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Non-traumatic abdominal surgical emergencies in children in Dapaong (TOGO) 大鹏儿童的非创伤性腹部手术急诊(多哥)
IF 1 Q3 Medicine Pub Date : 2023-10-11 DOI: 10.1016/j.ijso.2023.100697
Tamassi Bertrand Essobiyou , Sosso Piham Kebalo , Samuel Salem Laurent Ouedraogo , Alexandre Palissam Keheou , Mohamed Issa , Komla Gnassingbe , Ekoue David Dosseh

Introduction

Surgical abdominal emergencies in children are responsible for high morbidity and mortality. They are numerous and their management in Africa is difficult. The management of non-traumatic abdominal emergencies in children in a regional hospital in Togo is described.

Method

and study setting: This was a single-center, retrospective and descriptive study conducted over a 12-month period. It included all children aged 0–15 years treated at the hospital for non-traumatic abdominal surgical emergencies.

Results

We reported 217 cases of non-traumatic abdominal surgical emergencies in children. We noted a male predominance with a sex ratio of 1.57. Similarly, grandchildren were predominant (44.70 %). A low school attendance rate was noted (21.20 %) and the children were mostly from poor families (32.72 %). The average consultation time was 5.3 ± 1.03 days. Pain was the main symptom and was present in all children. An unprepared abdominal X-ray was the main imaging procedure performed (77.18 %). These conditions were dominated by peritonitis (56.68 %). These were mainly ileal perforations. All the children received surgical treatment. The postoperative course was marked by complications in 104 children (47,93 %) and 14 deaths (6,45 %).

Conclusion

Non-traumatic abdominal surgical emergencies in children are dominated by peritonitis in rural Togo. They could be related to poverty. An effective policy of universal access to health care is essential.

引言儿童腹部外科急症的发病率和死亡率较高。他们人数众多,在非洲的管理很困难。描述了多哥一家地区医院对儿童非创伤性腹部紧急情况的处理。方法和研究背景:这是一项为期12个月的单中心回顾性描述性研究。它包括所有在医院接受非创伤性腹部外科急诊治疗的0-15岁儿童。结果报告217例儿童非创伤性腹部外科急症。我们注意到男性占主导地位,性别比为1.57。同样,孙辈占主导地位(44.70%)。入学率低(21.20%),孩子大多来自贫困家庭(32.72%)。平均咨询时间为5.3±1.03天。疼痛是主要症状,所有儿童都有疼痛。未经准备的腹部X光检查是主要的成像程序(77.18%)。这些情况主要是腹膜炎(56.68%)。这些主要是回肠穿孔。所有的孩子都接受了手术治疗。术后发生并发症的儿童有104例(47.93%),死亡14例(6.45%)。结论多哥农村地区儿童非创伤性腹部外科急诊以腹膜炎为主。它们可能与贫困有关。普及医疗保健的有效政策至关重要。
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引用次数: 0
Jejunal perforation and multiple intestinal contusions following blunt abdominal trauma: A case report 钝性腹部外伤后空肠穿孔及多发肠挫伤1例
IF 1 Q3 Medicine Pub Date : 2023-10-11 DOI: 10.1016/j.ijso.2023.100695
Mahdi Hammami , Amine ben Safta , Imen Samaali , Salah Haddad , Iheb Sarhane , Hichem Jerraya , Ibtissem Bouasker , Ramzi Nouira

Introduction

and Importance: Trauma, particularly from motor vehicle accidents, causes significant morbidity and mortality worldwide. Isolated jejunal perforation resulting from blunt abdominal trauma is rare but challenging to diagnose. This article sheds light on this infrequent condition, emphasizing the need for early recognition for optimal outcomes.

Case presentation

A 30-year-old male presented with abdominal pain after a motor vehicle accident. Examination and tests showed signs of jejunal perforation. Urgent surgery revealed a 2 cm perforation, contusions, and deserosalizations. The perforation was repaired, and the patient recovered well postoperatively.

