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Corrosion of metal orthodontic brackets and archwires caused by fluoride-containing products: Cytotoxicity, metal ion release and surface roughness 含氟产品对金属正畸托架和弓线的腐蚀:细胞毒性、金属离子释放和表面粗糙度
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-06-01 DOI: 10.1016/j.odw.2018.02.001
Tipanan Yanisarapan , Pasutha Thunyakitpisal , Pintu-on Chantarawaratit

Purpose

The aims of this study were to determine the cytotoxicity, metal ion release and surface roughness of metal orthodontic appliances after immersion in different fluoride product solutions.

Materials and methods

Twelve sets of 20 brackets and four tubes were ligated with three types of archwires: stainless steel, nickel-titanium, and beta-titanium. The samples in each archwire group were divided into three subgroups and immersed in solutions of fluoride toothpaste, 1.23% acidulated phosphate fluoride (APF), or artificial saliva without fluoride as a control group. The immersion times were estimated from the recommended time of using each fluoride product for 3 months. The samples were immersed in cell culture medium for 7 days. Primary gingival fibroblast cell viability was determined by an MTT assay. Metal ion (nickel, chromium, iron, and molybdenum) release and surface roughness were measured by inductively coupled plasma mass spectroscopy and a noncontact optical 3-dimensional surface characterization and roughness measuring device, respectively. The bracket and wire surface morphology was observed using scanning electron microscopy. The data were analysed by Two-way ANOVA.

Results

In the APF groups, the four metal ion levels and surface roughness of the brackets and archwires significantly increased, while cell viability significantly decreased, especially in the TMA subgroup. The SEM results showed that the brackets and wires in the APF groups demonstrated more lines and grooves compared with the other groups.

Conclusion

Using APF gel during orthodontic treatment with fixed metal appliances should be avoided.

目的研究金属正畸矫治器在不同氟产品溶液中浸泡后的细胞毒性、金属离子释放量和表面粗糙度。材料与方法采用不锈钢、镍钛、β钛三种不同类型的弓线进行结扎,共12组共20个托槽和4根管。每个弓丝组的标本分为3个亚组,分别浸泡在含氟牙膏、1.23%酸化磷酸氟(APF)溶液和不含氟的人工唾液溶液中作为对照组。浸泡时间是根据每种氟化物产品推荐使用时间3个月估算的。样品在细胞培养基中浸泡7天。MTT法测定原代牙龈成纤维细胞活力。金属离子(镍、铬、铁和钼)释放和表面粗糙度分别采用电感耦合等离子体质谱和非接触式光学三维表面表征和粗糙度测量装置进行测量。用扫描电镜观察支架和金属丝的表面形貌。数据采用双向方差分析。结果APF组支架和弓丝的四种金属离子水平和表面粗糙度均显著升高,细胞活力显著降低,其中以TMA亚组明显降低。扫描电镜结果显示,APF组的托槽和导线与其他组相比呈现出更多的线条和凹槽。结论在固定金属矫治器正畸治疗中应避免使用APF凝胶。
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引用次数: 20
Questionnaire investigation after orthodontic treatment in patients with unilateral cleft lip and palate: An inter-clinic collaborative study 单侧唇腭裂患者正畸治疗后的问卷调查:一项临床合作研究
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-06-01 DOI: 10.1016/j.odw.2018.02.002
Mari Okayasu , Takafumi Susami , Toshikazu Asahito , Teruo Sakamoto , Kazuyuki Kurata , Yasuo Ishiwata , Kouhei Nagahama , Tsuyoshi Takato , Isao Saito

Purpose

This six-clinic collaborative study collected patient opinions after orthodontic treatment, for quality improvement.

Materials and methods

Participants comprised 477 patients with unilateral cleft lip and palate (UCLP) who had undergone orthodontic treatment at orthodontic clinics in five university hospitals and one private office in Japan. The questionnaire sent to patients contained 33 questions in five categories, about the respondent, before, during and after orthodontic treatment, and overall treatment. Questionnaires were returned by mail anonymously.

Results

Responses were received from 183 patients (response rate, 38.4%). Patients tended to anticipate esthetic improvements in anterior teeth and facial appearance, and reported great improvements with orthodontic treatment. Masticatory problems also improved and orthodontic treatment had positive effects on speech. Almost all respondents were satisfied with orthodontic treatment. Problems with overall treatment were long treatment period, difficulty attending clinics and maintenance of oral hygiene during treatment.

