M. A. B. Bigi, H. Faramarzi, A. Gaeini, A. Ravasi, M. R. Izadi, M. Delfan, Esmaeil Izadi
Background: To date, not sufficient information is available regarding the effect of High Intensity Interval Training (HIIT) on diabetes-induced myocardial dysfunctions. Objectives: The present study aimed to evaluate the effect of 4-week HIIT on change in expression levels of ryanodine receptor calcium channel (RyR2) and ATPase calcium pump (SERCA2a) in diabetic rats. Materials and Methods: This study was conducted on 24 Wistar rats with average weight of 245 ± 10 g. The rats were randomly divided into a sedentary diabetic group and a trained diabetic group. Training was started two weeks after diabetes induction by Streptozotocin (STZ) injection. The training program consisted of 4 weeks running on a treadmill and was considered to be intense for the two groups’ diabetic rats. After all, the animals’ characteristics and myocardial gene expression were compared using independent t-test. Results: Measurement of gene expression by Real Time-PCR revealed that cardiac mRNA expression of RyR2 was enhanced in the HIIT group. The results also revealed a significant (P = 0.03) difference between the hearts of the sedentary controls and the trained group regarding RyR2 levels. However, no significant difference was observed between the two groups with respect to SERCA2a levels (P = 0.14). Conclusions: The study results showed that treatment with HIIT could prevent and/or minimize the loss in expression of RyR2 and SERCA2a.
{"title":"UPREGULATION OF RYANODINE RECEPTOR CALCIUM CHANNELS (RYR2) IN RATS WITH INDUCED DIABETES AFTER 4 WEEKS OF HIGH INTENSITY INTERVAL TRAINING","authors":"M. A. B. Bigi, H. Faramarzi, A. Gaeini, A. Ravasi, M. R. Izadi, M. Delfan, Esmaeil Izadi","doi":"10.17795/ICRJ-10(1)1","DOIUrl":"https://doi.org/10.17795/ICRJ-10(1)1","url":null,"abstract":"Background: To date, not sufficient information is available regarding the effect of High Intensity Interval Training (HIIT) on diabetes-induced myocardial dysfunctions. Objectives: The present study aimed to evaluate the effect of 4-week HIIT on change in expression levels of ryanodine receptor calcium channel (RyR2) and ATPase calcium pump (SERCA2a) in diabetic rats. Materials and Methods: This study was conducted on 24 Wistar rats with average weight of 245 ± 10 g. The rats were randomly divided into a sedentary diabetic group and a trained diabetic group. Training was started two weeks after diabetes induction by Streptozotocin (STZ) injection. The training program consisted of 4 weeks running on a treadmill and was considered to be intense for the two groups’ diabetic rats. After all, the animals’ characteristics and myocardial gene expression were compared using independent t-test. Results: Measurement of gene expression by Real Time-PCR revealed that cardiac mRNA expression of RyR2 was enhanced in the HIIT group. The results also revealed a significant (P = 0.03) difference between the hearts of the sedentary controls and the trained group regarding RyR2 levels. However, no significant difference was observed between the two groups with respect to SERCA2a levels (P = 0.14). Conclusions: The study results showed that treatment with HIIT could prevent and/or minimize the loss in expression of RyR2 and SERCA2a.","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"10 1","pages":"1-5"},"PeriodicalIF":0.2,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68174955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Evidence have shown the relationship between vitamin D deficiency and cardiovascular disease. Objectives: The present study aimed to evaluate the effect of Vitamin D deficiency treatment on the occurrence of coronary post-Percutaneous Intervention (PCI) restenosis and Major Adverse Cardiac Events (MACE). Patients and Methods: This randomized semi-experimental non-controlled study was conducted on patients with coronary artery disease who were candidate for PCI and had referred to Baqiyatallah Hospital in a 2-month period. The patients with normal Vitamin D levels were allocated to the normal group and others were randomly assigned to treatment and non-treatment groups. All the patients were followed for 9 months. Vitamin D was measured again at the end of the 9th month and the patients were reassigned to normal and mild, moderate, and severe deficiency groups with respect to Holick classification. Results: This study was performed on 150 subjects with the mean age of 62.46 ± 10.80 years and male/female ratio of 94/56. The results showed no significant difference among the three groups regarding age, gender, diabetes, number of cardiovascular risk factors, and other underlying risk factors for restenosis. However, a significant difference was found between the patients with normal and abnormal vitamin D levels regarding the number of stenotic vessels and number of PCIs (both P 0.05). At the end of the study, 32 (55.1%) out of the 58 patients (55.1%) who were deficient reached normal vitamin D levels by consuming supplements, but 7 (12%) reached normal values without using supplements (P < 0.001). Conclusions: Treatment of vitamin D deficiency could reduce restenosis of PCI. However, this protocol is efficient for patients with moderate to severe deficiency and should be changed.
