Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/13073d
R. Garg, P. Kaur, N. Chopra
A placental polyp is a polypoidal or pedunculated mass of placental tissue that remains in the uterus after delivery or abortion for an indefinite period. For its rarity, there are few references in the literature, and there are many different approaches to diagnosis and management. A rare case of placenta accreta appearing as a uterine polyp is presented. This is the sole case that has been diagnosed and treated conservatively at our hospital. A proper preoperative diagnosis with accurate interpretation of imaging findings and satisfactory curettage or biopsy can prevent unnecessary hysterectomy as was in our case.
{"title":"Placenta Accreta Presenting as a Placental Polyp: A Rare Case Report","authors":"R. Garg, P. Kaur, N. Chopra","doi":"10.9734/bpi/nfmmr/v16/13073d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/13073d","url":null,"abstract":"A placental polyp is a polypoidal or pedunculated mass of placental tissue that remains in the uterus after delivery or abortion for an indefinite period. For its rarity, there are few references in the literature, and there are many different approaches to diagnosis and management. A rare case of placenta accreta appearing as a uterine polyp is presented. This is the sole case that has been diagnosed and treated conservatively at our hospital. A proper preoperative diagnosis with accurate interpretation of imaging findings and satisfactory curettage or biopsy can prevent unnecessary hysterectomy as was in our case.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132837853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/13030d
R. F. Duarte, Ricardo Osés Rodríguez, David del Valle Laveaga, María Patricia Zambrano Gavilanes, P. Rodriguez, Yanira Zaita Ferrer, F. González, I. Hurtado
The objective of the research was to determine the climatic impact of temperature on avian respiratory infections in Villa Clara province, Cuba. In this work retrospective data were used to obtain the epizootiological statistical information of susceptible and dead birds regarding avian respiratory infections, in specialized poultry farms of Villa Clara province, during the period 2005-2007. These data were correlated with the temperatures stockings average corresponding to this period in this county. The total of deaths was correlated with the total of susceptible; these last ones correlated in turn with the provincial temperatures stockings. For the information processing, the model Autoregressive Integrated Moving Averages (ARIMA) was used of Box-Jenkins Methodology through the statistical package SPSS Version 13. Techniques of multivariate regression for modeling the total of poultry deaths were also applied. The final ARIMA model expressed that an increase of 1 degree of temperature, which meant an increase of 53.37 deaths. It was also used a 95% of probability value. This work allows corroborating and quantifying the impact of mean temperature in the susceptible and in the poultry deaths in the study area of Villa Clara province, Cuba. It was obtained that with 1oC of monthly half temperature, it can be expected an increase of 8 894 susceptible cases and as the susceptible ones’ increase in 1000 the deaths, are increased in 6 birds, for what the susceptible ones for 0.06 will be the same approximately to the total of deaths.
