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Assessment of Salivary Levels of the RANKL and RANK in Patients with Healthy Gingiva on Reduced Periodontium Versus Periodontitis: An Analytical Cross-Sectional Study 评估牙周炎患者与牙周炎患者的唾液RANKL和RANK水平:一项分析性横断面研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-04-01 DOI: 10.4103/denthyp.denthyp_17_23
Shurooq Muhssin, H. Akram
Introduction: We aimed to compare the changes in the two salivary biomarkers, RANKL and RANK, among patients with healthy gingiva on reduced periodontium versus generalized periodontitis stages II and III. Methods: Study subjects were divided into three groups: (1) healthy periodontium (control group) (n = 15), (2) generalized periodontitis stages II and III (n = 30), and (3) healthy gingiva on reduced periodontium (n = 30). Salivary levels of RANKL and RANK were assessed using an enzyme-linked immunosorbent assay. Data analysis was done by the one-way ANOVA and the Tukey post hoc test using R software. Results: There was a statistically significant difference among the three study groups regarding salivary levels of the RANKL (P < 0.001) and RANK (P < 0.001). A Post hoc test showed that the difference between salivary levels of the RANKL (P = 0.50) and RANK (P = 0.86) among periodontitis groups and healthy gingiva in the reduced periodontium group was not statistically significant. Conclusion: High salivary levels of RANKL and RANK in comparison with healthy gingiva are not necessarily associated with the active phase of periodontal disease and progressive bone destruction.
引言:我们的目的是比较健康牙龈患者在II期和III期减少期和全身性牙周炎中两种唾液生物标志物RANKL和RANK的变化。方法:研究对象分为三组:(1)健康牙周组织(对照组)(n = 15) ,(2)全身性牙周炎II期和III期(n = 30)和(3)在减少的牙周组织上的健康牙龈(n = 30)。使用酶联免疫吸附测定法评估唾液中RANKL和RANK的水平。数据分析采用单因素方差分析和Tukey post-hoc检验,使用R软件。结果:三个研究组的唾液RANKL水平(P<0.001)和RANK水平(P>0.001)有统计学意义 = 0.50)和RANK(P = 0.86),而牙周组织减少组中的健康牙龈没有统计学意义。结论:与健康牙龈相比,唾液中RANKL和RANK水平高并不一定与牙周病的活动期和进行性骨破坏有关。
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引用次数: 0
Relationship between Salivary Levels of Protein Carbonyl and Total Antioxidant Capacity and Prevalence of Dental Caries among Type 1 Diabetic Children: An Analytical Cross-Sectional Study 唾液蛋白质羰基水平与1型糖尿病儿童总抗氧化能力和龋齿患病率的关系:一项横断面分析研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-04-01 DOI: 10.4103/denthyp.denthyp_44_23
Shahad Obaid, Shahba'a Munther, Marwa Abbas
Introduction: We aimed to assess the possible relationship between dental caries prevalence and oxidative stress markers such as protein carbonyl (PC) and total antioxidant capacity (TAOC) of saliva among type 1 diabetic children. Methods: An analytical cross-sectional study was performed among 45 type 1 diabetic children and compared with 45 healthy control children aged 10 to 12 years old. Dental caries was diagnosed and recorded using the decayed, missing, and filling index (DMFS/dmfs). Unstimulated salivary specimens were collected for evaluation of TAOC and PC using an enzyme-linked immune-sorbent assay (ELISA). A linear regression model and one-way ANOVA test were employed for data analysis using the R 4.3.0. Results: Salivary levels of TAOC and PC, having diabetes, and diabetes status (controlled or uncontrolled) were not statistically significant (P > 0.05) predicators regarding the prevalence of dental caries among type 1diabetic children. Conclusion: The diabetic status had a significant effect on salivary levels of TAOC and PC, but no significant effect on the prevalence of dental caries.