{"title":"The Effect of Vitamin D Deficiency Treatment on Post-PCI Coronary Restenosis and Major Adverse Cardiac Events","authors":"D. Saleh, Zahra Jozanikohan","doi":"10.17795/ICRJ-10(1)12","DOIUrl":"https://doi.org/10.17795/ICRJ-10(1)12","url":null,"abstract":"Background: Evidence have shown the relationship between vitamin D deficiency and cardiovascular disease. Objectives: The present study aimed to evaluate the effect of Vitamin D deficiency treatment on the occurrence of coronary post-Percutaneous Intervention (PCI) restenosis and Major Adverse Cardiac Events (MACE). Patients and Methods: This randomized semi-experimental non-controlled study was conducted on patients with coronary artery disease who were candidate for PCI and had referred to Baqiyatallah Hospital in a 2-month period. The patients with normal Vitamin D levels were allocated to the normal group and others were randomly assigned to treatment and non-treatment groups. All the patients were followed for 9 months. Vitamin D was measured again at the end of the 9th month and the patients were reassigned to normal and mild, moderate, and severe deficiency groups with respect to Holick classification. Results: This study was performed on 150 subjects with the mean age of 62.46 ± 10.80 years and male/female ratio of 94/56. The results showed no significant difference among the three groups regarding age, gender, diabetes, number of cardiovascular risk factors, and other underlying risk factors for restenosis. However, a significant difference was found between the patients with normal and abnormal vitamin D levels regarding the number of stenotic vessels and number of PCIs (both P 0.05). At the end of the study, 32 (55.1%) out of the 58 patients (55.1%) who were deficient reached normal vitamin D levels by consuming supplements, but 7 (12%) reached normal values without using supplements (P < 0.001). Conclusions: Treatment of vitamin D deficiency could reduce restenosis of PCI. However, this protocol is efficient for patients with moderate to severe deficiency and should be changed.","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"10 1","pages":"12-16"},"PeriodicalIF":0.2,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68175223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Depression is common among patients with heart disease. Depression is also associated with worse outcomes among patients with heart disease. Fewer studies have shown whether or not baseline depressive symptoms predict subsequent heart disease in general population. Objectives: This study aimed to investigate whether depressive symptoms at baseline predict risk of developing heart disease during the next 20 years in the United States. Patients and Methods: The data were extracted from the Health and Retirement Study (HRS), 1992 - 2012. The study was conducted on 8,375 individuals who were older than 50 years at entry, did not have heart disease at baseline, and had data on heart disease over the next 20 years. High depressive symptoms (modified Center for Epidemiologic Studies Depression Scale [CES-D]) were considered as the independent variable. Self-reported data on physician diagnosis of heart disease were measured on a biannual basis. Baseline demographic data (i.e., age and gender), socioeconomic status (i.e., race, marital status, and education level), health behaviors (i.e., drinking, smoking, and exercise), and body mass index were controlled. Cox proportional hazard model was used for data analysis. Results: Cox proportional hazard model revealed a link between high depressive symptoms at baseline and time to developing heart disease (Hazard ratio = 1.439, 95% CI = 1.253 1.652), suggesting that individuals with high depressive symptoms at baseline developed heart disease sooner than others. The association between baseline depressive symptoms and risk of heart disease was significant after controlling for all the covariates. Conclusions: Individuals with depressive symptomatology are at higher risk of development of heart disease over time. Thus, individuals with depressed mood may need more rigorous evaluation for heart disease.