Clinical discussion

Blunt abdominal trauma is a major cause of injury, with motor vehicle accidents being prominent. Hollow visceral injuries, though rare, pose diagnostic and management challenges. In this context, recognizing the indications for surgical intervention is complex. Imaging, especially CT scans, plays a critical role in diagnosis. This case underscores the importance of CT findings in diagnosing and deciding the need for surgical exploration.

Conclusion

Isolated jejunal perforation from blunt abdominal trauma is rare but demands clinical attention. Timely diagnosis through CT scans and immediate surgical intervention are crucial for successful outcomes. Surgery involves careful exploration, repairing the perforation and associated injuries, and meticulous postoperative care. Research and knowledge sharing are vital for improving approaches and reducing complications and mortality in these cases.

引言和重要性:创伤,特别是机动车事故造成的创伤,在世界范围内造成严重的发病率和死亡率。由钝性腹部创伤引起的孤立性空肠穿孔是罕见的,但诊断起来很有挑战性。这篇文章阐明了这种罕见的情况,强调了早期识别最佳结果的必要性。病例介绍:一名30岁男性在一次机动车事故后出现腹痛。检查和化验显示有空肠穿孔的迹象。紧急手术显示有2厘米的穿孔、挫伤和脱臼。穿孔得到修复,病人术后恢复良好。临床讨论钝性腹部创伤是损伤的主要原因,机动车事故尤为突出。中空内脏损伤虽然罕见,但对诊断和管理提出了挑战。在这种情况下,识别手术干预的适应症是复杂的。影像学,尤其是CT扫描,在诊断中起着至关重要的作用。该病例强调了CT检查结果在诊断和决定手术探查需求方面的重要性。结论腹部钝性损伤引起的孤立性空肠穿孔是罕见的,但需要临床注意。通过CT扫描及时诊断和立即手术干预对成功的结果至关重要。手术包括仔细探查、修复穿孔和相关损伤,以及细致的术后护理。研究和知识共享对于改进这些病例的治疗方法、减少并发症和死亡率至关重要。
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引用次数: 0
Right esophageal lung with associated pulmonary vascular anomaly: A rare case report 右食管肺伴肺血管异常1例
IF 1 Q3 Medicine Pub Date : 2023-10-08 DOI: 10.1016/j.ijso.2023.100694
Samuel Sisay Hailu , Zerihun Gelashe Hailu , Fadil Nuredin Abrar , Nardos Mulu Admasu , Woubedel Kiflu Aklilu , Fisseha Temesgen Gebru , Tesfahunegn Hailemariam

Introduction and Importance

Congenital bronchopulmonary foregut malformation (CBPFM) is a rare anomaly in which either a lung, a lung lobe or a segment has a patent congenital communication to the upper gastrointestinal tract. In esophageal lung, an anomalous main bronchus arises from the esophagus rather than the trachea.

Case presentation

A male neonate was admitted with respiratory distress immediately following birth. Radiographic evaluation included chest radiograph, chest Ultrasound, chest CT and an upper gastrointestinal (GI) contrast study. A completely opaque right hemithorax was initially visualized and identified as esophageal lung with associated anomalous partial systemic arterial supply and venous drainage. A right posterolateral thoracotomy with pneumonectomy of the hypoplastic lung was performed. However, the patient died of respiratory failure on the first postoperative day.

Clinical discussion

Esophageal lung is an extremely rare form of CBPFM in which a main stem bronchus, usually the right one, is abnormally connected to the esophagus. The diagnosis is suggested by chest x-ray and confirmed by upper GI contrast study, which is also available in resource-poor settings. A CT scan with 3D volume rendered images can make a diagnosis, although difficulties remain. Pneumonectomy is the preferred treatment for most patients.

Conclusion

Esophageal lung is a rare congenital abnormality with few reported cases. Radiologists and pediatricians should have a high index of suspicion for this anomaly in cases of neonatal respiratory distress and a persistently opacified lung with focal air bronchogram(s) and pursue a timely confirmatory contrast study.