引言:我们旨在评估1型糖尿病儿童的龋齿患病率与氧化应激标志物(如蛋白质羰基(PC)和唾液总抗氧化能力(TAOC))之间的可能关系。方法:对45名1型糖尿病儿童进行横断面分析研究,并与45名10至12岁的健康对照儿童进行比较。使用龋齿、缺失和填充指数(DMFS/DMFS)对龋齿进行诊断和记录。收集未刺激的唾液样本,使用酶联免疫吸附测定法(ELISA)评估TAOC和PC。采用线性回归模型和单因素方差分析检验,使用R 4.3.0进行数据分析。结果:唾液中TAOC和PC水平、患有糖尿病和糖尿病状态(控制或未控制)对1型糖尿病儿童龋齿患病率没有统计学意义(P>0.05)。结论:糖尿病状态对唾液TAOC和PC水平有显著影响,但对龋齿患病率无显著影响。
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引用次数: 0
Bibliometric Analysis of Dental Preprints which Published in 2022 2022年出版的牙科预印本的文献计量分析
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-01-01 DOI: 10.4103/denthyp.denthyp_35_23
Jafar Kolahi, H. Mirmohammadi, A. Khandan
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引用次数: 0
Assessment of Salivary Interleukin-1β Levels in Patients with Gingivitis and Periodontitis: An Analytical Cross-Sectional Study 牙龈炎和牙周炎患者唾液白细胞介素-1β水平的评估:一项分析性横断面研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-01-01 DOI: 10.4103/denthyp.denthyp_148_22
Muntadhr Al-Musawi, Omar Ali
Introduction: The study aimed to analyze the level of salivary Interleukin-1 beta (IL-1β) in subjects with healthy periodontium and patients with gingivitis and periodontitis stage I-III. Methods: A total of 90 individuals participated in the research, separated into five groups, clinically healthy (n = 10), gingivitis (n = 20), stage I periodintitis (n = 20), stage II periodontitis (n = 20), and stage III periodontitis (n = 20). Level of salivary IL-1β was assessed using the enzyme-linked immunosorbent assay. Result: A statically significant difference (P < 0.001) found amongst study groups, further multiple group comparison revealed a statistically significant difference (P < 0.05) when comparing the experimental groups with control and when comparing gingivitis with stage II and III groups. Conclusion: Within the limitations of this cross-sectional study, IL-1β can be considered as a potential salivary biomarkers to differentiate between healthy and unhealthy periodontium.
引言:本研究旨在分析健康牙周病患者和牙龈炎和牙周炎I-III期患者唾液白细胞介素-1β(IL-1β)的水平。方法:共有90名个体参与研究,分为5组,临床健康(n = 10) ,牙龈炎(n = 20) ,I期牙周炎(n = 20) ,II期牙周炎(n = 20) 和III期牙周炎(n = 20) 。唾液IL-1β水平采用酶联免疫吸附测定法进行评估。结果:研究组之间存在静态显著差异(P<0.001),进一步的多组比较显示,当将实验组与对照组进行比较时,以及当将牙龈炎与II期和III期组比较时,存在统计学显著差异(P<0.05)。结论:在本横断面研究的限制范围内,IL-1β可被认为是区分健康和不健康牙周组织的潜在唾液生物标志物。
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引用次数: 3
Effect of addition of polymerized polymethyl methacrylate (PMMA) and zirconia particles on impact strength, surface hardness, and roughness of heat cure PMMA: An in vitro study 加入聚合聚甲基丙烯酸甲酯(PMMA)和氧化锆颗粒对热固化PMMA冲击强度、表面硬度和粗糙度的影响:体外研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-01-01 DOI: 10.4103/denthyp.denthyp_151_22
Duaa Rasan, F. Farhan
Introduction: This study was designed to examine the effects of addition of the combination of polymerized polymethyl methacrylate (PMMA) and zirconia (ZrO2) particles to heat cure PMMA resin on impact strength, surface hardness, and roughness. Methods: The 70% (w/w) of polymerized PMMA powder (particle size: 0.70 µm) was mixed with 30% (w/w) of zirconia powder (ZrO2) (1 µm) to produce PMMA-ZrO2 filler. Ninety acrylic specimens created were divided into three groups containing 0% wt (Control group), 2% wt, and 4% wt, PMMA-ZrO2 filler. Ten specimens were used for impact strength, surface hardness and roughness test, blindly. Data were analyzed via one-way ANOVA and the Tukey post hoc test using R 3.6.3. Results: There was statistically significant difference among study groups regarding surface hardness and roughness (p < 0.001). Yet, nonsignificant difference was found on the subject of impact strength (p = 0.33). Post hoc test showed statistically significant difference for all pairwise comparisons as regards surface hardness and roughness (p < 0.05). Conclusion: The incorporation of PMMA-ZrO2 filler did not improve impact strength (resistance during an unexpected blows or dropping). Yet, increased surface roughness and hardness, concentration-dependently.