背景:抑郁症在心脏病患者中很常见。在心脏病患者中，抑郁也与较差的预后有关。很少有研究表明基线抑郁症状是否能预测一般人群随后的心脏病。目的:本研究旨在调查基线抑郁症状是否能预测未来20年美国人患心脏病的风险。患者和方法:数据来自1992 - 2012年的健康与退休研究(HRS)。这项研究对8375名年龄在50岁以上的人进行了研究，这些人在开始时没有心脏病，并且在接下来的20年里有心脏病的数据。以高抑郁症状(改良的流行病学研究中心抑郁量表[CES-D])作为自变量。医生诊断心脏病的自我报告数据每两年测量一次。控制基线人口统计数据(即年龄和性别)、社会经济地位(即种族、婚姻状况和教育水平)、健康行为(即饮酒、吸烟和锻炼)和体重指数。采用Cox比例风险模型进行数据分析。结果:Cox比例风险模型揭示了基线时高抑郁症状与发生心脏病的时间之间的联系(风险比= 1.439,95% CI = 1.253 1.652)，表明基线时高抑郁症状的个体比其他人更早发生心脏病。在控制了所有协变量后，基线抑郁症状与心脏病风险之间的关联是显著的。结论:随着时间的推移，具有抑郁症状的个体患心脏病的风险更高。因此，有抑郁情绪的人可能需要更严格的心脏病评估。
{"title":"Baseline Depressive Symptoms Predict Subsequent Heart Disease; A 20-Year Cohort","authors":"M. Lankarani, S. Assari","doi":"10.17795/ICRJ-10(1)29","DOIUrl":"https://doi.org/10.17795/ICRJ-10(1)29","url":null,"abstract":"Background: Depression is common among patients with heart disease. Depression is also associated with worse outcomes among patients with heart disease. Fewer studies have shown whether or not baseline depressive symptoms predict subsequent heart disease in general population. Objectives: This study aimed to investigate whether depressive symptoms at baseline predict risk of developing heart disease during the next 20 years in the United States. Patients and Methods: The data were extracted from the Health and Retirement Study (HRS), 1992 - 2012. The study was conducted on 8,375 individuals who were older than 50 years at entry, did not have heart disease at baseline, and had data on heart disease over the next 20 years. High depressive symptoms (modified Center for Epidemiologic Studies Depression Scale [CES-D]) were considered as the independent variable. Self-reported data on physician diagnosis of heart disease were measured on a biannual basis. Baseline demographic data (i.e., age and gender), socioeconomic status (i.e., race, marital status, and education level), health behaviors (i.e., drinking, smoking, and exercise), and body mass index were controlled. Cox proportional hazard model was used for data analysis. Results: Cox proportional hazard model revealed a link between high depressive symptoms at baseline and time to developing heart disease (Hazard ratio = 1.439, 95% CI = 1.253 1.652), suggesting that individuals with high depressive symptoms at baseline developed heart disease sooner than others. The association between baseline depressive symptoms and risk of heart disease was significant after controlling for all the covariates. Conclusions: Individuals with depressive symptomatology are at higher risk of development of heart disease over time. Thus, individuals with depressed mood may need more rigorous evaluation for heart disease.","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"10 1","pages":"29-34"},"PeriodicalIF":0.2,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68175286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coronary artery embolism is an uncommon cause of Acute Myocardial Infarction (AMI). Herein, we reported a 24-year-old male who was admitted with acute inferoposterior myocardial infarction and cerebral Transient Ischemic Attack (TIA). He had undergone mechanical Aortic Valve Replacement (AVR) surgery 6 years ago. Surprisingly, the patient had decided to stop taking his medication (warfarin) 20 days earlier without any medical advice. Coronary angiography revealed a thrombus located at the distal part of the left circumflex artery. Discontinuation of anticoagulant therapy in the presence of mechanical valve prosthesis, clinical evidence of coincidental TIA, and lack of atherosclerotic risk factors were highly suggestive of coronary thromboembolism as the cause of AMI. Overall, this case report emphasized the necessity of continuous education in patients with mechanical heart valves to prevent such undesired events. *Corresponding author: Fereshteh Ghaderi, Atherosclerosis Prevention Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Tel: +98-9151615412, Fax: +98-5138544504, E-mail: drghaderif@yahoo.com
{"title":"CORONARY EMBOLI IN A YOUNG PATIENT WITH MECHANICAL AORTIC VALVE: A RARE CAUSE OF ACUTE MYOCARDIAL INFARCTION","authors":"Gholoobi Arash, Ghaderi Fereshteh","doi":"10.17795/ICRJ-10(1)43","DOIUrl":"https://doi.org/10.17795/ICRJ-10(1)43","url":null,"abstract":"Coronary artery embolism is an uncommon cause of Acute Myocardial Infarction (AMI). Herein, we reported a 24-year-old male who was admitted with acute inferoposterior myocardial infarction and cerebral Transient Ischemic Attack (TIA). He had undergone mechanical Aortic Valve Replacement (AVR) surgery 6 years ago. Surprisingly, the patient had decided to stop taking his medication (warfarin) 20 days earlier without any medical advice. Coronary angiography revealed a thrombus located at the distal part of the left circumflex artery. Discontinuation of anticoagulant therapy in the presence of mechanical valve prosthesis, clinical evidence of coincidental TIA, and lack of atherosclerotic risk factors were highly suggestive of coronary thromboembolism as the cause of AMI. Overall, this case report emphasized the necessity of continuous