摘要外阴支气管肺前肠畸形(CBPFM)是一种罕见的异常,其肺、肺叶或肺段与上胃肠道有先天性通畅的交通。在食道肺中,异常的主支气管来自食道而不是气管。病例介绍:1例男婴出生后立即因呼吸窘迫入院。影像学评估包括胸片、胸部超声、胸部CT和上胃肠造影。完全不透明的右半胸最初可见并确定为食管肺,伴有部分全身动脉供应和静脉引流异常。右后外侧开胸并肺切除发育不全肺。然而,患者在术后第一天死于呼吸衰竭。单食道肺是一种极为罕见的CBPFM形式,其主要支气管(通常为右侧支气管)与食道异常相连。诊断建议通过胸部x线检查,并通过上消化道造影检查确认,这也可用于资源贫乏的地区。CT扫描和三维体渲染图像可以做出诊断,尽管仍然存在困难。全肺切除术是大多数患者的首选治疗方法。结论食管肺是一种罕见的先天性异常,文献报道较少。放射科医生和儿科医生在新生儿呼吸窘迫和持续肺混浊伴局灶性支气管空气征的病例中,应高度怀疑这种异常,并及时进行确证性对比研究。
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引用次数: 0
Unmasking BA.2.86 new COVID-19 variant : Genomic analysis to public health implications 揭示BA.2.86新COVID-19变体:对公共卫生影响的基因组分析
IF 1 Q3 Medicine Pub Date : 2023-10-07 DOI: 10.1016/j.ijso.2023.100692
Md Aminul Islam, Arun Sundar Mohana Sundaram, Sarawut Sangkham
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引用次数: 0
Artificial intelligence 2.0: Taking organoid intelligence a step ahead 人工智能2.0:将类器官智能向前推进一步
IF 1 Q3 Medicine Pub Date : 2023-10-05 DOI: 10.1016/j.ijso.2023.100693
Hitesh Chopra, Kavita Munjal, Talha Bin Emran
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引用次数: 0
The never-seen upsurge of eye flu cases in India: One more menace due to a virus 印度从未出现过的眼流感病例激增:又一种病毒带来的威胁
IF 1 Q3 Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.ijso.2023.100679
Ranjana Rohilla, Richa Agarwal, Aroop Mohanty, Hashem Abu Serhan, Ranjit Sah
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引用次数: 0
Outcomes of Endoscopic Retrograde Appendicitis Therapy (ERAT) Vs Laparoscopic Appendectomy (LA): A systematic review and meta-analysis 内镜逆行性阑尾炎治疗(ERAT)与腹腔镜阑尾切除术(LA)的结果:一项系统综述和荟萃分析
IF 1 Q3 Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.ijso.2023.100688
Sunil Basukala, Oshan Shrestha, Niranjan Thapa, Sagun Karki, Kabita Chaudhary, Kala Shrestha

Introduction

Endoscopic retrograde appendicitis therapy (ERAT) is a new colonoscopy-based, non-invasive procedure used in the management of acute appendicitis. The results and future prospects of ERAT seem promising. In this study, we aim to study and compare the outcomes of the management of acute appendicitis done through ERAT and laparoscopic appendectomy.

Methods

The protocol for this study was prospectively registered. Electronic databases were searched for relevant articles, and all the comparative studies that compared the results of ERAT and laparoscopic appendectomy published in English were included. The mean difference was used as an effect measure for continuous variables, and the odds ratio was used for dichotomous data.

Results

Compared to laparoscopic appendectomy, ERAT had 10.93 min lesser procedural time (MD: 10.93; 95% CI: (−14.46) – (−7.40); n = 404; I2 = 92%, p-value= < 0.00001), 5.46 times lesser odds of achieving technical success (OR: 5.46; 95% CI: 1.17–25.53; n = 329; I2 = 0%, p-value = 0.03), 14.25 times more odds of developing recurrence (OR: 14.25; 95% CI: 2.67–76.12; n = 327; I2 = 0%, p-value = 0.002), and cost of care was 611.99 USD lesser (MD: 611.99; 95% CI: (−940.48) – (−283.51); n = 204; I2 = 98%, p-value = 0.0003). Analysis of length of hospital stay and adverse events did not show a significant difference between the two groups.

