Pub Date : 2020-04-01DOI: 10.19439/J.SJOS.2020.02.006
Wang Xue-mei, J. Yong
PURPOSE To investigate the effect of disulfiram on epithelial-mesenchymal transformation(EMT) in oral squamous cell carcinoma(OSCC) cells based on Smad4 mutation. METHODS The cancer tissues and adjacent normal tissues of 46 patients with OSCC who underwent tumor resection in the Affiliated Stomatological Hospital of Anhui Medical University from June 2017 to June 2018 were included in the study. Immunohistochemical staining was used to observe the expression of Smad4 in tissues, Western blot was used to determine the expression of Smad4 in tumor cells. The effects of disulfiram on TGF-β1-induced cell EMT migration, invasion, morphology and expression of p38, JNK and ERK were analyzed. SPSS 20.0 software package was used to analyze the data. RESULTS The positive expression rate of Smad4 in cancer tissues was significantly lower than that in adjacent normal tissues (P 0.05). The survival rate of human tongue cancer SCC-25 and CAL-27 cells was significantly lower than that of the control group at disulfiram concentrations ≥30 μmol/L(P<0.05). After treatment with TGF-β1, the morphology of SCC-25 and CAL-27 cells changed from epithelial to mesenchymal. E-cadherin expression was significantly reduced, Vimentin and Snail expression were significantly increased, and migration and invasion were enhanced (P<0.05). After disulfiram + TGF-β1 treatment, as the concentration of disulfiram increased, the morphological changes of SCC-25 and CAL-27 cells gradually decreased, the expression of E-cadherin protein gradually increased, the expression of Vimentin and Snail protein gradually decreased, and migration ability gradually weakened (P<0.05). After 5 minutes of TGF-β1 stimulation, p-ERK levels in SCC-25 and CAL-27 cells gradually increased, reached a maximum at 15 minutes, and then gradually decreased (P<0.05). After 20 μmol/L disulfiram + TGF-β1 treatment, p-ERK levels in SCC-25 and CAL-27 cells gradually decreased with the increase of the treatment time(P<0.05). CONCLUSIONS Disulfiram can inhibit EMT of Smad4 mutant and Smad4 non-mutated OSCC cells by blocking ERK phosphorylation in the MAPK signaling pathway.
{"title":"[Effect of disulfiram on epithelial-mesenchymal transformation of oral squamous cell carcinoma cells].","authors":"Wang Xue-mei, J. Yong","doi":"10.19439/J.SJOS.2020.02.006","DOIUrl":"https://doi.org/10.19439/J.SJOS.2020.02.006","url":null,"abstract":"PURPOSE To investigate the effect of disulfiram on epithelial-mesenchymal transformation(EMT) in oral squamous cell carcinoma(OSCC) cells based on Smad4 mutation. METHODS The cancer tissues and adjacent normal tissues of 46 patients with OSCC who underwent tumor resection in the Affiliated Stomatological Hospital of Anhui Medical University from June 2017 to June 2018 were included in the study. Immunohistochemical staining was used to observe the expression of Smad4 in tissues, Western blot was used to determine the expression of Smad4 in tumor cells. The effects of disulfiram on TGF-β1-induced cell EMT migration, invasion, morphology and expression of p38, JNK and ERK were analyzed. SPSS 20.0 software package was used to analyze the data. RESULTS The positive expression rate of Smad4 in cancer tissues was significantly lower than that in adjacent normal tissues (P 0.05). The survival rate of human tongue cancer SCC-25 and CAL-27 cells was significantly lower than that of the control group at disulfiram concentrations ≥30 μmol/L(P<0.05). After treatment with TGF-β1, the morphology of SCC-25 and CAL-27 cells changed from epithelial to mesenchymal. E-cadherin expression was significantly reduced, Vimentin and Snail expression were significantly increased, and migration and invasion were enhanced (P<0.05). After disulfiram + TGF-β1 treatment, as the concentration of disulfiram increased, the morphological changes of SCC-25 and CAL-27 cells gradually decreased, the expression of E-cadherin protein gradually increased, the expression of Vimentin and Snail protein gradually decreased, and migration ability gradually weakened (P<0.05). After 5 minutes of TGF-β1 stimulation, p-ERK levels in SCC-25 and CAL-27 cells gradually increased, reached a maximum at 15 minutes, and then gradually decreased (P<0.05). After 20 μmol/L disulfiram + TGF-β1 treatment, p-ERK levels in SCC-25 and CAL-27 cells gradually decreased with the increase of the treatment time(P<0.05). CONCLUSIONS Disulfiram can inhibit EMT of Smad4 mutant and Smad4 non-mutated OSCC cells by blocking ERK phosphorylation in the MAPK signaling pathway.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131105373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-25DOI: 10.19439/J.SJOS.2019.05.021
Zhang Ai-hua, L. Jing