education in patients with mechanical heart valves to prevent such undesired events. *Corresponding author: Fereshteh Ghaderi, Atherosclerosis Prevention Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Tel: +98-9151615412, Fax: +98-5138544504, E-mail: drghaderif@yahoo.com","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"10 1","pages":"43-45"},"PeriodicalIF":0.2,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68175168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Speckle Tracking Echocardiography (STE) is a new non-invasive method, which has been recently used as an alternative technique to assess regional and global myocardial function, especially left ventricular function. It is also considered to be a valid technique to evaluate the patients with Acute Coronary Syndrome (ACS). Objectives: The present study aimed to evaluate the capability of STE as a trustable technique to indicate ischemic parts of the heart and compare the results to the information raised from angiography. Then, decision was made about capability of STE as a valid and reliable criterion for determining the indication of performing angiography. Patients and Methods: This case-control study was conducted on 37 patients between 30 and 70 years old with clinical diagnosis of ACS and clinical indications of coronary angiography who had referred to Faghihi hospital. Also, 46 healthy volunteers were selected as the control group. STE was performed for all the participants and angiography was done for the patients. Results: In 20 cases (55.6%), the results of echocardiography completely matched with those of angiography. In 10 cases (27.8%), echocardiography and angiography results were partially matched. According to the results, echocardiography showed involvement of both territories, while angiography revealed involvement of one territory or viceversa. However, the results were not matched at all in 6 cases. Conclusions: Our results showed that STE, with the current quality and capacity, could be effective in diagnosis of patients with Non-ST-segment Elevation Acute Coronary Syndrome (NSTE-ACS) and planning strategies for their treatment.
{"title":"Evaluation of Global and Regional Strain in Patients with Acute Coronary Syndrome without Previous Myocardial Infarction","authors":"A. Moaref, M. Zamirian, A. Safari, Yasaman Emami","doi":"10.17795/ICRJ-10(1)6","DOIUrl":"https://doi.org/10.17795/ICRJ-10(1)6","url":null,"abstract":"Background: Speckle Tracking Echocardiography (STE) is a new non-invasive method, which has been recently used as an alternative technique to assess regional and global myocardial function, especially left ventricular function. It is also considered to be a valid technique to evaluate the patients with Acute Coronary Syndrome (ACS). Objectives: The present study aimed to evaluate the capability of STE as a trustable technique to indicate ischemic parts of the heart and compare the results to the information raised from angiography. Then, decision was made about capability of STE as a valid and reliable criterion for determining the indication of performing angiography. Patients and Methods: This case-control study was conducted on 37 patients between 30 and 70 years old with clinical diagnosis of ACS and clinical indications of coronary angiography who had referred to Faghihi hospital. Also, 46 healthy volunteers were selected as the control group. STE was performed for all the participants and angiography was done for the patients. Results: In 20 cases (55.6%), the results of echocardiography completely matched with those of angiography. In 10 cases (27.8%), echocardiography and angiography results were partially matched. According to the results, echocardiography showed involvement of both territories, while angiography revealed involvement of one territory or viceversa. However, the results were not matched at all in 6 cases. Conclusions: Our results showed that STE, with the current quality and capacity, could be effective in diagnosis of patients with Non-ST-segment Elevation Acute Coronary Syndrome (NSTE-ACS) and planning strategies for their treatment.","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"10 1","pages":"6-11"},"PeriodicalIF":0.2,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68174974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Kouerinis, G. Chetty, G. Lazaros, G. Karagkiouzis, Ioannis Karathanasis, C. Kantsos, G. Georgiopoulos, G. Cooper
Bacterial pericarditis caused by Streptococcus Milleri Group (SMG) strains is a particularly exceptional pathology. All the eight previous reported cases were under the care of medical teams and the seven existed reports in medical journals were more or less from this perspective. Herein, we reported a unique case of a pericardial-cutaneous fistula resulting from a recurrent purulent pericardial effusion caused by SMG strains, which had been treated with open surgical drainage two months before. A thorough review of the surgical treatment options and the results has also been presented.
