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Scalp reconstruction with locoregional and free flaps - a retrospective cohort study. 用局部皮瓣和游离皮瓣重建头皮--一项回顾性队列研究。
IF 1 Q3 SURGERY Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI: 10.3205/iprs000187
Olimpiu Bota, Franziska Beyer, Johann Klein, Tareq A Juratli, Adrian Dragu, Kevin Bienger

Introduction: Scalp defect reconstruction requires interdisciplinary cooperation to restore soft tissue and osseous defects. While wound closure and form restoration, often a short-term treatment goal, ensures patient survival, the long-term preservation of the head and neck's integrity and aesthetics is crucial for maintaining quality of life. This study aims to compare, quantify, and establish a safe and reproducible approach to various reconstruction options and the postoperative complication profile for individual scalp defect areas.

Materials and methods: We retrospectively evaluated patients who underwent scalp reconstruction at our institution between March 2017 and April 2022. The inclusion criterion was the presence of a soft tissue defect at the cranium level.

Results: We included 31 patients in the study (17 males, 14 females), with an average age of 61 years (range 17-92 years). Eight patients had received radiotherapy in the affected region. The mean defect size was 72.5±116 cm2 (range 20-441 cm2), and an average of 3±2 surgeries had been performed before the plastic surgical treatment was initiated. Eleven patients had only a soft tissue defect, while 20 patients had an associated bone defect. Fifteen of these patients received a cranioplasty. The rotation flap was the most frequently used (n=23), with or without split-thickness skin grafting, followed by the free latissimus dorsi muscle flap with split-thickness skin grafting (n=5), and the free lateral arm flap (n=2). Revision surgeries were necessary in 38.7% of cases due to wound healing disorders (n=9), bleeding (n=2), and cerebrospinal fluid leaks (n=1). Eventually, all wounds were successfully closed.

Conclusion: Complex scalp defects can be closed using local flaps, thereby restoring aesthetics and tissue integrity. Free flaps remain a reliable solution for extensive defects. Moreover, in cases requiring cranioplasty, careful preoperative planning and an uncontaminated wound are essential for successful treatment.

介绍:头皮缺损重建需要多学科合作,以修复软组织和骨质缺损。虽然伤口闭合和形态恢复通常是短期治疗目标,可确保患者存活,但长期保持头颈部的完整性和美观对维持生活质量至关重要。本研究旨在比较、量化和确定各种重建方案的安全和可重复方法,以及各个头皮缺损区域的术后并发症情况:我们对 2017 年 3 月至 2022 年 4 月期间在我院接受头皮重建术的患者进行了回顾性评估。纳入标准为颅骨水平存在软组织缺损:我们共纳入了 31 名患者(17 名男性,14 名女性),平均年龄为 61 岁(17-92 岁不等)。八名患者曾在受影响区域接受过放射治疗。平均缺损面积为72.5±116平方厘米(范围20-441平方厘米),在开始整形手术治疗前平均进行过3±2次手术。11 名患者只有软组织缺损,20 名患者伴有骨缺损。其中15名患者接受了颅骨成形术。最常使用的是旋转皮瓣(23例),无论是否进行了分层厚皮移植,其次是游离背阔肌肌皮瓣,并进行了分层厚皮移植(5例),以及游离臂外侧皮瓣(2例)。由于伤口愈合障碍(9例)、出血(2例)和脑脊液漏(1例),38.7%的病例需要进行翻修手术。最终,所有伤口均成功闭合:结论:使用局部皮瓣可缝合复杂的头皮缺损,从而恢复美观和组织完整性。对于大面积缺损,游离皮瓣仍是一种可靠的解决方案。此外,对于需要进行颅骨成形术的病例,仔细的术前规划和无污染的伤口是成功治疗的关键。
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引用次数: 0
Results of a patient survey using an online questionnaire after implant removal for breast implant illness. 乳房植入物疾病患者在植入物取出后使用在线问卷进行调查的结果。
IF 0.4 Pub Date : 2024-03-11 eCollection Date: 2024-01-01 DOI: 10.3205/iprs000186
Ursula Tanzella, Klaus Ueberreiter, Lola Fanny Krapohl, Armin Bell, Björn Dirk Krapohl

