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2014 21th Iranian Conference on Biomedical Engineering (ICBME)最新文献

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Sparse representation-based super-resolution for diffusion weighted images 基于稀疏表示的扩散加权图像超分辨率
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043885
M. Afzali, E. Fatemizadeh, H. Soltanian-Zadeh
Diffusion weighted imaging (DWI) is a non-invasive method for investigating the brain white matter structure. It can be used to evaluate fiber bundles in the brain. However, clinical acquisitions are often low resolution. This paper proposes a method for improving the resolution using sparse representation. In this method a non-diffusion weighted image (bO) is utilized to learn the patches and then diffusion weighted images are reconstructed based on the trained dictionary. Our method is compared with bilinear, nearest neighbor and bicubic interpolation methods. The proposed method shows improvement in terms of Peak Signal-to-Noise Ratio (PSNR) and Structural SIMilarity (SSIM).
弥散加权成像(DWI)是一种研究脑白质结构的无创方法。它可以用来评估大脑中的纤维束。然而,临床收购往往是低分辨率。本文提出了一种利用稀疏表示提高分辨率的方法。该方法利用非扩散加权图像(bO)学习斑块,然后基于训练好的字典重构扩散加权图像。并与双线性、最近邻和双三次插值方法进行了比较。该方法在峰值信噪比(PSNR)和结构相似度(SSIM)方面都有改进。
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引用次数: 1
The effect of adding cherry tree gum on physical and mechanical properties of calcium phosphate bone cements 加入樱桃树胶对磷酸钙骨水泥物理力学性能的影响
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043942
Elahe Alipour, F. Moztarzadeh, S. Hesaraki
In this study, injectability and mechanical properties of calcium phosphate cement was improved by introducing cement powder (mixture of tetracalcium phosphate and dicalcium phosphate) with %75 cherry tree gum solution. Formations of hydroxyapatite (HA) were characterized by Fourier transform infrared spectrometer, X-ray diffraction, and scanning electron microscopy techniques. Moreover, the X-ray diffraction and FTIR patterns of the set cements indicated that, in both control group (cement without any gum) and HA containing cements, the primitive reactant components were completely converted to carbonated nanostructured apatite after soaking in simulated body fluid. Overal, the study indicated that calcium phosphate cement with improved injectability and mechanical properties can be procured by using cherry tree gum as an efficient additive.
本研究采用75%樱桃树胶溶液加入磷酸四钙和磷酸二钙混合的水泥粉,改善了磷酸钙水泥的注射性和力学性能。利用傅里叶变换红外光谱仪、x射线衍射和扫描电镜技术对羟基磷灰石(HA)的形成进行了表征。此外,固化水泥的x射线衍射和红外光谱表明,在对照组(不含胶的水泥)和含HA的水泥中,原始反应物成分在模拟体液中浸泡后完全转化为碳化的纳米磷灰石。综上所述,研究表明,以樱桃树胶作为有效添加剂,可获得注射性和力学性能均有所改善的磷酸钙水泥。
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引用次数: 0
A mathematical model for neuron astrocytes interactions in hippocampus during addiction 成瘾过程中海马神经元星形胶质细胞相互作用的数学模型
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043940
M. Borjkhani, A. Mahdavi, F. Bahrami
Addiction is a chronic disorder whereby addicted individuals compulsively engage in drug seeking despite its negative consequences. Hippocampus has unavoidable role in addiction because of its importance in learning and memory. Any modification of hippocampal cells alters dopamine levels in NAc and firing rates of VTA dopaminergic cells. In order to have a better understanding of the addiction in cellular level, we present a mathematical model of a tripartite synapse in hippocampus. The proposed model can show some functions of synapses under addiction that may contribute to drug seeking and relapse behaviors. The model is based on glutamate alterations in synaptic cleft during drug abuse. Experimental studies suggest that during drug abuse, NMD AR dependent synaptic transmission is increased. According to our simulation results, dysfunction of astrocyte has a significant role in initiating addiction. Since healthy astrocytes has a comprehensive control over synaptic interactions it may use to treat addicted related behaviors. Also, we may conclude that addiction causes abnormalities on postsynaptic signaling such as NMDA currents. Furthermore, we may suggest that drug induced D-serine enhancement in synaptic cleft potentiate post synaptic calcium influx and LTP.