{"title":"Purulent Pericarditis Caused by Streptococcus Milleri Strains; the Gained Experience from Nine Reported Cases","authors":"I. Kouerinis, G. Chetty, G. Lazaros, G. Karagkiouzis, Ioannis Karathanasis, C. Kantsos, G. Georgiopoulos, G. Cooper","doi":"10.17795/ICRJ-9(4)243","DOIUrl":"https://doi.org/10.17795/ICRJ-9(4)243","url":null,"abstract":"Bacterial pericarditis caused by Streptococcus Milleri Group (SMG) strains is a particularly exceptional pathology. All the eight previous reported cases were under the care of medical teams and the seven existed reports in medical journals were more or less from this perspective. Herein, we reported a unique case of a pericardial-cutaneous fistula resulting from a recurrent purulent pericardial effusion caused by SMG strains, which had been treated with open surgical drainage two months before. A thorough review of the surgical treatment options and the results has also been presented.","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"9 1","pages":"243-246"},"PeriodicalIF":0.2,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68176074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Rezaian, M. Moghaddas, Shahed Rezaian, Lida Liaghat, N. Zare
Background: Although P-wave dispersion has proven to be a reliable electrocardiographic predictor of Atrial Fibrillation (AF) in many clinical settings, its significance in patients with Constrictive Pericarditis (CP) of non-ischemic origin is to be reported. Objectives: This study aimed to find out whether p-wave dispersion is prolonged in patients with documented CP of non-ischemic origin. Patients and Methods: This study was conducted on twenty patients with CP, 16 males and 4 females, with the mean age of 39.0 ± 20.5 years and 20 age- and sex-matched healthy subjects. All the Electrocardiograms (ECGs) were scanned and the P-wave parameters were measured electronically after × 400% magnification. Results: Our main finding was a significantly prolonged maximum P-wave duration (P = 0.018) and P-wave dispersion (P = 0.049) in the patients with CP compared to the control group. These parameters, however, did not have any correlation with the patients’ age and disease duration. Conclusions: Since AF is common in patients with CP of any etiology and may have a negative impact on their outcome, detection of individuals susceptible to development of AF could be of great clinical value.
{"title":"P-Wave Dispersion in Patients with Constrictive Pericarditis of Non-Ischemic Etiology Including Tubercoulous and Non-Tuberculous Subjects: A Pilot Study","authors":"G. Rezaian, M. Moghaddas, Shahed Rezaian, Lida Liaghat, N. Zare","doi":"10.17795/ICRJ-9(4)199","DOIUrl":"https://doi.org/10.17795/ICRJ-9(4)199","url":null,"abstract":"Background: Although P-wave dispersion has proven to be a reliable electrocardiographic predictor of Atrial Fibrillation (AF) in many clinical settings, its significance in patients with Constrictive Pericarditis (CP) of non-ischemic origin is to be reported. Objectives: This study aimed to find out whether p-wave dispersion is prolonged in patients with documented CP of non-ischemic origin. Patients and Methods: This study was conducted on twenty patients with CP, 16 males and 4 females, with the mean age of 39.0 ± 20.5 years and 20 age- and sex-matched healthy subjects. All the Electrocardiograms (ECGs) were scanned and the P-wave parameters were measured electronically after × 400% magnification. Results: Our main finding was a significantly prolonged maximum P-wave duration (P = 0.018) and P-wave dispersion (P = 0.049) in the patients with CP compared to the control group. These parameters, however, did not have any correlation with the patients’ age and disease duration. Conclusions: Since AF is common in patients with CP of any etiology and may have a negative impact on their outcome, detection of individuals susceptible to development of AF could be of great clinical value.","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"9 1","pages":"199-202"},"PeriodicalIF":0.2,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68175812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Recently, some studies have revealed Osteonectin’s (OSN) promising role as a marker in cardiovascular diseases. Objectives: This study aimed to evaluate the prognostic value of circulating OSN for cumulative survival and hospitalization in patients with ischemic Chronic Heart Failure (CHF). Patients and Methods: This open cohort prospective study was conducted on 154 patients with ischemic symptomatic moderate-to-severe CHF at discharge from hospital. The observation period was up to 3 