The use of silicone breast implants has a history of over 60 years. In recent years, specific health issues among implant wearers have repeatedly come into focus. The term "breast implant illness" has been circulating in scientific literature and on social media for several years. It describes a cluster of up to 60 different symptoms. The present results of an online survey conducted within a clinic's patient population of the last 8 years show, among other things, the evolution of 8 reported symptoms before and after breast implant removal. In the comparison before and after, there is a significant reduction in the intensity of symptoms after implant removal. A causal relationship with the removal of the implants is to be presumed.

硅胶乳房植入物的使用已有 60 多年的历史。近年来,植入物佩戴者的具体健康问题一再成为关注焦点。几年来,科学文献和社交媒体上一直流传着 "乳房植入疾病 "这一术语。它描述了多达 60 种不同症状的组合。本研究对一家诊所过去 8 年的患者群体进行了在线调查,结果显示,除其他外,乳房假体取出前后报告的 8 种症状发生了变化。在前后对比中,假体取出后症状的强度明显降低。可以推测,这与取出假体有因果关系。
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引用次数: 0
Acral melanoma of the heel mimicking a pressure sore. 模仿褥疮的足跟骨黑色素瘤。
IF 0.4 Pub Date : 2024-03-04 eCollection Date: 2024-01-01 DOI: 10.3205/iprs000185
Matthias Fischer, Anita Sünkenberg, Reem Ali Deeb, Björn Dirk Krapohl

Background: The clinical appearance of acral melanoma is diverse and can cause diagnostic difficulties in individual cases.

Case description: We present a clinical case of an 83-year-old patient with a melanoma in the heel area that was initially interpreted as a pressure ulcer, resulting in delayed and more complicated treatment.

Conclusions: Melanomas should be included in the differential diagnosis even in "typical" pressure ulcer areas. Against the background of increasingly poor healthcare in rural areas, an increase in such cases can be expected.

背景:尖锐湿疣黑色素瘤的临床表现多种多样,在个别病例中可能会造成诊断困难:我们介绍了一例 83 岁患者的临床病例,患者脚后跟部位患有黑色素瘤,最初被解释为压疮,导致治疗延误且更加复杂:结论:即使是 "典型 "的压疮部位,也应将黑色素瘤纳入鉴别诊断。结论:即使在 "典型 "的压疮地区,黑色素瘤也应被纳入鉴别诊断中。在农村地区医疗条件越来越差的背景下,预计此类病例会越来越多。
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引用次数: 0
Intramedullary arthrodesis of the knee joint with additional femoral neck screw to prevent periprosthetic fracture of the proximal femur. A case report. 使用附加股骨颈螺钉进行膝关节髓内关节置换术,预防股骨近端假体周围骨折。病例报告。
IF 0.4 Pub Date : 2024-02-29 eCollection Date: 2024-01-01 DOI: 10.3205/iprs000184
Mohamed Ghanem, Christina Pempe, Andreas Roth

Arthrodesis of the knee joint has proven effective in the treatment of chronic periprosthetic infections as well as in cases of previous multiple revision surgery after total knee replacement with insufficiency of the extensor apparatus. In this case report, we report on the use of a custom-made intramedullary arthrodesis nail of the knee joint following multiple revisions due to aseptic loosening after total knee replacement. Surgery was performed according to preoperative computerized planning. Microbiological and histological samples obtained intraoperatively showed no evidence of infection. Yet, the patient presented postoperatively with complete loss of active dorsiflexion of the ipsilateral foot. On one-year follow-up, the patient did not complain of any pain. The radiological findings one year after surgery showed no sign of loosening or any other pathological findings. The neurological lesion has completely recovered. The Harris Hip Score HHS improved from 24 (prior to implantation of the arthrodesis) to 75 on one-year follow-up, the Western Ontario and McMaster Universities Osteoarthritis Index WOMAC improved from 86 to 20. The particularity of this case lies in the fact that an additional femoral neck screw was brought in to prevent periprosthetic fracture of the proximal femur. Careful preoperative planning as well as surgical performance were necessary to adjust the rotation of the femoral nail to allow adequate positioning of the femoral neck screw. Intramedullary arthrodesis of the knee is a suitable management option following multiple revision surgery after total knee replacement with insufficiency of the extensor apparatus. In many cases, an individual therapeutic plan is necessary ranging up to the use of custom-made implants.