成瘾是一种慢性疾病,成瘾者不顾其负面后果而强迫性地寻求药物。由于海马在学习和记忆中的重要性,它在成瘾中具有不可避免的作用。海马细胞的任何修饰都会改变NAc中的多巴胺水平和VTA多巴胺能细胞的放电率。为了更好地理解细胞水平上的成瘾,我们提出了海马三方突触的数学模型。该模型可以显示成瘾下突触的一些功能,这些功能可能有助于药物寻求和复发行为。该模型基于药物滥用期间突触间隙中谷氨酸的改变。实验研究表明,在药物滥用期间,NMD依赖性AR突触传递增加。根据我们的模拟结果,星形胶质细胞的功能障碍在成瘾的启动中起着重要作用。由于健康的星形胶质细胞具有对突触相互作用的全面控制,它可能用于治疗成瘾相关行为。此外,我们可以得出结论,成瘾导致突触后信号异常,如NMDA电流。此外,我们可能认为药物诱导d -丝氨酸增强突触裂电位、突触后钙内流和LTP。
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引用次数: 3
Evaluation of elastic properties of breast cancer stem-like/tumor initiating cells using Atomic Force Microscopy 利用原子力显微镜评价乳腺癌干细胞样细胞/肿瘤起始细胞的弹性特性
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043908
Neda Rashidi, M. Tafazzoli-Shadpour, Ramin Omidvar, M. Ebrahimi
In this study, we evaluated mechanical properties of breast cancer stem-like/tumor-initiating cells (CSC/TICs) from MCF7 cell line. By use of local measurement techniques, such as atomic force microscopy, magnetic or optical tweezers, determination of mechanical properties of an individual living cell in liquid conditions, similar to natural environment has become possible. In this study Young's modulus of individual cancer stem cells were measured as an indicator of cell elasticity using atomic force microscopy (AFM) compared to that of cancer cells. Results indicated that the enriched CSC/TICs population (0.357±0.092kPa) were softer than their cancer cells (MCF7 cell line) (1.04±0.27 kPa). Based on the significant difference between mechanical properties of CSC and cancer cells, the progression of cancer cells from cancer stem cells may be characterized.
在这项研究中,我们评估了来自MCF7细胞系的乳腺癌干细胞样/肿瘤起始细胞(CSC/TICs)的力学特性。通过使用局部测量技术,例如原子力显微镜,磁性或光学镊子,可以在类似于自然环境的液体条件下测定单个活细胞的机械特性。在这项研究中,使用原子力显微镜(AFM)测量单个癌症干细胞的杨氏模量作为细胞弹性的指标,并与癌细胞进行比较。结果表明,富集的CSC/TICs细胞群(0.357±0.092kPa)比MCF7细胞系(1.04±0.27 kPa)软;基于CSC与癌细胞力学特性的显著差异,可以表征肿瘤干细胞向癌细胞的发展过程。
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引用次数: 3
Optimal temporal resolution for decoding of visual stimuli in inferior temporal cortex 下颞叶皮层视觉刺激解码的最佳时间分辨率
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043903
A. Babolhavaeji, S. Karimi, A. Ghaffari, A. Hamidinekoo, B. Vosoughi-Vahdat
Inferior temporal (IT) cortex is the most important part of the brain and plays an important role in response to visual stimuli. In this study, object decoding has been performed using neuron spikes in IT cortex region. Single Unit Activity (SUA) was recorded from 123 neurons in IT cortex. Pseudo-population firing rate vectors were created, then dimension reduction was done and an Artificial Neural Network (ANN) was used for object decoding. Object decoding accuracy was calculated for various window lengths from 50 ms to 200 ms and various window steps from 25 ms to 100 ms. The results show that 150 ms length and 50 ms window step size gives an optimum performance in average accuracy.
