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2014 21th Iranian Conference on Biomedical Engineering (ICBME)最新文献

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Three dimensional modeling of axonal microtubules 轴突微管的三维建模
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043939
F. Manuchehrfar, A. Shamloo
Axon is a filament in neuronal system and axonal microtubules are bundles in axons. In axons, microtubules are coated with microtubule-associated protein tau, a natively unfolded profuse filamentous protein in the central nervous system. These proteins are responsible for the cross-linked structure of the axonal microtubule bundles. Through complimentary dimerization with other tau proteins, bridges are formed to nearby microtubules to create bundles. The transverse reinforcement of microtubules by cross-linking to the cytoskeleton has been shown to enhance their ability to bear compressive loads. Though microtubules are conventionally regarded as bearing compressive loads, in certain circumstances such as in traumatic stretch injury, they are placed in tension. We employ Standard Linear Solid, a viscoelastic model, to computationally simulate microtubules. This study investigates the dynamic response of two dimensional axonal microtubules under suddenly applied end forces. We obtain the results for steady state behavior of axonal microtubule for different forces.
轴突是神经系统中的细丝,轴突微管是轴突中的束。在轴突中,微管被微管相关蛋白tau包裹,这是一种在中枢神经系统中天然未折叠的大量丝状蛋白。这些蛋白质负责轴突微管束的交联结构。通过与其他tau蛋白的互补二聚化,与附近的微管形成桥接,形成束。通过与细胞骨架交联的微管横向增强已被证明可以增强其承受压缩载荷的能力。虽然微管通常被认为是承受压缩载荷,但在某些情况下,例如在创伤性拉伸损伤中,它们被置于张力状态。我们采用标准线性固体,粘弹性模型,计算模拟微管。本文研究了二维轴突微管在突然施加的末端力作用下的动态响应。得到了轴突微管在不同力作用下的稳态行为。
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引用次数: 0
Compliant Vs. rigid tendon models: A simulation study on precision, computational efficiency and numerical stability 柔性与刚性肌腱模型:精度、计算效率和数值稳定性的仿真研究
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043900
A. Mousavi, H. Ehsani, M. Rostami
Providing an efficient mathematical model of the skeletal muscles which takes both computational efficiency and accuracy into account is a crucial factor in the simulations of multiple-muscle problems. Previous studies stated that ignoring the elastic characteristics of the tendon can reduce the time cost of simulations at the expense of introducing some minor errors if the ratio of tendon slack length to muscle optimum length is less than or equal to unity. The purpose of this paper was to test the precision, efficiency and numerical stability of this criterion for the muscles of the human body in their usual length excursions. In this regard two muscles of the upper extremity (Brachioradialis (BRD) long head of biceps (BICL)) and one from the lower extremity (soleus (SOL)) of the human body have been chosen. Two variations of a general Hill-based musculotendon model have been considered in this study. In the first one, using a nonlinear spring the elastic properties of the tendon has been incorporated into the model and in the second one, ignoring this properties, a constant length for the tendon has been assumed. The mean absolute error between the force profiles of the two models for BRD, BICL and SOL were 4.2, 12 and 13.1 respectively. Also rigid-tendon model was 7.3 to 9.5 times faster than compliant-tendon model using the implicit integrator. For BRD the outcomes of the two models, have similar trends and the discrepancies between the force profiles are negligible. However, the results obtained from the compliant-tendon model illustrate some numerical stability problems. In the second muscle, i.e. BICL, likewise BRD the trends of the force profiles are the same; however, the disparity among the outcomes of the two models have escalated. Likewise BRD, the rigid-tendon model required less computational time. Inspecting the results obtained for SOL, one can easily spot the significant differences between the outcomes of the two models. Considering the tendon slack length to the optimum muscle length ratio for the three mentioned musculotendon units, one can draw this conclusion that, in case this value is less than unity using the rigid-tendon model is recommended. If this value is not much greater than unity, like BICL, exploiting the rigid-tendon model will increase the computational efficiency in expense of contaminating the outcomes with some amounts of error. However, if this ratio is far from unity, like SOL, ignoring the length alterations in the tendon is not recommended.
