{"title":"Assessment of Patient Safety Attitude Levels Among Healthcare Professionals Working in the Operating Room","authors":"M. Tamer","doi":"10.14744/etd.2022.52722","DOIUrl":"https://doi.org/10.14744/etd.2022.52722","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88075707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Transcatheter Ventricular Septal Defect Closure on Children's Appetite, Hormones and Growth","authors":"O. Taşcı","doi":"10.14744/etd.2022.41848","DOIUrl":"https://doi.org/10.14744/etd.2022.41848","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82156462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The primary aim of this study was to use metagenomic next-generation sequencing (mNGS) data to identify coronavirus 2019 (COVID-19)-related biomarker genes and to construct a machine learning model that could successfully differentiate patients with COVID-19 from healthy controls. Materials and Methods: The mNGS dataset used in the study demonstrated expression of 15,979 genes in the upper airway in 234 patients who were COVID-19 negative and COVID-19 positive. The Boruta method was used to select qualitative biomarker genes associated with COVID-19. Random forest (RF), gradient boosting tree (GBT), and multi-layer perceptron (MLP) models were used to predict COVID-19 based on the selected biomarker genes. Results: The MLP (0.936) model outperformed the GBT (0.851), and RF (0.809) models in predicting COVID-19. The three most important biomarker candidate genes associated with COVID-19 were IFI27, TPTI, and FAM83A. Conclusion: The proposed model (MLP) was able to predict COVID-19 successfully. The results showed that the generated model and selected biomarker candidate genes can be used as diagnostic models for clinical testing or potential therapeutic targets and vaccine design.
{"title":"Prediction of COVID-19 Based on Genomic Biomarkers of Metagenomic Next-Generation Sequencing Data Using Artificial Intelligence Technology","authors":"S. Akbulut","doi":"10.14744/etd.2022.00868","DOIUrl":"https://doi.org/10.14744/etd.2022.00868","url":null,"abstract":"Objective: The primary aim of this study was to use metagenomic next-generation sequencing (mNGS) data to identify coronavirus 2019 (COVID-19)-related biomarker genes and to construct a machine learning model that could successfully differentiate patients with COVID-19 from healthy controls. Materials and Methods: The mNGS dataset used in the study demonstrated expression of 15,979 genes in the upper airway in 234 patients who were COVID-19 negative and COVID-19 positive. The Boruta method was used to select qualitative biomarker genes associated with COVID-19. Random forest (RF), gradient boosting tree (GBT), and multi-layer perceptron (MLP) models were used to predict COVID-19 based on the selected biomarker genes. Results: The MLP (0.936) model outperformed the GBT (0.851), and RF (0.809) models in predicting COVID-19. The three most important biomarker candidate genes associated with COVID-19 were IFI27, TPTI, and FAM83A. Conclusion: The proposed model (MLP) was able to predict COVID-19 successfully. The results showed that the generated model and selected biomarker candidate genes can be used as diagnostic models for clinical testing or potential therapeutic targets and vaccine design.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80663257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rare cause of severe dyspnea and right upper quadrant pain: Tension hydrothorax","authors":"F. Ufuk","doi":"10.14744/etd.2022.40121","DOIUrl":"https://doi.org/10.14744/etd.2022.40121","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83372611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paranasal sinus osteomas are slowly growing and frequently asymptomatic benign tumors. Surgery is the treatment method, and the approach may vary according to many factors about the tumor. The prominent locations of tumors were in the frontal sinuses, and in the ethmoid sinus. The most common complaint was a headache. The diagnosis was made by paranasal computed tomography in all patients. This report describes the approach to mananging osteoma in the paranasal region in 13 patients. Information on demographic features, the clinical presentation of the cases, radiographical outcomes, and surgical procedures were gathered and analyzed. Five patients were operated on endoscopic technique, six with osteoplastic flap technique and two with a combined approach. Symptomatic osteomas require surgery. The surgery considers the localization, size of the lesion, and the experience of the surgeon.
