Pub Date : 2025-11-10DOI: 10.1016/j.tetlet.2025.155896
Ying Xie , Lixu You , Yi Liu , Yinlong Lai
Indole propionates are essential precursors for the construction of indole-propionic acid with TRPC6 inhibitory activity. Herein, we developed a novel approach to multisubstituted indole propionates via isothiourea-catalyzed addition of aryl acetates to vinylimine intermediates, which are generated in situ from arylsulfonyl indoles under mild conditions. This new method features a broad substrate scope and good yields. Importantly, it enabled us to complete the concise syntheses of indole-propionic acid with TRPC6 inhibitory activity through the hydrolysis of indole propionate.
{"title":"Isothiourea-catalyzed addition of aryl acetates to vinylogous imine intermediates generated in situ from arylsulfonyl indoles","authors":"Ying Xie , Lixu You , Yi Liu , Yinlong Lai","doi":"10.1016/j.tetlet.2025.155896","DOIUrl":"10.1016/j.tetlet.2025.155896","url":null,"abstract":"<div><div>Indole propionates are essential precursors for the construction of indole-propionic acid with TRPC6 inhibitory activity. Herein, we developed a novel approach to multisubstituted indole propionates via isothiourea-catalyzed addition of aryl acetates to vinylimine intermediates, which are generated in situ from arylsulfonyl indoles under mild conditions. This new method features a broad substrate scope and good yields. Importantly, it enabled us to complete the concise syntheses of indole-propionic acid with TRPC6 inhibitory activity through the hydrolysis of indole propionate.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155896"},"PeriodicalIF":1.5,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-08DOI: 10.1016/j.tetlet.2025.155892
Yu-Tao Sun , Jing-Yao Zhou , Dong-En Wu , Mei Hong , Liang Wang
Enabled by the formation of electron donor−acceptor complexes, a photoinduced arylation of 3-acyl-substituted indoles using diaryliodonium triflate as the arylation reagent has been disclosed. No photocatalyst, oxidant or base are required for this transformation. The direct irradiation of the mixture of 3-acyl-substituted indoles and diaryliodonium triflates under visible light in acetonitrile afforded 2-aryl indoles in moderate to good yields.
{"title":"Photoinduced arylation of 3-acyl-substituted indoles with diaryliodonium triflates enabled by electron donor − acceptor complexes","authors":"Yu-Tao Sun , Jing-Yao Zhou , Dong-En Wu , Mei Hong , Liang Wang","doi":"10.1016/j.tetlet.2025.155892","DOIUrl":"10.1016/j.tetlet.2025.155892","url":null,"abstract":"<div><div>Enabled by the formation of electron donor−acceptor complexes, a photoinduced arylation of 3-acyl-substituted indoles using diaryliodonium triflate as the arylation reagent has been disclosed. No photocatalyst, oxidant or base are required for this transformation. The direct irradiation of the mixture of 3-acyl-substituted indoles and diaryliodonium triflates under visible light in acetonitrile afforded 2-aryl indoles in moderate to good yields.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155892"},"PeriodicalIF":1.5,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-08DOI: 10.1016/j.tetlet.2025.155893
Suchandra Bhattacharjee, Sushmita Gajurel
The Ugi reaction is one of the prevailing multicomponent reactions (MCR) and has evolved into a vital part of contemporary synthetic chemistry. In recent years, using alternate reagents for the Ugi reaction and developing new catalysts have significantly expanded the substrate scope of this specific reaction. The reactions are increasingly being used in novel ways, particularly in materials science and medicinal chemistry. Therefore, there is a need for a comprehensive review article that helps to summarize the existing research articles, provides a relative analysis, and identifies the research gap. This mini review considers the recent developments in Ugi chemistry, mainly from the period 2020–2025, emphasizing the significant advances in reaction conditions, key innovations in substrate diversity, and their applications in medicinal chemistry, including site-selective protein bioconjugation and drug developments. Great attention is placed on the sustainable synthetic approaches, including the use of nano- and photocatalysts, visible-light-mediated synthesis, and the Ugi products synthesized from plant extracts. The review also highlights the advances in enantioselective Ugi reactions facilitated by chiral catalysts and the development of atropisomeric scaffolds. Besides these, it explores the growing utility of the reaction in constructing complex molecular architectures like heterocycles, spirocycles, peptidomimetics, glycomimetics, and functional polymers. In general, this article presents a detailed and current overview of the changing landscape of the Ugi chemistry and outlines future guidelines for its application in both academic as well as commercial research.