引言:本研究旨在研究在热固化PMMA树脂中添加聚合聚甲基丙烯酸甲酯(PMMA)和氧化锆(ZrO2)颗粒的组合对冲击强度、表面硬度和粗糙度的影响。方法:将70%(w/w)的聚合PMMA粉末(粒径:0.70 µm)与30%(w/w)的氧化锆粉末(ZrO2)(1 µm)制备PMMA-ZrO2填料。创建的90个丙烯酸样品被分为三组,分别含有0%重量(对照组)、2%重量和4%重量的PMMA-ZrO2填料。随机选取10个试样进行冲击强度、表面硬度和粗糙度试验。数据通过单因素方差分析和Tukey事后检验使用R 3.6.3进行分析。结果:研究组在表面硬度和粗糙度方面存在统计学显著差异(p<0.001),而在冲击强度方面则无显著差异(p = 0.33)。事后测试显示,在表面硬度和粗糙度方面,所有成对比较都存在统计学显著差异(p<0.05)。结论:加入PMMA-ZrO2填料并没有提高冲击强度(在意外打击或跌落过程中的阻力)。然而,表面粗糙度和硬度随浓度而增加。
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引用次数: 2
Assessment of Shear Bond Strength to Sound and Artificial Caries Affected Dentin Using Different Adhesive Systems: An In Vitro Study 不同黏合剂系统对牙本质影响的牙本质剪切粘接强度评估:体外研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-01-01 DOI: 10.4103/denthyp.denthyp_126_22
Zahraa Al-Obaidi, H. Jasim
Introduction: We aimed to determine how the various adhesive systems affect the shear bond strength (SBS) to normal and artificially create caries affected dentin (CAD) in permanent teeth. Methods: Forty eight sound premolars had their occlusal enamel ground to create flattened midcoronal dentin. According to the dentin substrate, specimens were allocated into sound and artificially created CAD induction using the pH-cycling technique. Each group was further subdivided according to the adhesive materials: Scotchbond Universal Plus, Scotchbond Universal, and Adper Single Bond 2 adhesives (applied in Etch and Rinse Adhesive Protocol). After that, a composite was put on and shear bond strength (SBS) tests were done. Data analyzed using two-way ANOVA and chi-squared tests. Results: Overall model test of the ANOVA statistics showed that both type of dentin and types of adhesive had a significant effect on the SBS values (P <  0.001). Tuckey post hoc comparisons showed a significant difference for type of dentin (P <  0.001) and types of adhesive (P ≤  0.005). Mode of failure assessment is non-statistically significant difference (P = 0.41). Conclusion: All adhesives showed a decrease in SBS when used on artificial CAD.
前言:我们的目的是确定不同的粘接剂系统如何影响剪切粘接强度(SBS)对正常恒牙和人工产生龋齿影响的牙本质(CAD)。方法:对48颗正常前磨牙的牙釉质进行磨平,形成扁平的中冠牙本质。根据牙本质基质,采用ph循环技术将标本分配到声音和人工创建的CAD诱导中。根据胶粘剂材料进一步细分为Scotchbond Universal Plus、Scotchbond Universal和Adper Single Bond 2胶粘剂(适用于蚀刻和漂洗胶粘剂协议)。然后,对复合材料进行了剪切粘结强度(SBS)试验。数据分析采用双向方差分析和卡方检验。结果:ANOVA统计的整体模型检验显示,牙本质类型和粘接剂类型对SBS值有显著影响(P < 0.001)。Tuckey事后比较显示牙本质类型(P < 0.001)和粘接剂类型(P≤0.005)有显著差异。失效评估方式差异无统计学意义(P = 0.41)。结论:所有胶粘剂应用于人工CAD时,SBS均有明显下降。
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引用次数: 0
Effect of Incorporation of Boron Nitride Nanoparticles on Impact Strength and Surface Roughness of Heat Cure Poly Methyl Methacrylate Resin: An In Vitro Study 纳米氮化硼对热固化聚甲基丙烯酸甲酯树脂冲击强度和表面粗糙度的影响:体外研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-01-01 DOI: 10.4103/denthyp.denthyp_140_22
Hussein Ali Hussein, H. Al-Judy
Background: The objective of this research was to explore how the addition of boron nitride (BN) nanoparticles in the concentrations of 1% and 1.5% w/w affect the impact strength and surface roughness of heat-cured poly methyl methacrylate resin (PMMA). Methods: Sixty specimens were made from heat-cured acrylic resin and then divided into control, 1%, and 1.5% w/w BN groups. The impact strength and surface roughness were investigated. One-way ANOVA and Tukey’s post hoc test were used for data analysis. Results: Statistically significant difference is found among the three study groups regarding impact strength (P = 0.011) and surface roughness test (P <  0.001). The post hoc test showed significant differences for all multiple comparisons for the surface roughness test (P < 0.001). Yet, multiple comparisons for the impact strength test revealed only a significant difference between the 1.5% BN and control groups (P = 0.005). Conclusion: The addition of boron BN into PMMA improves impact strength with 1.5% concentration; while adversely increase the surface roughness.