PURPOSE: To explore the effect of sodium fluoride tooth protector combined with pit and fissure sealing to prevent caries in preschool children. METHODS: Two hundred preschool children who were treated with pit and fissure closure from January 2014 to September 2014 were selected as subjects. According to random number table method, 100 cases were divided into the combined group and the control group. Children in the control group were treated with pit and fissure sealant for prevention of caries, while children in the combined group were treated with sodium fluoride tooth protector combined with pit and fissure sealant for caries prevention. The incidence of dental caries, proximal caries, mean DMFT, and expulsion rate of the sealants were compared between the two groups at 1 year and 2 years. Data analysis was performed using SPSS 16.0 software package for data analysis. RESULTS: At 1 year of follow-up, there was no significant difference in the incidence of dental caries, proximal caries, and mean DMFT between the two groups (P>0.05). The incidence of caries and mean DMFT in the combined group were significantly lower than those in the control group at 2 years of follow-up (P 0.05). The retension rate of the pit and fissure sealant in the combined group was significantly higher than that in the control group (P 0.05). CONCLUSIONS: Sodium fluoride tooth protector combined with pit and fissure sealing has better anti-caries effect than the use of pit and fissure sealant alone in preschool children.
{"title":"Evaluation of the efficacy of sodium fluoride dental protective agent combined with pit and fissure sealant in prevention of dental caries in preschool children","authors":"Zhang Ai-hua, L. Jing","doi":"10.19439/J.SJOS.2019.05.021","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.05.021","url":null,"abstract":"PURPOSE: To explore the effect of sodium fluoride tooth protector combined with pit and fissure sealing to prevent caries in preschool children. METHODS: Two hundred preschool children who were treated with pit and fissure closure from January 2014 to September 2014 were selected as subjects. According to random number table method, 100 cases were divided into the combined group and the control group. Children in the control group were treated with pit and fissure sealant for prevention of caries, while children in the combined group were treated with sodium fluoride tooth protector combined with pit and fissure sealant for caries prevention. The incidence of dental caries, proximal caries, mean DMFT, and expulsion rate of the sealants were compared between the two groups at 1 year and 2 years. Data analysis was performed using SPSS 16.0 software package for data analysis. RESULTS: At 1 year of follow-up, there was no significant difference in the incidence of dental caries, proximal caries, and mean DMFT between the two groups (P>0.05). The incidence of caries and mean DMFT in the combined group were significantly lower than those in the control group at 2 years of follow-up (P 0.05). The retension rate of the pit and fissure sealant in the combined group was significantly higher than that in the control group (P 0.05). CONCLUSIONS: Sodium fluoride tooth protector combined with pit and fissure sealing has better anti-caries effect than the use of pit and fissure sealant alone in preschool children.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123651225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-01DOI: 10.19439/J.SJOS.2019.05.012
Xu Pinpin, Lin Yan, L. Xiaomin
PURPOSE: To investigate the clinical normal values of juveniles with normal occlusions of She and Han nationality in Lishui area of Zhejiang province, and compare the craniofacial characteristics between She and Han nationality. METHODS: Two hundred juveniles of She nationality and 200 juveniles of Han nationality with normal occlusion were recruited. Lateral cephalometric radiographs were taken, and Downs cephalometric analysis was performed. The data were compared using paired samples t test with SPSS 12.0 software package. RESULTS: There was no significant difference between males and females in the values of juveniles of both She and Han nationality. Compared to the male and female juveniles of Han nationality, MP-FH and U1-L1 of the She juveniles increased (P<0.05), while convexity decreased significantly (P<0.05). In addition, L1-MP of She female juveniles decreased significantly in comparison to that of Han female juveniles (P<0.05). There was no significant difference in other values between She and Han nationality. CONCLUSIONS: Compared to Han juveniles, She juveniles present an orthognathous and long face with vertical growth pattern. Sex differences are not apparent in juveniles of both She and Han nationality.
