Background: Von Hippel–Lindau disease (VHL) is a rare multisystem neurocutaneous disorder. The abnormalities in the corpus callosum have been observed in patients with pha-comatosis, but this has not been previously described in VHL. In this report, we present a unique case of VHL with corpus callosum agenesis. Case Report: A 7-year-old boy was referred to the hospital because of left flank pain and vomiting. The abdominal ultrasound revealed multiple small simple cysts in both kidneys and pancreas. A radiological suspicion of VHL was raised, and further imaging examinations were recommended. Brain magnetic resonance imaging demonstrated a parallel arrangement of the lateral ventricles, confirming the diagnosis of complete agenesis of the corpus callosum. Brain hemangioblastomas were not detected. Conclusion: Our case is the first to report a corpus callosum agenesis in a child with VHL, thus expanding the spectrum of neurocutaneous disorders associated with callosal anomalies.
{"title":"Von Hippel–Lindau Disease and Agenesis of the Corpus Callosum: Report of a New Possible Association","authors":"Edis Çolak","doi":"10.14744/etd.2023.94910","DOIUrl":"https://doi.org/10.14744/etd.2023.94910","url":null,"abstract":"Background: Von Hippel–Lindau disease (VHL) is a rare multisystem neurocutaneous disorder. The abnormalities in the corpus callosum have been observed in patients with pha-comatosis, but this has not been previously described in VHL. In this report, we present a unique case of VHL with corpus callosum agenesis. Case Report: A 7-year-old boy was referred to the hospital because of left flank pain and vomiting. The abdominal ultrasound revealed multiple small simple cysts in both kidneys and pancreas. A radiological suspicion of VHL was raised, and further imaging examinations were recommended. Brain magnetic resonance imaging demonstrated a parallel arrangement of the lateral ventricles, confirming the diagnosis of complete agenesis of the corpus callosum. Brain hemangioblastomas were not detected. Conclusion: Our case is the first to report a corpus callosum agenesis in a child with VHL, thus expanding the spectrum of neurocutaneous disorders associated with callosal anomalies.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76616233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effects of Tibialis Posterior Muscle Fatigue and Walking Speed on Dynamic Plantar Pressure Characteristics: A single group Pre-Post test","authors":"Azize Reda Tunç","doi":"10.14744/etd.2023.77906","DOIUrl":"https://doi.org/10.14744/etd.2023.77906","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82148148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Acute hepatitis-associated aplastic anemia (AHAAA) is a rare clinical syndrome characterized by the development of aplastic anemia 2–3 months following an episode of acute hepatitis. Several immunosuppressive agents, but not mycophenolate mofetil (MMF), and bone marrow transplantation are the standard treatment options for AHAAA. Case Report: In this report, we present a case of a young boy with AHAAA manifesting as acute liver failure. The etiology was type 1 autoimmune hepatitis responsive to the second-line therapeutic combination of steroids and MMF. The liver has fully recovered, but bone marrow failure ensued. After 4 months, Clinical and laboratory improvement occurred without the need for bone marrow transplantation. An important aspect of this case is the full recovery of aplastic anemia without calcineurin inhibitors, anti-thymocyte globulin utilization, or bone marrow transplantation. Conclusion: Our case history supports MMF as a potentially crucial adjunctive therapy for patients with AHAAA who poorly respond to standard procedures.