背景:本研究的目的是探讨1%和1.5%w/w浓度的氮化硼(BN)纳米颗粒的添加对热固化聚甲基丙烯酸甲酯树脂(PMMA)的冲击强度和表面粗糙度的影响。方法:用热固化丙烯酸树脂制备60个试样,然后分为对照组、1%和1.5%w/w BN组。研究了冲击强度和表面粗糙度。数据分析采用单因素方差分析和Tukey的事后检验。结果:三个研究组在冲击强度方面差异有统计学意义(P = 0.011)和表面粗糙度试验(P< 0.001)。事后试验显示,表面粗糙度试验的所有多重比较均存在显著差异(P<0.001)。然而,冲击强度试验的多重比较仅显示1.5%BN组与对照组之间存在显著差异 = 0.005)。结论:硼氮化硼在PMMA中的加入提高了冲击强度,浓度为1.5%;同时不利地增加了表面粗糙度。
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引用次数: 0
Early and Delayed Effect of Cavity Disinfection with Chlorhexidine and Ozone on the Shear Bond Strength of Dentin to Glass Hybrid Restoration: An In Vitro Study 氯己定和臭氧口腔消毒对牙本质-玻璃混合修复体剪切结合强度的早期和延迟影响:体外研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-01-01 DOI: 10.4103/denthyp.denthyp_147_22
Murtatha AL-Anezi, Shahbaa Abduljabar
Introduction: We aimed to evaluate the early and delayed effects of chlorhexidine (CHX) and ozone disinfection on the shear bond strength (SBS) of dentin to glass hybrid restoration. Methods: The occlusal surfaces of 60 extracted premolars were trimmed to obtain a flat dentinal surface and randomly divided into three groups, including distilled water (control), 2% CHX, and ozonized water. Each group was further subjected to a shear bond strength test after 24 hours and 3 months. Results: The overall model test (P <  0.001), disinfectant and time (P <  0.001), and time (P = 0.017) showed statistically significant differences among study groups. Yet, the type of disinfectant revealed a non-significant difference (P = 0.238). Post hoc tests showed SBS significantly decreasing over time in the control group (P <  0.001) while the difference between 24 hours and 3 months for the CHX (P = 0.880) and ozone (P = 0.983) groups was not significant. Conclusion: Within the inherent limitations of in vitro studies, it can be concluded that cavity disinfection with CHX and ozone before glass hybrid restoration had a significant effect on the stability of SBS to dentin over 3 months. The type of disinfectant revealed non-significant difference.
引言:我们旨在评估氯己定(CHX)和臭氧消毒对牙本质-玻璃混合修复体剪切结合强度(SBS)的早期和延迟影响。方法:对60颗拔除的前磨牙的咬合面进行修整,获得平坦的牙本质表面,并将其随机分为三组,分别为蒸馏水(对照)、2%CHX和臭氧水。每组在24小时和3个月后进一步进行剪切结合强度测试。结果:整体模型试验(P<0.01) 0.001)、消毒剂和时间(P<0.01) 0.001)和时间(P = 0.017)显示出研究组之间的统计学显著差异。但消毒剂种类差异无统计学意义(P = 0.238)。事后检验显示对照组SBS随时间显著降低(P<0.01) 0.001),而CHX在24小时和3个月之间的差异(P = 0.880)和臭氧(P = 0.983)组间差异不显著。结论:在体外研究的固有局限性范围内,可以得出结论,玻璃混合修复前用CHX和臭氧进行空腔消毒对SBS在3个月内对牙本质的稳定性有显著影响。消毒剂种类差异不显著。
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引用次数: 1
Antibacterial Activity of Juglans regia L. Dry Husk Extract against Streptococcus mutans and Lactobacillus: An In Vitro Study 核桃干皮提取物对变形链球菌和乳酸菌的体外抑菌活性研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-01-01 DOI: 10.4103/denthyp.denthyp_144_22
O. Turki, Z. Jafar
Introduction: We aimed to evaluate the anti-bacterial effect of the Juglans regia dry husk ethanolic extract against Streptococcus mutans and Lactobacillus. Methods: A quantity of 200 g of dry husk was ground into powder and sieved until no large particles were found, then mixed with 1 L of 70% ethanol, yielding 20 g of J. regia paste after ethanol exclusion by vacuum evaporator and lyophilization. The Agar well diffusion method was used to detect the antibacterial activity. Statistical analysis was carried out using Welch’s t-test (unequal variances t-test) via R software. Results: The J. regia dry husk extract showed statistically significant higher bacterial growth inhibition in comparison with prophylaxis pumice paste for both S. mutans and Lactobacillus. Conclusion: Ethanolic dry husk extract has antibacterial activity against both S. mutans and Lactobacillus.