{"title":"Downs cephalometric analysis between juveniles of She and Han nationality in Lishui area of Zhejiang province","authors":"Xu Pinpin, Lin Yan, L. Xiaomin","doi":"10.19439/J.SJOS.2019.05.012","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.05.012","url":null,"abstract":"PURPOSE: To investigate the clinical normal values of juveniles with normal occlusions of She and Han nationality in Lishui area of Zhejiang province, and compare the craniofacial characteristics between She and Han nationality. METHODS: Two hundred juveniles of She nationality and 200 juveniles of Han nationality with normal occlusion were recruited. Lateral cephalometric radiographs were taken, and Downs cephalometric analysis was performed. The data were compared using paired samples t test with SPSS 12.0 software package. RESULTS: There was no significant difference between males and females in the values of juveniles of both She and Han nationality. Compared to the male and female juveniles of Han nationality, MP-FH and U1-L1 of the She juveniles increased (P<0.05), while convexity decreased significantly (P<0.05). In addition, L1-MP of She female juveniles decreased significantly in comparison to that of Han female juveniles (P<0.05). There was no significant difference in other values between She and Han nationality. CONCLUSIONS: Compared to Han juveniles, She juveniles present an orthognathous and long face with vertical growth pattern. Sex differences are not apparent in juveniles of both She and Han nationality.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126269825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-01DOI: 10.19439/J.SJOS.2019.05.008
Lang Miao-jie, OU Yue-jian
PURPOSE: Bisphosphonates are commonly used to treat bone-derived malignant tumors currently. In recent years, with the widespread use of these drugs, reports on the difficulty of wound healing (DWH) increase remarkably. However, the mechanism is still unclear. The soft tissue injury was suspected to cause DWH in many recent reports. This experiment was designed to explore the influence of zoledronic acid on fibroblast, and investigate the possible mechanisms leading to DWH. METHODS: NIH 3T3 fibroblasts were routinely cultured in vitro. The influence of zoledronic acid on apoptosis, proliferation and migration of fibroblast were tested with flow cytometry, MTT and cell migration assay, respectively. The results of each experimental group were compared with the control group using SPSS 17.0 software package. RESULTS: At a concentration of 5-50 μmol/L, zoledronic acid could dose-dependently inhibit the activity of fibroblast proliferation and migration, and up-regulate apoptosis with significant difference (P<0.05). CONCLUSIONS: Zoledronic acid can up-regulate cell apoptosis, inhibit proliferation and migration of fibroblast, suggesting that soft tissue impairment might contribute to the occurrence of DWH.
