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New Frontiers in Medicine and Medical Research Vol. 16最新文献

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Investigating the Effects of Standardised Treatment Protocols for Opportunistic Infection in Children Living with HIV/AIDS on Their Clinical Profile 调查艾滋病毒/艾滋病儿童机会性感染标准化治疗方案对其临床表现的影响
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/4351f
S. Pawar, Sadhana S. Raut, S. Mundada, A. Suryawanshi, P. Patil
Introduction: AIDS has become prevalent all across the world. As in adults, pediatric HIV/AIDS is on rise all over the world. Since 1981, about 25 million individuals have died around the world as a result of HIV. The risk of mother to child transmission of HIV infection varies from country to country and also within a country depending on the facilities available.   Aims and Objectives: To investigate a standardised treatment protocol for opportunistic infections in HIV/AIDS children. Methodology: A cross-sectional study was conducted on children living with HIV/AIDS at the A.R.T. Centre, government medical college and hospital in Aurangabad from July to December, 2007. One of the primary goals of this project was to develop a standard treatment protocol for the management of opportunistic infections in HIV/AIDS-infected children. Necessary permission from NACO, MSACS and Parents or Care takers Consent was taken. A total of 280 paediatric patients were enrolled, with 50 of them receiving antiretroviral therapy. Result: The most frequent OI in the study group was tuberculosis, which was followed by diarrhoea and acute respiratory infection. After initiating the Standard Treatment Protocol in Children with HIV/AIDS, there was an overall rise in height, weight, and CD4 count. Conclusion: After starting the Standard Treatment Protocol in Children with HIV/AIDS, there was a positive response in the form of increased height, weight, and overall increase in CD4 Count, indicating that these standard protocols should be strictly followed for a better prognosis for opportunistic infections in children with HIV/AIDS.
导言:艾滋病在全世界都很流行。与成人一样,世界各地的儿童艾滋病毒/艾滋病呈上升趋势。自1981年以来,全世界约有2500万人死于艾滋病毒。母婴传播艾滋病毒感染的风险因国家而异,在一个国家内也因现有设施而异。目的和目的:探讨艾滋病毒/艾滋病儿童机会性感染的标准化治疗方案。方法:2007年7月至12月,在奥兰加巴德的A.R.T.中心、政府医学院和医院对感染艾滋病毒/艾滋病的儿童进行了一项横断面研究。该项目的主要目标之一是制定一项标准治疗方案,以管理感染艾滋病毒/艾滋病的儿童的机会性感染。获得了NACO、MSACS和家长或看护人的必要许可。总共招募了280名儿科患者,其中50人接受了抗逆转录病毒治疗。结果:研究组中最常见的成骨不全是肺结核,其次是腹泻和急性呼吸道感染。在启动艾滋病毒/艾滋病儿童标准治疗方案后,身高、体重和CD4计数总体上有所上升。结论:启动《儿童HIV/AIDS标准治疗方案》后,出现了身高、体重增加、CD4计数总体升高等积极反应,提示应严格执行标准治疗方案,才能使儿童HIV/AIDS机会性感染获得较好的预后。
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引用次数: 0
A Descriptive Cross-sectional Study on Diet and Women Fertility 饮食与妇女生育能力的描述性横断面研究
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/13015d
H. G. Oufi, Ruaa E. Alabd
Aims: The goal of this study was to determine the impact of diet and dietary habits on women's fertility. Materials and Methods: Between January and September 2014, this study was conducted in seven different institutes and hospitals in Baghdad. The participants were 400 adult women, ranging in age from 17 to 47 years, who were separated into two groups. There were 300 fertile women in group I and 100 infertile women in group II.A specific questionnaire had been designed and used for data collection. Results: A significant difference in weight and body mass index (BMI) was discovered between the infertile and control groups. The mean weights for the infertile and control groups were 73.07 kg vs 69.06 kg, respectively, while the mean BMI was 28.83 vs 26.70 for the infertile and control groups. In addition, the infertile women consumed more carbonated beverages, tea, chicken, and fish than the control group, while consuming less milk and red meat. Furthermore, the infertile group consumed less corn oil and olive oil than the control group (5 and 0% vs 21 and 2%, respectively), but ingested more solid fat and mixed fat (2 and 6% vs 0 and 2.7%, respectively). Conclusion: Although there are treatment options for infertility, their high cost and high frequency of side effects have prompted researchers to look into dietary aspects that may contribute to infertility. This study confirmed the association between weight, BMI, and infertility. Diet was identified as one of the modifiable risk factors that may affect fertility in the selected groups in the current study; therefore, it is critical to focus more on the role of diet in women's fertility and raise women's awareness of it, as well as suggesting more educational programmes at the primary health care level.