Conclusion

This study clarified the subjective effects and problems with orthodontic treatment in patients with UCLP in Japan. Satisfaction after treatment was high. Anticipated esthetic improvement was accomplished and masticatory problems improved. Orthodontic treatment also positively affected speech. Efficient orthodontic treatment to minimize treatment duration and improved treatment systems for easier access are needed to reduce patient burdens in Japan.

目的:本研究收集患者正畸治疗后的意见,以提高正畸治疗质量。材料与方法研究对象为477例单侧唇腭裂(UCLP)患者,均在日本5家大学医院和1家私人诊所的正畸诊所接受了正畸治疗。发放给患者的问卷包含5类33个问题,分别是关于被调查者、正畸治疗前、治疗中、治疗后和整体治疗。问卷以匿名方式邮寄。结果183例患者获得应答,有效率为38.4%。患者倾向于预期前牙和面部外观的美观改善,并报告了正畸治疗的巨大改善。咀嚼问题也得到改善,正畸治疗对言语有积极影响。几乎所有受访者对正畸治疗满意。整体治疗存在治疗期长、就诊困难、治疗期间保持口腔卫生等问题。结论本研究明确了日本UCLP患者正畸治疗的主观影响及存在的问题。治疗后满意度高。预期的审美改善得以完成,咀嚼问题也得到改善。正畸治疗对言语也有积极影响。为了减轻日本患者的负担,需要有效的正畸治疗,以尽量缩短治疗时间,并改进治疗系统,使患者更容易获得治疗。
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引用次数: 1
Evaluation of prevalence and characteristics of ponticulus posticus among Japanese adults: A comparative study between CBCT imaging and lateral cephalogram 评价日本成人后丘的患病率和特征:CBCT成像和侧位脑电图的比较研究
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-06-01 DOI: 10.1016/j.odw.2018.04.001
Vajendra Joshi , Yukiko Matsuda , Yukinori Kimura , Kazuyuki Araki , Hideki Ishida

Purpose

Purpose of the study was to evaluate the prevalence and precise characteristics of ponticulus posticus (PP) among Japanese adults using CBCT, and to evaluate the accuracy of PP by using the lateral cephalogram.

Materials and methods

This retrospective study consisted of lateral cephalogram and CBCT scans of 204 subjects (46 Males and 158 Females) above the age of 20 years. Prevalence and characteristics of PP was assessed. Chi-square test was used for statistical analysis.

Results

30 PP positive cases (14.7%) were defined by using CBCT. 12.7% subjects were assessed PP positive cases on lateral cephalogram. The accuracy of PP by using cephalogram was 0.89, sensitivity was 0.56 and specificity was 0.95.On CBCT assessment, there were 16 PP (7.8%) present on right side of Atlas whereas 23 PP (11.2%) were present on left side. Statistically significant difference was seen in the prevalence of left side PP. Among the 158 females 25 (15.8%) had PP whereas out of 46 males 5 (10.8%) had PP. No statistical significant differences were seen in gender and age groups.

Conclusion

PP is quite a common finding in Japanese adults. There were cases in which PP was not detected on lateral cephalogram compared with CBCT.

目的应用CBCT评价日本成人后脑丛(PP)的患病率和准确性,并利用侧位脑电图评价后脑丛的准确性。材料与方法回顾性研究了204例年龄在20岁以上的患者(男46例,女158例)的侧位脑电图和CBCT扫描。评估PP的患病率和特征。采用卡方检验进行统计分析。结果CBCT诊断PP阳性30例(14.7%)。12.7%的受试者在侧位脑电图上被评估为PP阳性。脑电图诊断PP的准确性为0.89,敏感性为0.56,特异性为0.95。在CBCT评估中,右侧有16个PP(7.8%),左侧有23个PP(11.2%)。左侧PP患病率差异有统计学意义。158例女性中有25例(15.8%),而46例男性中有5例(10.8%)。性别和年龄组间差异无统计学意义。结论pp在日本成人中较为常见。与CBCT相比,有侧位脑电图未检出PP的病例。
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引用次数: 4
Dentofacial characteristics in a patient with Aarskog–Scott syndrome 阿斯科格-斯科特综合征患者的牙面特征
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-06-01 DOI: 10.1016/j.odw.2018.03.001
Chihiro Tanikawa , Hiroshi Kurosaka , Kohei Nakatsugawa , Takashi Yamashiro