{"title":"Revisit the progress in the Ugi reaction: notable advances in synthesis and applications","authors":"Suchandra Bhattacharjee, Sushmita Gajurel","doi":"10.1016/j.tetlet.2025.155893","DOIUrl":"10.1016/j.tetlet.2025.155893","url":null,"abstract":"<div><div>The Ugi reaction is one of the prevailing multicomponent reactions (MCR) and has evolved into a vital part of contemporary synthetic chemistry. In recent years, using alternate reagents for the Ugi reaction and developing new catalysts have significantly expanded the substrate scope of this specific reaction. The reactions are increasingly being used in novel ways, particularly in materials science and medicinal chemistry. Therefore, there is a need for a comprehensive review article that helps to summarize the existing research articles, provides a relative analysis, and identifies the research gap. This mini review considers the recent developments in Ugi chemistry, mainly from the period 2020–2025, emphasizing the significant advances in reaction conditions, key innovations in substrate diversity, and their applications in medicinal chemistry, including site-selective protein bioconjugation and drug developments. Great attention is placed on the sustainable synthetic approaches, including the use of nano- and photocatalysts, visible-light-mediated synthesis, and the Ugi products synthesized from plant extracts. The review also highlights the advances in enantioselective Ugi reactions facilitated by chiral catalysts and the development of atropisomeric scaffolds. Besides these, it explores the growing utility of the reaction in constructing complex molecular architectures like heterocycles, spirocycles, peptidomimetics, glycomimetics, and functional polymers. In general, this article presents a detailed and current overview of the changing landscape of the Ugi chemistry and outlines future guidelines for its application in both academic as well as commercial research.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155893"},"PeriodicalIF":1.5,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145526006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A mild and efficient method for the nitro radical-mediated addition and cyclization of N-tethered 1,5-enenitriles is presented. Utilizing commercially available tert-butyl nitrite (t-BuONO) as a practical nitro radical source, this transformation enables the straightforward synthesis of a diverse range of nitro-substituted pyrrolidine-2,4-dione derivatives. The reaction proceeds under metal-free conditions, exhibits broad substrate scope, and offers operational simplicity, highlighting its potential for rapid access to pharmacologically relevant scaffolds.
{"title":"Nitro radical addition and cyclization of 1,5-enenitriles for making pyrrolidine-2,4-diones","authors":"Mifei Yu, Wentao Shao, Lingfeng Luo, Yue Zhang, Shenghu Yan, Jia-Yin Wang, Xiaoming Ma","doi":"10.1016/j.tetlet.2025.155881","DOIUrl":"10.1016/j.tetlet.2025.155881","url":null,"abstract":"<div><div>A mild and efficient method for the nitro radical-mediated addition and cyclization of <em>N</em>-tethered 1,5-enenitriles is presented. Utilizing commercially available <em>tert</em>-butyl nitrite (<em>t-BuONO</em>) as a practical nitro radical source, this transformation enables the straightforward synthesis of a diverse range of nitro-substituted pyrrolidine-2,4-dione derivatives. The reaction proceeds under metal-free conditions, exhibits broad substrate scope, and offers operational simplicity, highlighting its potential for rapid access to pharmacologically relevant scaffolds.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155881"},"PeriodicalIF":1.5,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.tetlet.2025.155891
Tao Zhao, Zixin Chen, Jinghan Bu, Mengyi Huang, Qiang Yang
A novel method involving difluorocarbene-mediated dehydration and desulfurization-cyanation of amides and thioamides has been developed. This approach facilitates the efficient conversion of diverse substrates—including alkyl, alkenyl, alkynyl, and aryl amides, as well as thioamides, urea, and amino acid derivatives—under transition-metal-free conditions without an inert atmosphere. Notably, this strategy provides a straightforward protocol for the late-stage cyanation modification of pharmaceutical amides and other bioactive molecules. The procedure is operationally simple, and some products require only extraction and purification, eliminating the need for column chromatography.