膝关节假体置换术在治疗慢性假体周围感染以及曾在全膝关节置换术后进行多次翻修手术并伴有伸肌功能不全的病例中被证明是有效的。在本病例报告中,我们介绍了在全膝关节置换术后因无菌性松动而进行多次翻修手术后,使用定制的膝关节髓内关节置换钉的情况。手术是根据术前计算机规划进行的。术中获得的微生物学和组织学样本均未显示感染迹象。然而,患者术后同侧足部完全丧失了主动外展功能。在一年的随访中,患者没有抱怨任何疼痛。术后一年的放射学检查结果显示没有松动迹象或任何其他病理结果。神经损伤已完全恢复。哈里斯髋关节评分(Harris Hip Score HHS)从24分(关节置换术前)提高到一年随访时的75分,西安大略和麦克马斯特大学骨关节炎指数(Western Ontario and McMaster Universities Osteoarthritis Index WOMAC)从86分提高到20分。该病例的特殊之处在于,为了防止股骨近端假体周围骨折,还额外植入了一枚股骨颈螺钉。为了调整股骨钉的旋转位置,使股骨颈螺钉能够充分定位,术前的精心策划和手术操作都是必不可少的。膝关节髓内关节置换术是全膝关节置换术后因伸肌功能不全而进行多次翻修手术后的一种合适治疗方法。在许多情况下,需要制定个性化的治疗方案,甚至使用定制的植入物。
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引用次数: 0
Subtotal diaphyseal replacement of the femur with modular mega-endoprosthesis following interprosthetic fracture. A case report. 假体间骨折后使用模块化巨型内假体进行股骨骺端次全置换。病例报告。
IF 0.4 Pub Date : 2024-02-09 eCollection Date: 2024-01-01 DOI: 10.3205/iprs000183
Mohamed Ghanem, Christina Pempe, Andreas Roth

Mega-endoprostheses enable wide management options in the treatment of primary and periprosthetic fracture of the lower extremities. In this study, we report on the use of custom-made subtotal diaphyseal endoprosthetic replacement in treatment of interprosthetic femoral fracture. This procedure is off-label, but in this particular case, it was the safest and most stress-stable treatment option. The implant was delivered within three weeks. The surgical procedure for subtotal replacement of the femoral diaphysis was performed without any intra- or postoperative complication. The duration for the surgical intervention was one hour and 40 minutes. The patient was then mobilized with full weight bearing. At one-year follow-up, the patient did not complain of any pain. The Harris Hip Score HHS improved from 26 to 83 at one-year follow-up, the Western Ontario and McMaster Universities Osteoarthritis Index WOMAC improved from 88 to 16. Mega-endoprostheses enable a wide range of management options in the treatment of primary, peri- and interprosthetic fractures of the lower extremities. In many cases, an individual therapeutic plan is necessary ranging up to the use of custom-made implants.

