Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043889
Rana Zakerzadeh, P. Zunino
The objective of this work is modeling the interaction between pulsatile blood flow and arterial walls. We model blood flow in arteries as an incompressible viscous fluid with Newtonian rheology, confined by a poroelastic arterial wall modeled with the Biot equations. We propose loosely coupled solution strategy of the fluid-structure interaction problem, which allows solving the Navier-Stokes and Biot equations separately. In this way, we uncouple the original problem into two parts defined on separate subregions. At the end, the partitioned scheme is exploited as a preconditioner for the monolithic method, leading to a more accurate calculation of the numerical solution. The theoretical results are complemented by numerical simulations.
{"title":"Fluid-structure interaction in arteries with a poroelastic wall model","authors":"Rana Zakerzadeh, P. Zunino","doi":"10.1109/ICBME.2014.7043889","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043889","url":null,"abstract":"The objective of this work is modeling the interaction between pulsatile blood flow and arterial walls. We model blood flow in arteries as an incompressible viscous fluid with Newtonian rheology, confined by a poroelastic arterial wall modeled with the Biot equations. We propose loosely coupled solution strategy of the fluid-structure interaction problem, which allows solving the Navier-Stokes and Biot equations separately. In this way, we uncouple the original problem into two parts defined on separate subregions. At the end, the partitioned scheme is exploited as a preconditioner for the monolithic method, leading to a more accurate calculation of the numerical solution. The theoretical results are complemented by numerical simulations.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"206 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134540205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043890
M. Mohseni, A. Shamloo, Sina Ahmadpour Samani, M. Dodel
The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve compliance engineered blood vessels. Mechanical stress has great effect on both smooth muscle cells and endothelial cells and it is considered as a stimulus in plaque formation. In this study, we evaluate the role of thickness in wall stress of anastomosis region. For this purpose, two anastomosis models have been provided in ADINA and FSI simulations have been performed during pulsatile flow. In addition, the sensitivity of compliancy to thickness and diameter has been investigated. The vascular graft used in the simulations is a synthetic graft made up PCL and PVA by our group. Results show that thickness is an important parameter and even if vascular graft is compliant, improper thickness leads to an increase of wall stress pressure in anastomosis region.
{"title":"Thickness as an important parameter in designing vascular grafts","authors":"M. Mohseni, A. Shamloo, Sina Ahmadpour Samani, M. Dodel","doi":"10.1109/ICBME.2014.7043890","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043890","url":null,"abstract":"The main goal of this study is to investigate the role of vascular graft thickness in wall stress gradient in anastomosis region. Atherosclerosis is a common heart disease causes high mortality rates every year. The gold standard treatment of atherosclerosis is replacing with autologous vein extracted from patient's body. Since proper autologous vein is limited, researchers have made efforts to achieve compliance engineered blood vessels. Mechanical stress has great effect on both smooth muscle cells and endothelial cells and it is considered as a stimulus in plaque formation. In this study, we evaluate the role of thickness in wall stress of anastomosis region. For this purpose, two anastomosis models have been provided in ADINA and FSI simulations have been performed during pulsatile flow. In addition, the sensitivity of compliancy to thickness and diameter has been investigated. The vascular graft used in the simulations is a synthetic graft made up PCL and PVA by our group. Results show that thickness is an important parameter and even if vascular graft is compliant, improper thickness leads to an increase of wall stress pressure in anastomosis region.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115385350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043909
S. Esmaeili, Babak Nadjar Araabi, H. Soltanian-Zadeh, L. Schwabe
Epilepsy is a common neurological disorder characterized by abnormal excessive or synchronous neural activity in brain. In this study, we develop an unsupervised learning for seizure prediction. Extracting wavelet features of brain electroencephalogram (EEG), we propose a Hidden Markov Model (HMM) with a mixture of Gaussian observation model as an unsupervised learning setting for seizure prediction, where the seizure predictions are derived from the posterior distributions over the hidden states in the HMM. By using the Variational Bayesian (VB) method instead of the Maximum Likelihood estimation, which is the method commonly used for training HMMs, we overcome data overfltting and make it possible to compare models with different model orders by means of the variational free energy. VB learning also improves results in terms of convergence speed and achieved performance. The proposed method was evaluated using 20h of labeled EEG recordings from 7 epileptic rats with total number of 350 seizures. Our method obtained a high sensitivity of 90.7% and a specificity of 88.9% with early detection of 1.3s, which makes it more reliable than ML estimation with a sensitivity of 82.1% and a specificity of 86.2% and late detection of 4s.