{"title":"[The influence of zoledronic acid on proliferation, migration and apoptosis of fibroblasts].","authors":"Lang Miao-jie, OU Yue-jian","doi":"10.19439/J.SJOS.2019.05.008","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.05.008","url":null,"abstract":"PURPOSE: Bisphosphonates are commonly used to treat bone-derived malignant tumors currently. In recent years, with the widespread use of these drugs, reports on the difficulty of wound healing (DWH) increase remarkably. However, the mechanism is still unclear. The soft tissue injury was suspected to cause DWH in many recent reports. This experiment was designed to explore the influence of zoledronic acid on fibroblast, and investigate the possible mechanisms leading to DWH. METHODS: NIH 3T3 fibroblasts were routinely cultured in vitro. The influence of zoledronic acid on apoptosis, proliferation and migration of fibroblast were tested with flow cytometry, MTT and cell migration assay, respectively. The results of each experimental group were compared with the control group using SPSS 17.0 software package. RESULTS: At a concentration of 5-50 μmol/L, zoledronic acid could dose-dependently inhibit the activity of fibroblast proliferation and migration, and up-regulate apoptosis with significant difference (P<0.05). CONCLUSIONS: Zoledronic acid can up-regulate cell apoptosis, inhibit proliferation and migration of fibroblast, suggesting that soft tissue impairment might contribute to the occurrence of DWH.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122395555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-01DOI: 10.19439/J.SJOS.2019.05.017
Ding Hong-zhong, XU Cong-ping, Zhou Yong-min
PURPOSE To investigate the independent prognostic factors and establish survival prediction model for advanced oral squamous cell carcinoma (OSCC). METHODS At the time of admission, the general information and past medical history of 177 patients with advanced OSCC were collected in detail. All patients underwent radical resection. After surgery, radiotherapy and chemotherapy with hydroxycampothecin (HCPT) and pingyangmycin (PYM) were performed according to the patient's condition. All patients were followed up for 5 years after surgery, and the survival rate during that period and the risk factors for prognosis were analyzed. The data were analyzed by SPSS 20.0 software package. RESULTS During the follow-up period, 2 patients died due to other causes, 4 were excluded due to lost to follow-up, 42 of the remaining 111 patients died, 69 survived, the total survival rate was 62.16%. The survival status of patients with advanced OSCC with different age, T stage and M stage had no significant difference (P>0.05), while significant difference was found among patients with different gender, tissue differentiation degree, N stage and chemotherapy (P 0.05). The survival curves of gender, N stage and HCPT in combination of PYM chemotherapy had certain predictive value on the survival of patients with advanced OSCC. CONCLUSIONS Gender, N stage and HCPT in combination of PYM chemotherapy are independent risk factors for the survival of patients with advanced OSCC, and their survival curves can be used as a survival prediction model.
{"title":"Independent prognostic factors and survival prediction model for 117 patients with advanced oral squamous cell carcinoma","authors":"Ding Hong-zhong, XU Cong-ping, Zhou Yong-min","doi":"10.19439/J.SJOS.2019.05.017","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.05.017","url":null,"abstract":"PURPOSE To investigate the independent prognostic factors and establish survival prediction model for advanced oral squamous cell carcinoma (OSCC). METHODS At the time of admission, the general information and past medical history of 177 patients with advanced OSCC were collected in detail. All patients underwent radical resection. After surgery, radiotherapy and chemotherapy with hydroxycampothecin (HCPT) and pingyangmycin (PYM) were performed according to the patient's condition. All patients were followed up for 5 years after surgery, and the survival rate during that period and the risk factors for prognosis were analyzed. The data were analyzed by SPSS 20.0 software package. RESULTS During the follow-up