目的:本研究的目的是确定饮食和饮食习惯对女性生育能力的影响。材料和方法:2014年1月至9月,本研究在巴格达的7个不同的研究所和医院进行。参与者是400名年龄在17岁到47岁之间的成年女性,她们被分为两组。第一组有300名可生育妇女,第二组有100名不能生育妇女。已经设计并使用了一份具体的调查表来收集数据。结果:不育组与对照组在体重和身体质量指数(BMI)方面有显著差异。不育组和对照组的平均体重分别为73.07 kg和69.06 kg,而不育组和对照组的平均BMI分别为28.83和26.70。此外,与对照组相比,不孕妇女喝了更多的碳酸饮料、茶、鸡肉和鱼,而喝了更少的牛奶和红肉。此外,不育组摄入的玉米油和橄榄油比对照组少(分别为5%和0%对21%和2%),但摄入的固体脂肪和混合脂肪更多(分别为2%和6%对0%和2.7%)。结论:尽管不孕不育有多种治疗方案,但它们的高成本和高频率的副作用促使研究人员研究可能导致不孕不育的饮食方面。这项研究证实了体重、身体质量指数和不孕之间的联系。在当前的研究中,饮食被确定为可能影响生育能力的可变风险因素之一;因此,必须更多地关注饮食对妇女生育能力的作用,提高妇女对这一问题的认识,并建议在初级保健一级开展更多的教育方案。
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引用次数: 0
Perspectives Associated with an Increase in the Incidence of Colorectal Adenocarcinoma in Uganda: An Advanced Study 乌干达结直肠腺癌发病率增加的相关因素:一项高级研究
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/4522f
Richard Wismayer
This paper is a current review of work done on colorectal adenocarcinoma in Uganda highlighting the perspectives associated with the increased rate of cases observed in our hospitals. Differences in tumor location compared to the Western world and the challenges encountered in obtaining an early diagnosis of CRC in Ugandan patients are also highlighted in this work. A steady increase of CRC in other Sub-Saharan African countries is also currently being documented however this is associated with a higher CRC-associated morbidity and mortality. Reasons behind this increase may be the nutrition transition in Sub-Saharan Africa characterized by decreased consumption of dietary fibre, starch and plant proteins to a Western diet associated with consumption of fatty foods and red meat. The emergence of noncommunicable diseases such as diabetes and obesity coupled with increased alcohol consumption and smoking confers a higher risk to CRC. A shift in the demographics is observed in Uganda compared to high income countries with 22.8% of our CRC cases being diagnosed at <40years of age compared to 3-7% in high income countries. A challenge experienced with this early age onset is that it is associated with an aggressive biological behavior with a poor prognosis. The high proportion of left sided colon and rectal adenocarcinoma in Uganda makes our population more amenable to screening. However challenges experienced in Uganda and other Sub-Saharan African countries include the availability of endoscopic training and equipment, costs, availability of pathologic services and patient acceptance. The increased diagnosis of CRC cases that will result from screening will eventually require a parallel increase in surgical and oncological infrastructure to manage CRC patients. An improvement in diagnosing, screening and treating CRC by increasing surgical and endoscopic capacity with the aid of international medical and surgical societies should be a public health priority in Uganda given the observed epidemiological shifts. Future implementation of National screening programmes to detect CRC at an early stage is also necessary to reduce the mortality in the Ugandan population.
