Pub Date : 1900-01-01DOI: 10.29011/2638-003x.100036
M. Yordanova
Introduction: Diagnosis and monitoring of chronic gastritis are most commonly by invasive endoscopic-biopsy technique. Finding non-invasive laboratory markers would save money and inconvenience for the patient. Saliva, with its essential protective role for the digestive system, is increasingly recognised as a good non-invasive diagnostic material. Aim: To study several biochemical parameters in the saliva of patients with chronic gastritis (HP+ and HP-), to compare their levels with those of healthy subjects and to establish correlation relationships between their serum and salivary concentrations with a view to their possible use as a diagnostic tool. Material and method: 140 subjects were studied, of which 60 patients (mean 58.73±12.08y) with chronic gastritis (44HP+ and 16HP-) with disease activity assessed by subjective complaints, serological and endoscopic findings. The control group consisted of 80 healthynon-smoking volunteers (mean 56.86±8.67y). Unstimulated saliva and serum were used for analysis. The parameters we study are Uric Acid (UA), Total Protein (TPro), Albumin (Alb) and Secretory IgA (sIg A). They are analysed with B.Coulter ready-made kits with an adaptation of the oral fluid methods of an Olympus AU 640 biochemical analyser and ELISA Reader DiaMetra Italy. Results: Significantly higher values of sIgA(p<0.0001), Alb(p<0.0001) and TP(p=0.0434) were observed in HP+ patients compared to the control group, but not for UA. We found a correlation between saliva/serum values for UA only (r=0.3389, p=0.011). A moderate negative correlation existed between UA and endoscopic inflammatory changes (r=-0.4203, p=0.016). These changes are thought to be compensatory for the gastric inflammation, increased oxidative stress and altered salivary flow rate. Conclusion: The data indicate significant changes in salivary parameters in HP+ chronic gastritis. Saliva has its weaknesses as a biological material, but it reflects well the pathological processes in the digestive system, especially with HP+ infection.
慢性胃炎的诊断和监测最常用的是侵入性内镜活检技术。寻找非侵入性的实验室标记物将为患者节省资金和不便。唾液对消化系统具有重要的保护作用，越来越被认为是一种良好的非侵入性诊断材料。目的:研究慢性胃炎患者唾液中的几种生化参数(HP+和HP-)，并将其与健康人进行比较，建立血清和唾液浓度之间的相关性，以期将其作为诊断工具。材料与方法:140例受试者，其中60例(平均58.73±12.08岁)慢性胃炎(44HP+和16HP-)，通过主观主诉、血清学和内镜检查评估疾病活动性。对照组为80例健康非吸烟志愿者(平均56.86±8.67岁)。用未刺激的唾液和血清进行分析。我们研究的参数是尿酸(UA)、总蛋白(TPro)、白蛋白(Alb)和分泌IgA (sIg A)。这些参数采用B.Coulter现成试剂盒进行分析，该试剂盒采用Olympus AU 640生化分析仪的口腔液方法和ELISA Reader diameter意大利。结果:与对照组相比，HP+患者sIgA(p<0.0001)、Alb(p<0.0001)和TP(p=0.0434)均显著升高，UA无显著升高。我们发现唾液/血清值仅与UA相关(r=0.3389, p=0.011)。UA与内镜下炎症变化呈中度负相关(r=-0.4203, p=0.016)。这些变化被认为是对胃炎症、氧化应激增加和唾液流率改变的补偿。结论:HP+慢性胃炎患者唾液参数有明显变化。唾液作为一种生物材料有其弱点，但它能很好地反映消化系统的病理过程，尤其是HP+感染。
{"title":"Salivary Changes in Helicobacter Pylori-Positive (HP+) Chronic Gastritis","authors":"M. Yordanova","doi":"10.29011/2638-003x.100036","DOIUrl":"https://doi.org/10.29011/2638-003x.100036","url":null,"abstract":"Introduction: Diagnosis and monitoring of chronic gastritis are most commonly by invasive endoscopic-biopsy technique. Finding non-invasive laboratory markers would save money and inconvenience for the patient. Saliva, with its essential protective role for the digestive system, is increasingly recognised as a good non-invasive diagnostic material. Aim: To study several biochemical parameters in the saliva of patients with chronic gastritis (HP+ and HP-), to compare their levels with those of healthy subjects and to establish correlation relationships between their serum and salivary concentrations with a view to their possible use as a diagnostic tool. Material and method: 140 subjects were studied, of which 60 patients (mean 58.73±12.08y) with chronic gastritis (44HP+ and 16HP-) with disease activity assessed by subjective complaints, serological and endoscopic findings. The control group consisted of 80 healthynon-smoking volunteers (mean 56.86±8.67y). Unstimulated saliva and serum were used for analysis. The parameters we study are Uric Acid (UA), Total Protein (TPro), Albumin (Alb) and Secretory IgA (sIg A). They are analysed with B.Coulter ready-made kits with an adaptation of the oral fluid methods of an Olympus AU 640 biochemical analyser and ELISA Reader DiaMetra Italy. Results: Significantly higher values of sIgA(p<0.0001), Alb(p<0.0001) and TP(p=0.0434) were observed in HP+ patients compared to the control group, but not for UA. We found a correlation between saliva/serum values for UA only (r=0.3389, p=0.011). A moderate negative correlation existed between UA and endoscopic inflammatory changes (r=-0.4203, p=0.016). These changes are thought to be compensatory for the gastric inflammation, increased oxidative stress and altered salivary flow rate. Conclusion: The data indicate significant changes in salivary parameters in HP+ chronic gastritis. Saliva has its weaknesses as a biological material, but it reflects well the pathological processes in the digestive system, especially with HP+ infection.","PeriodicalId":431682,"journal":{"name":"Current trends in Internal Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128092181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29011/2638-003x.100046
A. Landwehr, N. Solomon, Susan Sanelli-Russo, V. Rizzo
This article discusses the challenges clinicians face between academic exploration, the good of the patient and the good of the many. This ethical debate was recently prompted by a case in which a rare disease was strongly suspected, but for which confirmation would potentially require unnecessary and arguably harmful intervention that would be unlikely to change management or prognosis. We explore some of the ethical dilemmas surrounding situations like these, namely weighing academic interest and potential benefit to the medical community and future patients against the risk of harm to patients, whose health we have vowed to protect.
{"title":"Chasing the Zebras: Choosing Between the One, the Many, and the Pursuit of Knowledge","authors":"A. Landwehr, N. Solomon, Susan Sanelli-Russo, V. Rizzo","doi":"10.29011/2638-003x.100046","DOIUrl":"https://doi.org/10.29011/2638-003x.100046","url":null,"abstract":"This article discusses the challenges clinicians face between academic exploration, the good of the patient and the good of the many. This ethical debate was recently prompted by a case in which a rare disease was strongly suspected, but for which confirmation would potentially require unnecessary and arguably harmful intervention that would be unlikely to change management or prognosis. We explore some of the ethical dilemmas surrounding situations like these, namely weighing academic interest and potential benefit to the medical community and future patients against the risk of harm to patients, whose health we have vowed to protect.","PeriodicalId":431682,"journal":{"name":"Current trends in Internal Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133315285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29011/2638-003x.100047
{"title":"Disease Dynamics, Communication, Anxiety, and Public Response: Lessons for and from COVID-19","authors":"","doi":"10.29011/2638-003x.100047","DOIUrl":"https://doi.org/10.29011/2638-003x.100047","url":null,"abstract":"","PeriodicalId":431682,"journal":{"name":"Current trends in Internal Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126240683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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