提供一个兼顾计算效率和精度的高效的骨骼肌数学模型是多肌肉问题仿真的关键因素。以往的研究表明,当肌腱松弛长度与肌肉最佳长度之比小于等于1时,忽略肌腱的弹性特性可以减少模拟的时间成本,但会引入一些小误差。本文的目的是测试该准则在人体肌肉通常长度运动中的精度、效率和数值稳定性。在这方面,我们选择了人体上肢的两块肌肉(肱桡肌(BRD)二头肌(BICL))和下肢的一块肌肉(比目鱼肌(SOL))。本研究考虑了一般Hill-based肌肌腱模型的两种变体。在第一个模型中,使用非线性弹簧将肌腱的弹性特性纳入模型,而在第二个模型中,忽略这一特性,假设肌腱的长度为恒定。BRD、BICL和SOL模型的力分布平均绝对误差分别为4.2、12和13.1。使用隐式积分器,刚性肌腱模型比柔性肌腱模型快7.3 ~ 9.5倍。对于BRD,两种模型的结果具有相似的趋势,并且力分布之间的差异可以忽略不计。然而,从柔顺肌腱模型得到的结果说明了一些数值稳定性问题。在第二个肌肉,即BICL,同样BRD,力剖面的趋势是相同的;然而,两种模式的结果差距已经扩大。与BRD类似,刚性肌腱模型所需的计算时间更少。检查为SOL获得的结果,可以很容易地发现两个模型的结果之间的显著差异。考虑到上述三个肌腱单元的肌腱松弛长度与最佳肌长之比,可以得出这样的结论:当该值小于1时,建议使用刚性肌腱模型。如果该值不大于1,如BICL,则利用刚性肌腱模型将提高计算效率,但代价是结果会受到一些误差的污染。然而,如果这一比例远不一致,如SOL,则不建议忽略肌腱的长度变化。
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引用次数: 3
Breast cancer detection using a multi-objective binary Krill Herd algorithm 基于多目标二元Krill Herd算法的乳腺癌检测
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043907
A. Mohammadi, M. S. Abadeh, Hamidreza Keshavarz
In this paper, an algorithm is presented for extracting fuzzy rules from the Breast Cancer dataset. To extract fuzzy rules, an imitation based evolutionary algorithm is used called Krill Herd (KH). The KH algorithm is converted to a binary algorithm here, and is used for the classification problem with innovation, named Binary Krill Herd-based Fuzzy Rule Miner (BKH-FRM). Choosing the best krill and local best of the Krills in each generation are performed according to a new multi-objective function. This algorithm achieves a higher accuracy than others with few rules and little sum of the rules lengths.
本文提出了一种从乳腺癌数据集中提取模糊规则的算法。为了提取模糊规则,使用了一种基于模仿的进化算法,称为Krill Herd (KH)。本文将KH算法转化为二进制算法,并创新地用于分类问题,命名为基于二进制磷虾群的模糊规则挖掘器(binary Krill Herd-based Fuzzy Rule Miner, BKH-FRM)。根据新的多目标函数选择每一代最优磷虾和局部最优磷虾。该算法以较少的规则和较小的规则长度和达到了比其他算法更高的精度。
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引用次数: 8
Plausibility assessment of a subject independent mental task-based BCI using electroencephalogram signals 利用脑电图信号评估受试者独立心理任务型脑机接口的合理性
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043911
S. Hatamikia, A. Nasrabadi, N. Shourie
In this research, we study the possibility of designing a mental-task based subject-independent Brain Computer Interface (BCI) using Electroencephalogram (EEG) signals. Due to major differences in the EEG signal of individuals during different mental tasks, designing a universal BCI seems impossible. Hence, almost all the previous studies concentrated on designing custom-based Brain Computer Interface systems (BCIs) which are appropriate to be used by only one particular subject. In order to overcome this limitation, this paper presents an efficient subject-independent procedure for EEG-based BCIs. The main aim of this research is to develop ready-to-use BCIs that can be applicable for all users. To achieve this goal, three feature extraction methods including Autoregressive modeling, Wavelet transform and Power spectral density were applied; then, a new method based on Genetic Algorithm (GA) wrapped Self Organization Map (SOM) feature selection was used to select the most related features with the use of leave-one-subject-out cross-validation strategy. According to the experimental results, the proposed algorithm based on GA wrapped SOM feature selection is an efficient method for designing subject-independent BCIs and is able to distinguished different cognitive tasks of different individuals, effectively.
在本研究中,我们研究了利用脑电图(EEG)信号设计基于心理任务的独立于主体的脑机接口(BCI)的可能性。由于个体在不同思维任务时的脑电图信号存在很大差异,设计一个通用的脑机接口似乎是不可能的。因此,以往几乎所有的研究都集中在设计定制化的脑机接口系统(bci)上,这些系统只适合某一特定的受试者使用。为了克服这一限制,本文提出了一种有效的基于脑电图的脑机接口的独立于主体的程序。本研究的主要目的是开发可适用于所有用户的即用型脑机接口。为此,采用自回归建模、小波变换和功率谱密度三种特征提取方法;然后,采用一种基于遗传算法(GA)包裹自组织映射(SOM)特征选择的新方法,利用留一主体交叉验证策略选择相关度最高的特征;实验结果表明,基于GA包裹SOM特征选择的算法是设计主体无关脑机接口的有效方法,能够有效区分不同个体的不同认知任务。
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引用次数: 6
Compensation of downbeat nystagmus with a modular controller 用模块化控制器补偿下拍眼球震颤
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043935
H. Haghighi, F. Abdollahi, Sahar Babaei, S. Gharibzadeh
In this study a modular control approach is used to provide target following ability for a patient eye suffering from downbeat nystagmus. To perform the task successfully, it is proposed to exploit the benefits of modular strategies. Therefore, vertical eye movements are decomposed to two distinct upward and downward motions, and the controller tries to dedicate each of them to one distinct module autonomously. By this way, target following task is apportioned between modules and each module's contribution is to learn and control one single subtask. Consequently, perfect target following, confirms the performance of the proposed approach.