巨型内假体为治疗下肢原发性骨折和假体周围骨折提供了广泛的治疗选择。在本研究中,我们报告了在治疗假体间股骨骨折时使用定制的次全骺端假体置换术的情况。这种手术属于非标示治疗,但在这个特殊病例中,它是最安全、应力最稳定的治疗方案。植入物在三周内完成。股骨头干骺端次全置换手术过程顺利,术中术后未出现任何并发症。手术时间为 1 小时 40 分钟。随后,患者可以完全负重活动。在一年的随访中,患者没有抱怨任何疼痛。一年随访时,哈里斯髋关节评分HHS从26分提高到83分,西安大略和麦克马斯特大学骨关节炎指数WOMAC从88分提高到16分。巨型内假体在治疗下肢原发性骨折、假体周围骨折和假体间骨折方面提供了多种治疗方案。在许多情况下,需要制定个性化的治疗方案,甚至使用定制的假体。
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引用次数: 0
Mandibular symmetry on posterior-anterior cephalograms of neurofibromatosis type 1 patients with facial plexiform neurofibroma. 患有面部丛状神经纤维瘤的 1 型神经纤维瘤病患者前后头颅影像中的下颌骨对称性。
IF 0.4 Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.3205/iprs000181
Reinhard E Friedrich, Georg Christ, Hanna A Scheuer

Introduction: Neurofibromatosis type 1 (NF1) is an is an autosomal dominant heritable tumor predisposition syndrome.. Peripheral nerve sheath tumors (PNST) are a hallmark of NF1. Plexiform neurofibromas (PNF) are neoplasms that are characteristic of NF1, often causing disfiguring effects (e.g., on the face), and are considered precancerous lesions. Previous studies have shown that facial PNF (FPNF) have an impact on the shape of facial bones. This study examines deviations of mandibular symmetry from cephalometric reference planes considering the topography of FPNF.

Material and methods: The posterior-anterior (PA) cephalograms of 168 patients with NF1 were examined. We compared three groups: patients with FPNF (n=74), with disseminated cutaneous neurofibroma (DNF (n=94)), and control subjects without NF1 (n=23). The PNF group was subtyped with respect to facial PNST type and location. Typical mandibular cephalometric reference points were determined (condyle, antegonion, and menton).

Results: The skeletal measurement points of the mandible in FPNF patients often differ significantly from those of the DNF group. It has been proven that typical asymmetries of the median-sagittal measurement points are indicators of PNF. Differences within the trigeminal tumor spread patterns are indicated in the measured values. A local tumor effect (PNF) on the relation of the measurement points to the reference planes is made plausible by the study results. The investigations prove that tumor type (FPNF) and the number of FPNF affected branches of the trigeminal nerve may correlate with significant deviations of mandible from symmetry on PA projections.

Conclusion: The presented study shows that characteristic patterns of mandibular deformity can be measured on standardized radiographs in NF1 patients with FPNF. Mandibular deformities imaged on standardized radiographs may be initial indicators of a previously unrecognized NF1. Tumor-associated alterations of the mandible should be considered in the classification systems of pathognomonic, diagnostically pioneering osseous findings in NF1. The radiological findings provide clues for planning mandibular osteotomies in NF1 patients, especially for assessing facial regions typically highly vascularized by tumor spread. Furthermore, the radiological findings are an indication of a tumor potentially invading and destroying adjacent masticatory and mimic muscle, findings that may have an influence on surgical measures (function, aesthetics, and wound healing).