下颞叶皮层是大脑中最重要的部分,对视觉刺激的反应起着重要的作用。在本研究中,利用IT皮质区域的神经元尖峰进行对象解码。记录123个IT皮质神经元的单单位活动(SUA)。首先建立伪种群发射率向量,然后进行降维,利用人工神经网络对目标进行解码。在不同的窗长(50 ms ~ 200 ms)和不同的窗步(25 ms ~ 100 ms)下计算对象解码精度。结果表明,150 ms的长度和50 ms的窗步长可以获得最佳的平均精度。
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引用次数: 1
A robust speaker recognition system combining factor analysis techniques 结合因子分析技术的鲁棒说话人识别系统
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043948
Shaghayegh Reza, Tahereh Emami Azadi, J. Kabudian, Y. Shekofteh
In this paper we implement state of the art factor analysis based methods and fused their scores to gain a channel robust speaker recognition system. These two methods are joint factor analysis (JFA) and i-Vector which define low-dimensional speaker and channel dependent spaces. For score fusion we propose a simple weight computation without training step. We experiment our method on two conditions; 1) in channel matched training and test channel (telephone in training phase/telephone in test phase) task and 2) the channel mismatched condition (telephone training phase/microphone, GSM and VOIP in test phase) task. Our strategies outperform a state-of-the-art GMM-UBM based system. We obtained more than 4% absolute EER improvement for both channel dependent and channel independent condition compared to the standard GMM-UBM based method. Simulation also results that the combined system based on i-Vector and JFA gives better performance than all implemented method.
在本文中,我们实现了最先进的基于因子分析的方法,并融合了它们的分数来获得一个信道鲁棒的说话人识别系统。这两种方法分别是联合因子分析(JFA)和i-Vector,它们定义了低维扬声器和通道相关空间。对于分数融合,我们提出了一种不需要训练步骤的简单权值计算方法。我们在两个条件下试验我们的方法;1)信道匹配训练和测试信道(训练阶段的电话/测试阶段的电话)任务和2)信道不匹配条件(电话训练阶段/麦克风,GSM和VOIP测试阶段)任务。我们的策略优于最先进的基于GMM-UBM的系统。与基于标准GMM-UBM的方法相比,我们在信道依赖和信道独立条件下都获得了超过4%的绝对EER改善。仿真结果表明,基于i-Vector和JFA的组合系统的性能优于所有实现方法。
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引用次数: 0
Online undersampled dynamic MRI reconstruction using mutual information 利用互信息的在线欠采样动态MRI重建
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043929
M. Farzi, A. Ghaffari, E. Fatemizadeh
We propose an algorithm based on mutual information to address the problem of online reconstruction of dynamic MRI from partial k-space measurements. Most of previous compressed sensing (CS) based methods successfully leverage sparsity constraint for offline reconstruction of MR images, yet they are not used in online applications due to their complexities. In this paper, we formulate the reconstruction as a constraint optimization problem and try to maximize the mutual information between the current and the previous time frames. Conjugate gradient method is used to solve the optimization problem. Using Cartesian mask to undersample k-space measurements, the proposed method reduces reconstruction error from 3.41% in ModCS, 1.57% in ModCS_Res and 1.16% in CaNNM to 0.61% on average per frame. Moreover, fast reconstruction of images at the rate of 2 to 10 frames per second makes our method a good alternative for current CS based methods in online dynamic MRI applications.
我们提出了一种基于互信息的算法来解决从部分k空间测量中在线重建动态MRI的问题。以往大多数基于压缩感知(CS)的方法成功地利用稀疏性约束进行MR图像的离线重建,但由于其复杂性,它们并未用于在线应用。在本文中,我们将重建描述为一个约束优化问题,并试图最大化当前和以前的时间框架之间的互信息。采用共轭梯度法求解优化问题。利用笛卡尔掩模对k空间测量进行下采样,将ModCS的3.41%、ModCS_Res的1.57%和canm的1.16%的平均每帧重构误差降低到0.61%。此外,以每秒2到10帧的速度快速重建图像使我们的方法成为当前在线动态MRI应用中基于CS的方法的一个很好的替代方案。
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引用次数: 0
A computational study of microscale flow and mass transport in vasculatized tumors 血管化肿瘤中微尺度流动和质量传递的计算研究
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043887
M. Nabil, P. Zunino, L. Cattaneo
We develop A computational finite element model to study microcirculation and drug delivery to tumors under drug bolus injection into the blood stream. The mathematical model is based on the fundamental laws of filtration and transport in biological tissues at the micro-scale level. The model consists of two separate regions. A network of vessels carrying blood flow (the capillaries), and the surrounding tissue (interstitial volume). A comparison of flow and mass transport in healthy and tumor tissue models is presented using four case studies with different physiological properties.