研究的目的是确定温度对古巴维拉克拉拉省禽类呼吸道感染的气候影响。本研究采用回顾性资料，对2005-2007年比利亚克拉拉省专业家禽养殖场禽类呼吸道感染的易感和死禽进行了流行病学统计。这些数据与该县同期的平均气温相关联。死亡总人数与易感人群总人数相关;这些最后的数据依次与各省的气温长袜相关。信息处理采用Box-Jenkins方法，通过SPSS Version 13统计软件包，采用自回归综合移动平均(ARIMA)模型。还应用了多变量回归技术对家禽死亡总数进行建模。最终的ARIMA模型表明，温度每升高1度，就意味着死亡人数增加53.37人。也使用了95%的概率值。这项工作可以证实和量化平均温度对古巴维拉克拉拉省研究地区易感人群和家禽死亡的影响。结果表明，当月平均气温为1℃时，预计易感病例增加8 894例，每增加1000例死亡，易感病例增加6例，0.06℃的易感病例与死亡总数大致相同。
{"title":"Determination of Climatic Impact of Temperature in Presence of Avian Respiratory Infections in Villa Clara Province, Cuba","authors":"R. F. Duarte, Ricardo Osés Rodríguez, David del Valle Laveaga, María Patricia Zambrano Gavilanes, P. Rodriguez, Yanira Zaita Ferrer, F. González, I. Hurtado","doi":"10.9734/bpi/nfmmr/v16/13030d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/13030d","url":null,"abstract":"The objective of the research was to determine the climatic impact of temperature on avian respiratory infections in Villa Clara province, Cuba. In this work retrospective data were used to obtain the epizootiological statistical information of susceptible and dead birds regarding avian respiratory infections, in specialized poultry farms of Villa Clara province, during the period 2005-2007. These data were correlated with the temperatures stockings average corresponding to this period in this county. The total of deaths was correlated with the total of susceptible; these last ones correlated in turn with the provincial temperatures stockings. For the information processing, the model Autoregressive Integrated Moving Averages (ARIMA) was used of Box-Jenkins Methodology through the statistical package SPSS Version 13. Techniques of multivariate regression for modeling the total of poultry deaths were also applied. The final ARIMA model expressed that an increase of 1 degree of temperature, which meant an increase of 53.37 deaths. It was also used a 95% of probability value. This work allows corroborating and quantifying the impact of mean temperature in the susceptible and in the poultry deaths in the study area of Villa Clara province, Cuba. It was obtained that with 1oC of monthly half temperature, it can be expected an increase of 8 894 susceptible cases and as the susceptible ones’ increase in 1000 the deaths, are increased in 6 birds, for what the susceptible ones for 0.06 will be the same approximately to the total of deaths.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125025841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/3955f
T. Mayuri
Purpose: To identify the most common cause and the most common stage of presentation of the patient in neovascular glaucoma. Methods: The current study is an observational prospective study. The study comprised 136 eyes from 109 patients with neovascular glaucoma in one or both eyes. Visual acuity, slit lamp biomicroscopy, intraocular pressure (IOP) measurement by Goldmann applanation tonometry, gonioscopy with Posner 4 mirror indirect gonioscope, and dilated fundus examination were all performed on all patients. Neovascularization of iris (NVI) was identified as tuft of new vessels on iris mostly at the pupillary margin in an undilated state, presence of any ectropion uveae, hyphema, anterior chamber reaction, pseudoexfoliative material, keratic precipitates and other signs of uveitis were noted. The number of neovascularized quadrants in the angle was counted. Results: The average age was58.18±13 years, with 80.73 percent of men and 19.26 percent of women. The average IOP was 27.14 ± 11.3 mm Hg. The rubeosis iridis stage was represented by 74 (54.4%), the angle closure stage by 38 (27.9%), and the open angle stage by 24 (17.6%). 89 (65.4%) of the participants had diabetic retinopathy of varying severity, whereas 16 (11.7%) had uveitis and 14 (10.2%) had retinal vein occlusion. The average IOP angle closure stage was 36.53±16.259 mm Hg, much greater than the other two stages (P = 0.000). Conclusion: The most common cause of NVG is proliferative diabetic retinopathy, and rubeosis iridis is the most common stage of presentation, according to the findings of this study.