{"title":"Efficient cyanation of amides and thioamides via difluorocarbene-mediated dehydration and desulfurization","authors":"Tao Zhao, Zixin Chen, Jinghan Bu, Mengyi Huang, Qiang Yang","doi":"10.1016/j.tetlet.2025.155891","DOIUrl":"10.1016/j.tetlet.2025.155891","url":null,"abstract":"<div><div>A novel method involving difluorocarbene-mediated dehydration and desulfurization-cyanation of amides and thioamides has been developed. This approach facilitates the efficient conversion of diverse substrates—including alkyl, alkenyl, alkynyl, and aryl amides, as well as thioamides, urea, and amino acid derivatives—under transition-metal-free conditions without an inert atmosphere. Notably, this strategy provides a straightforward protocol for the late-stage cyanation modification of pharmaceutical amides and other bioactive molecules. The procedure is operationally simple, and some products require only extraction and purification, eliminating the need for column chromatography.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155891"},"PeriodicalIF":1.5,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.tetlet.2025.155877
Fereshteh Khorasani, Reza Ranjbar-Karimi
Herein, we introduce novel triazole compounds comprising a perhalopyridine (PFP or PCP) core as the host with a perhalogenated azide. The SNAr reactions of pentafluoropyridine at positions 4, 2, 6, and two positions 4, 2 were evaluated. Ultimately, a concise synthetic approach utilizing copper-promoted click chemistry (CuAAC) was employed to prepare a library of structurally diverse mono-, di, and tri-1,4-disubstituted-1,2,3-triazoles moieties of (fluoro-chloro) aryl. The chemical structures of the produced compounds were confirmed using various techniques such as FT-IR and NMR spectroscopy.
{"title":"Synthesis of new cluster compounds of triazoles containing perhalogenated azides and mono-, tri-perhalopropargyl cores as cages or hostage","authors":"Fereshteh Khorasani, Reza Ranjbar-Karimi","doi":"10.1016/j.tetlet.2025.155877","DOIUrl":"10.1016/j.tetlet.2025.155877","url":null,"abstract":"<div><div>Herein, we introduce novel triazole compounds comprising a perhalopyridine (PFP or PCP) core as the host with a perhalogenated azide. The S<sub>N</sub>Ar reactions of pentafluoropyridine at positions 4, 2, 6, and two positions 4, 2 were evaluated. Ultimately, a concise synthetic approach utilizing copper-promoted click chemistry (CuAAC) was employed to prepare a library of structurally diverse mono-, di, and tri-1,4-disubstituted-1,2,3-triazoles moieties of (fluoro-chloro) aryl. The chemical structures of the produced compounds were confirmed using various techniques such as FT-IR and NMR spectroscopy.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155877"},"PeriodicalIF":1.5,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145526005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1016/j.tetlet.2025.155874
T'ea P. Cameron , Tamam El-Elimat , Sonja L. Knowles , Huzefa A. Raja , Jacques Fournier , Steven P. Maher , Dennis E. Kyle , Nicholas H. Oberlies
Two new compounds were isolated from a freshwater fungus [Hongkongmyces sp. (strain G892)] by bioactivity-directed fractionation against Plasmodium falciparum. The structures of 1 and 2 were elucidated with the use of HRMS and NMR data, and their absolute configurations were identified by ECD spectroscopy. Compound 1 was evaluated for antiplasmodial activity against P. falciparum and cytotoxicity against human liver cancer cell lines.
{"title":"Soudanones H and I from a freshwater fungus Hongkongmyces sp.","authors":"T'ea P. Cameron , Tamam El-Elimat , Sonja L. Knowles , Huzefa A. Raja , Jacques Fournier , Steven P. Maher , Dennis E. Kyle , Nicholas H. Oberlies","doi":"10.1016/j.tetlet.2025.155874","DOIUrl":"10.1016/j.tetlet.2025.155874","url":null,"abstract":"<div><div>Two new compounds were isolated from a freshwater fungus [<em>Hongkongmyce</em>s sp. (strain G892)] by bioactivity-directed fractionation against <em>Plasmodium falciparum</em>. The structures of <strong>1</strong> and <strong>2</strong> were elucidated with the use of HRMS and NMR data, and their absolute configurations were identified by ECD spectroscopy. Compound <strong>1</strong> was evaluated for antiplasmodial activity against <em>P. falciparum</em> and cytotoxicity against human liver cancer cell lines.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155874"},"PeriodicalIF":1.5,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A metal-free aerobic epoxidation of olefins was achieved using V-70 (2,2′-azobis(2,4-dimethyl-4-methoxyvaleronitrile)) as a low-temperature radical initiator in combination with pivalaldehyde as a co-oxidant. The method operates under mild conditions with air as the oxidant, converting a broad range of olefins to epoxides in good to excellent yields. This protocol avoids hazardous peroxides, high-valent metal reagents, and halogenated solvents, offering an environmentally benign and practical approach to olefin epoxidation.
