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Carrageenan: Future Potential Ingredient of Lubricant and Feminine Hygiene Product with Possible Protection Effects against HPV Infection 卡拉胶:未来潜在的润滑剂和女性卫生产品成分,可能对HPV感染有保护作用
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-01-16 DOI: 10.15255/kui.2022.032
J. Jumardi, R. Arfah, N. U. Permatasari
The discovery that human papillomavirus (HPV) infection is the primary cause of cervical cancer has opened up new avenues for prevention. Carrageenans are attractive candidates for developing potential HPV prevention due to their actions against a wide range of viruses, mainly through the blocking of the viral attachment stage. In addition, they are characterised by low production costs, abundant availability, biodegradability, biocompatibility, and non-toxicity. This review presents an overview of in vitro and in vivo studies of carrageenan antiviral properties, availability, and future liquid-sexual material. Based on the results of previous studies, both in vitro and in vivo carrageenan has the potential to be applied as a lubricant and feminine cleanser because it can reduce HPV infection, is non-toxic, and non-allergenic.
人类乳头瘤病毒(HPV)感染是宫颈癌的主要原因,这一发现为预防宫颈癌开辟了新的途径。卡拉胶是开发潜在的HPV预防的有吸引力的候选者,因为它们对多种病毒的作用,主要是通过阻断病毒的附着阶段。此外,它们还具有生产成本低、可利用性丰富、可生物降解性、生物相容性和无毒性等特点。本文综述了卡拉胶抗病毒特性、可用性和未来液体性材料的体外和体内研究概况。根据先前的研究结果,体外和体内的卡拉胶都有可能被用作润滑剂和女性清洁剂,因为它可以减少HPV感染,无毒,无过敏性。
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引用次数: 2
Transition towards Carbon Footprint Reduction and Energy Intensification in Natural Gas Reforming 天然气重整向减少碳足迹和强化能源转型
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2023-01-16 DOI: 10.15255/kui.2022.037
N. Zečević, O. Brasseur
One of the possible options for carbon footprint reduction in ammonia production is energy intensification of the natural gas reformer furnace. This paper addresses how process modelling and simulation concepts can be combined with proven meth-ods such as minimum energy consumption analysis and heat exchanger networks to identify and optimise the main bottlenecks in natural gas reformer furnaces. The main outcome is finding the best possible reconstruction options for natural gas savings and related CO 2 reduction. The applied method delivered an overall reduction of natural gas of 834 m 3 h −1 or 0.51 GJ with accompanying carbon footprint reduction of 0.026 t CO 2 per ton of NH 3 produced. A large part of EU’s ammonia producers will be able to reach net zero emissions by 2050 by following the policy initiatives of the “Green Deal” thanks to this case study. In addition, it provides the basis for the further execution of other possible non-conventional retrofit measures.
减少氨生产中碳足迹的可能选择之一是天然气重整炉的能源强化。本文介绍了如何将过程建模和模拟概念与已证实的方法相结合,如最小能耗分析和换热器网络,以识别和优化天然气转化炉的主要瓶颈。主要结果是找到了节省天然气和减少相关二氧化碳的最佳重建方案。所应用的方法使天然气的总减少量为834 m 3 h−1或0.51 GJ,同时每生产一吨NH3,碳足迹减少0.026 t CO2。得益于这一案例研究,通过遵循“绿色协议”的政策举措,到2050年,欧盟大部分氨生产商将能够实现净零排放。此外,它还为进一步执行其他可能的非常规改造措施提供了基础。
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引用次数: 0
Drying Process of Cement Mortar Composites Reinforced with Cellulosic Fibres: Experiment and Mathematical Modelling 纤维素纤维增强水泥砂浆复合材料干燥过程的实验与数学建模
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-11-17 DOI: 10.15255/kui.2022.010
Amina Lachenani‬, M. Bentchikou, Mouloud Boumahdi, S. Hanini, M. Laidi
In this paper, six novel mathematical models based on semi-empirical calculus are proposed and applied to characterise the oven-drying process of cement mortar composites reinforced with cellulosic fibres (CMCRCFs). The drying experiments were carried out on four levels of oven-drying temperatures (70, 85, 105, and 120 ° C), with four different cellulosic fibres content (0, 5, 10, and 20 %). Obtained results were compared to those derived by regression analysis of six most typically used math ematical drying models (Newton, Page, Page modified1, Page modified2, Handerson Pabis, and Logarithmic) in addition to six proposed models. The regression accuracy of the drying process was evaluated by the coefficient of determination ( R 2 ), low mean square error (MSE), low root mean squared error (RMSE), and mean absolute error (MAE). Additional criteria were used to ensure more validity of the selected models. The obtained values indicate a highly accurate fit of the proposed model MR9, meaning that the proposed model can clearly interpret the experimental drying data and predict the dry state of CMCRCFs.
