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Interdisciplinary Research—Future of Cardiology 跨学科研究——心脏病学的未来
Pub Date : 2022-11-28 DOI: 10.1177/26324636221141127
B. Rao
Corresponding author: B Hygriv Rao, KIMS Hospitals, Hyderabad, Telangana 500003, India. E-mail: hygriv@hotmail.com The spectacular innovations in technology in this century have fuelled the exponential growth of cardiovascular medicine in all dimensions eclipsing its conventional boundaries. Optimal diagnosis and management of cardiac patients is currently critically dependent on the interaction with sub-specialties in this field and contribution from other disciplines of medicine and engineering. The large burden of heart failure (HF) population has exposed the challenges in diagnosis, stratification of risk and economic prudence in utilization of healthcare resources. Advances in Radiology in the areas of cardiac MRI and positron emission tomography (PET) have succeeded in meeting some of these challenges. Late gadolinium enhancement (LGE) in cardiac MRI (CMRI ) has proven to be a reliable surrogate of myocardial scar which is the essential substrate for sudden death and worsening HF.1,2 Detailed imaging inputs from CMRI have helped to precisely define the endocardial and epicardial scar, assess accurately the ventricular function, and finely delineate the arrythmogenic channels in the substrate. Further it has aided substantially in prognostication in patients with substrates like hypertrophic cardiomyopathy and nonischemic cardiomyopathy (NICM). Similarly PET has contributed immensely in diagnosing sarcoidosis in patients presenting with new onset of HF, ventricular arrhythmias and conduction blocks. Further sophistication in imaging technology will undoubtedly refine the diagnostic criteria, and ease decision-making algorithms. Imaging has also enabled the clinician to understand and effectively correlate the anatomy in conceptualizing strategies for interventional procedures. This is particularly true in dissections and aneurysms of aorta, and trans-catheter interventions for aortic valves. The increasing safety and better outcomes of the procedures relate as much to the imaging technology as to the increasing operator experience. Ventricular tachycardia (VT) is a fatal arrhythmia conventionally treated with drugs, ablation and implantable defibrillators. Refractory VT and electrical storm is a challenging clinical problem with a high mortality, and radiotherapy has emerged as one of the least expected contender in the rescue of this difficult clinical
通讯作者:B Hygriv Rao, kim医院,海德拉巴,泰伦加纳500003,印度。电子邮件:hygriv@hotmail.com本世纪惊人的技术创新推动了心血管医学在各个方面的指数级增长,超越了传统的界限。心脏病患者的最佳诊断和管理目前严重依赖于与该领域的子专业的互动以及其他医学和工程学科的贡献。心力衰竭(HF)人群的巨大负担暴露了在诊断、风险分层和医疗资源利用的经济审慎方面的挑战。放射学在心脏MRI和正电子发射断层扫描(PET)领域的进步已经成功地应对了这些挑战。心肌MRI (CMRI)的晚期钆增强(LGE)已被证明是心肌疤痕的可靠替代品,心肌疤痕是猝死和hf恶化的重要基础。1,CMRI的详细成像输入有助于精确定义心内膜和心外膜疤痕,准确评估心室功能,并精细描绘基底中的心律失常通道。此外,它在肥厚性心肌病和非缺血性心肌病(NICM)患者的预后方面也有很大的帮助。同样,PET在诊断新发心衰、室性心律失常和传导阻滞患者的结节病方面也有很大贡献。成像技术的进一步成熟无疑将完善诊断标准,简化决策算法。成像也使临床医生能够理解并有效地将解剖学与介入手术策略概念化联系起来。在主动脉夹层和动脉瘤以及经导管主动脉瓣介入治疗中尤其如此。手术的安全性和效果的提高与成像技术和操作员经验的提高同样重要。室性心动过速(VT)是一种致命的心律失常,通常用药物、消融术和植入式除颤器治疗。难治性室速和电风暴是一个具有高死亡率的具有挑战性的临床问题,而放射治疗已成为拯救这一困难临床中最意想不到的竞争者之一
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引用次数: 0
Inferior Tricuspid Annular Atrial Tachycardia 下三尖瓣环状房性心动过速
Pub Date : 2022-11-28 DOI: 10.1177/26324636221140728
S. Deshpande
A 60-year-old male with recurrent episodes of supraventricular tachycardia on regular medications had another episode. Was taken up for electrophysiological study and radiofrequency ablation (EPS and RFA) under 3-D electro-anatomical mapping (EAM). The challenges in the case were need for isoprenaline infusion for sustenance of tachycardia and relatively wider area of ablation requirement for success.
