{"title":"Assessment of Patient Safety Attitude Levels Among Healthcare Professionals Working in the Operating Room","authors":"M. Tamer","doi":"10.14744/etd.2022.52722","DOIUrl":"https://doi.org/10.14744/etd.2022.52722","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"75 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88075707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The war against the resistance of Acinetobacter baumannii: A Meta-Analysis in Turkey","authors":"Imdat Kilbas","doi":"10.14744/etd.2022.94770","DOIUrl":"https://doi.org/10.14744/etd.2022.94770","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78744774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The primary aim of this study was to use metagenomic next-generation sequencing (mNGS) data to identify coronavirus 2019 (COVID-19)-related biomarker genes and to construct a machine learning model that could successfully differentiate patients with COVID-19 from healthy controls. Materials and Methods: The mNGS dataset used in the study demonstrated expression of 15,979 genes in the upper airway in 234 patients who were COVID-19 negative and COVID-19 positive. The Boruta method was used to select qualitative biomarker genes associated with COVID-19. Random forest (RF), gradient boosting tree (GBT), and multi-layer perceptron (MLP) models were used to predict COVID-19 based on the selected biomarker genes. Results: The MLP (0.936) model outperformed the GBT (0.851), and RF (0.809) models in predicting COVID-19. The three most important biomarker candidate genes associated with COVID-19 were IFI27, TPTI, and FAM83A. Conclusion: The proposed model (MLP) was able to predict COVID-19 successfully. The results showed that the generated model and selected biomarker candidate genes can be used as diagnostic models for clinical testing or potential therapeutic targets and vaccine design.
{"title":"Prediction of COVID-19 Based on Genomic Biomarkers of Metagenomic Next-Generation Sequencing Data Using Artificial Intelligence Technology","authors":"S. Akbulut","doi":"10.14744/etd.2022.00868","DOIUrl":"https://doi.org/10.14744/etd.2022.00868","url":null,"abstract":"Objective: The primary aim of this study was to use metagenomic next-generation sequencing (mNGS) data to identify coronavirus 2019 (COVID-19)-related biomarker genes and to construct a machine learning model that could successfully differentiate patients with COVID-19 from healthy controls. Materials and Methods: The mNGS dataset used in the study demonstrated expression of 15,979 genes in the upper airway in 234 patients who were COVID-19 negative and COVID-19 positive. The Boruta method was used to select qualitative biomarker genes associated with COVID-19. Random forest (RF), gradient boosting tree (GBT), and multi-layer perceptron (MLP) models were used to predict COVID-19 based on the selected biomarker genes. Results: The MLP (0.936) model outperformed the GBT (0.851), and RF (0.809) models in predicting COVID-19. The three most important biomarker candidate genes associated with COVID-19 were IFI27, TPTI, and FAM83A. Conclusion: The proposed model (MLP) was able to predict COVID-19 successfully. The results showed that the generated model and selected biomarker candidate genes can be used as diagnostic models for clinical testing or potential therapeutic targets and vaccine design.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"36 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80663257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Assessment Of CD63 And CD203c Basophil Activation Tests In Patients With Immediate Drug Hypersensitivity Reaction To Rocuronium","authors":"F. Doğruel","doi":"10.14744/etd.2022.80633","DOIUrl":"https://doi.org/10.14744/etd.2022.80633","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73201441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hematogenous metastases of primary brain tumors are extremely rare and often overlooked (1). Glioblastoma, medulloblastoma, germ cell tumors, and ependymoma are the most common primary brain tumors that can present with hematogenous metastasis (2). A 21-year-old male patient was referred for an abdominal ultrasound due to elevated liver enzymes. He had been diagnosed with pineal germinoma with spinal drop metastases 11 months ago (Fig. 1a, b), and was treated with gamma knife radiosurgery and craniospinal radiotherapy. The abdominal ultrasound revealed hy-poechoic liver nodules. Magnetic resonance imaging (MRI) showed multiple small liver nodules with diffusion restriction and peripheral enhancement, indicating metastases (Fig. 1c, d). A liver biopsy confirmed the diagnosis of liver metastasis of intracranial germinoma. Systemic chemotherapy was initiated, and the two years of follow-up were uneventful. Metastases should be considered in the differential diagnosis when nodular lesions are detected in solid organs in patients with aggressive brain tumors.
{"title":"Intracranial germinoma metastasizing to the liver","authors":"Ahmet Yasin Yitik","doi":"10.14744/etd.2022.78380","DOIUrl":"https://doi.org/10.14744/etd.2022.78380","url":null,"abstract":"Hematogenous metastases of primary brain tumors are extremely rare and often overlooked (1). Glioblastoma, medulloblastoma, germ cell tumors, and ependymoma are the most common primary brain tumors that can present with hematogenous metastasis (2). A 21-year-old male patient was referred for an abdominal ultrasound due to elevated liver enzymes. He had been diagnosed with pineal germinoma with spinal drop metastases 11 months ago (Fig. 1a, b), and was treated with gamma knife radiosurgery and craniospinal radiotherapy. The abdominal ultrasound revealed hy-poechoic liver nodules. Magnetic resonance imaging (MRI) showed multiple small liver nodules with diffusion restriction and peripheral enhancement, indicating metastases (Fig. 1c, d). A liver biopsy confirmed the diagnosis of liver metastasis of intracranial germinoma. Systemic chemotherapy was initiated, and the two years of follow-up were uneventful. Metastases should be considered in the differential diagnosis when nodular lesions are detected in solid organs in patients with aggressive brain tumors.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"26 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75785129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidence of SARS-CoV-2 Infection in Asthma Patients on Omalizumab Therapy","authors":"Ö. Özdemir","doi":"10.14744/etd.2022.28938","DOIUrl":"https://doi.org/10.14744/etd.2022.28938","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"41 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76358333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective analysis of tularemia cases in Tokat","authors":"Emine Türkoğlu","doi":"10.14744/etd.2022.45793","DOIUrl":"https://doi.org/10.14744/etd.2022.45793","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"153 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75381791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Duration of oral antioxidant therapy in male infertility with increased DNA damage: 3 month versus 6 month","authors":"E. Hasırcı","doi":"10.14744/etd.2022.49404","DOIUrl":"https://doi.org/10.14744/etd.2022.49404","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"36 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74057916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of serum growth arrest specific-6/sAXL levels in type 2 diabetes mellitus","authors":"Merve Özel","doi":"10.14744/etd.2022.45403","DOIUrl":"https://doi.org/10.14744/etd.2022.45403","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79346357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Historical Perspective of the Management of Scoliosis","authors":"G. Yagci","doi":"10.14744/etd.2022.23682","DOIUrl":"https://doi.org/10.14744/etd.2022.23682","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":"116 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79658690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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