International Cardiovascular Research Journal最新文献_第4页

Hypertensive Patients and Normotensive Individuals: Differences in Anger Inventory 高血压患者和正常个体:愤怒量表的差异

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2015-12-31 DOI: 10.17795/ICRJ-9(4)216

A. Sahraian, M. Mokhtari, A. Moaref, V. Rezaee, Ebrahim Moghimi, A. Mani

Background: Hypertension (HTN) is a common condition with increasing prevalence rate. Hypertensive patients have a high prevalence of mental disorders, including anger. Objectives: The present study aimed to investigate the score of anger in hypertensive patients in comparison to the individuals with normal blood pressure in Shiraz. Patients and Methods: This case-control study was conducted on 100 patients with HTN and 107 normal controls with the mean age of 52.48 and 53.78 years, respectively. These patients had referred to Shiraz HTN clinic in 2013. All the patients completed the Multidimensional Anger Inventory (MAI) and the results were analyzed using the SPSS statistical software, 2010. Results: The participants were matched regarding age and other demographic factors which might have influenced HTN. Distributions of these factors were partly similar and the differences were not significant. The HTN group obtained higher scores in all dimensions. Besides, the differences were significant in all subscales, except for anger. Conclusions: In line with the previous researches, the present study indicated that high level of aggression was correlated to high blood pressure. Therefore, it is necessary to have psychological interventions along with other interventions for hypertensive patients. Overall, this research confirmed biopsycho approach to psychosomatic diseases.

背景:高血压(HTN)是一种常见病，发病率呈上升趋势。高血压患者有高患病率的精神障碍，包括愤怒。目的:研究设拉子地区高血压患者的愤怒情绪得分，并与正常血压人群进行比较。患者与方法:选取HTN患者100例，正常对照107例，平均年龄分别为52.48岁和53.78岁。这些患者于2013年转诊到设拉子HTN诊所。所有患者均完成了多维愤怒量表(MAI)，并采用SPSS统计软件(2010)对结果进行分析。结果:参与者的年龄和其他可能影响HTN的人口因素相匹配。这些因子的分布部分相似，差异不显著。HTN组各维度得分均较高。此外，除愤怒外，所有量表的差异均显著。结论:本研究与以往研究一致，表明高攻击性与高血压相关。因此，在对高血压患者进行其他干预的同时，进行心理干预是必要的。总的来说，这项研究证实了生物心理治疗心身疾病的方法。

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引用次数: 5

The Relationship between Serum Hemoglobin and Creatinine Levels and Intra-Hospital Mortality and Morbidity in Acute Myocardial Infarction 血清血红蛋白和肌酐水平与急性心肌梗死院内病死率和发病率的关系

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2015-12-01 DOI: 10.17795/ICRJ-9(4)220

A. Fazlinezhad, M. Hami, M. Shakeri, Hoda Khatibi-Moghaddam, Maliheh DadgarMoghadam, Majid Khadem-Rezaiyan, S. Soflaei

Background: Studies have shown that Glomerular Filtration Rate (GFR) and Hemoglobin (Hb) concentrations are two predictive values for ST-elevation Myocardial Infarction (MI) mortality. Objectives: This study aimed to investigate the relationship between GFR and Hb concentrations and intra-hospital mortality and electrocardiographic (ECG) and echocardiographic abnormalities in ST-elevation MI patients admitted to a highly equipped hospital in Mashhad. The results will help define some factors to manage these patients more efficiently. Patients and Methods: This descriptive study aimed to assess the relationship between Hb and GFR concentrations and mortality and morbidity among 294 randomly selected patients with ST-elevation MI. Echocardiography, ECG, and routine laboratory tests, including Hb and creatinine, were performed for all the patients. Then, the data were entered into the SPSS statistical software, version 16 and were analyzed using chi-square, t-test, and ANOVA. P < 0.05 was considered as statistically significant. Results: Intra-hospital mortality rate was 10.5%. Besides, the results showed higher levels of serum blood sugar (P < 0.001), higher levels of creatinine (P < 0.001), lower levels of GFR (P < 0.001), lower ejection fraction (P < 0.001), higher grades of left ventricular diastolic dysfunction (P = 0.002), and lower mean Hb concentration (P = 0.022) in the dead compared to the alive cases. Besides, the patients with mechanical complications had lower Hb levels (P = 0.008). The results showed no significant relationship between creatinine level and mechanical and electrical complications (P = 0.430 and P = 0.095, respectively). However, ejection fraction was significantly associated with GFR (P = 0.016). Conclusions: According to the results, low levels of Hb and GFR could predict mortality caused by ST-elevation MI and ECG abnormalities could notify intra-hospital death. Moreover, lower Hb levels were associated with mechanical complications and could be used as a parameter for diagnosis of high-risk patients.

