Pub Date : 2025-11-01DOI: 10.1016/j.tetlet.2025.155872
Dong Xia , Jinghong Yang , Hao Peng , Lihu Zhang , Xiaobo Bao
A new facile one pot tandem sulfonylation and 6-exo-trig cyzlization/dearomatization of biaryl ynones was developed. Under metal free conditions, diversified sulfonated spiro[5.5]trienones were prepared using disulfides as sulfonylating reagents.
{"title":"Disulfides as sulfonylation reagents for the synthesis of sulfonated spiro[5.5]trienones under metal free conditions","authors":"Dong Xia , Jinghong Yang , Hao Peng , Lihu Zhang , Xiaobo Bao","doi":"10.1016/j.tetlet.2025.155872","DOIUrl":"10.1016/j.tetlet.2025.155872","url":null,"abstract":"<div><div>A new facile one pot tandem sulfonylation and 6-<em>exo</em>-trig cyzlization/dearomatization of biaryl ynones was developed. Under metal free conditions, diversified sulfonated spiro[5.5]trienones were prepared using disulfides as sulfonylating reagents.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155872"},"PeriodicalIF":1.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-31DOI: 10.1016/j.tetlet.2025.155875
Vittal Seema , Murali Mohan Achari Kamsali , Laxman Mahadev Alakonda , Ravi Varala , Mohamed Hussein , Mohammed Mujahid Alam
Sodium hypophosphite (NaH₂PO₂) is an inexpensive, abundant, and environmentally friendly reagent widely used in organophosphorus synthesis. Its stability, low toxicity, and ease of handling make it a versatile “green” phosphorus source. This mini-review highlights recent developments (2019–2025) in its applications, including as a phosphorus donor, reducing agent, catalyst, deuterio-deiodinating agent, and deoxyamination reagent. Related reagents such as H₃PO₂ and Ca(H₂PO₂)₂ are also briefly discussed. Mechanistic insights are provided where relevant, alongside the advantages and limitations of current methodologies. This concise overview aims to guide researchers in harnessing hypophosphite reagents for efficient and sustainable organic synthesis.
{"title":"Mini-update on the applications of Hypophosphites in organic synthesis with a special focus on sodium hypophosphite (NaH2PO2)","authors":"Vittal Seema , Murali Mohan Achari Kamsali , Laxman Mahadev Alakonda , Ravi Varala , Mohamed Hussein , Mohammed Mujahid Alam","doi":"10.1016/j.tetlet.2025.155875","DOIUrl":"10.1016/j.tetlet.2025.155875","url":null,"abstract":"<div><div>Sodium hypophosphite (NaH₂PO₂) is an inexpensive, abundant, and environmentally friendly reagent widely used in organophosphorus synthesis. Its stability, low toxicity, and ease of handling make it a versatile “green” phosphorus source. This mini-review highlights recent developments (2019–2025) in its applications, including as a phosphorus donor, reducing agent, catalyst, deuterio-deiodinating agent, and deoxyamination reagent. Related reagents such as H₃PO₂ and Ca(H₂PO₂)₂ are also briefly discussed. Mechanistic insights are provided where relevant, alongside the advantages and limitations of current methodologies. This concise overview aims to guide researchers in harnessing hypophosphite reagents for efficient and sustainable organic synthesis.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155875"},"PeriodicalIF":1.5,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.tetlet.2025.155876
Durgesh Sarothiya, Abhinay S. Chillal, Umesh A. Kshirsagar
In this report, we established an efficient synthetic strategy for the construction of heterodiarylmethanes via the coupling of pyrazolo[1,5-a]pyrimidine and indole using rongalite as methylene source under metal-free conditions at room temperature in HFIP solvent. Rongalite was used as a relatively benign and metal-free reagent and cost-effective C1 synthon. The present methodology offers a total of 21 examples, moderate to good yields of products and easy operations under the mild conditions. The newly synthesized molecules represent a unique class of functionalized heterocycles with potential biological relevance.
