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Mental Health or Cardiac Health. Is there a reason to choose? Cardiac arrhythmias induced b diac arrhythmias induced by Atomoxetine and etine and Methylphenidate 心理健康或心脏健康。有理由选择吗?阿托莫西汀、伊汀和哌甲酯诱发心律失常
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p209214
G. Cismaru, V. Lupu
The current treatment of Attention Deficit Disorder and Attention Deficit with Hyperactivity consists mainly in the administration of Straterra (Atomoxetine) Concerta and Ritalin (Methylphenidate). The FDA warned that the products might increase systolic, diastolic blood pressure, and lead to ventricular arrhythmias. Arrhythmic events and sudden cardiac death were described in adults with preexistent heart disease. However, studies on children have failed to demonstrate a clear association between the arrhythmic events and these drugs, as demonstrated in adults. What should the attitude of the pediatric psychiatrist be towards the administration of these products? What examination should be made by the psychiatrist before referring the child to a pediatric cardiologist? Which patients need a cardiology consultation before the administration of these products? What is the follow-up after drug initiation? These are some questions that this paper aims to answer.
目前治疗注意缺陷障碍和多动症的主要方法是服用strattera(托莫西汀)Concerta和利他林(哌醋甲酯)。FDA警告说,这些产品可能会增加收缩压和舒张压,并导致室性心律失常。心律失常事件和心源性猝死发生在先前存在心脏病的成年人中。然而,对儿童的研究未能证明心律失常事件与这些药物之间有明确的联系,就像在成人身上所证明的那样。儿科精神科医生对这些产品的使用应持何种态度?在将孩子转介给儿科心脏病专家之前,精神科医生应该做什么检查?哪些患者在使用这些产品前需要心脏病学咨询?起始用药后的随访是什么?这些都是本文想要回答的问题。
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引用次数: 0
Teachers’ Views on Preparation for Employment of Young Autistic People 教师对自闭症青少年就业准备的看法
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p229236
Biranavan Thavapalan, A. Remington, Liam Myles, E. Merlo
Background. Contemporary literature indicates that there is significant support and assistance provided by schools for young autistic people, which has had a positive impact on the accessibility of jobs. Nevertheless, the employment rate of autistic people is unacceptably low in the UK. The current study investigated teachers’ views on the preparation for employment of young autistic people in the UK. Methods. Interviews were conducted with individuals from the educational field and thematic analysis was used to explore the teachers’ views regarding the factors that have an impact on the preparation for employment of young autistic people. Results. Four main themes emerged from the analysis. These themes included awareness, funding and government support, action plans and motivation. Conclusion. These results have critical implications for the educational field and future research, which are discussed in the paper.
背景。当代文献表明,学校为年轻自闭症患者提供了大量的支持和帮助,这对就业的可及性产生了积极的影响。然而,在英国,自闭症患者的就业率低得令人无法接受。目前的研究调查了英国教师对年轻自闭症患者就业准备的看法。方法。对教育界人士进行访谈,并采用专题分析探讨教师对影响自闭症青少年就业准备的因素的看法。结果。分析中出现了四个主要主题。这些主题包括认识、资金和政府支持、行动计划和动机。结论。这些结果对教育领域和未来的研究具有重要意义,本文将对此进行讨论。
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引用次数: 2
Neuropsychological sympt chological symptoms related t elated to the CO o the COVID-19 pandemic VID-19 pandemic experienced by the general population and particularly by the healthcare personnel 普通人群,特别是医护人员经历的与COVID-19大流行CO相关的神经心理症状
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p197208
A. Stroe, A. Stuparu, S. Axelerad, D. Axelerad, A. Moraru
Undoubtedly, the outbreak of COVID-19 still represents an overanxious event for both society and population. The fear of getting infected is ubiquitous in the time of the pandemic. The population presented worrying thoughts related to the fact that the health care system was not able to provide enough services during the COVID-19 pandemic. The number of the hospital beds and ventilators was insufficient in order to ensure enough care, considering the increased number of COVID-19 cases that were admitted to the hospitals. Furthermore, people were fearful about the possibility of the global economy becoming decimated. The fright and also the feelings of anxiety related to the COVID-19 pandemic can become overpowering and create negative psychological states. In addition, mental health can be affected and influenced during outbreaks of infectious diseases and can be related to the misconception of symptoms, for example perception related phenomenon and corporal modifications. The population that could experiment these feelings, could instantly relate them to the coronavirus infection and express furthermore unpleasant sensations, in connection to more expressed anxiety and fear. Particularly affected were the healthcare workers of the medical system, who were the main combatants in this pandemic. The neuropsychological problems were difficult to avoid by the general population and this became even more difficult to be dealt with by the medical personnel.