years (156 weeks). Blood samples for biomarker measurements were collected at baseline. ELISA method was used for measurement of OSN circulating level. Then, Receiver Operating Characteristic (ROC) curve analysis was carried out to identify the optimal cut-off points of the OSN concentration with predicted values. Odds ratios were also calculated for all the independent predictors of patients’ survival. Kaplan-Meier survival curves were also structured for both cohorts with low and high OSN levels. Results: During a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repetitively. The median of circulating OSN levels were 670.96 ng/mL (95% Confidence Interval [CI] = 636.53 - 705.35 ng/mL) and 907.84 ng/mL (95% CI = 878.02 - 937.60 ng/mL) in the survived and dead patients cohorts, respectively. Besides, ROC curve analysis showed that optimal cut-off point of OSN for cumulative survival function was 845.15 ng/mL. The results also revealed significant divergence of KaplanMeier survival curves in the patients with high (> 845.15 ng/mL) and low (< 845.15 ng/ mL) concentrations of OSN. Conclusions: Increased circulating OSN levels were associated with increased 3-year CHF-related death, all-cause mortality, and risk of recurrent hospitalization due to CHF.
{"title":"Circulating Osteonectin as a Predictive Biomarker in Patients with Ischemic Symptomatic Chronic Heart Failure","authors":"A. Berezin, A. Kremzer","doi":"10.17795/ICRJ-9(4)203","DOIUrl":"https://doi.org/10.17795/ICRJ-9(4)203","url":null,"abstract":"Background: Recently, some studies have revealed Osteonectin’s (OSN) promising role as a marker in cardiovascular diseases. Objectives: This study aimed to evaluate the prognostic value of circulating OSN for cumulative survival and hospitalization in patients with ischemic Chronic Heart Failure (CHF). Patients and Methods: This open cohort prospective study was conducted on 154 patients with ischemic symptomatic moderate-to-severe CHF at discharge from hospital. The observation period was up to 3 years (156 weeks). Blood samples for biomarker measurements were collected at baseline. ELISA method was used for measurement of OSN circulating level. Then, Receiver Operating Characteristic (ROC) curve analysis was carried out to identify the optimal cut-off points of the OSN concentration with predicted values. Odds ratios were also calculated for all the independent predictors of patients’ survival. Kaplan-Meier survival curves were also structured for both cohorts with low and high OSN levels. Results: During a median follow-up of 2.18 years, 21 participants died and 106 subjects were hospitalized repetitively. The median of circulating OSN levels were 670.96 ng/mL (95% Confidence Interval [CI] = 636.53 - 705.35 ng/mL) and 907.84 ng/mL (95% CI = 878.02 - 937.60 ng/mL) in the survived and dead patients cohorts, respectively. Besides, ROC curve analysis showed that optimal cut-off point of OSN for cumulative survival function was 845.15 ng/mL. The results also revealed significant divergence of KaplanMeier survival curves in the patients with high (> 845.15 ng/mL) and low (< 845.15 ng/ mL) concentrations of OSN. Conclusions: Increased circulating OSN levels were associated with increased 3-year CHF-related death, all-cause mortality, and risk of recurrent hospitalization due to CHF.","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"9 1","pages":"203-209"},"PeriodicalIF":0.2,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68175857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Kamalipour, S. Shahbazi, M. M. Derakhshan, M. T. Moinvaziri, E. Allahyari
Background: Although some investigations have shown higher rates of successful first attempt and fewer attempts by using ultrasound-guided Internal Jugular Vein (IJV) catheterization, arterial puncture is still common. Objectives: The present study aimed to investigate US-guided catheterization of the right IJV via medial-oblique technique and also compare this technique to short-axis
{"title":"Comparison of US-Guided Catheterization of the Right Internal Jugular Vein Using Medial-Oblique and Short Axis Techniques","authors":"H. Kamalipour, S. Shahbazi, M. M. Derakhshan, M. T. Moinvaziri, E. Allahyari","doi":"10.17795/ICRJ-9(4)210","DOIUrl":"https://doi.org/10.17795/ICRJ-9(4)210","url":null,"abstract":"Background: Although some investigations have shown higher rates of successful first attempt and fewer attempts by using ultrasound-guided Internal Jugular Vein (IJV) catheterization, arterial puncture is still common. Objectives: The present study aimed to investigate US-guided catheterization of the right IJV via medial-oblique technique and also compare this technique to short-axis","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"9 1","pages":"210-215"},"PeriodicalIF":0.2,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68175545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Eftekhari, Z. Sohrabi, Nader Parsa, Mohammad Javad Zibaee Nezhad