Aarskog–Scott syndrome (ASS), also known as facio-digito-genital syndrome or faciogenital dysplasia, is a rare X-linked recessive disorder that mainly affects the musculoskeletal system of male individuals, and is related with mutations in FGD1. This study presents the case of a 9-year old Japanese boy who was diagnosed with ASS at the age of three. The patient presented to our orthodontic department with hypodontia, impacted teeth, and delayed eruption, with narrow upper arch and retrognathic mandibles. In the present report, we introduce the patient’s dentofacial characteristics.

Aarskog-Scott综合征(ASS),也被称为面部-手指-生殖器综合征或面部-生殖器发育不良,是一种罕见的X-linked隐性遗传病,主要影响男性个体的肌肉骨骼系统,与FGD1突变有关。本研究报告一名九岁日本男童在三岁时被诊断为ASS。该患者就诊于我们的正畸科,表现为牙缺损、阻生牙、延迟出牙、上弓狭窄和下颌后突。在本报告中,我们介绍了患者的牙面特征。
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引用次数: 0
Transverse adjustment of preformed stainless steel archwires to the dental arch form 将预制不锈钢弓线横向调整到牙弓形状
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-06-01 DOI: 10.1016/j.odw.2018.04.002
Takashi Koda, Naomi Saze, Keisuke Tochigi, Kazuhito Arai

Purpose

Stable orthodontic treatment results require the preservation of the pretreatment mandibular dental arch form. Therefore, this study aimed to evaluate the amount of transverse adjustment of preformed stainless steel archwires require to fit the dental arch form.

Materials and methods

A fourth-order polynomial curve was applied to the 30 normal mandibular dental arches, and interpolated widths at the mean depths at the canine, first and second premolars, and first molar were measured. Widths of 42 types of 0.016-in. stainless steel preformed archwires were measured at the same mean depths. The widths of the dental arch and archwires were compared by the Mann–Whitney U test. Transverse adjustment values as the difference between dental and archwire widths for each tooth from the canine to first molar were calculated for each archwire and compared between tooth types. Correlation coefficients between tooth types were also analyzed.

Results

Preformed archwire width was significantly narrower than the dental arch. Significant difference between transverse adjustment values between each tooth type were found except between canine and first premolar. Significant correlations between each tooth types were also observed.

Conclusion

To reduce these adjustments, preformed stainless steel archwires that are designed to be approximately 1–2 mm at the canine, 1–3 mm at first premolar, 2–4 mm at second premolar, and 3–6 mm at first molar wider in the transverse dimension could be clinically recommended.

目的稳定的正畸治疗效果需要保留预处理后的下颌牙弓形态。因此,本研究旨在评估预成型不锈钢弓丝为配合牙弓形状所需的横向调整量。材料与方法应用四阶多项式曲线对30个正常的下颌牙弓进行插值,测量犬齿、第一、第二前磨牙和第一磨牙平均深度处的插值宽度。宽度为42种0.016英寸。在相同的平均深度下测量不锈钢预制弧线。采用Mann-Whitney U检验比较牙弓和弓丝的宽度。从犬齿到第一磨牙,计算每颗牙弓丝宽度与牙弓丝宽度之差的横向调整值,并在牙齿类型之间进行比较。分析了齿型间的相关系数。结果改良弓丝宽度明显小于牙弓宽度。除犬齿与第一前磨牙外,各牙型间横向调节值差异显著。各牙型之间也观察到显著的相关性。结论为了减少这些调整,临床推荐将预制不锈钢弓丝设计成犬齿宽约1-2 mm,第一前磨牙宽约1-3 mm,第二前磨牙宽约2-4 mm,第一磨牙宽约3-6 mm的横向尺寸。
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引用次数: 2
Comparison of monozygotic twins who received orthodontic treatment with self-ligated and conventional brackets: Case report 自结扎托槽与常规托槽正畸治疗的同卵双生儿比较:病例报告
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-03-01 DOI: 10.1016/j.odw.2017.12.002
Ricardo Alves de Souza , Gregório Bonfim Dourado , Marcelo de Castellucci e Barbosa , João Batista de Paiva