毫无疑问,新冠肺炎疫情对社会和民众来说仍然是一个过度焦虑的事件。在大流行时期,对感染的恐惧无处不在。在新冠肺炎大流行期间,人们对医疗保健系统无法提供足够的服务表示担忧。考虑到新冠肺炎患者的增加,医院床位和呼吸机的数量不足以保证足够的护理。此外,人们担心全球经济可能遭受重创。与COVID-19大流行相关的恐惧和焦虑感可能会变得难以抗拒,并产生负面的心理状态。此外,在传染病爆发期间,心理健康可能受到影响和影响,并可能与对症状的误解有关,例如与感知有关的现象和身体变化。能够体验这些感觉的人群,可以立即将它们与冠状病毒感染联系起来,并表达出更多不愉快的感觉,与更多表达的焦虑和恐惧有关。受到特别影响的是医疗系统的卫生保健工作者,他们是这次大流行的主要战斗人员。神经心理问题是一般人群难以避免的,而医务人员更难处理。
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引用次数: 1
Stress and anxiety among physicians and nurses in Romania during the COVID-19 pandemic 新冠肺炎大流行期间罗马尼亚医生和护士的压力和焦虑
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p252258
R. Sima, O. Olaru, Anca Cazaceanu, C. Scheau, M. Dimitriu, M. Popescu, L. Pleș
Objective. This study aimed at identifying the stress and anxiety levels among physicians and nurses working in Romanian hospitals during the COVID-19 pandemic. Methods and Results. We conducted an online survey with a questionnaire completed by 169 healthcare providers aged between 25 and 69 years from COVID and non-COVID hospitals. There were 87.6% physicians and 12.4% nurses, with 61.5% women and 38.5% men. Clinicians experienced high levels of stress in 2.7% of the cases, medium stress in 68.9% of the cases, and low stress in 28.4% of the cases. Women experienced more stress (2.9% high level, 66.3% medium level) than men (1.5% high level, 64.6% medium level), while men are more anxious (73.8% high level, 26.2% medium level) than women (63.6% high level, 33.7% medium level). In both COVID and non-COVID healthcare providers, the stress score directly correlates with the anxiety score. Overall, during this period, the responders felt stressed and anxious (p=0.001). Conclusions. The COVID-19 pandemic is a strong reason for increased stress and anxiety among physicians and nurses. Men are more anxious and women more stressed. The stress and anxiety scores are different according to the hospital type.