{"title":"HFIP-promoted one-pot synthesis of (Pyrazolo[1,5-a]pyrimidinyl)(indolyl)methanes using Rongalite as a C1 synthon under mild conditions","authors":"Durgesh Sarothiya, Abhinay S. Chillal, Umesh A. Kshirsagar","doi":"10.1016/j.tetlet.2025.155876","DOIUrl":"10.1016/j.tetlet.2025.155876","url":null,"abstract":"<div><div>In this report, we established an efficient synthetic strategy for the construction of heterodiarylmethanes via the coupling of pyrazolo[1,5-<em>a</em>]pyrimidine and indole using rongalite as methylene source under metal-free conditions at room temperature in HFIP solvent. Rongalite was used as a relatively benign and metal-free reagent and cost-effective C1 synthon. The present methodology offers a total of 21 examples, moderate to good yields of products and easy operations under the mild conditions. The newly synthesized molecules represent a unique class of functionalized heterocycles with potential biological relevance.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155876"},"PeriodicalIF":1.5,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145463891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30Epub Date: 2025-08-05DOI: 10.1016/j.tetlet.2025.155765
Elizabeth A Davis, Megan S Hammett, Jonathan R Scheerer
This study explores the merged cycloaddition/cycloreversion of 1,4-oxazinone substrates with haloalkyne 2π reaction components. Haloalkynes proved generally competent in the Diels-Alder operation and exerted a small influence on the regioselection of the reaction sequence as compared to the reaction sequence with the derived terminal alkyne precursors. Following tandem cycloreversion and elimination of CO2, the haloalkynes showed a modest preference for formation of 4-halo pyridine products over 3-halo isomeric variants.
{"title":"Halogenated Pyridine Derivatives from Cycloaddition / Cycloreversion of Oxazinone and Haloalkyne Precursors.","authors":"Elizabeth A Davis, Megan S Hammett, Jonathan R Scheerer","doi":"10.1016/j.tetlet.2025.155765","DOIUrl":"10.1016/j.tetlet.2025.155765","url":null,"abstract":"<p><p>This study explores the merged cycloaddition/cycloreversion of 1,4-oxazinone substrates with haloalkyne 2π reaction components. Haloalkynes proved generally competent in the Diels-Alder operation and exerted a small influence on the regioselection of the reaction sequence as compared to the reaction sequence with the derived terminal alkyne precursors. Following tandem cycloreversion and elimination of CO<sub>2</sub>, the haloalkynes showed a modest preference for formation of 4-halo pyridine products over 3-halo isomeric variants.</p>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"170 ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-28DOI: 10.1016/j.tetlet.2025.155851
Maduabuchi Angus Modum , Stefan Smulik , James W. Kim , Andrea Gorrell , Kalindi D. Morgan
Transformation of L-sorbose via sequential acetonide protection, oxidation, and lactonization is a pivotal route towards vitamin C synthesis, yet traditional batch and large fermentation processes have not been radically re-imagined in decades. Herein, we report a step-wise flow platform that accomplishes three key transformations of L-sorbose in minutes with high yields and minimal purification. In the first module, L-sorbose undergoes diacetonide protection in a PTFE coil reactor at 0–5 °C, reaching 95 % (crude) conversion in 30 min. The protected sugar is then oxidized inline to the corresponding 2-keto-L-gluconic acid with final direct lactonization to l-ascorbic acid. Thus, under current conditions, the total conversion of L-sorbose to Vitamin C is achieved in 90 total minutes with 85 % crude Vitamin C yield and 57 % pure Vitamin C yield.
l -山梨糖通过连续的丙酮保护、氧化和内酯化转化是合成维生素C的关键途径，但传统的批量和大型发酵过程在几十年来没有从根本上重新设想。在此，我们报告了一个逐步流动平台，在几分钟内以高产量和最少的纯化完成l -山梨糖的三个关键转化。在第一个模块中，L-sorbose在0-5°C的聚四氟乙烯盘管反应器中接受二丙酮保护，在30分钟内达到95%（粗）转化率。然后，受保护的糖被氧化成相应的2-酮- l-葡萄糖酸，最后直接内酯化成l-抗坏血酸。因此，在目前的条件下，l -山梨糖到维生素C的总转化在90分钟内实现，粗维生素C收率为85%，纯维生素C收率为57%。
{"title":"Step-wise flow synthesis of l-ascorbic acid from L-sorbose","authors":"Maduabuchi Angus Modum , Stefan Smulik , James W. Kim , Andrea Gorrell , Kalindi D. Morgan","doi":"10.1016/j.tetlet.2025.155851","DOIUrl":"10.1016/j.tetlet.2025.155851","url":null,"abstract":"<div><div>Transformation of L-sorbose via sequential acetonide protection, oxidation, and lactonization is a pivotal route towards vitamin C synthesis, yet traditional batch and large fermentation processes have not been radically re-imagined in decades. Herein, we report a step-wise flow platform that accomplishes three key transformations of L-sorbose in minutes with high yields and minimal purification. In the first module, L-sorbose undergoes diacetonide protection in a PTFE coil reactor at 0–5 °C, reaching 95 % (crude) conversion in 30 min. The protected sugar is then oxidized inline to the corresponding 2-keto-L-gluconic acid with final direct lactonization to <span>l</span>-ascorbic acid. Thus, under current conditions, the total conversion of L-sorbose to Vitamin C is achieved in 90 total minutes with 85 % crude Vitamin C yield and 57 % pure Vitamin C yield.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155851"},"PeriodicalIF":1.5,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145414308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-25DOI: 10.1016/j.tetlet.2025.155873
Guiqin Yu , Xuming Liu , Yan Ming , Bei Wang, Xiang Liu
A novel benzindole-based donor–acceptor–donor (D–A–D) fluorescent probe (HST) has been rationally designed and synthesized for the highly selective and sensitive detection of hydrazine (N₂H₄). The sensing mechanism is based on the hydrazine-triggered nucleophilic addition to the conjugated double bond, which disrupts the intramolecular charge transfer (ICT) process, resulting in significant fluorescence quenching. HST demonstrates remarkable features including a large Stokes shift (136 nm), rapid response within 3 min, excellent selectivity, and a low detection limit (3.47 μM). Furthermore, HST enables direct, naked-eye recognition of hydrazine under both visible and UV light. These findings suggest HST as a promising tool for practical applications in environmental and biological hydrazine monitoring.