This study objectived to compare the performance of different brackets, conventional and self-ligated, under similar conditions, in monozygotic twins patients with severe tooth crowding. It was evaluated the rapidness of treatment, chair time, quality of finalization, comfort and hygiene of the patients. The treatments had a duration of 24 months in both cases, however, with the conventional appliance, less time was required for performing alignment and leveling. Whereas, treatment with the self-ligated appliance required fewer appointments, and chair time was reduced about 20%. Both patients had satisfactory hygiene, and did not complain of discomfort during the treatment. The self-ligated appliance was not superior, as both cases presented similar results and were concluded at the same time.

本研究的目的是比较不同的托槽,传统和自结扎,在类似的条件下,对同卵双胞胎严重牙拥挤的患者的性能。评估治疗的快速性、坐诊时间、手术质量、患者的舒适度和卫生状况。在这两种情况下,治疗持续时间为24个月,然而,使用传统矫治器,进行矫直和调平所需的时间更少。然而,使用自结扎器治疗需要较少的预约,并且椅子时间减少了约20%。两例患者均具有良好的卫生习惯,在治疗过程中均未出现不适。自结扎矫治器并不优越,因为两例的结果相似,并在同一时间得出结论。
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引用次数: 0
Influence of habitual mouth breathing on taste sensation 习惯性口呼吸对味觉的影响
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-03-01 DOI: 10.1016/j.odw.2017.12.003
Kayo Kimura-Ueda , Kazuo Shimazaki , Kumiko Sugimoto , Takashi Ono

Purpose

Although habitual mouth breathing is recognized to cause various disorders of orofacial growth and function, including taste sensation, the relationship between habitual mouth breathing and taste disorders has not been investigated sufficiently. This study aimed to examine the influence of habitual mouth breathing on taste sensitivity and relevant factors such as salivation, oral moisture, and olfactory function.

Materials and methods

Thirty volunteers (male, 18; female, 12) aged 22–35 years participated in this study. On the basis of their responses to a questionnaire regarding habitual breathing, 15 subjects each were assigned to the mouth-breathing (MB) and control groups. Recognition thresholds for sweet, salty, sour, bitter, and umami tastes at the tip and root of the tongue were measured using the filter-paper disk method. Salivary flow and spinnbarkeit (viscosity), oral moisture, and olfactory function were also measured as factors related to taste sensitivity. Additionally, a questionnaire about dry mouth, nasal obstruction, snoring, and olfaction was implemented.

Results

The MB group exhibited significantly higher recognition thresholds for sweetness and sourness at the tip and for bitterness and sourness at the root of the tongue compared with the control group. However, there was no significant intergroup difference in the threshold for salty or umami taste, salivary flow or spinnbarkeit, oral moisture, or olfactory function. The MB group exhibited a significantly higher subjective feeling of dry mouth, nasal obstruction, and snoring than the control group.

Conclusions

Mouth breathing habit poses a risk for taste deterioration without affecting salivary secretion and olfactory function.

目的:虽然人们认为习惯性口呼吸会引起包括味觉在内的各种口腔面部生长和功能障碍,但对习惯性口呼吸与味觉障碍之间的关系尚未进行充分的研究。本研究旨在探讨习惯性口呼吸对味觉敏感性的影响,以及唾液分泌、口腔水分和嗅觉功能等相关因素。材料与方法志愿者30人(男性18岁;女性,年龄22-35岁。根据他们对习惯性呼吸问卷的回答,15名受试者分别被分配到口腔呼吸组(MB)和对照组。使用滤纸圆盘法测量舌尖和舌根对甜、咸、酸、苦和鲜味的识别阈值。唾液流动和唾液黏度(粘度)、口腔水分和嗅觉功能也被测量为与味觉敏感性相关的因素。此外,还进行了关于口干、鼻塞、打鼾和嗅觉的问卷调查。结果与对照组相比,MB组对舌尖甜味和酸味以及舌根苦味和酸味的识别阈值显著提高。然而,在咸味或鲜味、唾液流动或吐口水、口腔水分或嗅觉功能的阈值方面,组间没有显著差异。MB组表现出明显高于对照组的口干、鼻塞和打鼾的主观感觉。结论口腔呼吸习惯有味觉恶化的危险,但不影响唾液分泌和嗅觉功能。
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引用次数: 3
Corrosion of laser-welded stainless steel orthodontic wires 激光焊接不锈钢正畸丝的腐蚀
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-03-01 DOI: 10.1016/j.odw.2017.12.004
Takeshi Muguruma, Masahiro Iijima, Itaru Mizoguchi

