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Involving patients in developing, refining and testing an implementation strategy to promote asthma self-management using the National Standards for Public Involvement 让患者参与制定、完善和测试一项实施战略,利用公众参与国家标准促进哮喘自我管理
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4007
T. Jackson, Elisabeth Ehrlich, K. McClatchey, Susan L. Morrow, Stephanie J. C. Taylor, H. Pinnock
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引用次数: 1
Gender aspect of comorbidities in COPD patients in primary care 初级保健中COPD患者合并症的性别方面
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa5019
K. Klester, E. Klester, V. Elykomov, A. Zharikov, Galina Ermachkova, M. Nikolaeva, E. Mukhtarova
Introduction: a problem of multi-morbidity - the increase in the multiplicity of diseases with age, which reflects, first of all, involutional processes and comorbidity - the deterministic possibility of their combination, is particularly difficult. Objective: to study gender characteristics of comorbid conditions and determine the degree of their influence on mortality in COPD. Materials and Methods: conducted a 6-year clinical observations in COPD p-s (n = 518; 389 were males, mean age - 66,2 ±13,9 years). The Carlson Comorbidity Index (CCI; 1987), the geriatric Cumulative Illness Rating Scale (CIRS-G), Barthel Index (BI) were evaluated. Results: CCI was in group A - 3,2 ± 1,1; in B - 3,8 ± 0,9; in C - 4,6 ± 1,0; in D - 3,9 ± 0,8 (all p 4 scores (odds ratio [OR] 4.92; 95% confidence interval [CI], 3.89-6.34; p Conclusion: Associated pathology forms a syndrome of mutual aggravation, which leads to an increased risk of death in the assessment by CCI with mandatory consideration of gender differences, which should be taken into account in the development of treatment plans for COPD patients.
导言:多重发病的问题——随着年龄增长,疾病的多样性增加,这首先反映了发病过程和合并症——它们结合的确定性可能性——特别困难。目的:研究COPD合并症的性别特征,确定其对死亡率的影响程度。材料与方法:对COPD p-s患者进行了为期6年的临床观察(n = 518;男性389例,平均年龄- 66,2±13.9岁)。卡尔森合并症指数;1987)、老年累积疾病评定量表(CIRS-G)、Barthel指数(BI)进行评估。结果:A组CCI为- 3,2±1,1;B - 3,8±0,9;C - 4,6±1,0;D - 3,9±0,8(均为4分)(优势比[OR] 4.92;95%置信区间[CI], 3.89-6.34;p结论:相关病理形成一种相互加重的综合征,导致CCI评估中死亡风险增加,并强制考虑性别差异,在制定COPD患者治疗方案时应考虑到这一点。
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引用次数: 0
Triple Therapy Pathways: A Multi-Country, Retrospective Observational Study in Chronic Obstructive Pulmonary Disease (COPD) 三联疗法途径:慢性阻塞性肺疾病(COPD)的多国回顾性观察研究
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa5153
J. Quint, C. O'Leary, A. Venerus, M. Myland, Nicholas Hudson, U. Holmgren, P. Varghese, H. Richter, G. Bizouard, C. Cabrera
Background: Maintenance treatment in COPD recommends triple therapy (TT), often following use of mono-or dual-therapy. We explored how pathways to TT vary across countries. Aims and Objectives: We investigated the proportion of patients on TT relative to the timing of their COPD diagnosis and the treatment pathway to TT including the time from diagnosis to initiation of TT and adherence. Methods: A retrospective cohort study was performed using anonymised patient-level data from UK, France, Germany, Italy, and Australia from 01/01/2005 to 01/05/2016. Patients were included if their first TT regimen was recorded during this period and they had ≥12 months data pre-index (COPD diagnosis). The proportion of patients on TT before COPD diagnosis was also determined. Treatment pathways and time to TT initiation following index were evaluated. Adherence to TT was estimated using proportion of days covered. Results: Overall 130,729 eligible patients were included. Mean age at diagnosis ranged from 63.4 (SD:10.4) years [pneumologist-treated in Germany] to 69.8 (9.9) years [Italy]. Time to TT ranged from median 16.9 months in Australia (IQR: 5.7 – 36.2) to 42.5 months in the UK (IQR: 13.9 -87.4). TT initiated first formed the largest treatment pathway (7.5% in UK to 17.1% in France). In meta-analyses of patients across all countries, 20.4% (95% CI: 13.8-29.1%) of patients initiated TT prior to COPD diagnosis. Estimated adherence was >80% in all countries during the time the patient was persistent with TT. Conclusions: Diverse patient pathways to TT were observed both between and within countries, many of which do not align with COPD treatment recommendations.