客观的这项研究旨在确定新冠肺炎大流行期间在罗马尼亚医院工作的医生和护士的压力和焦虑水平。方法和结果。我们对来自新冠肺炎和非新冠肺炎医院的169名年龄在25至69岁之间的医疗保健提供者进行了一项在线调查。医生和护士分别占87.6%和12.4%,女性和男性分别占61.5%和38.5%。临床医生在2.7%的病例中经历了高水平的压力,在68.9%的病例中体验了中等压力,在28.4%的病例中感受到了低压力。女性经历的压力(2.9%高水平,66.3%中等水平)比男性(1.5%高水平,64.6%中等水平)更多,而男性比女性(63.6%高水平,33.7%中等水平)更焦虑(73.8%高水平,26.2%中等水平)。在新冠肺炎和非新冠肺炎医疗保健提供者中,压力评分与焦虑评分直接相关。总的来说,在此期间,应答者感到压力和焦虑(p=0.001)。结论。新冠肺炎大流行是医生和护士压力和焦虑增加的一个有力原因。男人更焦虑,女人压力更大。压力和焦虑评分因医院类型而异。
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引用次数: 6
How opportune is multigene testing in metastatic colorectal cancer? A review 多基因检测在转移性结直肠癌中是否合适?回顾
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p215220
Cristina Orlov-Slavu, A. Paroșanu, M. Olaru, D. Serban, I. Păunică, C. Nitipir
Personalized treatment in oncology is the most innovative method of care. The best method to establish personalized treatment is by genetic characterization of the malignant cell. Theoretically, the more detailed the characterization, the more effective the choice of treatment becomes. Currently, there are fast and relatively low-cost options that allow such genetic characterization. However, test results sometimes do not detect targetable alterations and, even if they do detect, the use of the treatment-alteration combination does not always generate a satisfactory oncological response. The present paper aims to answer two questions. First, how targetable can the most common gene alterations in colorectal cancer be. Second, whether it makes sense to use broad molecular testing as a standard in all metastatic patients.
肿瘤学中的个性化治疗是最具创新性的护理方法。建立个性化治疗的最佳方法是对恶性细胞进行遗传特征鉴定。从理论上讲,表征越详细,治疗的选择就越有效。目前,有一些快速且相对低成本的选择可以进行这种基因表征。然而,测试结果有时不能检测到靶向改变,即使检测到,使用治疗改变组合也不能总是产生令人满意的肿瘤学反应。本文旨在回答两个问题。首先,癌症最常见的基因改变的靶向性如何。其次,在所有转移患者中使用广泛的分子检测作为标准是否有意义。
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引用次数: 3
Intestinal dysbiosis – a new treatment target in the prevention of colorectal cancer 肠道生态失调——预防结直肠癌的新治疗靶点
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p221228
Florinela-Andrada Dumitru, S. Micu, Roxana Popoiag, M. Musat, Andreea Caloian, V. Calu, V. Constantin, D. Balan, C. Nitipir, F. Enache
The gastrointestinal microbiome contains at least 100 trillion microorganisms (bacteria, viruses, fungi), whose distribution varies from the mouth to the rectum spatially and temporally throughout one's lifetime. The microbiome benefits from advancing research due to its major role in human health. Studies indicate that its functions are immunity, metabolic processes and mucosal barrier. The disturbances of these functions, dysbiosis, influence physiology, lead to diabetes, inflammatory bowel disease, obesity and colon tumorigenesis. The third most common form of cancer, colorectal cancer, is the result of many factors and genes, and although the link between dysbiosis and this type of cancer is poorly characterized, it has been shown that some bacterial species and their metabolites have a critical role in developing colorectal cancer. Also, gut microbiota plays a role in the inflammatory response and immune process perturbations during the progression of colorectal cancer. Some new technologies, such as metagenome sequencing, facilitated the progress by analyzing the metabolic and genetic profile of microbiota, revealing details about the bacterial composition, host interactions, and taxonomic alterations. This review summarizes the studies regarding the link between gut microbiota and colorectal cancer, targeting new therapeutic strategies.