{"title":"Benzindole-based donor-acceptor-donor ratiometric-type fluorescent probe for hydrazine","authors":"Guiqin Yu , Xuming Liu , Yan Ming , Bei Wang, Xiang Liu","doi":"10.1016/j.tetlet.2025.155873","DOIUrl":"10.1016/j.tetlet.2025.155873","url":null,"abstract":"<div><div>A novel benzindole-based donor–acceptor–donor (D–A–D) fluorescent probe (HST) has been rationally designed and synthesized for the highly selective and sensitive detection of hydrazine (N₂H₄). The sensing mechanism is based on the hydrazine-triggered nucleophilic addition to the conjugated double bond, which disrupts the intramolecular charge transfer (ICT) process, resulting in significant fluorescence quenching. HST demonstrates remarkable features including a large Stokes shift (136 nm), rapid response within 3 min, excellent selectivity, and a low detection limit (3.47 μM). Furthermore, HST enables direct, naked-eye recognition of hydrazine under both visible and UV light. These findings suggest HST as a promising tool for practical applications in environmental and biological hydrazine monitoring.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155873"},"PeriodicalIF":1.5,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We developed a practical synthesis method for aliphatic sulfonyl fluorides through transition metal-free fluorosulfonylation strategy. The reaction of cyclopropanol with K2S2O5 and NFSI is enforced under mild conditions. This reaction system is suitable for cyclopropanols such as aryl, benzyl, and alkyl cyclopropanol, to achieve the corresponding sulfonyl fluoride compounds in moderate to good yields, wide substrate range, good compatibility, and simple operation.
{"title":"Transition metal-free fluorosulfonylation of cyclopropanol for the synthesis of aliphatic sulfonyl fluorides","authors":"Jianquan Hong, Qiang Wang, Xifei Chen, Shengying Gu, Chunxiang Li, Jie Wang, Xinxin Gong, Xiaoyu Wang, Feng Zheng, Changge Zheng","doi":"10.1016/j.tetlet.2025.155867","DOIUrl":"10.1016/j.tetlet.2025.155867","url":null,"abstract":"<div><div>We developed a practical synthesis method for aliphatic sulfonyl fluorides through transition metal-free fluorosulfonylation strategy. The reaction of cyclopropanol with K<sub>2</sub>S<sub>2</sub>O<sub>5</sub> and NFSI is enforced under mild conditions. This reaction system is suitable for cyclopropanols such as aryl, benzyl, and alkyl cyclopropanol, to achieve the corresponding sulfonyl fluoride compounds in moderate to good yields, wide substrate range, good compatibility, and simple operation.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155867"},"PeriodicalIF":1.5,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-22DOI: 10.1016/j.tetlet.2025.155865
Sangni Jiang , Zhihui Lu
This study presents a novel and cost-effective method for synthesizing aryl sulfonyl fluorides using economically accessible starting materials, including the Et3N·HF complex as a safe HF surrogate. Upon reaction with SO2, this reagent generates the fluorosulfonating reagent triethylamine fluorosulfinate (FSO2−Et3NH+) in-situ. Acting as both a reducing agent and a reactive intermediate, it enables efficient reactions with aromatic diazonium salts at room temperature without requiring additional oxidants. The approach facilitates the synthesis of diverse aryl sulfonyl fluorides in high yields, addressing limitations of prior methods that often rely on costly reagents or catalysts.