背景:慢性阻塞性肺病的维持治疗推荐三联治疗(TT),通常在使用单一或双重治疗之后。我们探讨了各国TT途径的差异。目的和目的:我们调查了TT患者相对于COPD诊断时间的比例,以及TT的治疗途径,包括从诊断到开始TT和坚持治疗的时间。方法:采用2005年1月1日至2016年5月1日期间来自英国、法国、德国、意大利和澳大利亚的匿名患者数据进行回顾性队列研究。如果患者在此期间记录了他们的第一次TT方案,并且他们有≥12个月的前指数(COPD诊断)数据,则纳入患者。同时确定慢性阻塞性肺病诊断前接受TT治疗的患者比例。评估治疗途径和TT起始时间。使用覆盖天数的比例来估计TT的依从性。结果:共纳入130,729例符合条件的患者。诊断时的平均年龄从德国的63.4岁(SD:10.4)岁到意大利的69.8岁(9.9)岁不等。到TT的中位时间从澳大利亚的16.9个月(IQR: 5.7 - 36.2)到英国的42.5个月(IQR: 13.9 -87.4)不等。TT首先形成了最大的治疗途径(英国为7.5%,法国为17.1%)。在所有国家患者的荟萃分析中,20.4% (95% CI: 13.8-29.1%)的患者在COPD诊断前开始TT治疗。在所有国家,在患者持续接受TT治疗期间,估计依从性>80%。结论:在国家之间和国家内部观察到不同的患者TT途径,其中许多不符合COPD治疗建议。
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引用次数: 0
Correlation between COPD assessment test (CAT) and mMRC dyspnea scale in evaluationg COPD symptoms COPD评估试验(CAT)与mMRC呼吸困难量表评价COPD症状的相关性
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa703
F. Abdallah, I. Bachouch, N. Belloumi, S. Fenniche
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引用次数: 0
Efficacy of the association of inspiratory muscle training with whole body vibration on respiratory muscle strength, functionality, balance and physical performance in pre-frail older women: a randomized double-blind clinical trial 吸气肌训练与全身振动对体弱多病老年妇女呼吸肌力量、功能、平衡和体能表现的影响:一项随机双盲临床试验
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa724
H. Souza, M. Pessoa, Rafaela Clemente, A. Silva, Erika Andrade, C. Reinaux, Luciana Alcoforado, Juliana Fernandes Barbosa, P. Moura, A. Andrade
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引用次数: 0
Management of community-acquired pneumonia in primary care: an observational study 社区获得性肺炎在初级保健中的管理:一项观察性研究
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa723
N. Launders, D. Ryan, C. Winchester, D. Skinner, Priyanka Raju Konduru, D. Price
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引用次数: 0
Bronchodilator reversibility among patients with asthma presenting to tertiary care hospitals in Trivandrum, India 印度特里凡得琅三级医院哮喘患者的支气管扩张剂可逆性
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa715
S. Nair, P. Arjun
Introduction: Demonstration of post-bronchodilator reversibility is considered as an important tool for the diagnosis of Asthma, however this is not demonstrable in all patients. Aims and Objectives: To determine the proportion of patients with Asthma presenting to tertiary care hospital in Trivandrum, South India who show post-bronchodilator reversibility on spirometry and to determine the factors associated with reversibility Methods: Consecutive patients with clinician diagnosed asthma (by a senior pulmonologist, based on GINA guidelines) underwent spirometry as part of their diagnostic work-up at the time of their presentation in two tertiary care hospitals. Pre- and post bronchodilator spirometry were done by an expert technician. Reversibility was defined as increase in FEV1 by 200ml and 12% Results: 200 consecutive patients with Asthma were recruited. Mean age of the patients was 41.5 years (SD - 18.2). 59.5% of the patients were femaies. The proportion of patients with reversibility was 47% (95%CI-40%,54%). The factors associated with reversibility were low age( 0.05). Conclusion: While developing local guidelines for diagnosis of Asthma, the fact that reversibility can be demonstrated only less than 50% of patients must be considered, otherwise a significant proportion of cases with Asthma may be missed or misdiagnosed as COPD.