Conclusion

ERAT is a safe and appendix-conserving procedure that has a lesser procedural time compared to laparoscopic appendectomy; however, recurrence and therapeutic failure remain higher in the ERAT group.

内镜下逆行性阑尾炎治疗(ERAT)是一种新的基于结肠镜检查的非侵入性手术,用于治疗急性阑尾炎。ERAT的结果和未来前景似乎很有希望。在这项研究中,我们的目的是研究和比较通过ERAT和腹腔镜阑尾切除术治疗急性阑尾炎的结果。方法前瞻性登记本研究的方案。在电子数据库中搜索相关文章,并包括所有以英语发表的比较ERAT和腹腔镜阑尾切除术结果的比较研究。平均差被用作连续变量的效应度量,比值比被用于二分数据。结果与腹腔镜阑尾切除术相比,ERAT的手术时间缩短了10.93min(MD:10.93;95%CI:(-14.46)-(-7.40);n=404;I2=92%,p值=<;0.00001),获得技术成功的几率低5.46倍(OR:5.46;95%CI:1.17–25.53;n=329;I2=0%,p值=0.03),复发几率高14.25倍(OR:14.25;95%CI:2.67–76.12;n=327;I2=0%,p价值=0.002),护理成本低611.99美元(MD:611.99;95%CI:(-940.48)–(-283.51);n=204;I2=98%,p值=0.0003)。住院时间和不良事件的分析显示两组之间没有显著差异。结论ERAT是一种安全、保存阑尾的手术,与腹腔镜阑尾切除术相比,手术时间更短;然而,ERAT组的复发率和治疗失败率仍然较高。
{"title":"Outcomes of Endoscopic Retrograde Appendicitis Therapy (ERAT) Vs Laparoscopic Appendectomy (LA): A systematic review and meta-analysis","authors":"Sunil Basukala,&nbsp;Oshan Shrestha,&nbsp;Niranjan Thapa,&nbsp;Sagun Karki,&nbsp;Kabita Chaudhary,&nbsp;Kala Shrestha","doi":"10.1016/j.ijso.2023.100688","DOIUrl":"https://doi.org/10.1016/j.ijso.2023.100688","url":null,"abstract":"<div><h3>Introduction</h3><p>Endoscopic retrograde appendicitis therapy (ERAT) is a new colonoscopy-based, non-invasive procedure used in the management of acute appendicitis. The results and future prospects of ERAT seem promising. In this study, we aim to study and compare the outcomes of the management of acute appendicitis done through ERAT and laparoscopic appendectomy.</p></div><div><h3>Methods</h3><p>The protocol for this study was prospectively registered. Electronic databases were searched for relevant articles, and all the comparative studies that compared the results of ERAT and laparoscopic appendectomy published in English were included. The mean difference was used as an effect measure for continuous variables, and the odds ratio was used for dichotomous data.</p></div><div><h3>Results</h3><p>Compared to laparoscopic appendectomy, ERAT had 10.93 min lesser procedural time (MD: 10.93; 95% CI: (−14.46) – (−7.40); n = 404; I<sup>2</sup> = 92%, p-value= &lt; 0.00001), 5.46 times lesser odds of achieving technical success (OR: 5.46; 95% CI: 1.17–25.53; n = 329; I<sup>2</sup> = 0%, p-value = 0.03), 14.25 times more odds of developing recurrence (OR: 14.25; 95% CI: 2.67–76.12; n = 327; I<sup>2</sup> = 0%, p-value = 0.002), and cost of care was 611.99 USD lesser (MD: 611.99; 95% CI: (−940.48) – (−283.51); n = 204; I<sup>2</sup> = 98%, p-value = 0.0003). Analysis of length of hospital stay and adverse events did not show a significant difference between the two groups.</p></div><div><h3>Conclusion</h3><p>ERAT is a safe and appendix-conserving procedure that has a lesser procedural time compared to laparoscopic appendectomy; however, recurrence and therapeutic failure remain higher in the ERAT group.</p></div>","PeriodicalId":43872,"journal":{"name":"International Journal of Surgery Open","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49888582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urgent concerns regarding the recent dengue outbreak in Bangladesh 对孟加拉国最近爆发的登革热的紧急关切
IF 1 Q3 Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.ijso.2023.100682
Md Ariful Haque, Nazifa Tahseen M.B.B.S; M.D, Tungki Pratama Umar M.B.B.S; M.D, Md Rifat Al Mazid Bhuiyan M.B.B.S; M.P.H, ArunSundar MohanaSundaram Ph.D, Sayed Abdulla Jami M.B.B.S; M.D, Syed AlfakharAli Shah M.S
{"title":"Urgent concerns regarding the recent dengue outbreak in Bangladesh","authors":"Md Ariful Haque,&nbsp;Nazifa Tahseen M.B.B.S; M.D,&nbsp;Tungki Pratama Umar M.B.B.S; M.D,&nbsp;Md Rifat Al Mazid Bhuiyan M.B.B.S; M.P.H,&nbsp;ArunSundar MohanaSundaram Ph.D,&nbsp;Sayed Abdulla Jami M.B.B.S; M.D,&nbsp;Syed AlfakharAli Shah M.S","doi":"10.1016/j.ijso.2023.100682","DOIUrl":"10.1016/j.ijso.2023.100682","url":null,"abstract":"","PeriodicalId":43872,"journal":{"name":"International Journal of Surgery Open","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48622814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practice of continuous positive airway pressure application in Neonatal Intensive Care Unit. Cross sectional study 持续气道正压通气在新生儿重症监护室的应用实践。横断面研究
IF 1 Q3 Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.ijso.2023.100666
Fentahun Gedamu Asress , Yonas Admasu Ferede , Wubie Birlie Chekol , Yosef Belay Bizuneh