{"title":"Variational Bayesian learning for Gaussian mixture HMM in seizure prediction based on long term EEG of epileptic rats","authors":"S. Esmaeili, Babak Nadjar Araabi, H. Soltanian-Zadeh, L. Schwabe","doi":"10.1109/ICBME.2014.7043909","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043909","url":null,"abstract":"Epilepsy is a common neurological disorder characterized by abnormal excessive or synchronous neural activity in brain. In this study, we develop an unsupervised learning for seizure prediction. Extracting wavelet features of brain electroencephalogram (EEG), we propose a Hidden Markov Model (HMM) with a mixture of Gaussian observation model as an unsupervised learning setting for seizure prediction, where the seizure predictions are derived from the posterior distributions over the hidden states in the HMM. By using the Variational Bayesian (VB) method instead of the Maximum Likelihood estimation, which is the method commonly used for training HMMs, we overcome data overfltting and make it possible to compare models with different model orders by means of the variational free energy. VB learning also improves results in terms of convergence speed and achieved performance. The proposed method was evaluated using 20h of labeled EEG recordings from 7 epileptic rats with total number of 350 seizures. Our method obtained a high sensitivity of 90.7% and a specificity of 88.9% with early detection of 1.3s, which makes it more reliable than ML estimation with a sensitivity of 82.1% and a specificity of 86.2% and late detection of 4s.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123974318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043913
Amir Hossein Farhadi Shouli, Salahadin Lotfi, E. Arbabi
Dyslexia is a brain-based reading disability characterized by deficit in phonological processing. In this paper the effect of computer working memory (WM) training on EEG signals of 15 dyslexic children has been investigated. For this purpose, three sets of EEG were recorded from the subjects before and after the computer treatment. Each set of EEG was recorded while the subjects were doing a visual task that involves the working memory or the attention. Three spectrum feature types have been extracted from the recorded signals, t-test as a statistical approach for finding the most affected features due to the treatment, has been applied on the spectrum features. By analyzing the results, it could be found that slow wave index (SWI) and relative spectral power (RSP) features are more affected by the treatments, comparing to the harmonic parameters (HPs). In addition, it has been observed that the extracted features from theta and delta bands and RSP in theta sub-bands are more affected by the computer intervention. Finally, by analyzing the most repeated electrodes, among the responsive features to the treatments, the anatomic regions of brain affected by the treatment have been found.
{"title":"Brain plasticity in dyslexia after computer training: Spectral analysis based on statistical t-test","authors":"Amir Hossein Farhadi Shouli, Salahadin Lotfi, E. Arbabi","doi":"10.1109/ICBME.2014.7043913","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043913","url":null,"abstract":"Dyslexia is a brain-based reading disability characterized by deficit in phonological processing. In this paper the effect of computer working memory (WM) training on EEG signals of 15 dyslexic children has been investigated. For this purpose, three sets of EEG were recorded from the subjects before and after the computer treatment. Each set of EEG was recorded while the subjects were doing a visual task that involves the working memory or the attention. Three spectrum feature types have been extracted from the recorded signals, t-test as a statistical approach for finding the most affected features due to the treatment, has been applied on the spectrum features. By analyzing the results, it could be found that slow wave index (SWI) and relative spectral power (RSP) features are more affected by the treatments, comparing to the harmonic parameters (HPs). In addition, it has been observed that the extracted features from theta and delta bands and RSP in theta sub-bands are more affected by the computer intervention. Finally, by analyzing the most repeated electrodes, among the responsive features to the treatments, the anatomic regions of brain affected by the treatment have been found.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125945375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043926
Mehdi Delrobaei, A. Parrent, M. Jog, S. Tran, Kristina Ognjanovic, G. Gilmore, Fariborz Rahimi, K. Mclsaac
Clinical scale-based follow-up of patients undergoing bilateral subthalamic deep brain stimulation (STN-DBS) surgery has shown inconsistent effects on bradykinesia in Parkinson's disease patients. Furthermore, quantitative assessment of STN-DBS effect on bradykinesia has not been fully explored yet. Our group uses multisensory kinematic technologies to study short-term and long-term DBS effects on Parkinson's disease. In this paper we present a kinematic analysis of the short term (3 month) effects of STN-DBS on bradykinesia in five PD patients and compare the results with data obtained from healthy age-matched controls.