Background: Metabolic Syndrome (MetS) is defined as a group of cardiovascular risk factors and is an important health threat. Objectives: This study aimed to determine the role of gender in the prevalence of MetS among Shiraz Healthy Heart Center population. Patients and Methods: This study was performed on 350 adults aged 20 - 65 years from Shiraz Healthy Heart Center, Shiraz University of Medical Sciences. Individuals with obesity secondary to medication and genetic or endocrine disorders were excluded from the study. Weight and height were measured for calculating Body Mass Index (BMI). Waist circumference and blood pressure were measured, as well. Plasma glucose, serum High Density Lipoprotein-cholesterol (HDL-c), and Triglyceride (TG) were also analyzed. The presence of MetS was determined using Adult Treatment Panel-III (ATPIII) criteria. Results: The results showed significant correlations between age and waist circumference, Fasting Blood Sugar (FBS), Systolic Blood Pressure (SBP), and Diastolic Blood Pressure (DBP). Moreover, statistically significant relationships were found between waist circumference and TG, SBP, DBP, and BMI. Significant correlations were also observed between FBS and TG, SBP, and DBP. Besides, there were strong correlations between TG and HDL-c, SBP, DBP, and BMI. Moreover, BMI, SBP, and DBP were significantly correlated. In addition, serum HDL-c was negatively associated with most of the variables. The prevalence of pre-diabetes, pre-hypertension, and hypertriglyceridemia was higher among males. On the other hand, the prevalence of hypertension, diabetes, high waist circumference, and MetS was significantly higher among the female participants. Conclusions: A better understanding of the role of gender in the prevalence of MetS is important in developing prevention and treatment strategies.
{"title":"Role of Gender in the Prevalence of Metabolic Syndrome and Its Related Risk Factors in Shiraz Healthy Heart Center Population","authors":"M. Eftekhari, Z. Sohrabi, Nader Parsa, Mohammad Javad Zibaee Nezhad","doi":"10.17795/ICRJ-9(4)231","DOIUrl":"https://doi.org/10.17795/ICRJ-9(4)231","url":null,"abstract":"Background: Metabolic Syndrome (MetS) is defined as a group of cardiovascular risk factors and is an important health threat. Objectives: This study aimed to determine the role of gender in the prevalence of MetS among Shiraz Healthy Heart Center population. Patients and Methods: This study was performed on 350 adults aged 20 - 65 years from Shiraz Healthy Heart Center, Shiraz University of Medical Sciences. Individuals with obesity secondary to medication and genetic or endocrine disorders were excluded from the study. Weight and height were measured for calculating Body Mass Index (BMI). Waist circumference and blood pressure were measured, as well. Plasma glucose, serum High Density Lipoprotein-cholesterol (HDL-c), and Triglyceride (TG) were also analyzed. The presence of MetS was determined using Adult Treatment Panel-III (ATPIII) criteria. Results: The results showed significant correlations between age and waist circumference, Fasting Blood Sugar (FBS), Systolic Blood Pressure (SBP), and Diastolic Blood Pressure (DBP). Moreover, statistically significant relationships were found between waist circumference and TG, SBP, DBP, and BMI. Significant correlations were also observed between FBS and TG, SBP, and DBP. Besides, there were strong correlations between TG and HDL-c, SBP, DBP, and BMI. Moreover, BMI, SBP, and DBP were significantly correlated. In addition, serum HDL-c was negatively associated with most of the variables. The prevalence of pre-diabetes, pre-hypertension, and hypertriglyceridemia was higher among males. On the other hand, the prevalence of hypertension, diabetes, high waist circumference, and MetS was significantly higher among the female participants. Conclusions: A better understanding of the role of gender in the prevalence of MetS is important in developing prevention and treatment strategies.","PeriodicalId":43653,"journal":{"name":"International Cardiovascular Research Journal","volume":"9 1","pages":"231-237"},"PeriodicalIF":0.2,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68175951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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