Purpose

Fabricating orthodontic appliances using laser welding has the clinical advantage of biocompatibility, because the welded joint does not require soldered alloy. The purpose of this study was to investigate the corrosion of laser-welded stainless steel wires in acidic environments.

Materials and methods

Laser welding of stainless steel wires with a 0.021 × 0.025 in cross-section was performed at an energy output ranging from 0.5 to 1.3 kW. A control sample was prepared using conventional soldering. The samples were immersed in 1% lactic acid aqueous solution for 7 days. After immersion, the concentrations of metallic ions in solution were measured using inductively coupled plasma atomic emission spectroscopy. Tensile loading tests were carried out with and without lactic acid immersion. Scanning electron microscopy was used to examine the microstructure of laser-welded samples.

Results

The concentrations of metallic ions detected in solution for laser-welded samples were significantly lower than that for soldered sample. There was no significant difference among the mean tensile strengths with and without immersion for laser-welded samples. The penetration depth and the localized region fused by laser irradiation increased with energy output, and ductile fractures were observed in the fused region of laser-welded samples.

Conclusion

Laser welding of stainless steel orthodontic wires should be acceptable for clinical use, because the joints showed sufficient strength and the original structure was not significantly altered. Immersion in acidic solution had minimal effect on the mechanical performance at the joint regions, and showed minimal acceleration of metallic ion release.

目的激光焊接制造正畸矫治器具有生物相容性强的临床优势,焊接接头不需要焊接合金。本研究的目的是研究激光焊接不锈钢丝在酸性环境中的腐蚀。材料和方法在0.5 ~ 1.3 kW的功率输出下,对截面为0.021 × 0.025的不锈钢丝进行激光焊接。采用常规焊接工艺制备对照样品。样品在1%乳酸水溶液中浸泡7天。浸泡后,用电感耦合等离子体原子发射光谱法测定溶液中金属离子的浓度。在乳酸浸泡和不浸泡的情况下进行拉伸加载试验。采用扫描电镜对激光焊接试样的显微组织进行了观察。结果激光焊接样品溶液中金属离子的检测浓度明显低于焊接样品。激光焊接试样浸泡前后的平均抗拉强度无显著差异。随着能量输出的增加,激光辐照的熔透深度和局部熔接区域增加,熔接区域出现韧性断裂。结论激光焊接不锈钢正畸丝,其关节强度足够,且对原有结构无明显改变,可用于临床。浸泡在酸性溶液中对接头区域的力学性能影响最小,金属离子释放的加速最小。
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引用次数: 6
Treatment of severe maxillary hypoplasia with oligodontia and complete bilateral cleft lip and palate by maxillary anterior segmental distraction osteogenesis 上颌前节段牵张成骨术治疗严重上颌发育不全伴少齿畸形完全性双侧唇腭裂
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-03-01 DOI: 10.1016/j.odw.2017.12.001
Takakazu Yagi , Takashi Yamashiro , Shouich Miyawaki

Effective maxillary advance treatment is difficult to achieve without impairing velopharyngeal function in patients with severe maxillary deficiency. We describe successful orthodontic treatment using maxillary anterior segmental distraction osteogenesis (MASDO) in a patient with cleft lip and palate. A 20-year-old woman with bilateral cleft lip and palate, multiple congenitally missing teeth, reduced maxilla, concave soft-tissue profile, and skeletal Class III jaw relationship was treated with a combination of orthodontic treatment and MASDO. After treatment, the anterior maxilla was displaced forward with new bone formation induced in the distraction gap for insertion of dental implants. Maxillary hypoplasia was successfully treated while preserving the velopharyngeal function with MASDO. We suggest that MASDO is useful for patients with severe maxillary hypoplasia.