在本研究中,采用模块化控制方法为患有下拍性眼球震颤的患者提供目标跟踪能力。为了成功地完成任务,建议利用模块化策略的优势。因此,垂直眼动被分解为两个不同的向上和向下的运动,控制器试图将每个运动自主地奉献给一个不同的模块。通过这种方式,在模块之间分配目标跟踪任务,每个模块的贡献是学习和控制一个单独的子任务。因此,完美的目标跟踪,证实了所提方法的性能。
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引用次数: 0
Automatic detection of mitosis cell in breast cancer histopathology images using genetic algorithm 利用遗传算法自动检测乳腺癌组织病理图像中的有丝分裂细胞
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043883
R. Nateghi, H. Danyali, Mohammad SadeghHelfroush, Fattaneh Pourak Pour
Nowadays, pathologist grade breast cancer histopathology slides by microscopes based on Nottingham as an international standard. The mitotic counting is one of the three scoring criteria in Nottingham standard for breast cancer grading based on histopathology slide image studies. Large number of non-mitosis organs, which exists in histopathology slide tissue, is one of the most important challenges facing mitosis detection methods. In this paper, a system for automatic mitosis detection purpose from breast cancer histopathology slide images is proposed to aid pathologists for mitotic cells counting. In the proposed algorithm the number of non-mitosis candidates are defined as a cast function and by minimization using Genetic Optimization algorithm, the most of the non-mitosis candidates will be omitted. Then some features such as co-occurrence and run-length matrices and Gabor features are extracted from the rest of candidates and finally mitotic cells are classified using support vector machine (SVM) classifier. Experimental results demonstrate the efficiency of this method to detect mitotic cells in breast cancer histology images.
目前,病理学家在显微镜下对乳腺癌组织病理切片进行分级,以诺丁汉为国际标准。有丝分裂计数是基于组织病理学切片图像研究的诺丁汉乳腺癌分级的三个评分标准之一。组织病理学切片组织中存在大量的非有丝分裂器官,这是有丝分裂检测方法面临的最重要挑战之一。本文提出了一种从乳腺癌组织病理学切片图像中自动检测有丝分裂的系统,以帮助病理学家进行有丝分裂细胞计数。在该算法中,非有丝分裂候选基因的数量被定义为一个投射函数,通过使用遗传优化算法最小化,大多数非有丝分裂候选基因将被省略。然后从剩余候选样本中提取出共现矩阵、运行长度矩阵和Gabor特征,最后利用支持向量机(SVM)分类器对有丝分裂细胞进行分类。实验结果证明了该方法在乳腺癌组织学图像中检测有丝分裂细胞的有效性。
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引用次数: 22
Assessment of a newly designed PVC standing wheelchair by finite element method 新设计的PVC站立式轮椅的有限元评估
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043891
Morteza Teymori, M. Karimi, N. Jamshidi, N. Soltani
Spinal Cord Injury is one of the most important issues of medical society in the world. Problems that the disabled encounter after the accident are significant, namely pressure sores, bone mineral density loss, and disorders in circulation system. The proposed design is a new standing wheelchair that helps the disabled overcome these problems. Affordability and manufacturing problems still exist. Finite element method analysis to find the proper material has been done. The structure is analyzed to obtain the data. The human body was segmented into 11 parts. The result are obtained using ANSYS structural analysis. Results revealed that Poly vinyl chloride can be used instead of stainless steel or aluminum alloy. This concept can change the future of wheelchair production. The mass production will definitely affect the price and the market.