period, 2 patients died due to other causes, 4 were excluded due to lost to follow-up, 42 of the remaining 111 patients died, 69 survived, the total survival rate was 62.16%. The survival status of patients with advanced OSCC with different age, T stage and M stage had no significant difference (P>0.05), while significant difference was found among patients with different gender, tissue differentiation degree, N stage and chemotherapy (P 0.05). The survival curves of gender, N stage and HCPT in combination of PYM chemotherapy had certain predictive value on the survival of patients with advanced OSCC. CONCLUSIONS Gender, N stage and HCPT in combination of PYM chemotherapy are independent risk factors for the survival of patients with advanced OSCC, and their survival curves can be used as a survival prediction model.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"189 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116977778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-01DOI: 10.19439/J.SJOS.2019.05.020
Xiao Ling, Chen Rui-xia, Luo Na
PURPOSE: To investigate the effect of single low level laser therapy on initial pain during fixed orthodontic treatment. METHODS: Sixty patients who underwent fixed orthodontic treatment in our hospital from January 2015 to December 2017 were enrolled.Patients were divided into 2 groups by random number table method, 30 in each group. Patients in the experimental group were treated with a single low level laser therapy ,while patients in the control group were treated with a placebo.The results of the 2 groups were compared in regard to spontaneous pain and chewing pain during the day and night using SPSS 22.0 software package. RESULTS: Spontaneous pain during day and night with 0.012, 0.014 inch superelastic nickel-titanium (NiTi) line was significantly lower in the experimental group than in the control group(P 0.05).Chewing pain with 0.012, 0.014, 0.016, and 0.018 inch NiTi lines in the experimental group was significantly lower than that in the control group(P<0.05). CONCLUSIONS: Single low level laser therapy significantly reduced postoperative pain while placing a superelastic NiTi wire for initial alignment and correction.
{"title":"Effect of single low level laser therapy on initial pain during fixed orthodontic treatment","authors":"Xiao Ling, Chen Rui-xia, Luo Na","doi":"10.19439/J.SJOS.2019.05.020","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.05.020","url":null,"abstract":"PURPOSE: To investigate the effect of single low level laser therapy on initial pain during fixed orthodontic treatment. METHODS: Sixty patients who underwent fixed orthodontic treatment in our hospital from January 2015 to December 2017 were enrolled.Patients were divided into 2 groups by random number table method, 30 in each group. Patients in the experimental group were treated with a single low level laser therapy ,while patients in the control group were treated with a placebo.The results of the 2 groups were compared in regard to spontaneous pain and chewing pain during the day and night using SPSS 22.0 software package. RESULTS: Spontaneous pain during day and night with 0.012, 0.014 inch superelastic nickel-titanium (NiTi) line was significantly lower in the experimental group than in the control group(P 0.05).Chewing pain with 0.012, 0.014, 0.016, and 0.018 inch NiTi lines in the experimental group was significantly lower than that in the control group(P<0.05). CONCLUSIONS: Single low level laser therapy significantly reduced postoperative pain while placing a superelastic NiTi wire for initial alignment and correction.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126506442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-25DOI: 10.19439/J.SJOS.2019.04.022
Ding Zi-xue, Wang Meng-yao, Meng Jian
: Trigeminal herpes zoster is a common disease in clinic. However, Ramsay Hunt syndrome with facial paralysis, earache and external auditory meatus herpes triad caused by herpes virus invading knee ganglion is rare. This paper reported a case of trigeminal herpes zoster complicated with Ramsay Hunt syndrome and reviewed the literature in order to further understand the nervous system infection caused by herpes zoster virus.