简介神经纤维瘤病 1 型(NF1)是一种常染色体显性遗传性肿瘤易感综合征。外周神经鞘瘤(PNST)是 NF1 的特征之一。丛状神经纤维瘤(PNF)是 NF1 特征性肿瘤,通常会导致毁容(如面部),被认为是癌前病变。以往的研究表明,面部 NF1(FPNF)对面部骨骼的形状有影响。本研究考虑到 FPNF 的地形,研究了下颌骨对称性与头颅测量参考平面的偏差:对 168 名 NF1 患者的前后(PA)头影进行了检查。我们对三组患者进行了比较:FPNF 患者(74 人)、播散性皮肤神经纤维瘤(DNF,94 人)和无 NF1 的对照组(23 人)。PNF组根据面部PNST类型和位置进行了分型。确定了典型的下颌骨头骨测量参考点(髁状突、前髁突和门突):结果:FPNF 患者的下颌骨骨骼测量点往往与 DNF 组的测量点有明显差异。事实证明,中线-矢状线测量点的典型不对称是 PNF 的指标。测量值显示三叉神经肿瘤扩散模式的差异。研究结果表明,局部肿瘤效应(PNF)对测量点与参考平面之间的关系具有可信性。研究证明,肿瘤类型(FPNF)和受 FPNF 影响的三叉神经分支数量可能与下颌骨在 PA 投影上明显偏离对称性有关:本研究结果表明,下颌骨畸形的特征模式可通过标准化 X 光片测量出。标准X光片显示的下颌骨畸形可能是以前未被发现的NF1的初步指标。下颌骨的肿瘤相关改变应在NF1病理诊断先驱骨性发现的分类系统中予以考虑。放射学检查结果为规划 NF1 患者的下颌骨截骨手术提供了线索,尤其是在评估因肿瘤扩散而典型高血管化的面部区域时。此外,放射学检查结果还表明肿瘤可能会侵犯和破坏邻近的咀嚼肌和模仿肌,这些结果可能会对手术措施(功能、美观和伤口愈合)产生影响。
{"title":"Mandibular symmetry on posterior-anterior cephalograms of neurofibromatosis type 1 patients with facial plexiform neurofibroma.","authors":"Reinhard E Friedrich, Georg Christ, Hanna A Scheuer","doi":"10.3205/iprs000181","DOIUrl":"https://doi.org/10.3205/iprs000181","url":null,"abstract":"<p><strong>Introduction: </strong>Neurofibromatosis type 1 (NF1) is an is an autosomal dominant heritable tumor predisposition syndrome.. Peripheral nerve sheath tumors (PNST) are a hallmark of NF1. Plexiform neurofibromas (PNF) are neoplasms that are characteristic of NF1, often causing disfiguring effects (e.g., on the face), and are considered precancerous lesions. Previous studies have shown that facial PNF (FPNF) have an impact on the shape of facial bones. This study examines deviations of mandibular symmetry from cephalometric reference planes considering the topography of FPNF.</p><p><strong>Material and methods: </strong>The posterior-anterior (PA) cephalograms of 168 patients with NF1 were examined. We compared three groups: patients with FPNF (n=74), with disseminated cutaneous neurofibroma (DNF (n=94)), and control subjects without NF1 (n=23). The PNF group was subtyped with respect to facial PNST type and location. Typical mandibular cephalometric reference points were determined (condyle, antegonion, and menton).</p><p><strong>Results: </strong>The skeletal measurement points of the mandible in FPNF patients often differ significantly from those of the DNF group. It has been proven that typical asymmetries of the median-sagittal measurement points are indicators of PNF. Differences within the trigeminal tumor spread patterns are indicated in the measured values. A local tumor effect (PNF) on the relation of the measurement points to the reference planes is made plausible by the study results. The investigations prove that tumor type (FPNF) and the number of FPNF affected branches of the trigeminal nerve may correlate with significant deviations of mandible from symmetry on PA projections.</p><p><strong>Conclusion: </strong>The presented study shows that characteristic patterns of mandibular deformity can be measured on standardized radiographs in NF1 patients with FPNF. Mandibular deformities imaged on standardized radiographs may be initial indicators of a previously unrecognized NF1. Tumor-associated alterations of the mandible should be considered in the classification systems of pathognomonic, diagnostically pioneering osseous findings in NF1. The radiological findings provide clues for planning mandibular osteotomies in NF1 patients, especially for assessing facial regions typically highly vascularized by tumor spread. Furthermore, the radiological findings are an indication of a tumor potentially invading and destroying adjacent masticatory and mimic muscle, findings that may have an influence on surgical measures (function, aesthetics, and wound healing).</p>","PeriodicalId":43347,"journal":{"name":"GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fournier gangrene - would you KISS it? 傅尼叶坏疽--你会吻它吗?
IF 0.4 Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI: 10.3205/iprs000182
Miguel João Ribeiro Matias, Diogo Guimarães, Manuel Vilela, Juliana Sousa, Joaquim Bexiga