目的:确定新生血管性青光眼患者最常见的病因和最常见的表现阶段。方法:本研究为观察性前瞻性研究。该研究包括109例单眼或双眼新生血管性青光眼患者的136只眼睛。所有患者均行视力检查、裂隙灯生物显微镜检查、Goldmann压眼计测量眼压(IOP)、Posner 4镜间接眼角膜镜镜检及眼底扩张检查。虹膜新生血管(NVI)被认为是虹膜上的一簇新血管，主要位于瞳孔边缘，处于未扩张状态，存在任何外翻的葡萄膜，前房反应，假脱落物质，角化沉淀和其他葡萄膜炎的征象。计算角度内新生血管象限的个数。结果:平均年龄58.18±13岁，男性占80.73%，女性占19.26%。平均IOP为27.14±11.3 mm Hg，虹膜红肿期74例(54.4%)，闭角期38例(27.9%)，开角期24例(17.6%)。89人(65.4%)患有不同程度的糖尿病视网膜病变，16人(11.7%)患有葡萄膜炎，14人(10.2%)患有视网膜静脉闭塞。闭眼期平均为36.53±16.259 mm Hg，明显高于其他两期(P = 0.000)。结论:根据本研究结果，NVG最常见的病因是增殖性糖尿病视网膜病变，虹膜纤维化是最常见的表现阶段。
{"title":"Neovascular Glaucoma: Etiology and Staging","authors":"T. Mayuri","doi":"10.9734/bpi/nfmmr/v16/3955f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/3955f","url":null,"abstract":"Purpose: To identify the most common cause and the most common stage of presentation of the patient in neovascular glaucoma. \u0000Methods: The current study is an observational prospective study. The study comprised 136 eyes from 109 patients with neovascular glaucoma in one or both eyes. Visual acuity, slit lamp biomicroscopy, intraocular pressure (IOP) measurement by Goldmann applanation tonometry, gonioscopy with Posner 4 mirror indirect gonioscope, and dilated fundus examination were all performed on all patients. Neovascularization of iris (NVI) was identified as tuft of new vessels on iris mostly at the pupillary margin in an undilated state, presence of any ectropion uveae, hyphema, anterior chamber reaction, pseudoexfoliative material, keratic precipitates and other signs of uveitis were noted. The number of neovascularized quadrants in the angle was counted. \u0000Results: The average age was58.18±13 years, with 80.73 percent of men and 19.26 percent of women. The average IOP was 27.14 ± 11.3 mm Hg. The rubeosis iridis stage was represented by 74 (54.4%), the angle closure stage by 38 (27.9%), and the open angle stage by 24 (17.6%). 89 (65.4%) of the participants had diabetic retinopathy of varying severity, whereas 16 (11.7%) had uveitis and 14 (10.2%) had retinal vein occlusion. The average IOP angle closure stage was 36.53±16.259 mm Hg, much greater than the other two stages (P = 0.000). \u0000Conclusion: The most common cause of NVG is proliferative diabetic retinopathy, and rubeosis iridis is the most common stage of presentation, according to the findings of this study.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129952833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/4440f
E. Sfeir, Mona Gholmieh, Zouhair Skaf, A. Mourad
Aim: For the treatment of upper impacted central incisors (ICIs), two main surgical approaches are typically described: open and closed. The closed-eruption surgical method (CEST) is currently the most popular because it provides the best esthetic and periodontal benefits. The purpose of this study was to see how traction discontinuation affected maxillary central incisor sulcal depth and alveolar bone ridge levels when compared to contralateral incisors when CEST was used. Materials and Methods: CEST was used to treat 28 unilaterally impacted maxillary central incisors. At the time of crown emergence, thirteen teeth were subjected to a month of traction interruption, whereas 15 teeth were subjected to continuous traction. The ICIs and contralateral central incisors (CCIs) were subjected to periapical digital X-rays, anterosuperior cone beam computed tomography (CBCT) scanning, and periodontal probing one year following treatment. The CCI measurements were utilized as a reference, and the Student's t-test was employed to see if there was a statistically significant difference between continuous and interrupted tractions. Results: Only the following measurements showed a statistically significant difference between the two techniques: Mesial probing (p-value 0.039352), labial bone level (p-value 2.58E-08), and palatal bone level (p-value 2.56E-06). Limitations: To draw more robust conclusions, a larger sample size and longer term follow-up are required. Conclusion: On ICIs, a temporary discontinuation during tooth traction appears to improve treatment outcome. Technical modifications and the use of a temporary interruption during tooth traction can result in better treatment outcomes. Clinical significance: The CEST leads to the best periodontal status for ICIs. The discontinuation of traction at the emergence of the tooth allows the supracrestal fibers to insert into the cement in a proper way.