{"title":"Quantifying the short-term effects of deep brain stimulation surgery on bradykinesia in Parkinson's disease patients","authors":"Mehdi Delrobaei, A. Parrent, M. Jog, S. Tran, Kristina Ognjanovic, G. Gilmore, Fariborz Rahimi, K. Mclsaac","doi":"10.1109/ICBME.2014.7043926","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043926","url":null,"abstract":"Clinical scale-based follow-up of patients undergoing bilateral subthalamic deep brain stimulation (STN-DBS) surgery has shown inconsistent effects on bradykinesia in Parkinson's disease patients. Furthermore, quantitative assessment of STN-DBS effect on bradykinesia has not been fully explored yet. Our group uses multisensory kinematic technologies to study short-term and long-term DBS effects on Parkinson's disease. In this paper we present a kinematic analysis of the short term (3 month) effects of STN-DBS on bradykinesia in five PD patients and compare the results with data obtained from healthy age-matched controls.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128439570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043944
Safa Rafiei Vand, F. Ghassemi
In recent years, the number of Internet users amazingly has grown. As a result, number of Internet-related problems like Internet addiction has increased too. Many studies have been done in the past ten years and this issue has attracted attention of many researchers. It has reported some psychiatric disorders are associated with Internet addiction but mechanism of this relation has been not discovered yet. ADHD as one the most prevalent comorbidities of Internet addiction needs more work. This study has tried to explore the relation between these two disorders using CAARS, WURS and YIAT questionnaires in a sample group of Iranian university students. In-line with previous studies correlation has been observed between ADHD and Internet addiction. Furthermore, factor analysis has been done on CAARS and WURS and impact of each of the factors and questions of the questionnaires has been discussed.
{"title":"Could ADHD symptoms make individuals susceptible for Internet addiction?","authors":"Safa Rafiei Vand, F. Ghassemi","doi":"10.1109/ICBME.2014.7043944","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043944","url":null,"abstract":"In recent years, the number of Internet users amazingly has grown. As a result, number of Internet-related problems like Internet addiction has increased too. Many studies have been done in the past ten years and this issue has attracted attention of many researchers. It has reported some psychiatric disorders are associated with Internet addiction but mechanism of this relation has been not discovered yet. ADHD as one the most prevalent comorbidities of Internet addiction needs more work. This study has tried to explore the relation between these two disorders using CAARS, WURS and YIAT questionnaires in a sample group of Iranian university students. In-line with previous studies correlation has been observed between ADHD and Internet addiction. Furthermore, factor analysis has been done on CAARS and WURS and impact of each of the factors and questions of the questionnaires has been discussed.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127614861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043925
S. Shirazi, N. Fatouraee, Z. Safaeepour
Recent studies reveal significant reduction of postural stability in transtibial amputees (TAs) especially when a perturbation is applied. However, no record has been seen on the consequences of such perturbation on the stump-socket interface pressure (SSIP). Our objective was to investigate whether such perturbation impose excessive pressures on the stump. We were also interested on the type of the response and direction in which TAs may face more difficulties. A 52-year-old TA participated in the study. The trial was performed using a custom bidirectional perturbing mechanism in the pitch and roll axes of ankle. Center of Pressure and were recorded by two force platforms and five resistive pressure sensors respectively. Right and anterior perturbations imposed the maximum SSIP while several CoP measures were considerably greater for the prosthetic leg just in left perturbations. This supports the necessity of measurement of SSIP as well as CoP to provide a better understanding about the new situations of TAs in postural stability.
{"title":"The need for stump-socket interface pressure measurment during bidirectionally perturbed stance in transtibial amputees: A case study","authors":"S. Shirazi, N. Fatouraee, Z. Safaeepour","doi":"10.1109/ICBME.2014.7043925","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043925","url":null,"abstract":"Recent studies reveal significant reduction of postural stability in transtibial amputees (TAs) especially when a perturbation is applied. However, no record has been seen on the consequences of such perturbation on the stump-socket interface pressure (SSIP). Our objective was to investigate whether such perturbation impose excessive pressures on the stump. We were also interested on the type of the response and direction in which TAs may face more difficulties. A 52-year-old TA participated in the study. The trial was performed using a custom bidirectional perturbing mechanism in the pitch and roll axes of ankle. Center of Pressure and were recorded by two force platforms and five resistive pressure sensors respectively. Right and anterior perturbations imposed the maximum SSIP while several CoP measures were considerably greater for the prosthetic leg just in left perturbations. This supports the necessity of measurement of SSIP as well as CoP to provide a better understanding about the new situations of TAs in postural stability.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"315 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123158027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043922
P. Amiri, Mohamad Zinaty
For data transmission from the Implantable Biomedicai Microsystems (IBM) to outside the body by Pulse Harmonic Modulation (PHM), two narrow pulses with appropriate timing are used so as to increase the data rate and decrease the InterSymbol Interference (ISI). In this paper, a new structure based on clock width modification and its edge detection has been designed to generate pulses. To control the timing interval between the two pulses, one quantity is used, which is the advantage of this structure over the previous ones. The structure has been simulated in 0.18 μm technology by ADS and HSPICE software, data transmission rate reaches 20 Mbps.