脊髓损伤是当今世界医学界关注的热点问题之一。残疾人士在事故发生后遇到的问题很严重,即褥疮、骨密度损失、循环系统紊乱。提出的设计是一种新的站立式轮椅,帮助残疾人克服这些问题。价格和制造问题仍然存在。通过有限元分析,找到了合适的材料。对结构进行了分析,得到了数据。人体被分成11个部分。利用ANSYS进行了结构分析。结果表明,聚氯乙烯可以代替不锈钢或铝合金。这个概念可以改变轮椅生产的未来。大量生产肯定会影响价格和市场。
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引用次数: 3
A rotation invariant retina identification algorithm using tessellation-based spectral feature 一种基于细分的光谱特征旋转不变视网膜识别算法
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043941
Mahrokh Khakzar, H. Pourghassem
In this paper, a rotation-invariant retina identification algorithm based on tessellation of frequency spectrum is developed. In this algorithm, the proposed tessellation scheme provides rotation invariant, multi resolution and optimized features with low computational for our retina identification algorithm. The proposed algorithm is structured in two parts namely feature extraction and decision making. First step is forming feature vectors by applying proposed tessellation scheme on frequency spectrum of vessel skeleton of retinal image. Then, a specific scenario is defined based on energy spectrum of vessels to identify each individual. Finally, Euclidean distance criterion is used to evaluate the accuracy of proposed tessellation scheme. Experimental results show that the proposed algorithm obtains the accuracy rate of 99.29 % in presence of rotation and multi resolution samples.
本文提出了一种基于频谱细分的旋转不变视网膜识别算法。该算法为视网膜识别算法提供了旋转不变性、多分辨率和低计算量的优化特征。该算法分为特征提取和决策两部分。首先对视网膜图像血管骨架的频谱进行细分,形成特征向量。然后,根据船舶的能量谱定义一个特定的场景,以识别每个个体。最后,利用欧几里得距离准则对所提出的镶嵌方案的精度进行了评价。实验结果表明,该算法在存在旋转和多分辨率样本的情况下,准确率达到99.29%。
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引用次数: 6
Postural control assessment in Wushu by using fractal dimension analysis 基于分形维数分析的武术姿势控制评价
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043945
R. Saber, M. Rostami, A. Ramezani, A. Tanbakoosaz
In this study we investigated a nonlinear and a traditional time domain technique to analyze postural control of a balance motion in Wushu. For this goal we implemented fractal dimension analysis as the nonlinear method by using Higuchi algorithm which calculate fractal dimension directly from time series of movement of center of pressure in two directions of anterior/posterior and medial/lateral. Range of motion of center of pressure excursion was calculated as the traditional measure in both directions. One elite group and one non-elite group of Wushu sportsmen participated in this research. We found that the nonlinear method is sensitive to the level of proficiency.
本文研究了一种非线性和传统的时域技术来分析武术平衡动作的姿势控制。为此,我们采用Higuchi算法将分形维数分析作为非线性方法,直接从压力中心在前/后和内/外侧两个方向的运动时间序列中计算分形维数。在两个方向上按传统方法计算压力偏移中心的运动范围。武术运动员分为精英组和非精英组。我们发现非线性方法对熟练程度很敏感。
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引用次数: 0
Automated decomposition of needle EMG signal using STFT and wavelet transforms 用STFT和小波变换自动分解针肌电信号
Pub Date : 2014-11-01 DOI: 10.1109/ICBME.2014.7043951
H. Yousefi, Shahbaz Askari, G. Dumont, Zoya J. R. Bastany
We present an automated method for decomposing EMG signals into their components, motor-unit action-potential (MUAP) trains based on short time Fourier transform STFT and wavelet transform. Since the number of MUAP classes composing the EMG signal, the number of MUAP's per class, their firing pattern, and the expected shape of the MUAP waveforms are unknown, the decomposition of real EMG signals into their constituent MUAP's and their classification into groups of similar shapes is a typical case of an unsupervised learning pattern recognition problem. The method is able to handle single-or multi-channel signals, recorded by concentric needle electrodes during low and moderate levels of muscular contraction. The method uses empirical features in STFT transform, shape and template of MU and CWT in order to decompose the signal to its original MUAP. Also the discrete wavelet transform has been acquired in early steps in order to eliminate the level of low amplitude noise in signal. We compare the output of the automated algorithm with manual decomposition and results seems quiet acceptable. The average success rate for the FCM with wavelet coefficients as features was 91.01 %.
我们提出了一种基于短时傅立叶变换STFT和小波变换的自动肌电信号分解方法,将肌电信号分解为运动单元动作电位(MUAP)序列。由于构成肌电信号的MUAP类的数量、每类MUAP的数量、它们的发射模式以及MUAP波形的预期形状都是未知的,因此将真实肌电信号分解成它们的组成MUAP,并将它们分类为形状相似的组,是一个典型的无监督学习模式识别问题。该方法能够处理单通道或多通道信号,由同心针电极在低和中度肌肉收缩期间记录。该方法利用MU和CWT的STFT变换、形状和模板中的经验特征,将信号分解为其原始MUAP。为了消除信号中的低幅值噪声,在信号的早期阶段进行了离散小波变换。我们将自动算法的输出与人工分解进行比较,结果似乎是可以接受的。以小波系数为特征的FCM平均成功率为91.01%。
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引用次数: 9
期刊
2014 21th Iranian Conference on Biomedical Engineering (ICBME)
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