{"title":"Alveolar Bone and Epithelial Attachment Status following Two Different Closed-eruption Surgical Techniques for Impacted Maxillary Central Incisors: A Recent Study","authors":"E. Sfeir, Mona Gholmieh, Zouhair Skaf, A. Mourad","doi":"10.9734/bpi/nfmmr/v16/4440f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/4440f","url":null,"abstract":"Aim: For the treatment of upper impacted central incisors (ICIs), two main surgical approaches are typically described: open and closed. The closed-eruption surgical method (CEST) is currently the most popular because it provides the best esthetic and periodontal benefits. The purpose of this study was to see how traction discontinuation affected maxillary central incisor sulcal depth and alveolar bone ridge levels when compared to contralateral incisors when CEST was used. \u0000Materials and Methods: CEST was used to treat 28 unilaterally impacted maxillary central incisors. At the time of crown emergence, thirteen teeth were subjected to a month of traction interruption, whereas 15 teeth were subjected to continuous traction. The ICIs and contralateral central incisors (CCIs) were subjected to periapical digital X-rays, anterosuperior cone beam computed tomography (CBCT) scanning, and periodontal probing one year following treatment. The CCI measurements were utilized as a reference, and the Student's t-test was employed to see if there was a statistically significant difference between continuous and interrupted tractions. \u0000Results: Only the following measurements showed a statistically significant difference between the two techniques: Mesial probing (p-value 0.039352), labial bone level (p-value 2.58E-08), and palatal bone level (p-value 2.56E-06). \u0000Limitations: To draw more robust conclusions, a larger sample size and longer term follow-up are required. \u0000Conclusion: On ICIs, a temporary discontinuation during tooth traction appears to improve treatment outcome. Technical modifications and the use of a temporary interruption during tooth traction can result in better treatment outcomes. \u0000Clinical significance: \u0000 \u0000The CEST leads to the best periodontal status for ICIs. \u0000The discontinuation of traction at the emergence of the tooth allows the supracrestal fibers to insert into the cement in a proper way.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116768478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/13205d
N. Renu
Regional and local governments worldwide are working tirelessly towards effective ways of addressing the COVID-19 crisis. During this time, the government has had to ensure that they provide full usage of technological means to confront the pandemic and discourse a wide range of COVID-19 related problems. Herein, the objective of this paper is to discuss the application of technical means and the advancement of technology in different sectors as a consequence of the COVID-19 crisis. As will be discussed, how government and health organizations have introduced new policies intending to try to curb the spread of the coronavirus. These new policies, such as lockdowns and social distancing measures, have resulted in technological advancement and new means of interaction with government, businesses, and citizens. Such changes include increased online shopping, as well as robotic delivery systems, the introduction of digital as well as contactless payment systems, remote working, the role of technology in distance learning, Telehealth, 3D Printing, and online entertainment. These technological advancements have been embraced all the way during this pandemic by a few countries around the world, with its limitation in some underdeveloped and developing countries.