本文是对乌干达结直肠腺癌研究工作的综述,强调了与我国医院病例增加有关的观点。本文还强调了与西方国家相比,乌干达患者肿瘤位置的差异以及在获得早期诊断方面遇到的挑战。其他撒哈拉以南非洲国家的 CRC 发病率目前也在稳步上升,但这与 CRC 相关的发病率和死亡率较高有关。这种增长背后的原因可能是撒哈拉以南非洲的营养转型,其特点是膳食纤维、淀粉和植物蛋白的摄入量减少,而西方饮食习惯则与脂肪类食品和红肉的摄入量有关。糖尿病和肥胖症等非传染性疾病的出现,加上饮酒量和吸烟量的增加,都增加了患上儿童癌症的风险。与高收入国家相比,乌干达的人口统计学发生了变化,22.8%的 CRC 诊断年龄小于 40 岁,而在高收入国家,这一比例仅为 3-7%。发病年龄过早带来的一个挑战是,它与预后不良的侵袭性生物学行为有关。在乌干达,左侧结肠和直肠腺癌的比例较高,这使得我们的人口更适合筛查。然而,乌干达和其他撒哈拉以南非洲国家面临的挑战包括内窥镜培训和设备的可用性、成本、病理服务的可用性以及患者的接受程度。由于筛查导致的 CRC 诊断病例增加,最终需要同时增加外科和肿瘤科基础设施,以管理 CRC 患者。鉴于观察到的流行病学变化,在国际医学和外科协会的帮助下,通过提高外科和内窥镜能力来改善对 CRC 的诊断、筛查和治疗,应成为乌干达公共卫生的优先事项。今后还必须实施国家筛查计划,及早发现儿童癌症,以降低乌干达人口的死亡率。
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引用次数: 0
Study on Nasopalatine Duct Cyst: A Common Lesion with Uncommon Presentation in a Young Girl 鼻腭管囊肿的研究:一种常见的病变,在一个年轻的女孩不寻常的表现
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/4496f
S. Desai, Sanika G. S. Kulkarni, Jaydeep N Pol, D. Patil
Nasopalatine cysts are developing cysts that are not odontogenic. These are the most common asymptomatic cysts in the oral cavity, and they appear as a bulge in the front maxillary region. Nasopalatine duct cyst is more common in men in their fourth to sixth decades of life. The objective of this study is to review the prevalence, epidemiology and clinical presentation, to describe the radiographic and pathological findings, and to explain surgical management of this entity in a 11-year-old female patient.
鼻腭囊肿是发展中的囊肿,不是牙源性的。这些是口腔中最常见的无症状囊肿,它们在上颌前区表现为隆起。鼻腭管囊肿常见于40至60岁的男性。本研究的目的是回顾一名11岁女性患者的患病率、流行病学和临床表现,描述x线和病理表现,并解释手术治疗。
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引用次数: 0
A Review and Update on Clinical Management on Burning Mouth Syndrome 灼口综合征临床治疗的回顾与进展
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/12068d
J. Spanemberg, Eugenia Rodríguez de Rivera Campillo, E. J. Salas, A. E. Devesa, Jose L. Lopez
Burning Mouth Syndrome (BMS) is a persistent condition that primarily affects postmenopausal middle-aged women. The absence of clinical indications and burning feelings of the oral mucosa identify this illness.BMS has a complicated aetiology that incorporates a number of factors.BMS can be caused by a variety of local, systemic, and psychological conditions, including stress, anxiety, and depression. BMS Type I, II, or III are possible classifications. Although there are no obvious organic changes and no health hazards associated with this illness, it can drastically affect the patient's quality of life. The objective is to review the available literature related to BMS, and makes special reference to its therapeutic management. The sections that follow will also go through important diagnostic criteria, etiological factors, and clinical aspects. The main objective of management is that of providing support to the patient and working towards symptom reduction, rather than total elimination of such symptoms. Tricyclic antidepressants, benzodiazepines, and antipsychotic medicines are the most frequently accepted therapy alternatives with variable results; nevertheless, there are other therapies that will be presented that can also be used.  The management of this group of patients should be done by professionals who talk and reaffirm to them the nature of the disease and discuss the benefits of intended therapies or possibility of pain relief. Patients should be educated about the need for a multidisciplinary team approach and the probability of needing multiple changes in therapies until effective treatment is achieved. Professionals in the field of dentistry should develop standardised symptoms and diagnostic criteria so that multidisciplinary research can more easily discover the most successful and reliable BMS treatment techniques.