{"title":"Successful Treatment of Acute Hepatitis Associated Aplastic Anemia in a Young Boy, a case report","authors":"M. Anicic","doi":"10.14744/etd.2023.75271","DOIUrl":"https://doi.org/10.14744/etd.2023.75271","url":null,"abstract":"Background: Acute hepatitis-associated aplastic anemia (AHAAA) is a rare clinical syndrome characterized by the development of aplastic anemia 2–3 months following an episode of acute hepatitis. Several immunosuppressive agents, but not mycophenolate mofetil (MMF), and bone marrow transplantation are the standard treatment options for AHAAA. Case Report: In this report, we present a case of a young boy with AHAAA manifesting as acute liver failure. The etiology was type 1 autoimmune hepatitis responsive to the second-line therapeutic combination of steroids and MMF. The liver has fully recovered, but bone marrow failure ensued. After 4 months, Clinical and laboratory improvement occurred without the need for bone marrow transplantation. An important aspect of this case is the full recovery of aplastic anemia without calcineurin inhibitors, anti-thymocyte globulin utilization, or bone marrow transplantation. Conclusion: Our case history supports MMF as a potentially crucial adjunctive therapy for patients with AHAAA who poorly respond to standard procedures.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90452560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In some cases, it may be challenging to differentiate radiologically between ischemic gliotic foci and multiple sclerosis (MS) plaques. This study aims to evaluate the effectiveness of histogram analysis in the differentiation of MS plaque and ischemic gliosis lesions on the T2-weighted (T2WI) FLAIR sequence. Materials and Methods: This study was conducted on the Magnetic Resonance Imaging (MRI) examinations of patients diagnosed with ischemic gliosis and multiple sclerosis. Inactive lesions of 43 patients with ischemic gliosis and 46 with multiple sclerosis imaged by the same device were included in the study. Histogram analysis parameters of both groups were calculated. The entire image analysis algorithm was obtained through in-house software coded in MATLAB. Both groups were compared using a student’s t-test. The diagnostic value of the parameters was detected with the receiver operating characteristic (ROC) curve. Results: Mean gray level intensity, the standard deviation of the histogram, and entropy values calculated via minimum, maximum and median values were significantly higher in patients with ischemic gliosis. ROC curve analysis indicated that a threshold value of 545.19 for mean gray level intensity has 69.8% specificity and 69.6% sensitivity. Conclusion: Histogram analysis may help differentiate MS and ischemic gliosis.
{"title":"Comparison of T2W FLAIR images of patients with multiple sclerosis and ischemic gliosis via histogram analysis","authors":"M. Baykara","doi":"10.14744/etd.2023.35306","DOIUrl":"https://doi.org/10.14744/etd.2023.35306","url":null,"abstract":"Objective: In some cases, it may be challenging to differentiate radiologically between ischemic gliotic foci and multiple sclerosis (MS) plaques. This study aims to evaluate the effectiveness of histogram analysis in the differentiation of MS plaque and ischemic gliosis lesions on the T2-weighted (T2WI) FLAIR sequence. Materials and Methods: This study was conducted on the Magnetic Resonance Imaging (MRI) examinations of patients diagnosed with ischemic gliosis and multiple sclerosis. Inactive lesions of 43 patients with ischemic gliosis and 46 with multiple sclerosis imaged by the same device were included in the study. Histogram analysis parameters of both groups were calculated. The entire image analysis algorithm was obtained through in-house software coded in MATLAB. Both groups were compared using a student’s t-test. The diagnostic value of the parameters was detected with the receiver operating characteristic (ROC) curve. Results: Mean gray level intensity, the standard deviation of the histogram, and entropy values calculated via minimum, maximum and median values were significantly higher in patients with ischemic gliosis. ROC curve analysis indicated that a threshold value of 545.19 for mean gray level intensity has 69.8% specificity and 69.6% sensitivity. Conclusion: Histogram analysis may help differentiate MS and ischemic gliosis.