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Bacterial Bloodstream Infection in Renal Transplant Recipients: 15 years experience in an university hospital 肾移植受者细菌性血流感染:15年大学医院经验
IF 0.4 Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.63600
Nursel Çalık Başaran
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引用次数: 1
The Effect of Sex-Specific Genetic Factors on the Host Immune Response to COVID-19: A Pilot Study 性别特异性遗传因素对宿主COVID-19免疫反应的影响:一项初步研究
IF 0.4 Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.32955
D. Akin
Objective: The aim of this study was to investigate the impact of sex-specific genetic factors in the pathogenesis and prog-nosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-induced macrophage activation syndrome (MAS), independent of age and comorbidity presence. Material(s) and Method(s): Patients aged 18-50 years who had been diagnosed with coronavirus 2019 (COVID-19), the disease caused by the SARS-CoV2 virus, were enrolled in a prospective, case-control, multi-center study. Genetic alterations and messenger RNA (m-RNA) expression levels of the TLR7, TLR8, ACE2, CD40L, CXCR3, and TASL genes were determined using DNA sequencing analysis, and gene expression was determined using quantitative reverse transcriptase polymerase chain reaction testing. PolyPhen-2 (Polymorphism Phenotyping v2;Adzhubei et al., 2010) and SNAP2 (Rostlab, Munich, Germany) genetic analysis tools were used to define the pathogenic effects of detected mutations by sequencing the selected genes in hotspot regions. Result(s): The study group consisted of 80 patients diagnosed with COVID-19 and was divided into groups based on sex and MAS status. Twenty-nine mutations were detected in 6 genes. Among the alterations, 15 were identified in this study for the first time and 9 were pathogenic. Pathogenic missense mutations in the TLR7, TLR8, ACE2, and TASL genes were detected in the MAS (+) group. In males, decreased TLR7, TLR8, and CXCR3 expression was statistically significant in the MAS (+) group (p<0.050). CXCR3 expression was lower in the female and male MAS (+) groups compared with the MAS (-) groups (p<0.050). Conclusion(s): In the absence of major risk factors for COVID-19, the TLR7/8, ACE2, and CXCR3 variants and decreased m-RNA expression levels associated with genetic susceptibility may be independent prognostic risk factors for COVID-19. Copyright © 2022 by Erciyes University Faculty of Medicine.
目的:本研究旨在探讨性别特异性遗传因素对严重急性呼吸综合征冠状病毒2 (SARS-CoV2)诱导的巨噬细胞激活综合征(MAS)发病和预后的影响,不受年龄和合并症的影响。材料和方法:年龄在18-50岁、被诊断为冠状病毒2019 (COVID-19)(由SARS-CoV2病毒引起的疾病)的患者入组一项前瞻性、病例对照、多中心研究。采用DNA测序分析检测TLR7、TLR8、ACE2、CD40L、CXCR3、TASL基因的遗传改变及信使RNA (m-RNA)表达水平,采用定量逆转录酶聚合酶链式反应检测检测基因表达。采用polyphen2 (Polymorphism Phenotyping v2;Adzhubei et al., 2010)和SNAP2 (Rostlab, Munich, Germany)遗传分析工具,对热点区域选择的基因进行测序,确定检测突变的致病作用。结果:研究组由80例确诊为COVID-19的患者组成,根据性别和MAS状况分为两组。6个基因共检测到29个突变。其中15个为本研究首次发现,9个为致病性。在MAS(+)组中检测到TLR7、TLR8、ACE2和TASL基因的致病性错义突变。在男性中,MAS(+)组TLR7、TLR8和CXCR3表达降低具有统计学意义(p<0.050)。与MAS(-)组相比,女性和男性MAS(+)组CXCR3的表达均较低(p<0.050)。结论:在没有COVID-19主要危险因素的情况下,与遗传易感性相关的TLR7/8、ACE2和CXCR3变异和m-RNA表达水平下降可能是COVID-19的独立预后危险因素。埃尔西耶斯大学医学院版权所有©2022。
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引用次数: 1
Determinants of Frailty and Gait Speed in People Over 65 Years of Age 65岁以上人群虚弱和步态速度的决定因素
IF 0.4 Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.33396
Mehmet Arslan
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引用次数: 1
Imaging in Pediatric Spinal Infections 儿童脊柱感染的影像学研究
IF 0.4 Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.49465
Merve Yazol
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引用次数: 0
Comparison of the Exosome Profile in Ankylosing Spondylitis and Healthy Controls 强直性脊柱炎与健康对照外显体的比较
IF 0.4 Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.54614
E. Karakaya
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引用次数: 0
Evaluation of metacarpophalangeal joint cartilage thickness in patients with rheumatoid arthritis: a clinical and ultrasonographic study 类风湿关节炎患者掌指关节软骨厚度的评价:临床和超声研究