本文提出了六个基于半经验微积分的新数学模型,并将其应用于表征纤维素纤维增强水泥砂浆复合材料的烘箱干燥过程。干燥实验在四个水平的烘箱干燥温度(70、85、105和120°C)下进行,四种不同的纤维素纤维含量(0、5、10和20%)。除了六个提出的模型外,还将获得的结果与六个最常用的数学干燥模型(牛顿、佩奇、佩奇修正1、佩奇修正2、Handerson-Pabis和对数)的回归分析得出的结果进行了比较。干燥过程的回归精度通过决定系数(R2)、低均方误差(MSE)、低方根误差(RMSE)和平均绝对误差(MAE)来评估。使用了额外的标准来确保所选模型的有效性。所获得的值表明所提出的模型MR9具有高度精确的拟合,这意味着所提出的模式可以清楚地解释实验干燥数据并预测CMCRCF的干燥状态。
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引用次数: 0
Boric Acid Modified Chitosan Scaffolds Chemically Crosslinked by Genipin Genipin化学交联硼酸改性壳聚糖支架
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-11-17 DOI: 10.15255/kui.2022.018
Luka Dornjak, Karla Ostojić, Teodoro Klaser, Inga Urlić, Anamarija Rogina
Chitosan scaffolds are an effective biologically active material with versatile application in chemistry and medicine. Chitosan is a linear polysaccharide, a derivative of chitin, with great biocompatibility due to the possession of functional groups such as −OH and −NH 2 , which allow for biodegradability and antibacterial function. Chitosan has a polycation nature allowing complex formation with metal ions and many biomolecules such as DNA, proteins and lipids, while its specific structure and functional groups are responsible for antibacterial, hemostatic, and analgesic properties. To improve its angiogenic and antimi- crobial potential, chitosan can be modified by boron (borate ions). The aim of this work was to prepare boric acid modified chitosan scaffolds, using boric acid as a boron precursor, as potential bioactive scaffolds for tissue regeneration. Borate ions tend to form complexes with hydroxyl groups, however, such physical interactions between boron and chitosan functional groups result in poor encapsulation efficiency. To ensure higher boron incorporation, chitosan scaffolds were cross-linked by genipin, a cross linker with lower cytotoxicity in contrast to glutaraldehyde commonly used to prepare stable chitosan-based materials. The degree of deacetylation ( DD ) and concentration of chitosan solution as well as the concentration of a solvent are impor tant parameters that affect the crosslinking process. Moreover, the addition of boric acid could interfere with the crosslinking process by occupying chitosan functional groups. Here, chitosan scaffolds were modified with different concentrations of boric acid, while the concentrations of chitosan solution (1.2 w/v), genipin (2 % w/w), and acetic acid (0.5 % v/v) were kept constant. Obtained scaffolds were characterised by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), differential scanning calorimetry (DSC), Fourier transformation infrared spectroscopy (FTIR), while cytotoxicity was evaluated as a function of materials concentration and exposure time. The results indicated successful incorporation of boron into crosslinked chitosan scaffolds with highly porous structure and low cytotoxicity.
壳聚糖支架是一种有效的生物活性材料,在化学和医学领域有着广泛的应用。壳聚糖是一种线性多糖,是甲壳素的衍生物,由于具有−OH和−NH2等官能团,具有良好的生物相容性,具有生物降解性和抗菌功能。壳聚糖具有聚阳离子性质,允许与金属离子和许多生物分子(如DNA、蛋白质和脂质)形成复合物,而其特定的结构和官能团负责抗菌、止血和镇痛性能。为了提高壳聚糖的血管生成和抗菌潜力,可以用硼(硼酸盐离子)对其进行改性。本工作的目的是以硼酸为硼前体,制备硼酸修饰的壳聚糖支架,作为组织再生的潜在生物活性支架。硼酸盐离子倾向于与羟基形成络合物,然而,硼和壳聚糖官能团之间的这种物理相互作用导致较差的包封效率。为了确保更高的硼掺入,壳聚糖支架通过染料木酚交联,染料木酚是一种交联剂,与通常用于制备稳定壳聚糖基材料的戊二醛相比,其细胞毒性更低。脱乙酰度(DD)、壳聚糖溶液的浓度以及溶剂的浓度是影响交联过程的重要参数。此外,硼酸的加入可能通过占据壳聚糖官能团来干扰交联过程。在此,用不同浓度的硼酸对壳聚糖支架进行改性,同时保持壳聚糖溶液(1.2w/v)、京尼平(2%w/w)和乙酸(0.5%v/v)的浓度不变。通过扫描电子显微镜(SEM)、能量色散X射线光谱(EDS)、差示扫描量热法(DSC)、傅立叶变换红外光谱(FTIR)对所获得的支架进行表征,同时将细胞毒性作为材料浓度和暴露时间的函数进行评估。结果表明,硼成功地掺入交联壳聚糖支架中,具有高度多孔结构和低细胞毒性。
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引用次数: 0
Razdvajanje faza u sustavu La0.5Sr0.5MnO3
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-11-17 DOI: 10.15255/kui.2022.016
Andreja Žužić, J. Macan
Perovskites are investigated as potential working materials in new technologies, such as solid ox - ide fuel cells, thermochemical energy storage, and magnetic refrigerators. They are interesting due to their application properties, such as electrical conductivity, ferromagnetic properties, and reducibility. Properties of perovskites can be improved by doping and the formation of structural defects. The aim of this work was to investigate the possibility of preparing Sr-doped lanthanum manganite with the chemical formula La 0.5 Sr 0.5 MnO 3 by coprecipitation procedure, and to analyse the observed phase separation. The material was prepared by procedure in which sources of metal cations (La 3+ , 2+ phase, especially when in tablet form.