研究表明，肾小球滤过率(GFR)和血红蛋白(Hb)浓度是st段抬高型心肌梗死(MI)死亡率的两个预测值。目的:本研究旨在探讨住在马什哈德一家设备精良的医院的st段抬高心肌梗死患者GFR和Hb浓度与院内死亡率、心电图和超声心动图异常之间的关系。结果将有助于确定一些因素，以更有效地管理这些患者。患者和方法:本描述性研究旨在评估随机选择的294例st段抬高型心肌梗死患者Hb和GFR浓度与死亡率和发病率之间的关系。对所有患者进行超声心动图、心电图和常规实验室检查，包括Hb和肌酐。然后将数据输入SPSS统计软件第16版，采用卡方、t检验和方差分析进行分析。P < 0.05为差异有统计学意义。结果:院内死亡率为10.5%。此外，结果显示，与活着的患者相比，死亡患者的血清血糖水平较高(P < 0.001)，肌酐水平较高(P < 0.001)， GFR水平较低(P < 0.001)，射血分数较低(P < 0.001)，左室舒张功能障碍程度较高(P = 0.002)，平均Hb浓度较低(P = 0.022)。机械并发症患者Hb水平较低(P = 0.008)。结果显示肌酐水平与机械、电并发症无显著相关性(P = 0.430, P = 0.095)。然而，射血分数与GFR显著相关(P = 0.016)。结论:结果表明，Hb和GFR水平低可预测st段抬高型心肌梗死的死亡率，心电图异常可提示院内死亡。此外，较低的Hb水平与机械并发症有关，可作为诊断高危患者的参数。

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引用次数: 2

Oral Selenium: Can It Prevent Contrast-Induced Nephropathy Following Coronary Angiography and Angioplasty 口服硒:能预防冠脉造影术和血管成形术后造影剂肾病吗

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2015-12-01 DOI: 10.17795/ICRJ-9(4)226

Hashem Danesh Sani, Moosa Karami Kharat, Mohammad Vejdanparast, A. Eshraghi, Alireza, Abdollahi Moghaddam, Hamid Eshraghi

Background: Alteration of kidney function called Contrast-Induced Nephropathy (CIN) is commonly encountered in diagnostic and interventional cardiology procedures. It results in considerable morbidity and mortality besides imposing significant costs on the healthcare system. Today, it is accounted as the third cause of hospital-acquired acute renal failure. Objectives: Considering anti-oxidant and free radical scavenging properties of selenium and the role of free radicals in CIN, the present study aimed to investigate the effects of oral selenium (in the form of Se-yeast capsule) on preventing or decreasing the rate of CIN in patients undergoing angiography and angioplasty. Patients and Methods: This prospective, non-randomized, single-blind, single-center clinical trial was conducted on 175 consecutive patients admitted for elective coronary angiography (N = 105) or angioplasty (N = 70). Selenium was prescribed as a single dose of 200 micrograms the day before and after the procedure. Routine hydration based on the ward protocol was administered for all the patients. For the control group, the researchers made use of the data of another survey performed in the same hospitals for determining the prevalence of CIN a year before. The data were analyzed using student's t-test and logistic regression analysis and P < 0.05 was considered as statistically significant. Results: Based on the results of student's t-test, the mean difference between the two groups was significant only in hematocrit levels. The incidence of CIN was 9% in the selenium group compared to 22% in the control group (P = 0.027). There was no case of in-hospital mortality and none of the CIN patients required renal replacement therapy during hospitalization. Conclusions: Prophylactic selenium administration may significantly reduce the incidence of CIN.