{"title":"Determination of Technological Advancement in the Era of COVID-19","authors":"N. Renu","doi":"10.9734/bpi/nfmmr/v16/13205d","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/13205d","url":null,"abstract":"Regional and local governments worldwide are working tirelessly towards effective ways of addressing the COVID-19 crisis. During this time, the government has had to ensure that they provide full usage of technological means to confront the pandemic and discourse a wide range of COVID-19 related problems. Herein, the objective of this paper is to discuss the application of technical means and the advancement of technology in different sectors as a consequence of the COVID-19 crisis. As will be discussed, how government and health organizations have introduced new policies intending to try to curb the spread of the coronavirus. These new policies, such as lockdowns and social distancing measures, have resulted in technological advancement and new means of interaction with government, businesses, and citizens. Such changes include increased online shopping, as well as robotic delivery systems, the introduction of digital as well as contactless payment systems, remote working, the role of technology in distance learning, Telehealth, 3D Printing, and online entertainment. These technological advancements have been embraced all the way during this pandemic by a few countries around the world, with its limitation in some underdeveloped and developing countries.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133601862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/4495f
G. Nandini, Jessica C. Fernandes, P. Sindhu
Introduction: In developing countries, cervical cancer is still the most frequent gynaecological cancer among women. Objective: The goal of this study was to look at the clinical presentation and histological pattern of carcinoma cervix over a three-year period. Design: This was a retrospective analysis. Results: The majority of the patients were between the ages of 40 and 50.The majority of the patients were in stage III of the disease. The most common histological pattern was squamous cell carcinoma. The treatment modality was radiotherapy with concurrent chemotherapy. Conclusion: The result clearly demonstrates the inadequacy of the screening programme for detecting preinvasive stages of cervix carcinoma. Early diagnosis of the preinvasive stage by screening and appropriate treatment should be instituted at the preinvasive stage.
{"title":"A Retrospective Clinicopathological Study of Cervical Cancer","authors":"G. Nandini, Jessica C. Fernandes, P. Sindhu","doi":"10.9734/bpi/nfmmr/v16/4495f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/4495f","url":null,"abstract":"Introduction: In developing countries, cervical cancer is still the most frequent gynaecological cancer among women. \u0000Objective: The goal of this study was to look at the clinical presentation and histological pattern of carcinoma cervix over a three-year period. \u0000Design: This was a retrospective analysis. \u0000Results: The majority of the patients were between the ages of 40 and 50.The majority of the patients were in stage III of the disease. The most common histological pattern was squamous cell carcinoma. The treatment modality was radiotherapy with concurrent chemotherapy. \u0000Conclusion: The result clearly demonstrates the inadequacy of the screening programme for detecting preinvasive stages of cervix carcinoma. Early diagnosis of the preinvasive stage by screening and appropriate treatment should be instituted at the preinvasive stage.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115162196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/1816c
A. Kuznetsov, J. Hagenbuchner, M. Ausserlechner
Objectives: Study of complex ROS dynamics and ROS mito-flashes in various living cells using fluorescent confocal imaging. Simultaneous analysis of the mitochondrial and extra-mitochondrial ROS dynamics. Analysis of the mitochondrial membrane potential and depolarization. Simultaneous analysis of mitochondrial calcium and ROS kinetics. It is well documented that mitochondria can produce a major amount of reactive oxygen species (ROS) which are involved in many physiological and pathological processes. The complex interrelationships, however, between ROS, mitochondrial inner membrane potential ((DeltaPsi)m) and mitochondrial Ca2+ were not entirely investigated. In this work, we further underline biphasic ROS dynamics, demonstrating initial and continuing ROS expansion, followed by mitochondrial ROS flashes. Additionally, a huge heterogeneity in the rates of mitochondrial ROS production and ROS flashes start times has been shown. Comparing mitochondrial and extra mitochondrial fluorescence signals, we demonstrated that the mechanisms of ROS flashes may be a triggering of flashes by certain amounts of external ROS. These mechanisms involve mitochondrial permeability transition pore opening (collapse of mitochondrial membrane potential, (DeltaPsi)m) and mitochondrial calcium sparks. Furthermore, mitochondria to mitochondria interactions can be seen as a wave propagation of mitochondrial ROS flashes and (DeltaPsi)m collapses similar to the phenomenon of ROS-induced ROS release first demonstrated for cardiomyocytes. Our data show that mechanisms of mitochondrial ROS flashes activation and simultaneous depolarization can entail involvement of extra mitochondrial ROS produced either by individual mitochondrion or by adjacent mitochondria. This could represent common processes in ROS-ROS and mitochondria-mitochondria signaling, playing thus an important role in the cellular and mitochondrial physiology.
