method can not only replace film measurements, it is also more exact and less time consuming.
其目的是开发和测试一种使用电子二维探测器阵列(2D阵列)测量后载系统源位置的技术。使用了“GammaMed plus IX”高剂量率后装装置(Varian Medical Systems, Palo Alto, USA)和Seven29 2D探测器阵列(PTW Freiburg GmbH, Freiburg, Germany)。一空心针已连接到后装装置。外径3.0 mm,长约220mm。将14毫米厚的有机玻璃板固定在二维阵列上的可重复位置。在所述第14排探测器上方,在所述平板上切割一凹槽,该凹槽将所述空心针置于相对于所述二维阵列的固定位置。为了确定源的位置,对第14排探测器的信号进行了评估。一个理论曲线取决于源的位置和强度,已拟合到采集的探测器信号。研究表明,测量技术的再现性——包括源位置的再现性——在0.15mm以内。该方法不仅可以代替胶片测量,而且精度更高,耗时更短。
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引用次数: 3
Pilot Study of a Radiation Oncology Telemedicine Platform 放射肿瘤学远程医疗平台的试点研究
Pub Date : 2010-10-13 DOI: 10.3933/JROI-2-1-10
B. Mueller, C. Obcemea, James Lee, S. Sim
Purpose: A pilot study was undertaken to develop an integrated telemedicine platform for radiation oncology at Memorial Sloan-Kettering Cancer Center (MSKCC) and its regional sites. The platform consisted of a computer system with simultaneous display of multiple live data portals including 1) video-conferencing between physicians, 2) radiology, and 3) radiation treatment-planning system (RTPS). Methods and Materials: Two MSKCC regional centers were set up with a widescreen monitor, a dedicated computer, and a web camera with microphone. Each computer ran a Microsoft operating system, utilized video-conferencing software, and connected to the MSKCC Ethernet. This allowed for access to the health information system, radiology (web-based picture archiving and communication systems), RTPS, shared network drives and the internet. Results: After 3 months, physicians at two MSKCC sites were successfully able to implement the proposed telemedicine platform. A small sample of cases (prostate, breast, head and neck, and anal cases) were tested. Radiology images, radiation treatment volumes and plans, and portal images were reviewed. Side-by-side comparison of contouring techniques was performed. The platform allowed physicians to remotely review details of cases efficiently. The interactions of the telemedicine platform improved clinical understanding of each case and often resulted in contouring changes. Conclusion: From this experience, we feel that telemedicine could have a significant clinical impact on patient care, especially at centers with satellite clinics. The future goal of the system will be the development of a virtual tumor board for radiation oncologists. We envision the simultaneous display of multiple clinical components, including face photo, pathology, tumor images/videos of procedures, radiology, RTPS, and anatomy/contouring databases, on one screen surface.
目的:开展一项试点研究,在纪念斯隆-凯特琳癌症中心(MSKCC)及其区域站点开发放射肿瘤学综合远程医疗平台。该平台由一个计算机系统组成,该系统同时显示多个实时数据门户,包括1)医生之间的视频会议,2)放射学和3)放射治疗计划系统(RTPS)。方法与材料:设置两个MSKCC区域中心,配备宽屏显示器、专用计算机和带麦克风的网络摄像机。每台电脑都运行微软操作系统,使用视频会议软件,并连接到MSKCC以太网。这允许访问卫生信息系统、放射学(基于网络的图片存档和通信系统)、RTPS、共享网络驱动器和互联网。结果:3个月后,两个MSKCC站点的医生成功实施了所提出的远程医疗平台。对一小部分病例(前列腺、乳房、头颈和肛门病例)进行了检测。我们回顾了放射学图像、放射治疗量和计划以及门静脉图像。进行了轮廓技术的并排比较。该平台允许医生远程有效地查看病例细节。远程医疗平台的相互作用提高了对每个病例的临床理解,并经常导致轮廓变化。结论:根据这一经验,我们认为远程医疗可以对患者护理产生重大的临床影响,特别是在拥有卫星诊所的中心。该系统未来的目标是为放射肿瘤学家开发一个虚拟肿瘤板。我们设想在一个屏幕表面上同时显示多种临床成分,包括面部照片、病理、肿瘤图像/手术视频、放射学、RTPS和解剖/轮廓数据库。
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引用次数: 9
Dodes (diagnostic nodes) for Guideline Manipulation 指南操作的诊断节点
Pub Date : 2010-09-30 DOI: 10.3933/JROI-2-1-6
P. Putora, Marcel Blattner, A. Papachristofilou, Fabio Mariotti, Beatrice Paoli, L. Plasswilm
Background: Treatment recommendations (guidelines) are commonly represented in text form. Based on parameters (questions) recommendations are defined (answers). Objectives: To improve handling, alternative forms of representation are required. Methods: The concept of Dodes (diagnostic nodes) has been developed. Dodes contain answers and questions. Dodes are based on linked nodes and additionally contain descriptive information and recommendations. Dodes are organized hierarchically into Dode trees. Dode categories must be defined to prevent redundancy. Results: A centralized and neutral Dode database can provide standardization, which is a requirement for the comparison of recommendations. Centralized administration of Dode categories can provide information about diagnostic criteria (Dode categories) underutilized in existing recommendations (Dode trees). Conclusions: Representing clinical recommendations in Dode trees improves their manageability, handling and updateability.
背景:治疗建议(指南)通常以文本形式表示。根据参数(问题)定义建议(答案)。目的:为了改善处理,需要其他形式的代表。方法:提出诊断节点(Dodes)概念。谜语包含答案和问题。Dodes基于链接节点,另外还包含描述性信息和推荐。Dode按层次结构组织到Dode树中。必须定义代码类别以防止冗余。结果:一个集中、中立的Dode数据库可以提供标准化,这是比较推荐的必要条件。对Dode分类的集中管理可以提供有关诊断标准(Dode分类)的信息,这些诊断标准在现有建议(Dode树)中未得到充分利用。结论:在Dode树中表示临床建议可提高其可管理性、处理性和可更新性。
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引用次数: 7
期刊
Journal of Radiation Oncology Informatics
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