Fournier gangrene is a disease characterized by necrotizing fasciitis of the perineal and genital region, resulting from synergistic polymicrobiotic infection. Most infections can be localized to a cutaneous, urethral, or rectal source and can culminate in a fulminant sepsis. Current state of the art is systemic broad-spectrum antibiotics and serial aggressive debridement which result in superficial perineal defect of wide dimensions. We compiled all the cases of Fournier gangrene that required reconstruction after debridement in Centro Hospitalar Universitário Lisboa Central from 2018 to 2022. Inclusion criteria were reconstruction for Fournier defects and patients' age 18 to 90 years old. Exclusion criteria were patients who didn't require reconstruction or didn't complete it due to death or transfer to another healthcare institution. Reconstructive procedures and complication rates are reported as whole numbers and percentages of total. The initial search yielded 32 patients. There were 2 (6.2%) patients with defects that healed by secondary intention, 6 (18.7%) with delayed primary closure, 4 (12.5%) with implantation of the testicle in a medial thigh pocket, 12 (37.5%) with skin grafts, 4 (12.5%) with scrotal advancement flaps, 2 (6.2%) with flaps, and 2 (6.2%) with flaps and skin grafts in combination. Four outcomes were evaluated: number of patients, defect size, method of reconstruction, and wound-healing complications. Most reconstructive techniques provide reliable coverage and protection of testicular function with an acceptable cosmetic result. The reconstructive options need to be patient tailored in order to achieve long lasting results with a minimum of postoperative morbidity.

福尼尔坏疽是一种以会阴部和生殖器区域坏死性筋膜炎为特征的疾病,由多微生物协同感染引起。大多数感染可发生在皮肤、尿道或直肠局部,并最终导致严重败血症。目前最先进的治疗方法是全身使用广谱抗生素和连续积极的清创术,这将导致会阴浅表大面积缺损。我们汇编了2018年至2022年期间葡京赌场中央大学中心医院所有清创后需要重建的Fournier坏疽病例。纳入标准为Fournier缺损重建,患者年龄为18至90岁。排除标准为不需要重建或因死亡或转至其他医疗机构而未完成重建的患者。重建手术和并发症发生率以整数和占总数的百分比形式报告。初步搜索共发现 32 名患者。其中,2 例(6.2%)患者的缺损通过二次意向愈合,6 例(18.7%)患者的初次闭合延迟,4 例(12.5%)患者将睾丸植入大腿内侧口袋,12 例(37.5%)患者植皮,4 例(12.5%)患者阴囊前移皮瓣,2 例(6.2%)患者皮瓣,2 例(6.2%)患者皮瓣和植皮相结合。对四项结果进行了评估:患者人数、缺损大小、重建方法和伤口愈合并发症。大多数重建技术都能可靠地覆盖和保护睾丸功能,并达到可接受的美容效果。重建方案需要根据患者的具体情况而定,以达到持久的效果,并将术后发病率降到最低。
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引用次数: 0
Current standards in the diagnosis and treatment of oral squamous cell carcinoma - a multicenter analysis. 口腔鳞状细胞癌诊断和治疗的现行标准——一项多中心分析。
IF 0.4 Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.3205/iprs000180
Karsten Schreder, Oliver Thiele, Alexander Eckert

The German guideline for oral squamous cell carcinoma (OSCC) describes the recommended diagnosis and treatment procedures for OSCC and ensures the highest quality patient care. However, the current German guideline for OSCC is indistinct and therapy planning is not standardized in detail between centers. To address this, the current diagnostic and therapeutic strategies in different oral and maxillofacial surgery departments in Germany were summarized using a uniform questionnaire. The results revealed high standards in oncologic maxillofacial care, but non-uniform standards exist between centers. Moreover, an increasing use of diagnostic and treatment methods that are not included in the German guideline for OSCC, such as positron emission tomography computed tomography (PET-CT) and tumor biomarkers, were used by different centers. These results support the updated German guideline for OSCC but highlight the need to consider other additive methods to improve patient care and outcomes. Furthermore, a recommendation to introduce tumor passports to simplify OSCC diagnosis and treatment should be discussed. These changes will improve the prognosis and quality of life of patients with OSCC.