{"title":"ROS Flashes in Mitochondria Occur Concomitantly with Inner Mitochondrial Membrane Depolarization and Mitochondrial Calcium Sparks","authors":"A. Kuznetsov, J. Hagenbuchner, M. Ausserlechner","doi":"10.9734/bpi/nfmmr/v16/1816c","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/1816c","url":null,"abstract":"Objectives: Study of complex ROS dynamics and ROS mito-flashes in various living cells using fluorescent confocal imaging. Simultaneous analysis of the mitochondrial and extra-mitochondrial ROS dynamics. Analysis of the mitochondrial membrane potential and depolarization. Simultaneous analysis of mitochondrial calcium and ROS kinetics.\u0000It is well documented that mitochondria can produce a major amount of reactive oxygen species (ROS) which are involved in many physiological and pathological processes. The complex interrelationships, however, between ROS, mitochondrial inner membrane potential ((DeltaPsi)m) and mitochondrial Ca2+ were not entirely investigated. In this work, we further underline biphasic ROS dynamics, demonstrating initial and continuing ROS expansion, followed by mitochondrial ROS flashes. Additionally, a huge heterogeneity in the rates of mitochondrial ROS production and ROS flashes start times has been shown. Comparing mitochondrial and extra mitochondrial fluorescence signals, we demonstrated that the mechanisms of ROS flashes may be a triggering of flashes by certain amounts of external ROS. These mechanisms involve mitochondrial permeability transition pore opening (collapse of mitochondrial membrane potential, (DeltaPsi)m) and mitochondrial calcium sparks. Furthermore, mitochondria to mitochondria interactions can be seen as a wave propagation of mitochondrial ROS flashes and (DeltaPsi)m collapses similar to the phenomenon of ROS-induced ROS release first demonstrated for cardiomyocytes. Our data show that mechanisms of mitochondrial ROS flashes activation and simultaneous depolarization can entail involvement of extra mitochondrial ROS produced either by individual mitochondrion or by adjacent mitochondria. This could represent common processes in ROS-ROS and mitochondria-mitochondria signaling, playing thus an important role in the cellular and mitochondrial physiology.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127951167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/3775f
S. Ambasta, S. Mahapatra
Introduction: Esmolol and Labetalol, at low doses, were evaluated for attenuation of sympathomimetic reaction to laryngoscopy and intubation in this prospective, randomised, double-blind, comparative clinical study. Materials and Methods: This study involved 50 ASA 1 patients of either sex who were undergoing elective surgery under general anaesthesia. Prior to induction, patients were randomly assigned to one of two groups: group E got intravenous Esmolol (0.5 mg/kg) or group L received intravenous Labetalol (0.25 mg/kg), and hemodynamic parameters were monitored as per the procedure to determine stress response to laryngoscopy and intubation. Results: The demographic profiles of both research groups were similar. For statistical calculations, Instat version 3.10 was utilised. The data from the study was evaluated using statistical approaches such as mean and standard deviation. During laryngoscopy and intubation, esmolol (0.5 mg/kg) and Labetalol (0.25 mg/kg) significantly reduced the increase in heart rate, systolic blood pressure, and RPP. However, the difference was not statistically significant among the values for DBP and MAP. Conclusion: In lower doses, intravenous Labetalol (0.25 mg/kg) is a better agent than intravenous Esmolol (0.5 mg/kg) in attenuating the sympathomimetic reaction to laryngoscopy and intubation, according to our clinical trial. The typical dose of esmolol used to obtund intubation response is 2-4 mg/kg, whereas labetalol has been tested in all doses ranging from 0.25, 0.5, 0.75, and 1 mg/kg [1].