背景:被称为造影剂肾病(CIN)的肾功能改变在诊断和介入心脏病学程序中很常见。除了对医疗保健系统施加巨大成本外，它还导致相当高的发病率和死亡率。今天，它被认为是医院获得性急性肾衰竭的第三大原因。目的:考虑到硒的抗氧化和自由基清除特性以及自由基在CIN中的作用，本研究旨在探讨口服硒(以硒酵母胶囊的形式)对血管造影和血管成形术患者预防或降低CIN发生率的作用。患者和方法:这项前瞻性、非随机、单盲、单中心临床试验对175例连续接受择期冠状动脉造影(N = 105)或血管成形术(N = 70)的患者进行了研究。在手术的前一天和之后，硒被规定为200微克的单剂量。所有患者均按病房方案进行常规水合治疗。对于对照组，研究人员利用在同一家医院进行的另一项调查的数据来确定一年前CIN的患病率。数据采用学生t检验和logistic回归分析，以P < 0.05为差异有统计学意义。结果:根据学生t检验的结果，两组之间的平均差异仅在红细胞压积水平上有显著性差异。硒组CIN发生率为9%，对照组为22% (P = 0.027)。没有住院死亡病例，没有CIN患者在住院期间需要肾脏替代治疗。结论:预防性给硒可显著降低CIN的发生率。

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引用次数: 0

Tissue Doppler Findings in Patients with Pulmonary Arterial Hypertension 肺动脉高压患者的组织多普勒表现

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2015-07-19 DOI: 10.17795/ICRJ-10(03)113

F. Abtahi, M. Zibaeenezhad, Fatemeh Shafazadeh, M. Tahamtan

: Background: Pulmonary hypertension is an untreatable condition with poor prognosis and factors such as more elevated pulmonary arterial systolic pressure and right ventricular dysfunction are associated with a worse outcome. Objectives: Considering the limitations of the current modalities, this study aimed to find the relationship between tissue Doppler-derived systolic and diastolic parameters and elevated pulmonary arterial pressure in order to assess the routine application of tissue Doppler imaging in evaluation of pulmonary arterial hypertension. Patients and Methods: This study was conducted on 100 inpatient and outpatient individuals referred to the Department of Echocardiography in Shahid Faghihi hospital, Shiraz, Iran from July 2012 to March 2013. The individuals who had preserved right ventricular function in the presence of pulmonary arterial hypertension were included in the case group. On the other hand, the patients who did not have echocardiographic signs of pulmonary arterial hypertension were enrolled into the control group. All the patients underwent a complete transthoracic echocardiogram including 2-dimensional, color flow, and spectral Doppler as well as tissue Doppler imaging using a vivid E9 system, and the desired systolic and diastolic parameters were recorded. The relationship among these parameters was evaluated by independent sample t-test using the SPSS statistical software, version 16. Besides, P Results: The mean time to peak strain was significantly longer in the case group (203.98 ± 47.54 milliseconds) compared to the controls (81.20 ± 25.76 milliseconds). The mean early diastolic tricuspid inflow velocity/early diastolic tricuspid annulus velocity (E/E’a) ratio was also significantly higher in the case group (10.24 ± 6.19) compared to the controls (4.70 ± 0.80). In contrast, Isovolumic Contraction (IVC) acceleration time/IVC time ratio was reduced in the case group (0.44 ± 0.09) in comparison to the control patients (0.56 ± 0.05). Conclusions: In conclusion, our results suggested that increasing degrees of pulmonary artery systolic pressure affected timing of some tissue Doppler-derived intervals within the cardiac cycle, including IVC time, time to peak systolic myocardial velocity (Sm), and time to peak strain. Therefore, tissue Doppler imaging could be used in assessment of patients with suspected pulmonary arterial hypertension.