德国口腔鳞状细胞癌指南(OSCC)描述了OSCC的推荐诊断和治疗程序,并确保了最高质量的患者护理。然而,目前德国的OSCC指南不明确,各中心之间的治疗计划也没有详细标准化。为了解决这个问题,目前在德国不同的口腔颌面外科部门的诊断和治疗策略进行总结,使用统一的问卷调查。结果显示,肿瘤颌面护理水平较高,但各中心间标准不统一。此外,不同的中心越来越多地使用未包括在德国OSCC指南中的诊断和治疗方法,如正电子发射断层扫描计算机断层扫描(PET-CT)和肿瘤生物标志物。这些结果支持更新的德国OSCC指南,但强调需要考虑其他附加方法来改善患者护理和结果。此外,建议引入肿瘤护照以简化OSCC的诊断和治疗。这些改变将改善OSCC患者的预后和生活质量。
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引用次数: 0
Investigating the effects of Argireline in a skin serum containing hyaluronic acids on skin surface wrinkles using the Visia® Complexion Analysis camera system for objective skin analysis. 使用Visia®肤色分析相机系统进行客观皮肤分析,研究含有透明质酸的皮肤血清中Argireline对皮肤表面皱纹的影响。
IF 0.4 Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.3205/iprs000179
Helga Henseler

Objective: To analyze the effects of Argireline on skin surface wrinkles using the Visia® camera system developed by Canfield Scientific Inc., U.S.A., for facial image capture.

Method: Nineteen female participants were recruited from a plastic surgery clinic. Initial facial images captured the left, front, and right sides of the participants' faces, which were documented as timepoint one. Following this, the participants immediately began to apply a facial skin serum containing triple hyaluronic acids produced by CNC cosmetic GmbH, Philippsburg, Germany. The serum was applied once in the morning and once in the evening. Participants received two identical containers labeled L for left and R for right, with each container to be used on the corresponding facial side, particularly around the eye area. One container contained Argireline, a synthetic hexapeptide, which previously was deemed to be a biosafe alternative to botulinum neurotoxin. The study was conducted as double-blind; neither the participants nor researchers knew which of the two containers contained Argireline. Participants were allowed to use their own cosmetic products throughout the study. After four weeks, the participants returned to have their faces recaptured using the Visia® camera, which was documented as timepoint two. The absolute scores of the wrinkles were noted, and results on both sides of the face were calculated and compared. The "TruSkinAge®" measurement provided by the Visia® camera was reviewed for each face side. Results between both time points and both sides of the face were compared. After the data analysis was complete, the company was contacted to determine which container contained Argireline.

Results: Nineteen participants returned for facial image capture. There were no significant adverse events, allergic reactions, or skin irritations. The investigation revealed that the wrinkle score slightly decreased for the right and left side of the face following four weeks of serum application. However, this decrease was not significant (p>0.05) based on the Wilcoxon matched pairs tests for the wrinkle scores (right side p=0.060 and left side p=0.176) and Truskin Ages® results (right side p=0.096 and left side p=0.489).Comparing the data from the right side with that from the left side of the face revealed that neither demonstrated a significant reduction in wrinkle score (p=0.829) or Truskin Ages® results (p=0.804). Argireline was included in the serum applied to the right side of the face. However, no statistical significance was seen in the results on this side of the face indicating any possible effects.