一名60岁男性,反复发作室上性心动过速,经常规药物治疗后再次发作。在三维电解剖成像(EAM)下进行电生理研究和射频消融(EPS和RFA)。本病例面临的挑战是需要异丙肾上腺素输注维持心动过速和相对较宽的消融面积才能成功。
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引用次数: 0
Severe Concentric Calcific Neo Atherosclerosis: Effectiveness of Ultra-high-pressure Balloon 严重同心钙化新发动脉粥样硬化:超高压球囊的有效性
Pub Date : 2022-11-17 DOI: 10.1177/26324636221136348
S. Yerram, Bharathi Vanaparty, Srinivas Bhyravavajhala
Concentric calcific neo atherosclerosis is a rare cause of in-stent restenosis, which is more common in bare metal stents (BMS). It is a cause of undilatable lesions during the intervention and needs additional lesion preparation. 1 We report the use and effectiveness of ultra-high pressure balloons in this setting with intravascular imaging. A 68-year-old man with a history of percutaneous coronary intervention (PCI) to the left anterior descending artery (LAD) in 2008 with a bare-metal stent now presented with unstable angina. Coronary angiography showed severe restenosis of the LAD stent with slow flow (Figure 1A). The first optical coherence tomography (OCT) run showed intimal hyperplasia with severe concentric calcific neoatherosclerosis in the proximal stent with calcium extending more than 180 degrees in circumference (Figure 1B). Predilation with noncompliant
同心钙化性新发动脉粥样硬化是支架内再狭窄的罕见原因,在裸金属支架(BMS)中更为常见。这是干预期间不可扩张病变的原因,需要额外的病变准备。我们报道超高压球囊在这种情况下血管内成像的使用和有效性。一名68岁男性,2008年曾行左前降支经皮冠状动脉介入治疗(PCI),置入裸金属支架,现表现为不稳定型心绞痛。冠状动脉造影显示LAD支架严重再狭窄,血流缓慢(图1A)。第一次光学相干断层扫描(OCT)显示近端支架内膜增生伴严重同心钙化新动脉粥样硬化,钙周长超过180度(图1B)。预扩张与不合规
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引用次数: 0
Acute Coronary Syndrome Presenting as Sudden Cardiac Death 急性冠状动脉综合征表现为心源性猝死
Pub Date : 2022-11-11 DOI: 10.1177/26324636221135997
A. Kapoor, A. Sahu
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引用次数: 0
Latest Development in Interventional Cardiology 介入心脏病学最新进展
Pub Date : 2022-11-10 DOI: 10.1177/26324636221135984
K. Jadhav
Background: Drug-coated balloons (DCB) are frequently used to treat femoropopliteal artery disease. However, patency loss occurs in ≥10% of patients within 12 months posttreatment with poor understanding of the underlying mechanisms. Objectives: The authors sought to investigate the determinants of DCB failure in femoropopliteal disease. Methods: Data from randomized clinical trials (IN.PACT SFA, MDT-2113 SFA Japan) and 2 prespecified imaging cohorts of the IN.PACT Global Clinical Study were included. Influential procedural characteristics were evaluated by an independent angiographic core laboratory. The primary endpoint was DCB failure (patency loss during follow-up). Additional endpoints were binary restenosis and clinically driven target lesion revascularization. Multivariable analyses evaluated the clinical, anatomical, and procedural predictors of DCB failure. Results: Included were 557 participants with single lesions and 12-month core laboratory-adjudicated duplex ultrasonography. Key clinical characteristics were as follows:
背景:药物包被球囊(DCB)常用于治疗股腘动脉疾病。然而,在治疗后12个月内,由于对潜在机制的了解不足,至少10%的患者出现了通畅丧失。目的:作者试图研究股腘动脉疾病中DCB失效的决定因素。方法:随机临床试验(IN。PACT SFA, MDT-2113 SFA Japan)和2个预先指定的IN成像队列。包括PACT全球临床研究。有影响的程序特征由独立的血管造影核心实验室评估。主要终点为DCB失败(随访期间通畅丧失)。其他终点是二元再狭窄和临床驱动的靶病变血运重建。多变量分析评估了DCB失败的临床、解剖和程序预测因素。结果:纳入557例单一病变和12个月核心实验室判定的双工超声检查。主要临床特征如下:
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引用次数: 0
T-Wave Inversion in Young Female 年轻女性的t波反转
Pub Date : 2022-11-03 DOI: 10.1177/26324636221132973
Juan Salazar, R. Sánchez, Renner Portillo