{"title":"[Trigeminal herpes zoster with Ramsay Hunt syndrome: a report of one case and review of literature].","authors":"Ding Zi-xue, Wang Meng-yao, Meng Jian","doi":"10.19439/J.SJOS.2019.04.022","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.04.022","url":null,"abstract":": Trigeminal herpes zoster is a common disease in clinic. However, Ramsay Hunt syndrome with facial paralysis, earache and external auditory meatus herpes triad caused by herpes virus invading knee ganglion is rare. This paper reported a case of trigeminal herpes zoster complicated with Ramsay Hunt syndrome and reviewed the literature in order to further understand the nervous system infection caused by herpes zoster virus.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"238 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132361962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.19439/J.SJOS.2019.04.013
Zheng Chong-yang, Zhang Xin-yu, C. Rui, Liu Liu, Hu Yong-jie
PURPOSE To investigate the clinical outcomes and prognosis of harmonic scalpel assisted extracapsular dissection for benign parotid tumors. METHODS A total of 132 patients with full medical archives who were diagnosed as benign parotid tumors from 3 medical centers were retrospectively analyzed. The included patients were divided into 3 groups according to tumor positions, namely, superficial pre-auricular, superficial tail, and deep lobe. The intra- and peri-operative variables, complications, functional outcomes and recurrence rates were analyzed with SPSS 16.0 software package. RESULTS The surgical and drainage time were longer and the blood loss and drainage amount were significantly greater in deep lobe group (P 0.05). More patients with decreased sensation or sialocele were observed in deep lobe group (P=0.004, 0.043, respectively), and no significant differences were found for wound infection and Frey's syndrome among 3 groups (P>0.05).Transient facial nerve paralysis occurred more frequently in deep lobe group (P<0.01), while permanent facial nerve paralysis was similar (P=0.052). No significant difference was observed for tumor recurrence (P=1.000). CONCLUSIONS HS-ECD displays good outcomes and prognosis for benign tumor of parotid gland, with improved esthetic and functional results as well as fewer complications and recurrence rate postoperatively.
{"title":"Evaluation of harmonic scalpel assisted extracapsular dissection for benign parotid tumors","authors":"Zheng Chong-yang, Zhang Xin-yu, C. Rui, Liu Liu, Hu Yong-jie","doi":"10.19439/J.SJOS.2019.04.013","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.04.013","url":null,"abstract":"PURPOSE To investigate the clinical outcomes and prognosis of harmonic scalpel assisted extracapsular dissection for benign parotid tumors. METHODS A total of 132 patients with full medical archives who were diagnosed as benign parotid tumors from 3 medical centers were retrospectively analyzed. The included patients were divided into 3 groups according to tumor positions, namely, superficial pre-auricular, superficial tail, and deep lobe. The intra- and peri-operative variables, complications, functional outcomes and recurrence rates were analyzed with SPSS 16.0 software package. RESULTS The surgical and drainage time were longer and the blood loss and drainage amount were significantly greater in deep lobe group (P 0.05). More patients with decreased sensation or sialocele were observed in deep lobe group (P=0.004, 0.043, respectively), and no significant differences were found for wound infection and Frey's syndrome among 3 groups (P>0.05).Transient facial nerve paralysis occurred more frequently in deep lobe group (P<0.01), while permanent facial nerve paralysis was similar (P=0.052). No significant difference was observed for tumor recurrence (P=1.000). CONCLUSIONS HS-ECD displays good outcomes and prognosis for benign tumor of parotid gland, with improved esthetic and functional results as well as fewer complications and recurrence rate postoperatively.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123579834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.19439/J.SJOS.2019.03.018
Liu Wei-dong, Zhao Min
PURPOSE: To investigate the clinical effect and safety of modified Xiaoyao pill on the treatment of oral lichen planus (OLP) patients with anxiety or depression. METHODS: Sixty OLP patients with anxiety and depression were randomly divided into 2 groups, treated separately with hydroxychloroquine(HCQ, control group) and HCQ+modified Xiaoyao pill(experimental group). The results were measured with semi quantitative reticular erosive and ulcerative lesion (REU) and visual analogue scale（VAS） scoring system at the first visit, the second week, the fourth week and the eighth week, respectively. Data analysis was performed using SPSS 18.0 software package. RESULTS: The clinical effect of HCQ+modified Xiaoyao pill was better than that of the HCQ. The REU, VAS scores were lower after treatment in both groups (P 0.05). CONCLUSIONS: Modified Xiaoyao pill was effective and safe in the treatment of OLP patients with anxiety or depression, especially for EOLP.