背景:肺动脉高压是一种预后不良的不治之症，肺动脉收缩压升高和右心室功能障碍等因素与预后不良相关。目的:考虑到现有方法的局限性，本研究旨在寻找组织多普勒衍生的收缩和舒张参数与肺动脉压升高的关系，以评估组织多普勒成像在肺动脉高压评估中的常规应用。患者和方法:本研究于2012年7月至2013年3月对伊朗设拉子Shahid Faghihi医院超声心动图科的100名住院和门诊患者进行了研究。在肺动脉高压存在的情况下保留右心室功能的个体被纳入病例组。另一方面，没有肺动脉高压超声心动图征象的患者被纳入对照组。所有患者均行完整的经胸超声心动图，包括二维、彩色血流、频谱多普勒和组织多普勒成像，并记录所需的收缩和舒张参数。各参数之间的关系采用独立样本t检验，采用SPSS统计软件，版本16。P结果:病例组平均应变峰值时间(203.98±47.54毫秒)明显长于对照组(81.20±25.76毫秒)。病例组平均舒张早期三尖瓣流入速度/舒张早期三尖瓣环速度(E/E’a)比(10.24±6.19)显著高于对照组(4.70±0.80)。病例组等容积收缩(IVC)加速时间/IVC时间比(0.44±0.09)低于对照组(0.56±0.05)。结论:肺动脉收缩压的升高程度影响心动周期内一些组织多普勒衍生间隔的时间，包括IVC时间、收缩心肌速度峰值时间(Sm)和应变峰值时间。因此，组织多普勒成像可用于评估疑似肺动脉高压患者。

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引用次数: 3

Intra-Hospital Outcomes in ST Elevation Myocardial Infarction: Comparison of Diabetic and Non-Diabetic Patients ST段抬高型心肌梗死的院内结局:糖尿病与非糖尿病患者的比较

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2015-01-01 DOI: 10.17795/ICRJ-9(4)251

T. Kazemi, F. Shafiee, T. Shafiee

引用次数: 0

Mitral Prosthetic Valve Obstruction and Its Complications 二尖瓣人工阻塞及其并发症

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2015-01-01 DOI: 10.17795/ICRJ-9(4)247

R. Rajan, V. Krishnakumar, C. G. Bahuleyan, P. Nair

Prosthetic Valve Obstruction (PVO) is a serious complication which is associated with increased morbidity and mortality. This could result from thrombus formation, development of pannus, or a combination of both. Patients with this complication often present with symptoms and signs of heart failure, systemic embolism, acute cardiovascular collapse, and sudden death. Transesophageal echocardiography and cine fluoroscopy play a vital role in diagnosis of this potentially lethal condition. Herein, we reported a 56-year-old male patient who presented with severe heart failure and was found to have obstructed ATS27 bileaflet mitral prosthetic valve. Thrombolysis and redo surgery are two important options for treating this condition although guidelines for choosing between the two are not very definite.

人工瓣膜梗阻(PVO)是一种严重的并发症，与发病率和死亡率增加有关。这可能是由血栓形成、输卵管发育或两者的结合引起的。这种并发症的患者通常表现为心衰、全身栓塞、急性心血管衰竭和猝死的症状和体征。经食管超声心动图和电影透视在诊断这种潜在的致命疾病中起着至关重要的作用。在此，我们报告了一位56岁的男性患者，他表现出严重的心力衰竭，并被发现有ATS27双小叶二尖瓣人工瓣膜阻塞。溶栓和重做手术是治疗这种疾病的两种重要选择，尽管两者之间的选择指南并不十分明确。

引用次数: 0

Focal treatment for genetic disorders (a fairy tale or a true story?). 遗传性疾病的局部治疗(童话故事还是真实故事?)