Background

Continuous positive airway pressure (CPAP) is a simple, inexpensive, and gentle mode of respiratory support for neonates.This is beneficial for spontaneously breathing neonates by maintaining functional residual capacity in the alveoli to prevent atelectasis and improve oxygen exchange. The aim of this study was to assess the practice of continuous positive airway pressure application in neonatal intensive care.

Methods

A hospital based prospective observational descriptive study was conducted on 60 neonates from March 15, 2022 to July 30, 2022 at NICU Unit at XXX Comprehensive Specialized Hospital, July 2022, North-west Ethiopia.

Descriptive statistical analysis with SPSS version 25 was used.

Results

The overall practice of CPAP use were (73.4%), with assessment of parameters such as initial nursing care before initiation of CPAP (82.2%), Setting up of CPAP (94.1%), preparing the Baby for CPAP (65.3%), Connecting the nasal prong system to the neonate (50%), Methods of Securing CPAP device (96.7%), Performing safety check for Troubleshooting in CPAP (78.3%) and Monitor of CPAP and On-going assessments (46.6%).

Conclusion

The practice of CPAP application was good at Initial nursing care before initiation of CPAP, Setting up of CPAP, and Methods of Securing CPAP device. However, there was poor practice in connecting the nasal prong system to the neonate, preparing the Baby for CPAP, performing safety checks for troubleshooting in CPAP, Monitoring of CPAP and On-going assessments.