Corresponding author: Juan Salazar, Instituto de Investigaciones de Enfermedades Cardiovasculares de La Universidad del Zulia, Maracaibo, Venezuela. E-mail: juanjsv18@hotmail.com A 24-year-old female patient, without family or personal pathological history, came to the outpatient service because of frequent episodes of palpitations accompanied by generalized weakness and dizziness without loss of consciousness, a duration of several hours, and their selflimited nature. A 12-lead electrocardiogram was performed, which showed sinus rhythm, 88 beats per minute, a short PR interval, a widened QRS complex with initial slurring, and repolarization changes, findings that are consistent with that of Wolff–Parkinson–White (WPW) pattern, possibly right inferior paraseptal atrioventricular accessory pathway (Figure 1A). During the procedure, a right inferior paraseptal atrioventricular (previously called right posteroseptal) accessory pathway was found, with right atria stimulation radiofrequency energy applied with fixed cycles of 500 ms, acquiring atrioventricular (AV) separation and dissociation of ventriculoatrial retroconduction, and an electrocardiogram in sinus rhythm with 88 beats per minute, a PR interval of 160 ms, a QRS complex of 80 ms, a QRS axis of 60°, and symmetrical T-wave inversion (TWI) in DII, DIII, and aVF leads (Figure 1B). Radiofrequency ablation was performed without atrial pacing. The patient was discharged without instantaneous complications. During the follow-up evaluation, 10 days after the procedure, the patient was asymptomatic, with no new episodes of palpitations, and an electrocardiogram in sinus rhythm with 83 beats per minute, PR interval of 160 ms, QRS complex of 80 ms, QRS axis of 60°, and normal repolarization changes (Figure 2). The patient was managed conservatively due to a suspicion of cardiac memory phenomenon . The secondary changes in ST segment and T-wave are due to alterations in the ventricular activation sequence. When this is normalized, the repolarization changes are immediately
通讯作者:Juan Salazar,委内瑞拉马拉开波苏利亚大学心血管研究中心。E-mail: juanjsv18@hotmail.com 24岁女性患者,无家族病史,无个人病史,因心悸频繁发作,伴全身乏力,头晕,无意识丧失,持续数小时,自限性就诊。12导联心电图显示窦性心律,每分钟88次,PR间期短,QRS复合物增宽伴初始模糊,复极改变,与Wolff-Parkinson-White (WPW)模式一致,可能为右下隔旁房室副通路(图1A)。术中发现右下隔旁房室(前称右隔后)副通路,右心房射频能量刺激,固定周期500 ms,获得房室(AV)分离和室房反传导解离,窦性心律88次/分钟,PR间隔160 ms, QRS复核80 ms, QRS轴60°。以及DII、DIII和aVF导联的对称t波反演(TWI)(图1B)。射频消融无需心房起搏。病人出院时没有立即出现并发症。术后10天随访评估,患者无症状,无新的心悸发作,心电图窦性心律83次/分,PR间隔160 ms, QRS复音80 ms, QRS轴60°,复极改变正常(图2)。因怀疑心脏记忆现象,对患者进行保守处理。ST段和t波的继发性改变是由于心室激活顺序的改变。当这个归一化时,复极变化是立即的
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引用次数: 0
Combined Pharmacological and Complex and High-risk Coronary Intervention of Chronic Total Occlusion for Ischemic Mitral Regurgitation 慢性全闭塞治疗缺血性二尖瓣反流的综合药物和复杂高危冠状动脉介入治疗
Pub Date : 2022-11-03 DOI: 10.1177/26324636221133618
P. Jariwala, S. Khetan
Percutaneous coronary intervention for chronic total occlusion is a complex and high-risk intervention (CHIP). Even though persistent ischemia-induced mitral regurgitation is rare, ischemic mitral regurgitation is a frequent complication of an acute coronary crisis. Transcatheter mitral repair has the potential to supplant surgical repair or replacement as the gold-standard treatment for persistent mitral regurgitation. Currently, these interventions are only performed on high-risk surgical candidates, but the indications may eventually be expanded to include low-to-intermediate risk patients as well, in a manner like transcatheter aortic valve replacement. In patients with ischemic cardiomyopathy who still had considerable viable myocardium, combining current guideline-directed pharmacological treatment with interventional complete revascularization decreased hospitalizations for heart failure. We performed a CHIP intervention on the left circumflex artery, which was chronically totally occluded, to address the severe ischemic mitral regurgitation that had been present for a long time.