{"title":"A Comparative Study of Attenuation of Hypertensive Response with Esmolol and Labetalol in Low doses in Orotracheal Intubation","authors":"S. Ambasta, S. Mahapatra","doi":"10.9734/bpi/nfmmr/v16/3775f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/3775f","url":null,"abstract":"Introduction: Esmolol and Labetalol, at low doses, were evaluated for attenuation of sympathomimetic reaction to laryngoscopy and intubation in this prospective, randomised, double-blind, comparative clinical study. \u0000Materials and Methods: This study involved 50 ASA 1 patients of either sex who were undergoing elective surgery under general anaesthesia. Prior to induction, patients were randomly assigned to one of two groups: group E got intravenous Esmolol (0.5 mg/kg) or group L received intravenous Labetalol (0.25 mg/kg), and hemodynamic parameters were monitored as per the procedure to determine stress response to laryngoscopy and intubation. \u0000Results: The demographic profiles of both research groups were similar. For statistical calculations, Instat version 3.10 was utilised. The data from the study was evaluated using statistical approaches such as mean and standard deviation. During laryngoscopy and intubation, esmolol (0.5 mg/kg) and Labetalol (0.25 mg/kg) significantly reduced the increase in heart rate, systolic blood pressure, and RPP. However, the difference was not statistically significant among the values for DBP and MAP. \u0000Conclusion: In lower doses, intravenous Labetalol (0.25 mg/kg) is a better agent than intravenous Esmolol (0.5 mg/kg) in attenuating the sympathomimetic reaction to laryngoscopy and intubation, according to our clinical trial. The typical dose of esmolol used to obtund intubation response is 2-4 mg/kg, whereas labetalol has been tested in all doses ranging from 0.25, 0.5, 0.75, and 1 mg/kg [1].","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121907377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/4482f
Pramod K Chahar, Abir Sarkar, E. Gowda, P. Prakash
Aim: To make a silicone auricular prosthesis, that perfectly mimics the healthy contralateral ear for a unilateral auricular defect. Background: Any loss of facial structure, whether congenital or acquired, has a significant detrimental influence on an individual's life. Replicating the complicated anatomy of an auricle while imitating the contralateral ear is a difficult issue in prosthetic rehabilitation of a patient with unilateral auricular impairment. Case description: This case report discusses an innovative, accurate, and simple technique for fabricating the wax pattern of the auricular prosthesis without the use of any expensive or complicated equipment that is yet to be described in the literature. The only disadvantage seen in this technique is the loss of some anatomic details while merging the margins of wax slices with a hot spatula, which require finer adjustment by minor carving and finishing of the wax pattern. Conclusion: This case report describes a technique for replicating the anatomy of the auricle in ordinary clinical practice without the need of expensive equipment.
{"title":"Application of an Innovative Technique for Fabrication of Silicone Auricular Prosthesis","authors":"Pramod K Chahar, Abir Sarkar, E. Gowda, P. Prakash","doi":"10.9734/bpi/nfmmr/v16/4482f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/4482f","url":null,"abstract":"Aim: To make a silicone auricular prosthesis, that perfectly mimics the healthy contralateral ear for a unilateral auricular defect. \u0000Background: Any loss of facial structure, whether congenital or acquired, has a significant detrimental influence on an individual's life. Replicating the complicated anatomy of an auricle while imitating the contralateral ear is a difficult issue in prosthetic rehabilitation of a patient with unilateral auricular impairment. \u0000Case description: This case report discusses an innovative, accurate, and simple technique for fabricating the wax pattern of the auricular prosthesis without the use of any expensive or complicated equipment that is yet to be described in the literature. The only disadvantage seen in this technique is the loss of some anatomic details while merging the margins of wax slices with a hot spatula, which require finer adjustment by minor carving and finishing of the wax pattern. \u0000Conclusion: This case report describes a technique for replicating the anatomy of the auricle in ordinary clinical practice without the need of expensive equipment.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124682701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-30DOI: 10.9734/bpi/nfmmr/v16/4447f