胃肠道微生物组包含至少100万亿种微生物(细菌、病毒、真菌),其在一生中从口腔到直肠的分布在空间和时间上各不相同。微生物组因其在人类健康中的重要作用而受益于先进的研究。研究表明,它的功能包括免疫、代谢过程和粘膜屏障。这些功能紊乱、失调、影响生理,导致糖尿病、炎症性肠病、肥胖和结肠肿瘤发生。第三种最常见的癌症,癌症,是多种因素和基因共同作用的结果,尽管生态失调与这种类型的癌症之间的联系尚不明确,但已经表明,一些细菌种类及其代谢产物在结直肠癌癌症的发展中起着关键作用。此外,肠道微生物群在癌症发展过程中的炎症反应和免疫过程扰动中发挥作用。一些新技术,如宏基因组测序,通过分析微生物群的代谢和遗传特征,揭示了细菌组成、宿主相互作用和分类变化的细节,促进了这一进展。这篇综述总结了关于肠道微生物群与结直肠癌癌症之间联系的研究,针对新的治疗策略。
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引用次数: 0
Klebsiella pneumoniae cryptogenic liver abscess and endophthalmitis – a case report and review of literature 肺炎克雷伯菌隐源性肝脓肿和眼内炎一例报告及文献复习
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p330335
M. Grecescu, Monica Grecescu, Andreea-Maria Smarandache, C. Branescu, Anca Anghelache, A. Dumitriu, S. Păunică, A. Costea
Klebsiella pneumoniae has emerged as the predominant pathogenic agent of liver abscess in Asia, and the incidence is increasing worldwide. Hypervirulent strains are associated with septic metastatic dissemination in the eyes, lungs, and central nervous system, causing severe morbidity. We present the case of a 54year old man, with no previous comorbidities, admitted in emergency for the blind red painful eye. Further investigation documented septic endophthalmitis with transscleral extension and orbital cellulitis. Thoraco-abdominal computed tomography evidenced a hepatic abscess as the locus of the primary infection. Intravenous antibiotherapy with cefuroxime, followed by meropenem and vancomycin were efficient for managing the hepatic abscess. However, as the eyeball was perforated at the admission, evisceration was performed. The vitreous sample revealed Klebsiella pneumoniae, with a positive string test as the etiologic agent. The diagnostic and therapeutic management required a permanent collaboration between an ophthalmologist, infectious diseases specialist, surgeon, and radiologist.
肺炎克雷伯菌已成为亚洲肝脓肿的主要病原体,并且在全球范围内发病率正在增加。高毒力菌株与脓毒症在眼睛、肺部和中枢神经系统的转移性传播有关,导致严重的发病率。我们报告了一例54岁的男性,既往无合并症,因失明的眼睛发红疼痛而急诊入院。进一步的调查记录了感染性眼内炎伴经巩膜扩张和眼眶蜂窝组织炎。胸腹计算机断层扫描证实肝脓肿是原发性感染的部位。静脉注射头孢呋辛、美罗培南和万古霉素是治疗肝脓肿的有效药物。然而,由于眼球在入院时穿孔,因此进行了摘除。玻璃体样本显示肺炎克雷伯菌,病因为阳性字符串测试。诊断和治疗管理需要眼科医生、传染病专家、外科医生和放射科医生之间的长期合作。
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引用次数: 0
The diagnostic algorithm in pre-invasive cervical lesions 宫颈浸润前病变的诊断算法
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p191196
M. Loghin, O. Bălălău, N. Bacalbaşa, A. Vasilache, O. Olaru, A. Vasilache, A. Stănescu
The screening for pre-invasive cervical lesions has significantly decreased the incidence of cervical neoplasm. It is recommended to be performed starting with the age of 21 with a frequency of 3-5 years and it consists of pap smear testing and HPV genotyping, and, if required, it can be continued with colposcopy or biopsy followed by pathological assessment. The importance of the early diagnosis of pre-invasive cervical lesions has led to several studies on this topic. The paper analyzed the modern literature published on the PubMed and Scopus databases. Reference studies have found that most intraepithelial lesions are caused by the presence of HPV. Other commonly associated factors are immunosuppression, multiparity and other viral infections. HPV infection can be prevented by vaccination. It is recommended for people between 11 and 26 years old and also over 27 years old if they associate risk factors. A meta-analysis performed on patients diagnosed with CIN2 revealed a lower recurrence rate in vaccinated women than in unvaccinated women. Other studies have shown the transient nature of HPV infection and spontaneous regression of pre-invasive lesions. The early diagnosis of pre-invasive lesions is necessary for the initiation of therapeutic and follow-up behavior as soon as possible, with the aim of reducing the incidence of cervical cancer. This is possible and easy to access through national health programs.