我们建立了一个计算有限元模型来研究微循环和药物注射到血液中的肿瘤。该数学模型是基于微观尺度上生物组织中过滤和输送的基本规律。该模型由两个独立的区域组成。输送血液的血管网络(毛细血管)和周围的组织(间质容积)。通过四个具有不同生理特性的案例研究,比较了健康和肿瘤组织模型中的流量和质量传输。
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引用次数: 1
Design and fabrication of cell adhesion measuring device 电池黏附测量装置的设计与制造
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043943
Saeed Salehipour, N. Abolfathi, A. Hashemi
Cell adhesion phenomena has an important role on different behavior of cell. Therefore qualitative and quantitative understanding of cell adhesion force is necessary. A low cost micro device has been developed that can demonstrate cell adhesion force against a specific mechanical stimuli. The device that we developed here allows the measuring cell adhesion. This device is made based on poly methyl methacrylate (PMMA). Finally, to test the system functions, we obtained viscoelastic parameters of cell by applying 10 micron displacement that had a good agreement with literature.
细胞粘附现象对细胞的不同行为具有重要的影响。因此,对细胞粘附力的定性和定量了解是必要的。一种低成本的微型装置已经开发出来,可以证明细胞对特定机械刺激的粘附力。我们在这里开发的设备可以测量细胞粘附。该装置是由聚甲基丙烯酸甲酯(PMMA)制成的。最后,为了测试系统的功能,我们用10微米的位移得到了细胞的粘弹性参数,与文献吻合较好。
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引用次数: 0
3D reconstruction of vessels from two uncalibrated mammography images 从两张未校准的乳房x线摄影图像中重建血管
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043914
M. Babaee, A. R. Naghsh Nilchi
Three dimensional modeling of organs plays a crucial role in the treatment of cancer and radio vascular diseases. The purpose of this work is 3D modeling of breast vessels using only two uncalibrated two-dimensional mammography images in order to have the patient less exposed to X-ray radiation. In the proposed method, we first optimize the internal and external parameters using a nonlinear optimization framework. To this end, we use the data stored in the header of files and key features in the mammography images. Using the optimized parameters, 3D active contours is proposed for 3D modeling of the vessels. Then using the parameters obtained from the previous step, an initial active curve gradually evolves until the energy of active curve is minimized. The surface reconstruction of the vessels is done by employing the methods converting a set of surface points to lattice surface. The proposed method is implied for a set of mammography images. Assuming optimized parameters are achieved, the method can yield promising 3D reconstruction.
器官的三维建模在癌症和放射性血管疾病的治疗中起着至关重要的作用。这项工作的目的是仅使用两张未经校准的二维乳房x线摄影图像对乳腺血管进行3D建模,以便使患者较少暴露于x射线辐射。在该方法中,我们首先使用非线性优化框架对内外参数进行优化。为此,我们使用存储在文件头中的数据和乳房x线摄影图像中的关键特征。利用优化后的参数,提出了用于血管三维建模的三维活动轮廓。然后利用前一步得到的参数,逐渐演化出一条初始活动曲线,直到活动曲线能量最小。采用将一组表面点转换为点阵表面的方法对容器进行表面重建。该方法适用于一组乳房x线摄影图像。在参数得到优化的前提下,该方法可以得到很好的三维重建效果。
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引用次数: 1
期刊
2014 21th Iranian Conference on Biomedical Engineering (ICBME)
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