摘要:研究核桃干皮乙醇提取物对变形链球菌和乳酸菌的抑菌作用。方法:取干果皮200 g磨成粉末,筛分至无大颗粒,与70%乙醇1 L混合,经真空蒸发器排除乙醇,冻干后得王参膏20 g。采用琼脂孔扩散法检测其抑菌活性。通过R软件采用Welch’s t检验(不等方差t检验)进行统计分析。结果:王参干壳提取物对变形链球菌和乳酸菌的抑菌作用明显高于浮石膏。结论:乙醇干壳提取物对变形链球菌和乳酸菌均有抑菌作用。
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引用次数: 2
Effect of Amoxicillin and Azithromycin Suspensions on Microhardness of Sliver Reinforced and Nano Resin-Modified Glass Ionomers: An In Vitro Study 阿莫西林和阿奇霉素混悬液对银增强和纳米树脂改性玻璃离聚体显微硬度的影响:体外研究
IF 0.5 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-01-01 DOI: 10.4103/denthyp.denthyp_149_22
Z. Hasan, Noor R. Al-Hasani, M. Mahmood, Ali I Ibrahim
Introduction: We aimed to examine the effect of amoxicillin and azithromycin suspensions on the microhardness of sliver-reinforced glass ionomer and nano-resin modified glass ionomer (GI). Method: Thirty discs (2 mm height x 4 mm diameter) of each type of GI were prepared, which were randomly assigned to amoxicillin, azithromycin, and artificial saliva groups. Microhardness was evaluated by Vickers hardness test before and after three immersion cycles. Results: The overall model (P <  0.001), before/after intervention (P <  0.001), intervention group (type of antibiotic) (P = 0.013), and type of glass ionomer (P <  0.001) showed significant differences among study groups (P <  0.001). Post hoc test showed only non-significant before/after difference for Azithromycin and artificial saliva (control) groups regarding nano resin-modified GI. Conclusion: We found significant microhardness loss for sliver reinforced GI in comparison to nano resin-modified GI after the immersion cycles. Yet, sliver reinforced GI would have higher level of microhardness than nano resin-modified GI after the immersion cycles. Longer time studies are required to assess trend of microhardness loss.
前言:我们旨在研究阿莫西林和阿奇霉素悬浮液对银增强玻璃离聚物和纳米树脂改性玻璃离聚体(GI)显微硬度的影响。方法:30片(2片 mm高x4 mm直径),将其随机分配到阿莫西林、阿奇霉素和人工唾液组。在三次浸渍循环之前和之后通过维氏硬度测试来评估显微硬度。结果:整体模型(P<0.01) 0.001)、干预前后(P<0.01) 0.001)、干预组(抗生素种类)(P = 0.013)和玻璃离聚物的类型(P<  0.001)显示出研究组之间的显著差异(P<  0.001)。事后测试显示,阿奇霉素组和人工唾液组(对照组)在纳米树脂改性GI方面的前后差异不显著。结论:与纳米树脂改质GI相比,浸渍循环后银增强GI的显微硬度显著下降。然而,银条增强的GI在浸渍循环后将具有比纳米树脂改性的GI更高的显微硬度水平。需要更长时间的研究来评估显微硬度损失的趋势。
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引用次数: 1
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Dental Hypotheses
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