钙钛矿在固体氧化物燃料电池、热化学储能和磁性冰箱等新技术中具有潜在的应用前景。由于它们的应用特性,如导电性、铁磁性和可还原性,它们很有趣。通过掺杂和结构缺陷的形成可以改善钙钛矿的性能。本文的目的是研究用共沉淀法以La 0.5 Sr 0.5 mno3的化学式制备Sr掺杂锰酸镧的可能性,并分析所观察到的相分离情况。该材料的制备过程中,金属阳离子(la3 +, 2+相)的来源,特别是片剂形式。
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引用次数: 0
Combined Application of Membrane and Advanced Oxidation Processes for Removal of Pharmaceuticals from Water 膜法和高级氧化法联合应用于水中药物的去除
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-11-17 DOI: 10.15255/kui.2022.008
Josipa Papac Zjačić, Silvia Morović, K. Košutić, D. Ašperger
The presence of pharmaceuticals in the aquatic environment is problematic in many aspects, mainly due to their specific mode of action, and physical and chemical properties that make them highly resistant to degradation. This new group of contaminants is frequently detected in conventional wastewater treatment plants. Removal of pharmaceuticals from water by primary and secondary methods (filtration, sedimentation, biological treatment) is not satisfactory, therefore advanced methods involving membrane and advanced oxidation processes are increasingly being de -veloped. The most significant advantage of membrane technologies is their wide industrial applicability while maintaining the highest water standards. Advanced oxidation processes can effectively decompose complex pollutants into simpler ones, and mineralize organic pollutants in wastewater without generating secondary waste. In order to improve their advantages, but also to eliminate disadvantages, these technologies are increasingly complemented and combined, resulting in higher efficiency in removing pharmaceuticals from water and reducing their toxicity.
药物在水生环境中的存在在许多方面都存在问题,主要是由于其特定的作用模式以及使其具有高度抗降解性的物理和化学性质。在传统的污水处理厂中经常检测到这种新的污染物。通过一级和二级方法(过滤、沉淀、生物处理)从水中去除药物并不令人满意,因此越来越多地开发涉及膜和高级氧化工艺的先进方法。膜技术最显著的优点是其广泛的工业适用性,同时保持最高的水标准。先进的氧化工艺可以有效地将复杂的污染物分解成更简单的污染物,并在不产生二次废物的情况下矿化废水中的有机污染物。为了提高它们的优势,同时也为了消除缺点,这些技术越来越多地得到补充和组合,从而提高了从水中去除药物的效率并降低了它们的毒性。
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引用次数: 1
Poboljšana ekstrakcija fenolnih spojeva iz kore mandarine primjenom visokonaponskog električnog pražnjenja: Utjecaj procesnih parametara i optimizacija
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-11-17 DOI: 10.15255/kui.2022.023
Marija Banožić, Silvija Šafranko, Dora Bogadi, K. Aladić, S. Jokić
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引用次数: 0
Mjere dezinfekcije i sanitacije u akreditiranom ispitnom laboratoriju – osvrt na COVID-19 infekciju
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-11-17 DOI: 10.15255/kui.2022.015
Rea Janda, Nataša Mikulec, Damir Andabaka, Ksenija Vitale
Living and working environments are most often closed spaces where it is necessary to provide health protection for family members and employees. Some activities require special protection, especially during a pandemic. The living and working environments can be kept clean and tidy in three ways: by cleaning, disinfecting, and sanitising. This paper presents a review of the literature linking disinfectants, their use, and resistance of microorganisms to disinfectants. In addition, it gives an overview of critical points that have arisen in various testing laboratories in the Republic of Croatia, related to the COVID-19 pandemic, and as a consequence of the lack of guidelines in norms. The literature search was conducted based on the keyword 'disinfection' in PubMed, Science Direct, Web of Science, Scopus and Google Scholar databases, and on the CDC and HZJZ websites due to the latest recommendations regarding COVID-19 infections. Results have shown that a norm is a basic document that needs a specific upgrade depending on the type of laboratory and its activities, and it should not be an independent decision of each individual laboratory. Based on the identified needs and problems, state institutions should provide detailed instructions depending on the laboratory activity. Therefore, this situation and the experience gained should be used as a starting point for document development that could be applicable in crisis states generally. In addition, it could be used as a basis for education and training in crisis states.