证明支气管扩张剂后可逆性被认为是诊断哮喘的重要工具,但并非在所有患者中都能证明这一点。目的和目的:确定到印度南部特里vandrum三级医院就诊的支气管扩张剂后肺活量测定显示可逆性的哮喘患者的比例,并确定与可逆性相关的因素。方法:连续的临床医生诊断为哮喘的患者(由高级肺科医生根据GINA指南)在两家三级医院就诊时进行了肺活量测定,作为诊断检查的一部分。支气管扩张剂前后肺活量测定由专业技术人员完成。可逆性定义为FEV1增加200ml和12%。结果:连续招募200例哮喘患者。患者平均年龄41.5岁(SD - 18.2)。女性占59.5%。可逆性患者比例为47% (95%CI-40%,54%)。与可逆性相关的因素是低年龄(0.05)。结论:在制定当地哮喘诊断指南时,必须考虑到只有不到50%的患者可以证明可逆性,否则可能会有很大比例的哮喘病例被漏诊或误诊为COPD。
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引用次数: 0
Health Care Expenses for COPD with Late Do-Not-Resuscitate (DNR) Decisions Escalate Nearly 2-Fold in Final Admission of Life 慢性阻塞性肺病晚期不复苏(DNR)决定的医疗费用在最终入院时上升近2倍
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa732
Pin-Kuei Fu
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引用次数: 0
Implementation of simplified method for SAHS diagnosis in primary care 初级保健中SAHS简易诊断方法的实施
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4001
C. Muñoz-Pindado, V. Arribas-Peña, E. Muñoz-Herrera, S. Sánchez-Belmonte, B. Mateu-Carralero, A. Darnés-Surroca, M. Callís-Privat, I. Casademunt-Codina, F. Ruiz-Mori, N. Roger-Casals
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引用次数: 0
Withdrawal of high-dose inhaled corticosteroids in COPD patients with mild or moderate airflow limitation: a feasibility study in primary care 轻度或中度气流受限的COPD患者停用大剂量吸入皮质类固醇:一项初级保健的可行性研究
Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa5007
P. White, G. Gilworth, M. Thomas, C. Corrigan, Patrick J. Murphy, N. Hart, Leslie A. Hamilton, T. Harries
Background: High-dose inhaled corticosteroids (HD-ICS) are prescribed frequently outside guidelines in COPD, especially with mild or moderate airflow limitation. The acceptability and safety of withdrawal of HD-ICS in these patients is unknown. Aim: Feasibility study of a trial of the safe withdrawal of HD-ICS prescribed outside guidelines in COPD patients with mild or moderate airflow limitation. Method: COPD patients with mild or moderate airflow limitation using HD-ICS were invited to participate by their GPs. The challenges of identifying those suitable for inclusion have been described elsewhere. Participants were randomised to withdrawal from or continued use of HD-ICS. Impact of withdrawal was assessed through measures of lung function, quality of life, exacerbations, cellular and molecular biomarkers and neural respiratory drive. Measures were repeated at 3 and 6 months. Results: 61 patients attended. All agreed to undertake HD-ICS withdrawal. 21 patients were excluded due to: FEV1 reversibility (49%), severe airflow limitation (29%), no airflow obstruction (10%), frequent exacerbations in past year (4%), hospital admission for exacerbation (4%), BMI >35 (4%). 40 patients were recruited to the feasibility study. 20 were randomised to withdraw from HD-ICS use, 20 to continue HD-ICS use. Among the withdrawal arm, 5 resumed HD-ICS because of a decline in lung function or patient choice. Conclusions: A trial of the withdrawal of HD-ICS is feasible and acceptable to eligible patients responding to invitation. Of priority are identification of suitable patients and careful monitoring to detect a decline in lung function following withdrawal.
背景:大剂量吸入性皮质类固醇(HD-ICS)经常在COPD指南之外使用,特别是轻度或中度气流受限的患者。这些患者停用HD-ICS的可接受性和安全性尚不清楚。目的:对轻度或中度气流受限COPD患者安全停用指南外HD-ICS的可行性研究。方法:由全科医生邀请轻度或中度气流受限的COPD患者使用HD-ICS进行参与。在其他地方已经描述了确定那些适合纳入的挑战。参与者被随机分配到停止或继续使用HD-ICS。通过测量肺功能、生活质量、恶化情况、细胞和分子生物标志物以及神经呼吸驱动来评估停药的影响。在3个月和6个月时重复测量。结果:61例患者就诊。所有国家都同意撤出HD-ICS。21例患者因FEV1可逆性(49%)、严重气流受限(29%)、无气流阻塞(10%)、过去一年频繁加重(4%)、因加重住院(4%)、BMI >35(4%)被排除。选取40例患者进行可行性研究。20人随机退出HD-ICS使用,20人继续使用HD-ICS。在停药组中,5例因肺功能下降或患者选择恢复HD-ICS。结论:对于响应邀请的符合条件的患者,撤销HD-ICS的试验是可行和可接受的。优先考虑的是确定合适的患者,并仔细监测停药后肺功能的下降。
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General practice and primary care
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