{"title":"Efficient synthesis of aryl sulfonyl fluorides via an economical reductive fluorosulfonation strategy under mild conditions","authors":"Sangni Jiang , Zhihui Lu","doi":"10.1016/j.tetlet.2025.155865","DOIUrl":"10.1016/j.tetlet.2025.155865","url":null,"abstract":"<div><div>This study presents a novel and cost-effective method for synthesizing aryl sulfonyl fluorides using economically accessible starting materials, including the Et<sub>3</sub>N·HF complex as a safe HF surrogate. Upon reaction with SO<sub>2</sub>, this reagent generates the fluorosulfonating reagent triethylamine fluorosulfinate (FSO<sub>2</sub><sup>−</sup>Et<sub>3</sub>NH<sup>+</sup>) in-situ<sub>.</sub> Acting as both a reducing agent and a reactive intermediate, it enables efficient reactions with aromatic diazonium salts at room temperature without requiring additional oxidants. The approach facilitates the synthesis of diverse aryl sulfonyl fluorides in high yields, addressing limitations of prior methods that often rely on costly reagents or catalysts.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155865"},"PeriodicalIF":1.5,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-21DOI: 10.1016/j.tetlet.2025.155869
Sai Zhao , Lijuan Zhu , Nian Tong , Qi Qi
A novel synthetic route has been developed for the preparation of a key drug impurity of alectinib, a highly potent ALK inhibitor used in the treatment of non-small cell lung cancer. This impurity, designated as compound 1 and chemically identified as 9-ethyl-6,6-dimethyl-8-[4-(1,4-oxazinan-4-yl)hexahydropyridin-1-yl]-11-oxo-6,11-dihydrobenzo[d]naphtho[3,2-b]furan-3‑carbonitrile, originates from the initial cyclization step in the synthetic procedure of alectinib. In comparison to the method described in the patent, the new route offers several advantages, including higher yields, reduced Pd catalyst loading, and enhanced sustainability. This approach is expected to contribute significantly to the advancement of process chemistry and to improved quality control in the manufacture of alectinib.
{"title":"A novel synthetic route to a process-related impurity of alectinib","authors":"Sai Zhao , Lijuan Zhu , Nian Tong , Qi Qi","doi":"10.1016/j.tetlet.2025.155869","DOIUrl":"10.1016/j.tetlet.2025.155869","url":null,"abstract":"<div><div>A novel synthetic route has been developed for the preparation of a key drug impurity of alectinib, a highly potent ALK inhibitor used in the treatment of non-small cell lung cancer. This impurity, designated as compound <strong>1</strong> and chemically identified as 9-ethyl-6,6-dimethyl-8-[4-(1,4-oxazinan-4-yl)hexahydropyridin-1-yl]-11-oxo-6,11-dihydrobenzo[<em>d</em>]naphtho[3,2-b]furan-3‑carbonitrile, originates from the initial cyclization step in the synthetic procedure of alectinib. In comparison to the method described in the patent, the new route offers several advantages, including higher yields, reduced Pd catalyst loading, and enhanced sustainability. This approach is expected to contribute significantly to the advancement of process chemistry and to improved quality control in the manufacture of alectinib.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155869"},"PeriodicalIF":1.5,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145414307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-21DOI: 10.1016/j.tetlet.2025.155868
Na Wang , Xilan Jiang , Yujiao He , Mengqi Wang , Yuanwei You , Yufei Che , Dexiu Cui , Hongbo Dong
Acronyculatin S is a naturally occurring benzofuran derivative isolated from Acronychia pedunculata and has been reported to exhibit antibacterial activity. In this study, the first total synthesis of acronyculatin S was achieved through a concise and scalable route involving a Friedel–Crafts acylation, a Sonogashira coupling, and an europium(III)-catalyzed Claisen rearrangement as key steps. However, antibacterial evaluation of the synthetic sample against a panel of Gram-positive bacterial strains revealed no significant inhibitory activity under the tested conditions (MIC > 64 μg/mL). This work provides a reliable synthetic route for accessing acronyculatin S and related analogues, facilitating further studies on the chemical and biological properties of this class of natural products.
{"title":"First total synthesis of acronyculatin S","authors":"Na Wang , Xilan Jiang , Yujiao He , Mengqi Wang , Yuanwei You , Yufei Che , Dexiu Cui , Hongbo Dong","doi":"10.1016/j.tetlet.2025.155868","DOIUrl":"10.1016/j.tetlet.2025.155868","url":null,"abstract":"<div><div>Acronyculatin S is a naturally occurring benzofuran derivative isolated from <em>Acronychia pedunculata</em> and has been reported to exhibit antibacterial activity. In this study, the first total synthesis of acronyculatin S was achieved through a concise and scalable route involving a Friedel–Crafts acylation, a Sonogashira coupling, and an europium(III)-catalyzed Claisen rearrangement as key steps. However, antibacterial evaluation of the synthetic sample against a panel of Gram-positive bacterial strains revealed no significant inhibitory activity under the tested conditions (MIC > 64 μg/mL). This work provides a reliable synthetic route for accessing acronyculatin S and related analogues, facilitating further studies on the chemical and biological properties of this class of natural products.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"174 ","pages":"Article 155868"},"PeriodicalIF":1.5,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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