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85541268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
[27]中华医学杂志2019;41(3): 327-32•DOI: 10.14744/etd.2019.22230原创文章-开放获取本作品采用知识共享署名-非商业4.0国际许可协议。Halil İbrahim Erdoğdu, Fatih Kara血液透析患者的残留肾功能及相关因素目的:残留肾功能(RKF)是终末期肾病(ESRD)患者肾脏剩余容量的重要标志。RKF在血液透析(HD)第一年下降的事实最近引起了更多的关注。本研究的目的是确定和分析接受HD治疗的患者当前RKF水平及相关因素。材料和方法:研究在卡尔斯州立医院进行，共73例HD患者。测定残余肾尿素清除率(KRU)以测定RKF。患者的尿量在一周的第一次HD治疗结束和下一次HD治疗开始之间测定。按KRU水平分为3组:2 mL/min。比较两组间HD治疗时间、生物统计学特征、生化和激素分析、HD充分性、ESRD病因和合并症。p值小于0.05被认为具有统计学意义(置信区间为95%)。结果:KRU值与HD治疗时间(p<0.001)、ESRD病因(p=0.037)、血钾水平(p=0.028)、磷水平(p=0.036)、尿量(p<0.001)、超滤(UF)量(p=0.002)、体重指数(p=0.002)差异均有统计学意义。尿量<100 mL/d的患者HD治疗持续时间较长，为6.9±4.2年(p=0.021)，用用量较大(723±230 mL/h) (p<0.001)。结论:本研究的发现可能有助于对HD治疗的月度解释和调节，而不是提供RKF丧失的因果关系的解释。需要更多的研究，包括在一定时间间隔测量RKF和长期观察。
{"title":"Residual Kidney Function in Hemodialyzed Patients and Related Factors","authors":"H. Erdoğdu","doi":"10.14744/etd.2019.22230","DOIUrl":"https://doi.org/10.14744/etd.2019.22230","url":null,"abstract":"ABSTRACT","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87703046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Polyphenolic Compounds on MAPK Signaling Pathway against Carcinogenesis","authors":"Adem Keskin","doi":"10.14744/etd.2023.94422","DOIUrl":"https://doi.org/10.14744/etd.2023.94422","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135585728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study was to investigate the effect of percutaneous tracheotomy on mortality and length of stay in the intensive care unit (ICU) for patients with COVID-19-associated acute respiratory distress syndrome (ARDS). Materials and Methods: This study included patients with coronavirus disease-19 (COVID-19-associated) acute respiratory distress syndrome who were treated with invasive mechanical ventilation in a pandemic intensive care unit. Patients admitted to the pandemic intensive care unit between March and July 2021 were retrospectively reviewed. Patients who underwent percutaneous tracheotomy and did not have a tracheotomy during the follow-up were statistically compared in terms of laboratory and clinical characteristics such as mortality and length of stay in the intensive care unit. Results: The study included 102 orotracheally intubated patients diagnosed with COVID-19 acute respiratory distress syndrome. The number of tracheotomized and not-tracheotomized patients was 34 and 68, respectively. The mean age of the patients was 60.39 +/- 14.10 years. The mean time to perform percutaneous tracheotomy was 7.94 +/- 6.11 days. There was no significant difference in mortality rate between the two groups (p=0.298). However, patients who underwent tracheotomy had a longer length of stay in the intensive care unit compared to those who did not (35.00 +/- 24.60 days vs 13.20 +/- 11.69 days, p<0.001). Conclusion: Our study found no statistically significant difference in mortality rate between the two groups in our study. Additionally, the length of stay in the intensive care unit was not better in tracheotomized patients. While tracheotomy has some advantages in other severe lung diseases, its effect on mortality in patients with severe lung disease associated with COVID-19 should be evaluated further in randomized controlled trials.