背景:持续气道正压通气(CPAP)是一种简单、廉价、温和的新生儿呼吸支持方式。这有利于新生儿自主呼吸,维持肺泡的功能剩余容量,防止肺不张,改善氧交换。本研究的目的是评估持续气道正压通气在新生儿重症监护中的应用。方法对2022年3月15日至2022年7月30日在埃塞俄比亚西北部XXX综合专科医院新生儿重症监护病房出生的60例新生儿进行前瞻性观察性描述性研究。采用SPSS version 25进行描述性统计分析。结果CPAP使用的总体实践情况为(73.4%),评估参数包括启动CPAP前的初始护理(82.2%)、CPAP的设置(94.1%)、为婴儿准备CPAP(65.3%)、将鼻刺系统与新生儿连接(50%)、固定CPAP设备的方法(96.7%)、进行CPAP故障排除的安全检查(78.3%)和CPAP监测及持续评估(46.6%)。结论CPAP应用实践在启动CPAP前的初始护理、CPAP的设置、CPAP装置的固定方法等方面做得很好。然而,在将鼻尖系统连接到新生儿,为婴儿进行CPAP准备,进行CPAP故障排除的安全检查,CPAP监测和持续评估方面的实践很差。
{"title":"Practice of continuous positive airway pressure application in Neonatal Intensive Care Unit. Cross sectional study","authors":"Fentahun Gedamu Asress ,&nbsp;Yonas Admasu Ferede ,&nbsp;Wubie Birlie Chekol ,&nbsp;Yosef Belay Bizuneh","doi":"10.1016/j.ijso.2023.100666","DOIUrl":"10.1016/j.ijso.2023.100666","url":null,"abstract":"<div><h3>Background</h3><p>Continuous positive airway pressure (CPAP) is a simple, inexpensive, and gentle mode of respiratory support for neonates.This is beneficial for spontaneously breathing neonates by maintaining functional residual capacity in the alveoli to prevent atelectasis and improve oxygen exchange. The aim of this study was to assess the practice of continuous positive airway pressure application in neonatal intensive care.</p></div><div><h3>Methods</h3><p>A hospital based prospective observational descriptive study was conducted on 60 neonates from March 15, 2022 to July 30, 2022 at NICU Unit at XXX Comprehensive Specialized Hospital, July 2022, North-west Ethiopia.</p><p>Descriptive statistical analysis with SPSS version 25 was used.</p></div><div><h3>Results</h3><p>The overall practice of CPAP use were (73.4%), with assessment of parameters such as initial nursing care before initiation of CPAP (82.2%), Setting up of CPAP (94.1%), preparing the Baby for CPAP (65.3%), Connecting the nasal prong system to the neonate (50%), Methods of Securing CPAP device (96.7%), Performing safety check for Troubleshooting in CPAP (78.3%) and Monitor of CPAP and On-going assessments (46.6%).</p></div><div><h3>Conclusion</h3><p>The practice of CPAP application was good at Initial nursing care before initiation of CPAP, Setting up of CPAP, and Methods of Securing CPAP device. However, there was poor practice in connecting the nasal prong system to the neonate, preparing the Baby for CPAP, performing safety checks for troubleshooting in CPAP, Monitoring of CPAP and On-going assessments.</p></div>","PeriodicalId":43872,"journal":{"name":"International Journal of Surgery Open","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49017346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and feasibility of stromal vascular fraction containing adipose derived stem cells obtained from freshly prepared lipoaspirate for treatment of complex anorectal fistulas- A novel approach 从新鲜制备的抽脂液中获得含有脂肪干细胞的间质血管部分用于治疗复杂肛瘘的有效性和可行性-一种新方法
IF 1 Q3 Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.ijso.2023.100686
Ibrahim Falih Noori , Qais Khadim Bakir , Ahmed Falih Noori

Background

Anal fistulas are relatively common. Despite diverse treatment modalities and tremendous advance and optimization of surgical approaches, considerable recurrence and high failure rates are not uncommon especially after surgery for complex anal fistulas. Therefore, autologous adipose-derived stem cell therapy for the treatment of complex perianal fistula can be an innovative and promising option with potential high cure rate and long-term healing.