Conclusion: Wrinkle scores and Truskin Ages® results were observed to decrease non-significantly following the application of a skin serum involving hyaluronic acid. The Visia® imaging m

目的:利用美国Canfield科学公司开发的Visia®面部图像采集系统,分析Argireline对皮肤表面皱纹的影响。方法:从某整形外科诊所招募19名女性受试者。最初的面部图像捕捉了参与者的左、前、右脸,这些图像被记录为时间点1。在此之后,参与者立即开始使用由德国菲利普堡CNC化妆品有限公司生产的含有三重透明质酸的面部皮肤精华液。早晚各涂一次精华液。参与者收到了两个相同的容器,左边标记为L,右边标记为R,每个容器都用于面部相应的一侧,特别是眼睛周围。一个容器里装着Argireline,一种合成的六肽,以前被认为是肉毒杆菌神经毒素的生物安全替代品。该研究采用双盲法进行;参与者和研究人员都不知道这两个容器中哪一个装的是Argireline。在整个研究过程中,参与者被允许使用自己的化妆品。四周后,参与者返回使用Visia®相机重新捕捉他们的面部,记录为时间点2。记录皱纹的绝对分数,并计算面部两侧的结果并进行比较。Visia®相机提供的“TruSkinAge®”测量对每个面侧进行了审查。比较两个时间点及两侧面部的结果。数据分析完成后,他们联系了该公司,以确定哪个集装箱装有Argireline。结果:19名参与者返回进行面部图像捕获。没有明显的不良事件、过敏反应或皮肤刺激。调查显示,在四周的血清应用后,左右脸的皱纹评分略有下降。然而,基于Wilcoxon配对对测试的皱纹评分(右侧p=0.060,左侧p=0.176)和Truskin Ages®结果(右侧p=0.096,左侧p=0.489),这种下降并不显著(p>0.05)。比较右脸和左脸的数据显示,皱纹评分(p=0.829)和Truskin Ages®结果(p=0.804)都没有显著减少。阿吉力兰包含在涂抹于右侧面部的血清中。然而,在这一侧面部的结果中没有看到统计学意义,表明任何可能的影响。结论:在使用含有透明质酸的皮肤血清后,观察到皱纹评分和Truskin Ages®结果无显著降低。采用Visia®成像方法对数据进行客观分析。使用阿吉列林和不使用阿吉列林治疗的两侧面部之间的差异没有统计学意义。因此,Argireline的效果尚未得到证实。虽然阿吉兰的毒性较低,但其疗效并不显著。因此,它不被认为是肉毒杆菌毒素的替代治疗方法。
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引用次数: 0
Localized pigmented villo-nodular synovitis of trochanteric bursa. 转子滑囊局部色素性结节性滑膜炎。
IF 0.4 Pub Date : 2023-10-13 eCollection Date: 2023-01-01 DOI: 10.3205/iprs000178
Juergen Bruns, Benedikt Rosenbaum, Christoph Thorns

This is the first report on a localized pigmented villo-nodular synovitis (PVNS or TSGCT) occurring in the trochanteric bursa. Bursal involvement in PVNS is extremely rare. Most often PVNS occurs either as a localized or diffuse lesion in a major synovial joint, such as the knee, ankle joint or hip joint. In principle, all synovial structures can be involved. The case reported here is remarkable regarding the long period between the occurrence of the first symptoms and the final diagnosis as well as the age of the female patient (75 yrs). Therapeutically a complete resection was performed in order to avoid recurrence. More then three years later the patient did well and there has been no evidence of recurrence yet.

本文首次报道了发生在转子滑囊的局部色素性绒毛结节滑膜炎(PVNS或TSGCT)。法氏囊受累于PVNS是极为罕见的。大多数情况下,PVNS发生在主要滑膜关节(如膝关节、踝关节或髋关节)的局部或弥漫性病变。原则上,所有滑膜结构均可受累。这里报告的病例值得注意的是,从出现最初症状到最终诊断之间的漫长时间,以及女性患者的年龄(75岁)。治疗上,为了避免复发,进行了完全切除。三年多以后,病人恢复得很好,至今没有复发的迹象。
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GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
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