经皮冠状动脉介入治疗慢性全闭塞是一种复杂的高风险介入治疗(CHIP)。尽管持续缺血引起的二尖瓣反流是罕见的,但缺血性二尖瓣反流是急性冠状动脉危象的常见并发症。经导管二尖瓣修复有可能取代手术修复或置换术,成为治疗持续性二尖瓣反流的金标准。目前,这些干预措施仅适用于高风险的手术候选人,但适应症最终可能会扩大到包括低至中等风险的患者,如经导管主动脉瓣置换术。对于仍有大量存活心肌的缺血性心肌病患者,结合目前指南指导的药物治疗和介入完全血运重建术可减少心力衰竭的住院率。我们对慢性完全闭塞的左旋动脉进行CHIP干预,以解决长期存在的严重缺血性二尖瓣反流。
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引用次数: 0
Atrial Fibrillation Triggered by Adenosine During Fractional Flow Reserve Measurement: Common Arrhythmia in an Uncommon Scenario 部分血流储备测量时腺苷触发心房颤动:不常见情况下的常见心律失常
Pub Date : 2022-11-01 DOI: 10.1177/26324636221133614
P. Jariwala
Recently, we came across the development of new-onset atrial fibrillation (AF) while performing fractional flow reserve (FFR) for the two patients with borderline lesions of the left anterior descending (LAD) and right coronary arteries (RCA). The use of adenosine for the termination of supraventricular tachycardia is a common indication. The hemodynamic evaluation of a coronary lesion prior to revascularization has grown after the publication of the FAME and FAME 2 trials.1,2 In the catheterization laboratory, intracoronary or intravenous adenosine is used to document the significance of borderline lesions as a vasodilator. Transient bradyarrhythmia is known as an adverse effect. The development of AF following intracoronary or intravenous infusions of adenosine is a rare occurrence.3,4
最近,我们在对两名左前降支(LAD)和右冠状动脉(RCA)交界性病变的患者进行分流血流储备(FFR)时发现了新发心房颤动(AF)的发展。使用腺苷终止室上性心动过速是一个常见的适应症。在FAME和FAME 2试验发表后,冠状动脉病变血运重建术前的血流动力学评估得到了发展。1,2在导管实验室,冠状动脉内或静脉注射腺苷被用来记录边缘病变作为血管扩张剂的意义。一过性慢性心律失常被称为不良反应。冠状动脉内或静脉输注腺苷后发生房颤是很少见的
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引用次数: 0
Iatrogenic Left Main Coronary Artery Dissection During Non-Left Main Intervention: A Case Series 非左主干介入治疗期间医源性左主干冠状动脉夹层:一个病例系列
Pub Date : 2022-11-01 DOI: 10.1177/26324636221133230
A. Raj, A. Singh, R. Nath
Iatrogenic left main coronary artery (LMCA) dissection is a rare complication of percutaneous coronary intervention (PCI), it is mainly attributed to the catheter-based manipulation during engagement of Ostia or during the intervention. LMCA dissections are very dynamic ranging from a small, stable, and localized tear to extensive dissection obstructing coronary branches and cardiac arrest. Without prompt intervention, it often is a fatal complication. In this case series, we report three cases of LMCA dissection and their management with intravascular ultrasound-guided PCI.
医源性左主干冠状动脉剥离是经皮冠状动脉介入治疗(PCI)中一种罕见的并发症,其发生主要是由于介入时或介入时导管的操作所致。LMCA剥离是非常动态的,从小的、稳定的、局部的撕裂到广泛的剥离阻塞冠状动脉分支和心脏骤停。如果不及时干预,它往往是致命的并发症。在这个病例系列中,我们报告了三例LMCA夹层及其血管内超声引导下的PCI治疗。
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引用次数: 0
A Case Report of Percutaneous Closure of Bilateral PDA in a Case of Isolated Left Subclavian Artery with Bilateral PDA 经皮双侧PDA闭锁术治疗左锁骨下动脉孤立性双侧PDA 1例报告
Pub Date : 2022-10-20 DOI: 10.1177/26324636221129023
Rajesh Babu Gudipati, N. Rao, Suman Vyas
Isolated subclavian artery is a rare anomaly where the subclavian artery, instead of originating from the aorta, is connected to the ipsilateral pulmonary artery via ductus arteriosus. Presentation varies from asymptomatic to vertebrobasilar insufficiency and claudication of the ipsilateral arm. About 100 odd cases were reported in the literature. Some of them underwent definitive surgical repair, ie, reimplantation and others underwent percutaneous closure of patent ductus arteriosus thereby reducing stealing of blood and improvement of circulation in the ipsilateral arm. We are reporting a case of isolated left subclavian artery with a rare association of bilateral PDA.
孤立的锁骨下动脉是一种罕见的异常,锁骨下动脉不是起源于主动脉,而是通过动脉导管与同侧肺动脉相连。表现从无症状到椎基底动脉功能不全和同侧手臂跛行不等。文献中报道了大约100个奇怪的病例。其中一些患者接受了明确的手术修复,即再植,另一些患者接受了经皮动脉导管未闭闭合,从而减少了血液的盗窃,改善了同侧手臂的循环。我们报告一例孤立的左锁骨下动脉伴罕见的双侧PDA。
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引用次数: 0
期刊
Indian Journal of Clinical Cardiology
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