灼口综合征(BMS)是一种主要影响绝经后中年妇女的持续性疾病。缺乏临床适应症和口腔黏膜灼烧感是本病的特征。BMS有一个复杂的病因,包括许多因素。BMS可由多种局部、全身和心理状况引起,包括压力、焦虑和抑郁。BMS类型I、II或III是可能的分类。虽然没有明显的器官变化,也没有与这种疾病相关的健康危害,但它可以严重影响患者的生活质量。目的是回顾有关BMS的现有文献,并特别提到其治疗管理。接下来的部分也将通过重要的诊断标准,病因因素和临床方面。管理的主要目标是为患者提供支持并努力减轻症状,而不是完全消除这些症状。三环抗抑郁药、苯二氮卓类药物和抗精神病药物是最常被接受的治疗方案,但结果不一;然而,还有其他的治疗方法也可以使用。这类患者的管理应由专业人员进行,专业人员应与患者交谈并重申疾病的性质,并讨论预期治疗的益处或缓解疼痛的可能性。应该教育患者,让他们了解多学科团队治疗的必要性,以及在获得有效治疗之前可能需要多次改变治疗方法的可能性。牙科领域的专业人员应该制定标准化的症状和诊断标准,以便多学科研究可以更容易地发现最成功和最可靠的BMS治疗技术。
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引用次数: 0
Determining the Seroprevalence of HIV Infection among Tuberculosis Patients in a Tertiary Care Hospital 某三级医院肺结核患者血清HIV感染的测定
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/9260d
D. Kinariwala
Introduction: The Human Immunodeficiency Virus (HIV) is the most potent risk factor for Tuberculosis progression (TB). Surveillance of HIV among & TB patients has been recognized to be important as the HIV epidemic continues to fuel TB epidemic. In those who are infected with both HIV and TB, the interaction is bidirectional and synergistic. The purpose of this study was to determine the seroprevalence of HIV infection among patients with tuberculosis in a tertiary care hospital. Method: A one-year study of 4500 confirmed tuberculosis patients was conducted, and HIV antibodies were tested in accordance with National AIDS Control Organisation (NACO) guidelines. The results showed that 244 (5.42 percent) of the 4500 patients screened were HIV positive. The male to female ratio was 2.34 (171/73), and the prevalence of co-infection was highest among those aged 35 to 50 years. Conclusion: The current study found 5.42 percent HIV seroprevalence in tuberculosis patients. Early diagnosis of HIV infection in tuberculosis patients will allow for quicker access to care and treatment, including antiretroviral therapy (ART).  This will reduce the number of deaths and illnesses among HIV-TB co-infected patients.