Aim

To assess the efficacy and feasibility intralesional administration of stromal vascular fraction containing autologous, adipose-derived stem cells prepared from fresh lipoaspirate for management of complex and recurrent anal fistula.

Methods

Totally, 28 patients with complex perianal fistulas were enrolled in this prospective case-series study from March 2018 and August 2022. They were 22 male and 6 females patient) with 38.8 years average ages (ranges from 26 to 54 years). All patients were assigned to receive intralesional injection with autologous freshly prepared adipose-derived stem cells from lipoaspirate suction in a concentration of 1 × 107 cell/ml. The healing of fistulas, confirmed by clinical assessment and magnetic resonance imaging was evaluated at week 6 weeks, 12 weeks and 6 months after treatment. If no evidence of healing was not seen at 6 weeks, a second dose of same concentration was administered. In addition to fistula healing, adverse effect (functional outcomes), complications and procedure safety were also evaluated.

Results

The overall healing rate of fistulas treated by injection of ADSCs was 60.7% (17/28), while healing rate after first injection was 50% (14/28) and after second injection was 30% (3/10).Three patients were lost after first injection. During the follow up period of 6 months none of the patients who showed complete healing, recorded relapse of their fistulas (recurrence 0%). Further, none of the patients recorded complications or adverse reactions related to stem cell therapy during the study and none of them had worsening fecal incontinence during follow-up period. Postoperative pain assessed by.

VAS score was significantly low (>3). Fecal continence assessed by Wexner score of all patients was not changed or affected.

Conclusions

Injection of complex perianal fistulas by freshly prepared autologous ADSCs could be a valid and effective treatment modality. It is safe, feasible and minimally invasive procedure that lacks the risk of injury to anal sphincter complex, unlike other surgical procedures that endanger the anal continence.Further, second dose of ADSCs injection could improve the rate of healing, without adding adverse effects.

背景肛门瘘相对常见。尽管治疗方式多种多样,手术方法也取得了巨大进步和优化,但相当大的复发率和高失败率并不罕见,尤其是在复杂肛瘘手术后。因此,自体脂肪干细胞治疗复杂肛周瘘是一种创新且有前景的选择,具有潜在的高治愈率和长期愈合。目的评估用新鲜脂肪抽吸物制备的含有自体脂肪来源干细胞的基质血管部分在病变内给药治疗复杂和复发性肛瘘的疗效和可行性。方法从2018年3月至2022年8月,共有28例复杂肛周瘘患者参与本前瞻性病例系列研究。患者为22名男性和6名女性,平均年龄38.8岁(26至54岁)。所有患者都被分配接受病灶内注射,从脂肪抽吸中提取新鲜制备的自体脂肪干细胞,浓度为1×107细胞/ml。在治疗后第6周、12周和6个月,通过临床评估和磁共振成像确认瘘管的愈合情况。如果在6周时没有发现愈合的迹象,则给予相同浓度的第二剂。除了瘘管愈合外,还评估了不良反应(功能结果)、并发症和手术安全性。结果注射ADSCs治疗瘘管的总治愈率为60.7%(17/28),第一次注射后治愈率为50%(14/28),第二次注射后愈合率为30%(3/10)。三名患者在第一次注射后丢失。在6个月的随访期间,没有一名患者表现出完全愈合,记录到瘘管复发(复发率0%)。此外,在研究期间,没有一名患者记录到与干细胞治疗相关的并发症或不良反应,在随访期间,也没有一名病人的大便失禁恶化。通过VAS评分评估的术后疼痛显著较低(>;3)。通过Wexner评分评估的所有患者的排便控制没有改变或受到影响。结论新鲜制备的自体ADSCs注入复杂肛周瘘是一种有效的治疗方法。这是一种安全、可行且微创的手术,与其他危及肛门失禁的手术不同,它没有损伤肛门括约肌复合体的风险。此外,第二剂ADSCs注射可以提高愈合率,而不会增加不良反应。
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引用次数: 0
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International Journal of Surgery Open
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