对浸润前宫颈病变的筛查显著降低了宫颈肿瘤的发生率。建议从21岁开始进行,频率为3-5年,包括巴氏涂片检查和HPV基因分型,如果需要,可以继续进行阴道镜检查或活检,然后进行病理评估。早期诊断浸润前宫颈病变的重要性导致了对这一主题的几项研究。本文分析了PubMed和Scopus数据库上发表的现代文献。参考研究发现,大多数上皮内病变是由HPV的存在引起的。其他常见的相关因素包括免疫抑制、多胎性和其他病毒感染。接种疫苗可以预防HPV感染。建议11至26岁的人使用,如果他们与风险因素有关,也建议27岁以上的人使用。对诊断为CIN2的患者进行的荟萃分析显示,接种疫苗的女性的复发率低于未接种疫苗的妇女。其他研究显示了HPV感染的短暂性和侵袭前病变的自发消退。早期诊断浸润前病变对于尽早开始治疗和随访行为是必要的,目的是降低宫颈癌症的发病率。这是可能的,而且很容易通过国家卫生计划获得。
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引用次数: 0
Analysis of potentially toxic contaminants in milk powder 奶粉中潜在有毒污染物的分析
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p237244
M. Mititelu, Lucian Hîncu, E. Ozon, D. Baconi, I. Păunică, O. Bălălău
The aim of this study was to identify potentially toxic contaminants in milk powder. Powdered milk contains a range of toxic and non-toxic substances that are present in a wide variety, also having very different origins. A number of seven milk powder samples from different producers sold on the Romanian market were analyzed, the samples that were collected from the original packaging: P1, P 2, P3, P4, P5, P6 and P7. The concentration of the following elements was analyzed using the X-ray (XRF) fluorescence method: potassium (K), chlorine (Cl), calcium (Ca), phosphorus (P) and aluminum (Al). The vast majority of the samples showed the levels of elements K, Ca, Cl, Al, P well above the maximum allowable limit (AML). In a single test, the elements potassium, calcium, chlorine, phosphorus showed levels below the maximum allowable limit, but the level of aluminum was much above. The experimental results showed that the market sells assortments of milk powder that exceed concentrations above the maximum limits established by the legislation in force for some constituent elements. Concentrations of constituent elements are not always specified on food labels, and if this information appears, they are not always the correct values.
本研究的目的是确定奶粉中潜在的有毒污染物。奶粉含有一系列有毒和无毒物质,种类繁多,来源也非常不同。对罗马尼亚市场上销售的来自不同生产商的七个奶粉样本进行了分析,这些样本是从原始包装中收集的:P1、P2、P3、P4、P5、P6和P7。使用X射线(XRF)荧光法分析以下元素的浓度:钾(K)、氯(Cl)、钙(Ca)、磷(P)和铝(Al)。绝大多数样品显示元素K、Ca、Cl、Al、P的含量远高于最大允许限量(AML)。在一次测试中,元素钾、钙、氯、磷的含量低于最高允许限量,但铝的含量远高于最高允许限量。实验结果表明,市场上销售的各种奶粉的浓度超过了现行立法对某些成分规定的最高限值。食品标签上并不总是规定成分的浓度,如果出现这种信息,它们并不总是正确的值。
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引用次数: 2
A rare complication in a Covid-19 positive patient with sigmoid colon cancer-hemoperitoneum due to gallbladder necrosis following micro-thrombosis 一例新冠肺炎阳性乙状结肠癌患者的罕见并发症——微血栓形成后胆囊坏死引起的气腹
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2021-10-11 DOI: 10.22543/7674.82.p317323
Mihai Faur, A. Moisin, C. Mohor, D. Sabau
Covid-19, also known as acute respiratory syndrome 2019-nCoV, severe acute respiratory syndrome (SARS) 2, and Wuhan pneumonia, is a viral respiratory disease caused by a SARS-associated coronavirus (SARS-CoV2). The most serious complications of Covid-19 are due to the development of micro-thrombosis in various organs and systems as a result of the high levels of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin 1 and 6) which initiate the activation of coagulation and the generation of thrombin. Several studies demonstrated the poor outcome of Covid-19-infected patients who underwent surgery, suggesting that surgery may accelerate and exacerbate Covid-19 progression. We report the case of an 81-year-old patient admitted as an emergency with Covid-19 pneumonia, hemoperitoneum, ischemic acute cholecystitis and obstructive sigmoid cancer. Cholecystectomy, pneumoperitoneal lavage, and Hartmann operation were performed under combined epidural-spinal anesthesia. This technique has some advantages compared to spinal and epidural techniques, such as: rapid onset of analgesia and the possibility of obtaining the desired sensory level, control of the anesthetic block, and ensuring postoperative analgesia. The unfavorable outcome of this case is due to the occurrence of the cytokine storm and coagulation disorders, with the change in the related biological constants, both from a biochemical and systemic point of view.