人类免疫缺陷病毒(HIV)是结核病进展(TB)最有效的危险因素。由于艾滋病毒流行继续助长结核病流行,对结核病患者进行艾滋病毒监测已被认为是重要的。在同时感染艾滋病毒和结核病的人中,这种相互作用是双向的和协同的。本研究的目的是确定在三级护理医院肺结核患者的血清艾滋病毒感染的患病率。方法:对4500例确诊结核病患者进行了为期一年的研究,并按照国家艾滋病控制组织(NACO)的指导方针检测了HIV抗体。结果显示,在接受筛查的4500名患者中,有244人(5.42%)呈HIV阳性。男女比例为2.34(171/73),35 ~ 50岁人群共感染发生率最高。结论:目前的研究发现结核病患者的HIV血清阳性率为5.42%。结核病患者感染艾滋病毒的早期诊断将有助于更快地获得护理和治疗,包括抗逆转录病毒治疗。这将减少艾滋病毒-结核病合并感染患者的死亡和患病人数。
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引用次数: 0
A Rare Uterine Cancer: Epithelioid Leiomyosarcoma 一例罕见子宫癌:上皮样平滑肌肉瘤
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/1906c
Upadhya Rekha, V. G. Poojari, M. Pai, J. Nambiar
A uterine epithelioid leiomyosarcoma is a type of uterine mesenchymal tumour that arises from the smooth muscle lining the walls of the uterus. The specific cause of leiomyosarcoma is uncertain, with uterine leiomyosarcoma accounting for 5 to 10% of cases. The most prevalent subtype of uterine sarcoma, leiomyosarcoma, accounts for 1-2 percent of all uterine malignancies. Recent application of molecular techniques has identified numerous lesions with distinctive genetic abnormalities and clinicopathological characteristics. Menopausal women who are not on hormonal replacement medication and have tumour development should be suspected of malignancy. A 64-year-old woman had reached menopause 16 years prior and had been experiencing postmenopausal haemorrhage for the past two months, with a palpable mass measuring 16 weeks in size. The whorled mass lesions, endometrium, and myometrium could not be seen separately on ultrasonography. Uterus with both ovaries removed. Intraoperative investigations revealed a 16-week-old uterine mass with a diameter of 15x15 cm and a weight of 1kg, as well as an intramural fibroid. On cut section, necrotic and haemorrhagic regions with degenerative alterations suggest cancer. Epithelioid leiomyosarcoma was discovered using histopathology and immunohistochemistry.
子宫上皮样平滑肌肉瘤是一种起源于子宫壁平滑肌的子宫间质肿瘤。平滑肌肉瘤的具体病因不确定,子宫平滑肌肉瘤占病例的5% ~ 10%。子宫肉瘤最常见的亚型是平滑肌肉瘤,占所有子宫恶性肿瘤的1- 2%。最近应用分子技术已经确定了许多病变具有独特的遗传异常和临床病理特征。绝经期妇女未使用激素替代药物,肿瘤发展应怀疑恶性肿瘤。一名64岁女性,16年前进入更年期,在过去的两个月里经历了绝经后出血,可触及的肿块有16周大。螺旋状肿块病变、子宫内膜和子宫肌层在超声检查中不能单独显示。切除了两个卵巢的子宫。术中检查发现16周大的子宫肿块,直径15x15cm,重量1kg,同时发现子宫壁内肌瘤。在切面上,坏死和出血区域伴有退行性改变提示癌症。上皮样平滑肌肉瘤经组织病理学和免疫组织化学检查发现。
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引用次数: 0
The Study of Financial Impact of COVID-19 on Ophthalmic Practices COVID-19对眼科业务的财务影响研究
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/13204d
N. Renu
The unprecedented threat of Covid-19 has forced transition from the normal way of life. The new norm now includes social distancing, the use of face masks, and reduced contact to only necessary cases. In ophthalmology, practice procedures are currently only limited to emergency procedures such as trauma and endophthalmitis. The state of affairs, as described in this review, is greatly reduced the number of patients seeking ophthalmology services. There are fewer patients making visits as a result of extreme caution on both their parts and the medics. Expectedly, many private practitioners are feeling the financial pinch, with as many as 90% of private practices seeking federal loans, among other initiatives to cushion their practices. Despite these efforts, the outlook is grim, with an estimated 6% of private practices expected to close, while those that pull through are predicted to be smaller in size and poor financial positions.