对于严重上颌缺陷的患者,很难在不损害腭咽功能的情况下进行有效的上颌提前治疗。我们描述了成功的正畸治疗使用上颌前段牵张成骨(MASDO)的病人唇腭裂。我们对一名20岁的双侧唇腭裂,先天性多颗缺牙,上颌缩小,软组织凹陷,骨骼III级颌关系的女性进行了正畸治疗和MASDO的联合治疗。治疗后,上颌前牙向前移位,在牵张间隙形成新骨,用于种植体的插入。在保留腭咽功能的同时,成功地治疗了上颌发育不全。我们认为MASDO对严重上颌发育不全的患者是有用的。
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引用次数: 1
Lessons learned as a student of craniofacial biology: What this might mean for orthodontic professional education and clinical practice in the 21st century 作为颅面生物学学生的经验教训:这对21世纪正畸专业教育和临床实践的意义
IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2018-03-01 DOI: 10.1016/j.odw.2017.08.002
Harold C. Slavkin

The National Institute of Dental Research (NIDR) supported the international symposium “Congenital Anomalies of the Face and Associated Structures” led by Professor Sam Pruzansky and members of the first Dental Study Section in 1959. The plan was unique in that it examined the human face as a biological continuum, from conception through postnatal growth and development, to maturity in terms of functions, structures, and behavior. The symposium forged foundations for what we now term “craniofacial biology.” In tandem, the first grant by NIDR was funded in 1957 to Dr. Herbert K. Cooper, orthodontist, for his landmark animal and human studies of cleft lip and cleft palate. What followed were decades of multidisciplinary studies in embryology, anatomy, and physiology coupled with diagnostics, therapeutics, biomaterials, imaging, speech pathology, and studies of human behaviors to promote health and health literacy. In 1998, as Director of the NIDR, I championed a name change for the Institute to become the National Institute of Dental and Craniofacial Research (NIDCR) to better reflect our scientific portfolio. Today I ask how craniofacial biology evolved from teratology to neural crest cell mapping, to experimental embryology, to correlating single gene mutations to phenotype(s), and knowledge of gene functions. Now in the 21st century, craniofacial biology contributes to genomics and epigenetics in animal models and human soft and hard tissue diseases and disorders. For the near future, biomedical scientists and clinical scholars seek to understand how human and microbial genomics impact diseases, how to use gene editing to treat diseases, how to employ precision dentistry and medicine, and how to advance major revisions in professional health education and interprofessional clinical practice. As in the past, orthodontists and many other disciplines will continue to play key roles involving critical thinking and sound clinical acumen to improve the quality and precision of craniofacial–oral–dental healthcare.

国家牙科研究所(NIDR)于1959年支持了由Sam Pruzansky教授和第一牙科研究部成员领导的“面部先天性异常和相关结构”国际研讨会。该计划的独特之处在于,它将人脸作为一个生物连续体进行研究,从受孕到出生后的生长发育,再到功能、结构和行为的成熟。这次研讨会为我们现在所说的“颅面生物学”奠定了基础。与此同时,NIDR的第一笔拨款于1957年被资助给正畸医生赫伯特·k·库珀博士,以表彰他对唇裂和腭裂进行的具有里程碑意义的动物和人类研究。随后是数十年的多学科研究,包括胚胎学、解剖学和生理学,以及诊断学、治疗学、生物材料、成像、语言病理学和人类行为研究,以促进健康和健康素养。1998年,作为NIDR的主任,我支持将研究所更名为国家牙科和颅面研究所(NIDCR),以更好地反映我们的科学组合。今天我要问颅面生物学是如何从畸形学发展到神经嵴细胞定位,再到实验胚胎学,再到单基因突变与表型的关联,以及基因功能的知识。现在在21世纪,颅面生物学对动物模型和人类软硬组织疾病和失调的基因组学和表观遗传学做出了贡献。在不久的将来,生物医学科学家和临床学者试图了解人类和微生物基因组学如何影响疾病,如何使用基因编辑来治疗疾病,如何使用精密牙科和医学,以及如何推进专业健康教育和跨专业临床实践的重大修订。与过去一样,正畸医生和许多其他学科将继续发挥关键作用,涉及批判性思维和良好的临床敏锐度,以提高颅面-口腔-牙科保健的质量和精度。
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引用次数: 4
期刊
Orthodontic Waves
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