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2014-12-01

Mohamad Hossein Nikoo, Mohamad Vahid Jorat, Amir Aslani

引用次数: 0

Metabolic syndrome and inflammatory biomarkers in adults: a population-based survey in Western region of iran. 成人代谢综合征和炎症生物标志物:伊朗西部地区一项基于人群的调查。

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2014-12-01

Ali Maleki, Negin Rashidi, Hamidreza Aghaei Meybodi, Mahdi Montazeri, Mohammad Montazeri, Farid Falsafi, Reza Ghanavati, Saeid Forughi, Farshid Alyari

Background: There is evidence that inflammation may be involved in pathogenesis of MetS. Inflammatory biomarkers are moving to the forefront as the potent predictors of MetS.

Objectives: The present study aimed to evaluate the association between MetS and some inflammatory biomarkers.

Patients and methods: This community-based cross-sectional study was conducted on 800 subjects aged above 35 years selected through random sampling in Borujerd (west of Iran) from 2011 to 2013. MetS was defined based on ATP III criteria and the subjects were divided into two groups (MetS and non-MetS groups). Waist circumference and Body Mass Index (BMI) were calculated. In addition, blood samples were taken and C-Reactive Protein (CRP), lipid profile, Fasting Blood Sugar (FBS), and Bleeding Time (BT) were measured. Then, the correlations between MetS and the above-mentioned variables were estimated. After all, the data were entered into the SPSS statistical software (v. 17) and analyzed using T-test, chi-square, median test, and spearman's rank correlation.

Results: In this study, 344 subjects (43%) met the ATP III criteria. The results showed a significant difference between MetS and non-MetS groups regarding BMI, white blood cell, total cholesterol, LDL, platelet, and high-sensitivity CPR (hs-CRP) (P < 0.0001, P = 0.040, P < 0.0001, P < 0.0001, and P = 0.045, respectively). Besides, waist circumference, Triglyceride (TG), FBS, and systolic and diastolic blood pressure were significantly higher, while HDL was significantly lower in the MetS group (P < 0.0001).

Conclusions: The incidence rate of MetS in our survey was higher compared to the previous reports. In addition, this incidence rate was higher in females in comparison to males. The results also showed a significant correlation between inflammatory biomarkers and MetS and that the higher levels of hs-CRP were associated with higher rate of MetS.

背景:有证据表明炎症可能参与了MetS的发病机制。炎症生物标志物作为代谢转移的有效预测指标正走向前沿。目的:本研究旨在评估MetS与一些炎症生物标志物之间的关系。患者和方法:本研究于2011 - 2013年在伊朗西部Borujerd地区随机抽取年龄在35岁以上的800名受试者，以社区为基础进行横断面研究。根据ATP III标准定义MetS，并将受试者分为两组(MetS组和非MetS组)。计算腰围和体重指数(BMI)。同时采集血样，测定c -反应蛋白(CRP)、血脂、空腹血糖(FBS)、出血时间(BT)。然后，估计met与上述变量之间的相关性。毕竟，数据输入SPSS统计软件(v. 17)，并使用t检验、卡方检验、中位数检验和spearman秩相关进行分析。结果:本组344例(43%)符合ATP III标准。结果显示，MetS组与非MetS组在BMI、白细胞、总胆固醇、LDL、血小板和高敏CPR (hs-CRP)方面存在显著差异(P < 0.0001, P = 0.040, P < 0.0001, P < 0.0001, P = 0.045)。腰围、甘油三酯(TG)、FBS、收缩压和舒张压显著升高，HDL显著降低(P < 0.0001)。结论:与以往报道相比，我们的调查中MetS的发生率更高。此外，与男性相比，女性的发病率更高。结果还显示炎症生物标志物与MetS之间存在显著相关性，高水平的hs-CRP与较高的MetS发生率相关。

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引用次数: 0

QT Dispersion after Thrombolytic Therapy. 溶栓治疗后QT离散度。

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2014-12-01

Saeed Oni Heris, Behzad Rahimi, Gholamreza Faridaalaee, Mojgan Hajahmadi, Hojjat Sayyadi, Bahman Naghipour

Background: QT dispersion (QTd) is equal to longer QTc minus shorter QTc measured by 12-lead electrocardiogram (ECG). QTd reflects inhomogeneity in repolarization of ventricular myocardium and because of easy and fast measurement of QTd, it can be used to predict high-risk patients for dysrhythmia after Acute Myocardial Infarction (AMI).