生活和工作环境通常是封闭空间,因此有必要为家庭成员和雇员提供健康保护。有些活动需要特别保护,特别是在大流行期间。生活和工作环境可以通过三种方式保持干净整洁:清洁、消毒和消毒。本文综述了有关消毒剂、消毒剂的使用和微生物对消毒剂的耐药性的文献。此外,报告还概述了克罗地亚共和国各检测实验室因COVID-19大流行以及规范中缺乏指导方针而出现的关键点。根据最新的COVID-19感染建议,在PubMed、Science Direct、Web of Science、Scopus和谷歌Scholar数据库以及CDC和HZJZ网站上以“消毒”为关键词进行文献检索。结果表明,规范是一项基本文件,需要根据实验室的类型及其活动进行具体的升级,而不应由每个实验室独立决定。根据确定的需求和问题,国家机构应根据实验室活动提供详细的说明。因此,这种情况和所获得的经验应该作为文件开发的起点,可以普遍适用于危机状态。此外,它还可以作为危机国家教育和培训的基础。
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引用次数: 0
Adsorpcija Zn(II) iona na metalurškom otpadu 金属废物中的Zn(II)离子
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-11-17 DOI: 10.15255/kui.2022.013
Anita Štrkalj, Luka Mesek, Vesna Ocelić Bulatović, Zoran Glavaš
adsorption isotherm models. It was found that the Langmuir model is more appropriate, and that adsorption takes place as chemisorption.
吸附等温线模型。发现Langmuir模型更为合适,吸附以化学吸附的方式进行。
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引用次数: 0
Ispitivanje fizikalno-kemijske kompatibilnosti lijekova primjenom analitičkih tehnika: pregled istraživanja razvoja fiksne kombinacije 5-aminosalicilata i folne kiseline 应用分析技术进行理化相容性研究:固定5-氨基水杨酸和叶酸的研究
IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-11-17 DOI: 10.15255/kui.2022.014
M. Jeličić
Skupina protuupalnih lijekova pod nazivom 5-aminosalicilati upotrebljava se u ranoj fazi liječenja upalnih bolesti crijeva s ciljem postizanja remisije i sprječavanja relapsa bolesti.1 U skupinu 5-aminosalicilata spadaju protuupalni lijek mesalazin, odnosno 5-aminosalicilna kiselina te njezina tri prolijeka; sulfasalazin, balsalazid i olsalazin (slika 1). Terapijski učinak “prvog” 5-aminosalicilata, sulfasalazina, otkriven je početkom 19. stoljeća, a tek se naknadnim studijama utvrdilo da mesalazin, sastavnica njegove strukture djeluje protuupalno.2,3 Sulfasalazin se uspješno upotrebljava u liječenju upalnih bolesti crijeva još i danas, međutim poznato je da sulfapiridin, antibiotik vezan za mesalazin azo vezom, uzrokuje nuspojave kod gotovo trećine paciIspitivanje fizikalno-kemijske kompatibilnosti lijekova primjenom analitičkih tehnika: pregled istraživanja razvoja fiksne kombinacije 5-aminosalicilata i folne kiseline https://doi.org/10.15255/KUI.2022.014 KUI-63/2022 Pregled Prispjelo 22. veljače 2022. Prihvaćeno 6. travnja 2022.
一组名为5-氨基水杨酸的抗炎药用于炎症性肠病治疗的早期阶段,以达到缓解和预防复发。1在5-氨基水杨酸组中,抗炎药物,即5-氨基水杨酸及其三个弹簧会脱落。柳氮磺胺吡啶、巴沙拉嗪和奥沙拉嗪(坏1)。5-氨基水杨酸的治疗效果“第一次”是在基线19发现的。在最近的研究中,美沙拉秦的结构已被确定为具有避孕作用。2.3即使在今天,硫柳氮嗪也已成功用于治疗炎症性肠病,但众所周知,硫柳吡啶是一种与偶氮美沙拉秦相关的抗生素,近三分之一患者的不良反应药物物理化学兼容性与分析技术的研究:固定5-氨基水杨酸和叶酸的开发研究https://doi.org/10.15255/KUI.2022.014KUI-63/2022审查附录22。2022年2月通过6。2022年4月。
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引用次数: 0
期刊
Kemija u Industriji-Journal of Chemists and Chemical Engineers
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