{"title":"Metal-free aerobic epoxidation of aromatic olefins using V-70 and pivalaldehyde","authors":"Yamato Kato, Miho Kanoh, Hazuki Itoh, Shiori Itoh, Sakura Tanaka, Takayuki Shioiri, Masato Matsugi","doi":"10.1016/j.tetlet.2025.155878","DOIUrl":"10.1016/j.tetlet.2025.155878","url":null,"abstract":"<div><div>A metal-free aerobic epoxidation of olefins was achieved using V-70 (2,2′-azobis(2,4-dimethyl-4-methoxyvaleronitrile)) as a low-temperature radical initiator in combination with pivalaldehyde as a co-oxidant. The method operates under mild conditions with air as the oxidant, converting a broad range of olefins to epoxides in good to excellent yields. This protocol avoids hazardous peroxides, high-valent metal reagents, and halogenated solvents, offering an environmentally benign and practical approach to olefin epoxidation.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155878"},"PeriodicalIF":1.5,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tetlet.2025.155880
Jia-Yu Jin , Fan Xu , Chun-Hao Du , Li-Na Zou , Ting Huang , Qin Ma , Ping Zhao , Zheng-Hui Li , Bao-Bao Shi , Ji-Kai Liu
Chemical investigation of the secondary metabolites of the aerial parts of Ophiorrhiza brevidentata H. S. Lo resulted in the isolation of a new pimarane-type diterpenoid glucoside, named ophiogluconoid A (1), along with a known biogenic precursor (2). Their structures were elucidated through extensive spectroscopic analysis. Ophiogluconoid A represents the first diterpenoid isolated from genus Ophiorrhiza. Additionally, it inhibited ConA-induced T cell proliferation (IC50 = 4.3 μM) and LPS-induced B cell proliferation (IC50 = 1.6 μM), demonstrating excellent selectivity indices (SI > 10).
{"title":"Ophiogluconoid A: The first pimarane-type diterpenoid glucoside with immunosuppressive activity from Ophiorrhiza brevidentata","authors":"Jia-Yu Jin , Fan Xu , Chun-Hao Du , Li-Na Zou , Ting Huang , Qin Ma , Ping Zhao , Zheng-Hui Li , Bao-Bao Shi , Ji-Kai Liu","doi":"10.1016/j.tetlet.2025.155880","DOIUrl":"10.1016/j.tetlet.2025.155880","url":null,"abstract":"<div><div>Chemical investigation of the secondary metabolites of the aerial parts of <em>Ophiorrhiza brevidentata</em> H. S. Lo resulted in the isolation of a new pimarane-type diterpenoid glucoside, named ophiogluconoid A (<strong>1</strong>), along with a known biogenic precursor (<strong>2</strong>). Their structures were elucidated through extensive spectroscopic analysis. Ophiogluconoid A represents the first diterpenoid isolated from genus <em>Ophiorrhiza</em>. Additionally, it inhibited ConA-induced T cell proliferation (IC<sub>50</sub> = 4.3 μM) and LPS-induced B cell proliferation (IC<sub>50</sub> = 1.6 μM), demonstrating excellent selectivity indices (SI > 10).</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155880"},"PeriodicalIF":1.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.tetlet.2025.155871
S. Karthik , C. Sandhya , Ch. Ajay , B. Sridhar , B.V. Subba Reddy
A highly efficient Rh(III)-catalyzed oxidative CH annulation of 3-arylisoquinolin-1-ones with diarylacetylenes has been developed for the synthesis of structurally diverse diaryl-8H-isoquinolino[3,2-a]isoquinolin-8-one scaffolds. This method offers special features such as excellent atom economy, broad substrate scope and high functional group tolerance, offering a valuable synthetic route for accessing polycyclic frameworks. It is a first example on the oxidative annulation of 3-arylisoquinolin-1-ones with alkynes employing a transition metal catalysis.
{"title":"Rh(III)-catalyzed oxidative CH annulation of 3-arylisoquinolin-1-ones with diarylalkynes: Direct access to fused isoquinolinone frameworks","authors":"S. Karthik , C. Sandhya , Ch. Ajay , B. Sridhar , B.V. Subba Reddy","doi":"10.1016/j.tetlet.2025.155871","DOIUrl":"10.1016/j.tetlet.2025.155871","url":null,"abstract":"<div><div>A highly efficient Rh(III)-catalyzed oxidative C<img>H annulation of 3-arylisoquinolin-1-ones with diarylacetylenes has been developed for the synthesis of structurally diverse diaryl-8<em>H</em>-isoquinolino[3,2-<em>a</em>]isoquinolin-8-one scaffolds. This method offers special features such as excellent atom economy, broad substrate scope and high functional group tolerance, offering a valuable synthetic route for accessing polycyclic frameworks. It is a first example on the oxidative annulation of 3-arylisoquinolin-1-ones with alkynes employing a transition metal catalysis.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155871"},"PeriodicalIF":1.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145414306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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