IF 0.4 Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.35714
H. Harman
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引用次数: 0
Evaluation of Stereopsis in Children with Corrected Anisometropia according to the Type, Severity and, Presence of Amblyopia 根据弱视的类型、严重程度和存在程度评价矫正后屈光参差儿童的立体视
IF 0.4 Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.07742
F. Dikkaya
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引用次数: 0
Methods of Pain Self-Care Used by Patients with Chronic Musculoskeletal Pain During the COVID-19 Pandemic in Turkey 2019冠状病毒病大流行期间土耳其慢性肌肉骨骼疼痛患者的疼痛自我护理方法
IF 0.4 Pub Date : 2022-01-01 DOI: 10.14744/etd.2022.54889
Şule Şimşek
Objective: The aim of this study was to determine the methods of pain self-care used by patients in Türkiye with chronic musculoskeletal pain who could not access a healthcare provider during the coronavirus 2019 (COVID-19) pandemic. Materials and Methods: A total of 255 participants (mean age 40.8±13.2 years) diagnosed with chronic musculoskeletal pain were included in the study. The Nordic Musculoskeletal Questionnaire and a form created by the researchers were used to assess the prevalence of musculoskeletal symptoms and methods of pain management. Results: The primary site of symptoms during the previous 12-month period was the low back, neck, and upper back regions (69%, 64.7%, and 60% respectively). The detailed assessment revealed that in the prior 7 days, patients experienced symptoms most often in the lower back (56.9%), upper back (45.1%), and neck (43.9%). The most frequently used methods of pain self-care were massage (71%), pain relief medication (68.2%), and topical analgesics (55.3%). Conclusion: Patients most often reported symptoms in the spinal area, and the most used means of self-care for pain management were massaging the painful area, pain medication, and topical analgesics. Self-care initiatives can be very valuable, however, at least some initial guidance from health professionals is advisable. Additional exploration of technological means of intervention and awareness of appropriate self-care could be of substantial benefit individuals and society.
目的:本研究的目的是确定在2019年冠状病毒(COVID-19)大流行期间无法获得医疗服务的慢性肌肉骨骼疼痛患者 rkiye患者使用的疼痛自我保健方法。材料与方法:共纳入255名诊断为慢性肌肉骨骼疼痛的参与者(平均年龄40.8±13.2岁)。北欧肌肉骨骼问卷和研究人员创建的表格用于评估肌肉骨骼症状的患病率和疼痛管理方法。结果:前12个月症状的主要部位为下背部、颈部和上背部(分别为69%、64.7%和60%)。详细评估显示,在前7天,患者最常出现的症状是下背部(56.9%)、上背部(45.1%)和颈部(43.9%)。最常用的疼痛自我护理方法为按摩(71%)、镇痛药物(68.2%)和外用镇痛药(55.3%)。结论:患者最常报告的症状出现在脊柱区域,疼痛管理中最常用的自我护理手段是按摩疼痛区、止痛药和局部镇痛药。自我护理的主动性是非常有价值的,然而,至少一些健康专业人士的初步指导是可取的。进一步探索干预的技术手段和适当的自我护理意识可能对个人和社会都有实质性的好处。
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引用次数: 0
Effect of an Active Distraction Method for Pediatric Venipuncture Related Pain and Anxiety 主动牵张法治疗小儿静脉穿刺相关疼痛和焦虑的效果
IF 0.4 Pub Date : 2021-07-26 DOI: 10.21203/rs.3.rs-715971/v1
E. Isiyel, Melehat Yurttas, Ezgi Perktas, E. Ozmert, O. Teksam
Needle-associated fear and pain in children can lead to poor health consequences and lower uptake rates of medical services. Information and distraction are significant methods in reducing pain and anxiety in children. We aimed to evaluate the effects of giving information and an active distraction method for pediatric venipuncture -related pain and anxiety in 3-8 years old children. Children were randomized into three groups as the control, the informed, the informed and distracted. Fear and pain experience were found to be significantly lower in the informed and distracted group rather than the control and the informed group according to the parents/caregivers. Fear and pain experience were similarly found to be significantly lower in the informed and distracted group than the other groups according to the independent observer. Informing, preparing, coping, distracting methods should be used before, during, and after the invasive procedures to reduce children's pain and anxiety.