Objectives: This study aimed to assess the effect of thrombolytic therapy on QTd before and 1 hour and 4 days after beginning of thrombolytic therapy.

Patients and methods: The patients with chest pain and ST Elevated Myocardial Infarction (STEMI) that underwent thrombolytic therapy were enrolled into this study. Streptokinase was the thrombolytic agent in all the patients. Standard 12-lead (ECG) was evaluated before beginning of thrombolytic therapy (QTd 1) and 1 hour (QTd2) and 4 days (QTd3) after thrombolytic therapy. First, ECG was magnified × 10 for exact calculation of QT and QTd. After all, the variables were compared using one-way analysis of variance (ANOVA). Besides, P ≤ 0.05 was considered as statistically significant.

Results: This study was conducted on 160 patients. The results revealed no significant differences among QTd 1, QTd 2, and QTd 3 (P > 0.05). At inferior AMI, however, a significant difference was observed among QTd1, QTd2, and QTd3 (P = 0.031).

Conclusions: Thrombolytic therapy had no significant effects on QTd. Thus, thrombolytic therapy does not increase the risk of arrhythmia.

背景:QT离散度(QTd)等于12导联心电图(ECG)测量的较长QTc减去较短QTc。QTd反映了心室心肌复极的不均匀性，由于QTd测量简便、快速，可用于预测急性心肌梗死(AMI)后心律失常的高危患者。目的:本研究旨在评估溶栓治疗对溶栓治疗前、开始溶栓治疗1小时和开始溶栓治疗后4天QTd的影响。患者和方法:将胸痛合并ST段抬高型心肌梗死(STEMI)患者纳入本研究。所有患者的溶栓药物均为链激酶。在溶栓治疗开始前(qtd1)和溶栓治疗后1小时(QTd2)和4天(QTd3)评估标准12导联(ECG)。首先将心电图放大10倍，精确计算QT和QTd。毕竟，变量是使用单因素方差分析(ANOVA)进行比较的。P≤0.05为差异有统计学意义。结果:本研究共纳入160例患者。结果显示，QTd 1、QTd 2和QTd 3之间无显著差异(P > 0.05)。然而，在急性心肌梗死中，QTd1、QTd2和QTd3之间存在显著差异(P = 0.031)。结论:溶栓治疗对QTd无明显影响。因此，溶栓治疗不会增加心律失常的风险。

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引用次数: 0

Improvement of dilated cardiomyopathy with methylprednisolone in a patient with multiple fibrosclerosis. 甲强的松龙治疗多发性硬化症扩张型心肌病的疗效

IF 0.2 Q4 Medicine

International Cardiovascular Research Journal

Pub Date : 2014-12-01

Ibrahim Altun, Goksel Guz, Fatih Akin, Nuri Kose, Ilknur Altun, Zeki Yuksel Gunaydin, Cem Sahin

Multifocal fibrosclerosis is a rare syndrome of unknown cause that is characterized by fibrosis involving multiple organ systems. Definitive diagnosis can only be made based on biopsy findings. In this case, the biopsy specimen of the patient demonstrates pulmonary hyalinated granuloma or sclerosing mediastinitis. There are few reports of multiple fibrosclerosis with heart failure. Here, we reported a case of retroperitoneal fibrosis with massive mediastinal involvement extending to pleura and pericardium causing pleuro- pericardial effusion with dilated cardiomyopathy. Systolic dysfunction was improved and pericardial effusion disappeared with methylprednisolone treatment.

多灶性纤维硬化是一种病因不明的罕见综合征，其特点是多器官系统纤维化。明确的诊断只能根据活检结果作出。本例患者活检标本显示肺透明肉芽肿或硬化性纵隔炎。多发性硬化症合并心力衰竭的报道很少。在此，我们报告一例腹膜后纤维化伴大量纵隔累及胸膜和心包膜，引起胸膜-心包积液并扩张性心肌病。甲强的松龙治疗可改善收缩功能障碍，心包积液消失。

引用次数: 0