Shubham Jain, P. Mittal, Amit Kumar
Background: The number of vertebral levels involved in fixing a spine fracture is reduced with short same-segment posterior fixation (SSPF). Short same-segment posterior fixation with pedicle fixation at the fracture level provides biomechanical advantages for kyphosis correction maintenance, lowering failure rates, and increasing spinal motion and early rehabilitation [1-4]. Materials and Methods: Between 2014 and 2016, all patients with thoracolumbar junction fractures in our study were analysed using biomechanical criteria and clinical outcomes. The immediate postoperative radiographs were compared to follow-up radiographs to assess any loss of correction by measuring the kyphotic angle using Cobb's technique. Clinical result was also assessed using the Oswestry disability score at each follow-up. The reliability of the intraobserver and interobserver was investigated. Results: In our study, 35 patients with unstable thoracolumbar fractures were operated on with a posterior spinal fixation system and pedicle screw insertion at the level of the fractured vertebrae during 2014 to 2016. The average time between visits was 18 months. In all of the cases, the average preoperative kyphotic angle was 17.2°, which improved to 5.9° immediately postoperatively, resulting in a mean of 65 percent correction. The average postoperative Cobb's angle was 7.7° at final follow-up, retaining a 55 percent correction. Disability improved from 78% mean preoperatively to 47.27% mean postoperatively at final follow-up. Conclusion: When compared to traditional SSPF, short same-segment posterior fixation has a lower implantation failure rate and improved biomechanical stability; nevertheless, long-term kyphosis correction was not maintained to the same level, which was statistically insignificant. Despite the lack of kyphosis correction, long-term clinical pain and disability improved. This study indicated that SSPF decreases implantation failure rate and reoperation rate and offers greater biomechanical advantages.
{"title":"Clinical Outcomes of Short Same-segment Fixation in Thoracolumbar Junction Fractures","authors":"Shubham Jain, P. Mittal, Amit Kumar","doi":"10.9734/bpi/nfmmr/v16/4447f","DOIUrl":"https://doi.org/10.9734/bpi/nfmmr/v16/4447f","url":null,"abstract":"Background: The number of vertebral levels involved in fixing a spine fracture is reduced with short same-segment posterior fixation (SSPF). Short same-segment posterior fixation with pedicle fixation at the fracture level provides biomechanical advantages for kyphosis correction maintenance, lowering failure rates, and increasing spinal motion and early rehabilitation [1-4]. \u0000Materials and Methods: Between 2014 and 2016, all patients with thoracolumbar junction fractures in our study were analysed using biomechanical criteria and clinical outcomes. The immediate postoperative radiographs were compared to follow-up radiographs to assess any loss of correction by measuring the kyphotic angle using Cobb's technique. Clinical result was also assessed using the Oswestry disability score at each follow-up. The reliability of the intraobserver and interobserver was investigated. \u0000Results: In our study, 35 patients with unstable thoracolumbar fractures were operated on with a posterior spinal fixation system and pedicle screw insertion at the level of the fractured vertebrae during 2014 to 2016. The average time between visits was 18 months. In all of the cases, the average preoperative kyphotic angle was 17.2°, which improved to 5.9° immediately postoperatively, resulting in a mean of 65 percent correction. The average postoperative Cobb's angle was 7.7° at final follow-up, retaining a 55 percent correction. Disability improved from 78% mean preoperatively to 47.27% mean postoperatively at final follow-up. \u0000Conclusion: When compared to traditional SSPF, short same-segment posterior fixation has a lower implantation failure rate and improved biomechanical stability; nevertheless, long-term kyphosis correction was not maintained to the same level, which was statistically insignificant. Despite the lack of kyphosis correction, long-term clinical pain and disability improved. This study indicated that SSPF decreases implantation failure rate and reoperation rate and offers greater biomechanical advantages.","PeriodicalId":436259,"journal":{"name":"New Frontiers in Medicine and Medical Research Vol. 16","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132571521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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