{"title":"The Impact of Percutaneus Tracheotomy on Patients with COVID-19 ARDS' Mortality and Length of Stay in The Critical Care Unit","authors":"G. Alay","doi":"10.14744/etd.2023.63832","DOIUrl":"https://doi.org/10.14744/etd.2023.63832","url":null,"abstract":"Objective: The aim of this study was to investigate the effect of percutaneous tracheotomy on mortality and length of stay in the intensive care unit (ICU) for patients with COVID-19-associated acute respiratory distress syndrome (ARDS). Materials and Methods: This study included patients with coronavirus disease-19 (COVID-19-associated) acute respiratory distress syndrome who were treated with invasive mechanical ventilation in a pandemic intensive care unit. Patients admitted to the pandemic intensive care unit between March and July 2021 were retrospectively reviewed. Patients who underwent percutaneous tracheotomy and did not have a tracheotomy during the follow-up were statistically compared in terms of laboratory and clinical characteristics such as mortality and length of stay in the intensive care unit. Results: The study included 102 orotracheally intubated patients diagnosed with COVID-19 acute respiratory distress syndrome. The number of tracheotomized and not-tracheotomized patients was 34 and 68, respectively. The mean age of the patients was 60.39 +/- 14.10 years. The mean time to perform percutaneous tracheotomy was 7.94 +/- 6.11 days. There was no significant difference in mortality rate between the two groups (p=0.298). However, patients who underwent tracheotomy had a longer length of stay in the intensive care unit compared to those who did not (35.00 +/- 24.60 days vs 13.20 +/- 11.69 days, p<0.001). Conclusion: Our study found no statistically significant difference in mortality rate between the two groups in our study. Additionally, the length of stay in the intensive care unit was not better in tracheotomized patients. While tracheotomy has some advantages in other severe lung diseases, its effect on mortality in patients with severe lung disease associated with COVID-19 should be evaluated further in randomized controlled trials.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81578512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The term post-COVID (coronavirus disease) is used to refer to the presence of prolonged symptoms 12 weeks or more after the disease treatment. This study aimed to evaluate the presence of symptoms and anxiety in patients with COVID-19 who did not require inpatient care at the third and sixth months following symptom onset. Materials and Methods: The study is a prospective cohort study involving 471 university employees who contracted COVID-19 between October 2020 and October 2021. Data were obtained through the disease contact follow-up program implemented at the university and phone interviews conducted at the third and sixth months from symptom onset. Results: The study group comprised 361 individuals at three months and 109 at six months from symptom onset. The study found that symptoms persisted in 116 (32.1%) people in the third month and in 47 (13.0%) people in the sixth month. The most common symptoms at three months were shortness of breath, fatigue, and fatigue, while fatigue, fatigue, and shortness of breath were the most common symptoms at six months. Conclusion: Understanding the long-term effects of coronavirus will enhance the management of the disease. As a result, the follow-up of symptomatic COVID-19 and post-COVID-19 patients will become more systematic and effective.
{"title":"Prevalence of Post-COVID-19 Syndrome and Related Factors in University Employees: A Prospective Cohort Study","authors":"Feyza Nehir Öznur Muz","doi":"10.14744/etd.2023.56313","DOIUrl":"https://doi.org/10.14744/etd.2023.56313","url":null,"abstract":"Objective: The term post-COVID (coronavirus disease) is used to refer to the presence of prolonged symptoms 12 weeks or more after the disease treatment. This study aimed to evaluate the presence of symptoms and anxiety in patients with COVID-19 who did not require inpatient care at the third and sixth months following symptom onset. Materials and Methods: The study is a prospective cohort study involving 471 university employees who contracted COVID-19 between October 2020 and October 2021. Data were obtained through the disease contact follow-up program implemented at the university and phone interviews conducted at the third and sixth months from symptom onset. Results: The study group comprised 361 individuals at three months and 109 at six months from symptom onset. The study found that symptoms persisted in 116 (32.1%) people in the third month and in 47 (13.0%) people in the sixth month. The most common symptoms at three months were shortness of breath, fatigue, and fatigue, while fatigue, fatigue, and shortness of breath were the most common symptoms at six months. Conclusion: Understanding the long-term effects of coronavirus will enhance the management of the disease. As a result, the follow-up of symptomatic COVID-19 and post-COVID-19 patients will become more systematic and effective.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77165743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Panitumumab- induced paronychia and trichomegaly","authors":"O. Ünsal","doi":"10.14744/etd.2023.78646","DOIUrl":"https://doi.org/10.14744/etd.2023.78646","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78054067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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