前所未有的Covid-19威胁迫使人们从正常的生活方式过渡。新规范现在包括保持社交距离,使用口罩,并将接触减少到必要的病例。在眼科,实践程序目前只局限于紧急程序,如创伤和眼内炎。如本文所述,现状是寻求眼科服务的患者数量大大减少。由于病人和医护人员都非常谨慎,前来就诊的病人越来越少。不出所料,许多私人执业医生都感到了财务压力,多达90%的私人执业医生寻求联邦贷款,并采取了其他措施来缓解他们的执业压力。尽管做出了这些努力,但前景依然黯淡,估计有6%的私人诊所将倒闭,而那些幸存下来的私人诊所预计规模更小,财务状况也更差。
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引用次数: 0
Study on Recurrent Anterior Shoulder Dislocation: An Approach to Boytchev Treatment 复发性肩前脱位的Boytchev治疗方法研究
Pub Date : 2021-08-30 DOI: 10.9734/bpi/nfmmr/v16/13265d
O. Benabdallah, A. Khamlichi
Background: The Boytchev method, which has been used since 1951 to treat anterior glenohumeral instability, is an open anterior repair that entails rerouting the muscles that join the coracoid process deep to the subscapularis muscle between this and the capsule. In the anatomical position, the tip of the coracoid is reattached to its base by its muscles. Methods: We conducted a prospective study of twenty patients with recurrent shoulder dislocations who were treated by the Boytchev procedure. All are men, with an average age of 29.2 years (age range from 17 to 42 years). 14 patients were affected on the right shoulder, 6 on the left. All had a clinical history of recurrent dislocation. We also performed a search of all published articles in the literature (16),17 studies including our series, with the aim of estimating, via a statistical analysis, to shed light on the post-operative results of recurrent anterior dislocations of the shoulder, for determining the reliability of this technique and possible specific risk factors that might lead to recurrence. Results: Evaluated using the Rowe score in our series, 19 patients had excellent and good results; one patient, who suffered a recurrence, had a poor result in terms of stability. Another patient developed osteoarthrosis. For the 17 studies, the number of patients is 477 with 485 dislocated shoulders. The rate of recurrence is 7.33% .In 12 studies, the rate is 2%, versus 21.05% in 5 studies with a significant difference (1-p=99.89%). Concerning the gradation of results, we have 441 excellent and good results and 44 fair and poor (91% versus 9% with p=>99.9% which is also very significant). Conclusion: The Boytchev procedure exhibits low recurrence rates in compiled studies and so can be considered a reliable surgical technique.
背景:Boytchev方法自1951年以来一直用于治疗肱骨前关节不稳,这是一种开放的前路修复,需要改变连接喙突和肩胛下肌之间的肌肉的路线。在解剖位置上,喙的尖端通过它的肌肉重新连接到它的基部。方法:我们对20例采用Boytchev手术治疗的复发性肩关节脱位患者进行了前瞻性研究。全部为男性,平均年龄29.2岁(年龄范围从17岁到42岁)。右肩14例,左肩6例。所有患者均有复发性脱位的临床病史。我们还检索了所有已发表的文献(16),包括我们的系列研究在内的17项研究,目的是通过统计分析来估计肩关节前脱位复发的术后结果,以确定该技术的可靠性和可能导致复发的特定危险因素。结果:在我们的研究中,使用Rowe评分进行评估,19例患者获得优异和良好的结果;一个复发的病人,在稳定性方面的结果很差。另一名患者出现骨关节病。在这17项研究中,患者人数为477人,肩关节脱位485人。复发率为7.33%,12项研究中复发率为2%,5项研究复发率为21.05%,差异有统计学意义(1-p=99.89%)。关于结果的分级,我们有441个优秀和良好的结果,44个一般和差的结果(91%对9%,p=>99.9%,这也是非常显著的)。结论:Boytchev手术复发率低,是一种可靠的手术技术。
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引用次数: 0
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New Frontiers in Medicine and Medical Research Vol. 16
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