{"title":"Clinical evaluation of modified Xiaoyao pill on the treatment of oral lichen planus patients with anxiety or depression","authors":"Liu Wei-dong, Zhao Min","doi":"10.19439/J.SJOS.2019.03.018","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.03.018","url":null,"abstract":"PURPOSE: To investigate the clinical effect and safety of modified Xiaoyao pill on the treatment of oral lichen planus (OLP) patients with anxiety or depression. METHODS: Sixty OLP patients with anxiety and depression were randomly divided into 2 groups, treated separately with hydroxychloroquine(HCQ, control group) and HCQ+modified Xiaoyao pill(experimental group). The results were measured with semi quantitative reticular erosive and ulcerative lesion (REU) and visual analogue scale（VAS） scoring system at the first visit, the second week, the fourth week and the eighth week, respectively. Data analysis was performed using SPSS 18.0 software package. RESULTS: The clinical effect of HCQ+modified Xiaoyao pill was better than that of the HCQ. The REU, VAS scores were lower after treatment in both groups (P 0.05). CONCLUSIONS: Modified Xiaoyao pill was effective and safe in the treatment of OLP patients with anxiety or depression, especially for EOLP.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"69 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120919318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.19439/J.SJOS.2019.03.012
Yang Jang, Lin Ya-zhen, L. Ying, Zhang Qiang, Yuan Xiao
PURPOSE To investigate the prevalence of malocclusion and the correlation between caries and malocclusion in mixed dentition of primary students in Laoshan district of Qingdao city, to provide a scientific basis for early orthodontic treatment. METHODS According to WHO's oral health survey (basic methods), a survey concerning oral health was performed in 1803 children aged 8-9 years old. SPSS 17.0 software package was used for statistical analysis . RESULTS 1322 of 1803 pupils suffered from malocclusion, the prevalence of malocclusion in children surveyed was (73.32%). There were 519 cases(39.26%) of Class I malocclusion, 374 cases(28.29%) of Class II malocclusion, 357(27.00%) cases of Class III malocclusion, 72 cases (5.45%) with asymmetric malformation. As regard to clinical manifestations, deep overbite accounted for(37.67%) ,followed by deep overjet(29.19%), dental crowding (16.94%) and crossbite(16.03%). The prevalence of caries was 64.23%. Among them, there were 625 males (34.66%) and 532 females(29.51%). CONCLUSIONS The prevalence rate of malocclusion in mixed dentition of primary students in Laoshan district of Qingdao district is not optimistic, the incidence of malocclusion is closely related to caries.
{"title":"Epidemiological survey of malocclusion in 8-9 year-old children in Qingdao Laoshan district","authors":"Yang Jang, Lin Ya-zhen, L. Ying, Zhang Qiang, Yuan Xiao","doi":"10.19439/J.SJOS.2019.03.012","DOIUrl":"https://doi.org/10.19439/J.SJOS.2019.03.012","url":null,"abstract":"PURPOSE To investigate the prevalence of malocclusion and the correlation between caries and malocclusion in mixed dentition of primary students in Laoshan district of Qingdao city, to provide a scientific basis for early orthodontic treatment. METHODS According to WHO's oral health survey (basic methods), a survey concerning oral health was performed in 1803 children aged 8-9 years old. SPSS 17.0 software package was used for statistical analysis . RESULTS 1322 of 1803 pupils suffered from malocclusion, the prevalence of malocclusion in children surveyed was (73.32%). There were 519 cases(39.26%) of Class I malocclusion, 374 cases(28.29%) of Class II malocclusion, 357(27.00%) cases of Class III malocclusion, 72 cases (5.45%) with asymmetric malformation. As regard to clinical manifestations, deep overbite accounted for(37.67%) ,followed by deep overjet(29.19%), dental crowding (16.94%) and crossbite(16.03%). The prevalence of caries was 64.23%. Among them, there were 625 males (34.66%) and 532 females(29.51%). CONCLUSIONS The prevalence rate of malocclusion in mixed dentition of primary students in Laoshan district of Qingdao district is not optimistic, the incidence of malocclusion is closely related to caries.","PeriodicalId":436266,"journal":{"name":"Chinese Journal of Oral Implantology","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132086527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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