儿童因针而产生的恐惧和疼痛可导致不良的健康后果和较低的医疗服务使用率。信息和分散注意力是减轻儿童疼痛和焦虑的重要方法。我们的目的是评估提供信息和主动分心方法对3-8岁儿童静脉穿刺相关疼痛和焦虑的影响。孩子们被随机分为三组作为对照组,知情者,知情者和分心者。根据父母/看护人的说法,恐惧和疼痛体验在知情和分心组中明显低于对照组和知情组。根据独立观察者的说法,恐惧和痛苦体验同样被发现在知情和分心的组中明显低于其他组。在侵入性手术之前、期间和之后,应采用告知、准备、应对和分散注意力的方法,以减少儿童的痛苦和焦虑。
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引用次数: 0
Ventricular Repolarization Parameters In Hospitalized Patients With COVID-19 COVID-19住院患者心室复极参数的研究
IF 0.4 Pub Date : 2021-01-01 DOI: 10.14744/ETD.2021.93902
Serkan Sivri
Objective: Coronavirus disease-2019 (COVID-19) may cause atrial and/or ventricular arrhythmias and sudden cardiac deaths, especially in severe cases. In this study, we aimed to investigate whether COVID-19 affects the ventricular repolarization parameters. Materials and Methods: In this study, 152 hospitalized patients with COVID-19 were included retrospectively. Age and sex-matched 151 healthy subjects were assigned as the control group. QT, QTc, Tpe, Tpe/QT, and Tpe/QTc values of all participants were determined and compared between both groups. The relationship between high sensitive-troponin I (hsTnI) and the parameters mentioned was analyzed using the Spearman correlation test. Results: Mean age, male gender and comorbidity rates were similar in both groups (p>0.05 for each). Heart rate, QTc, Tpe, Tpe/QT, and Tpe/QTc values were higher in the study group (p<0.001 for each). However, QT and QRS values were comparable in both groups (p>0.05 for each). There were positive correlations between hsTnI and QT (rho=0.218, p=0.008), QTc (rho=0.308, p<0.001), Tpe (rho=0.646, p<0.001), Tpe/QT (rho=0.571, p<0.001), and Tpe/QTc (rho=0.608, p<0.001). Conclusion: In patients with COVID-19, QTc, Tpe, Tpe/QT, and Tpe/QTc values are higher than the control group and these parameters correlate positively with hsTnI. Therefore, ECG follow-up may be beneficial in preventing arrhythmic events, especially in patients with acute cardiac injuries. [ FROM AUTHOR] Copyright of Erciyes Medical Journal / Erciyes Tip Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.)
目的:冠状病毒病-2019 (COVID-19)可能导致心房和/或室性心律失常和心源性猝死,尤其是重症。在本研究中,我们旨在探讨COVID-19是否影响心室复极参数。材料与方法:回顾性分析152例住院COVID-19患者。选取年龄和性别匹配的151名健康受试者作为对照组。测定两组受试者的QT、QTc、Tpe、Tpe/QT、Tpe/QTc值并进行比较。采用Spearman相关检验分析高敏感肌钙蛋白I (hsTnI)与上述参数的关系。结果:两组患者平均年龄、男性性别及合并症发生率相近(p>0.05)。研究组患者心率、QTc、Tpe、Tpe/QT、Tpe/QTc值均高于对照组(p0.05)。hsTnI与QT (rho=0.218, p=0.008)、QTc (rho=0.308, p<0.001)、Tpe (rho=0.646, p<0.001)、Tpe/QT (rho=0.571, p<0.001)、Tpe/QTc (rho=0.608, p<0.001)呈正相关。结论:新冠肺炎患者QTc、Tpe、Tpe/QT、Tpe/QTc值均高于对照组,且这些参数与hsTnI呈正相关。因此,心电图随访可能有助于预防心律失常事件,特别是对急性心脏损伤患者。Erciyes Medical Journal / Erciyes Tip Dergisi是KARE Publishing的财产,未经版权所有者的明确书面许可,其内容不得复制或通过电子邮件发送到多个网站或发布到listserv。但是,用户可以打印、下载或通过电子邮件发送文章供个人使用。这可以删节。对副本的准确性不作任何保证。用户应参阅原始出版版本的材料的完整。(版权适用于所有摘要。)
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Erciyes Medical Journal
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