新冠肺炎,也称为急性呼吸综合征2019-nCoV、严重急性呼吸综合症(SARS)2和武汉肺炎,是一种由SARS-CoV2相关冠状病毒引起的病毒性呼吸道疾病。新冠肺炎最严重的并发症是由于高水平的促炎细胞因子(肿瘤坏死因子α、白细胞介素1和6)引发凝血激活和凝血酶生成,导致各种器官和系统发生微血栓。几项研究表明,接受手术的新冠肺炎感染患者的预后不佳,这表明手术可能会加速和加剧新冠肺炎的进展。我们报告了一例81岁的患者因新冠肺炎肺炎、腹腔积血、缺血性急性胆囊炎和阻塞性乙状结肠癌症急诊入院。胆囊切除术、腹膜灌洗术和Hartmann手术在硬膜外-脊髓联合麻醉下进行。与脊髓和硬膜外技术相比,该技术具有一些优势,例如:镇痛的快速开始和获得所需感觉水平的可能性,麻醉阻滞的控制,以及确保术后镇痛。从生化和系统的角度来看,这种情况的不利结果是由于细胞因子风暴和凝血障碍的发生,以及相关生物常数的变化。
{"title":"A rare complication in a Covid-19 positive patient with sigmoid colon cancer-hemoperitoneum due to gallbladder necrosis following micro-thrombosis","authors":"Mihai Faur, A. Moisin, C. Mohor, D. Sabau","doi":"10.22543/7674.82.p317323","DOIUrl":"https://doi.org/10.22543/7674.82.p317323","url":null,"abstract":"Covid-19, also known as acute respiratory syndrome 2019-nCoV, severe acute respiratory syndrome (SARS) 2, and Wuhan pneumonia, is a viral respiratory disease caused by a SARS-associated coronavirus (SARS-CoV2). The most serious complications of Covid-19 are due to the development of micro-thrombosis in various organs and systems as a result of the high levels of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin 1 and 6) which initiate the activation of coagulation and the generation of thrombin. Several studies demonstrated the poor outcome of Covid-19-infected patients who underwent surgery, suggesting that surgery may accelerate and exacerbate Covid-19 progression. We report the case of an 81-year-old patient admitted as an emergency with Covid-19 pneumonia, hemoperitoneum, ischemic acute cholecystitis and obstructive sigmoid cancer. Cholecystectomy, pneumoperitoneal lavage, and Hartmann operation were performed under combined epidural-spinal anesthesia. This technique has some advantages compared to spinal and epidural techniques, such as: rapid onset of analgesia and the possibility of obtaining the desired sensory level, control of the anesthetic block, and ensuring postoperative analgesia. The unfavorable outcome of this case is due to the occurrence of the cytokine storm and coagulation disorders, with the change in the related biological constants, both from a biochemical and systemic point of view.","PeriodicalId":43987,"journal":{"name":"Journal of Mind and Medical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43024616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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