{"title":"Data transmission in implantable biomedicai microsystems by pulse harmonic modulation: A new structure","authors":"P. Amiri, Mohamad Zinaty","doi":"10.1109/ICBME.2014.7043922","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043922","url":null,"abstract":"For data transmission from the Implantable Biomedicai Microsystems (IBM) to outside the body by Pulse Harmonic Modulation (PHM), two narrow pulses with appropriate timing are used so as to increase the data rate and decrease the InterSymbol Interference (ISI). In this paper, a new structure based on clock width modification and its edge detection has been designed to generate pulses. To control the timing interval between the two pulses, one quantity is used, which is the advantage of this structure over the previous ones. The structure has been simulated in 0.18 μm technology by ADS and HSPICE software, data transmission rate reaches 20 Mbps.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123039419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043921
Hesam Aliniazare, H. Behnam, E. Fatemizadeh, Z. Sani
In this study a new method is proposed for quantification of cardiac muscle motions in echocardiography frames based on empirical mode decomposition (EMD) and manifold learning method. EMD algorithm is able to extract intrinsic mode functions (IMF) from a signal. In the first bi-dimension intrinsic mode functions (BIMF) of echocardiography frames myocardial is shown with more details than the second BIMF and the second BIMF shows more details than the third BIMF. By using manifold learning method, quantification difference between each pair of consecutive frames in the first, second and third BIMF series (similarities between the frames were extracted). Acquired trajectories of three manifolds for ischemie hearts are similar to each other but they are different for healthy hearts. This finding can be used for classifying ischemie and healthy hearts.
{"title":"Echocardiography frames quantification by empirical mode decomposition method","authors":"Hesam Aliniazare, H. Behnam, E. Fatemizadeh, Z. Sani","doi":"10.1109/ICBME.2014.7043921","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043921","url":null,"abstract":"In this study a new method is proposed for quantification of cardiac muscle motions in echocardiography frames based on empirical mode decomposition (EMD) and manifold learning method. EMD algorithm is able to extract intrinsic mode functions (IMF) from a signal. In the first bi-dimension intrinsic mode functions (BIMF) of echocardiography frames myocardial is shown with more details than the second BIMF and the second BIMF shows more details than the third BIMF. By using manifold learning method, quantification difference between each pair of consecutive frames in the first, second and third BIMF series (similarities between the frames were extracted). Acquired trajectories of three manifolds for ischemie hearts are similar to each other but they are different for healthy hearts. This finding can be used for classifying ischemie and healthy hearts.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123403510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-01DOI: 10.1109/ICBME.2014.7043937
M. Sefidgar, H. Bazmara, M. Mousavi, M. Bazargan, M. Soltani
A solid tumor is investigated as porous media for simulation fluid flow through it. Most of the research used Darcy model for porous media. In Darcy model the fluid friction is neglected and some simplified assumption is implemented. In this study the effect of these assumptions is studied by considering Brinkman model. A multi scale mathematical method which calculates fluid flow to a solid tumor is used in this study to investigate how neglecting fluid friction affects on solid tumor simulation. The mathematical method involves processes such as blood flow through vessels and solute and fluid diffusion, convective transport in extracellular matrix, and extravasation from blood vessels. The sprouting angiogenesis model is used for generating capillary network and then fluid flow governing equations are implemented to calculate blood flow through the tumor-induced capillary network Finally, two models of porous media are used for modeling fluid flow in normal and tumor tissues. Simulations of interstitial fluid transport in a solid tumor demonstrate that the simplification used in Darcy model affects on interstitial velocity and Brinkman model predicts a lower value for interstitial velocity than Darcy model.
{"title":"Interstitial flow in cancerous tissue: Effect of fluid friction","authors":"M. Sefidgar, H. Bazmara, M. Mousavi, M. Bazargan, M. Soltani","doi":"10.1109/ICBME.2014.7043937","DOIUrl":"https://doi.org/10.1109/ICBME.2014.7043937","url":null,"abstract":"A solid tumor is investigated as porous media for simulation fluid flow through it. Most of the research used Darcy model for porous media. In Darcy model the fluid friction is neglected and some simplified assumption is implemented. In this study the effect of these assumptions is studied by considering Brinkman model. A multi scale mathematical method which calculates fluid flow to a solid tumor is used in this study to investigate how neglecting fluid friction affects on solid tumor simulation. The mathematical method involves processes such as blood flow through vessels and solute and fluid diffusion, convective transport in extracellular matrix, and extravasation from blood vessels. The sprouting angiogenesis model is used for generating capillary network and then fluid flow governing equations are implemented to calculate blood flow through the tumor-induced capillary network Finally, two models of porous media are used for modeling fluid flow in normal and tumor tissues. Simulations of interstitial fluid transport in a solid tumor demonstrate that the simplification used in Darcy model affects on interstitial velocity and Brinkman model predicts a lower value for interstitial velocity than Darcy model.","PeriodicalId":434822,"journal":{"name":"2014 21th Iranian Conference on Biomedical Engineering (ICBME)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124461830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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