{"title":"Paranasal Sinus Osteomas: Evaluation of Surgical Management with 13 Cases","authors":"Irfan Kara","doi":"10.14744/etd.2022.27243","DOIUrl":"https://doi.org/10.14744/etd.2022.27243","url":null,"abstract":"Paranasal sinus osteomas are slowly growing and frequently asymptomatic benign tumors. Surgery is the treatment method, and the approach may vary according to many factors about the tumor. The prominent locations of tumors were in the frontal sinuses, and in the ethmoid sinus. The most common complaint was a headache. The diagnosis was made by paranasal computed tomography in all patients. This report describes the approach to mananging osteoma in the paranasal region in 13 patients. Information on demographic features, the clinical presentation of the cases, radiographical outcomes, and surgical procedures were gathered and analyzed. Five patients were operated on endoscopic technique, six with osteoplastic flap technique and two with a combined approach. Symptomatic osteomas require surgery. The surgery considers the localization, size of the lesion, and the experience of the surgeon.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83270897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Familial Hypokalemic Periodic Paralysis with Mutation in a Voltage-gated Calcium Channel","authors":"E. Altınel Açoğlu","doi":"10.14744/etd.2021.66066","DOIUrl":"https://doi.org/10.14744/etd.2021.66066","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90122172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of Novel NF1 Variants with Next Generation-based DNA Sequencing Technology, and Genotype-Phenotype Characteristics of Neurofibromatosis","authors":"A. Kiraz","doi":"10.14744/etd.2022.90023","DOIUrl":"https://doi.org/10.14744/etd.2022.90023","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90470286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differences between chronological age and height age in goiter interpretation","authors":"S. Koca","doi":"10.14744/etd.2022.56687","DOIUrl":"https://doi.org/10.14744/etd.2022.56687","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82631381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study was to evaluate the exposure and risk of contracting coronavirus disease (COVID-19), the infectious disease caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), among healthcare workers (HCWs) at a tertiary hospital early in the pandemic. Materials and Methods: HCWs who presented at an occupational health outpatient clinic for COVID-19 contact tracing or assessment before returning to work between March 30, 2020 and May 31, 2020 were evaluated in this cross-sectional study. The dependent variable used was a COVID-19 diagnosis;the independent variables used were gender, marital status, age, occupation, smoking, presence of chronic disease, symptoms of COVID-19, source of contact, risk classification, and work in a COVID-19 unit. Logistic regression analysis was used to assess factors associated with the risk of COVID-19 and sources of infection. Results: A total of 603 HCWs presented at the clinic during the study period. The most frequent sources of contact with SARS-CoV-2 were infected co-workers (50.7%) and patients at work (28.2%), followed by household contacts (9.9%). Those who worked in a COVID-19 unit had a 3.55 times greater risk of a COVID-19 diagnosis than other HCWs when adjusted for age, gender, and risk classification. Conclusion: HCWs frequently face exposure to potential infection. Sufficient support for these workers to ensure adequate awareness of and compliance with protocols is of critical importance to protect public health. The results of this study also suggest consideration of the possibility of another source of contact for HCWs included in the no risk category. Regular screening for COVID-19 may be advisable.
{"title":"Sources of Infection and Risk of COVID-19 for Healthcare Workers at a Tertiary Hospital","authors":"Ceyda Şahan","doi":"10.14744/etd.2022.22566","DOIUrl":"https://doi.org/10.14744/etd.2022.22566","url":null,"abstract":"Objective: The aim of this study was to evaluate the exposure and risk of contracting coronavirus disease (COVID-19), the infectious disease caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), among healthcare workers (HCWs) at a tertiary hospital early in the pandemic. Materials and Methods: HCWs who presented at an occupational health outpatient clinic for COVID-19 contact tracing or assessment before returning to work between March 30, 2020 and May 31, 2020 were evaluated in this cross-sectional study. The dependent variable used was a COVID-19 diagnosis;the independent variables used were gender, marital status, age, occupation, smoking, presence of chronic disease, symptoms of COVID-19, source of contact, risk classification, and work in a COVID-19 unit. Logistic regression analysis was used to assess factors associated with the risk of COVID-19 and sources of infection. Results: A total of 603 HCWs presented at the clinic during the study period. The most frequent sources of contact with SARS-CoV-2 were infected co-workers (50.7%) and patients at work (28.2%), followed by household contacts (9.9%). Those who worked in a COVID-19 unit had a 3.55 times greater risk of a COVID-19 diagnosis than other HCWs when adjusted for age, gender, and risk classification. Conclusion: HCWs frequently face exposure to potential infection. Sufficient support for these workers to ensure adequate awareness of and compliance with protocols is of critical importance to protect public health. The results of this study also suggest consideration of the possibility of another source of contact for HCWs included in the no risk category. Regular screening for COVID-19 may be advisable.","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88188384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of the Effects of Probiotics and Their Metabolites in the Treatment of Liver Cancer: an Update on Probiotics as a New Treatment","authors":"R. Bakhtiari","doi":"10.14744/etd.2022.25477","DOIUrl":"https://doi.org/10.14744/etd.2022.25477","url":null,"abstract":"","PeriodicalId":43995,"journal":{"name":"Erciyes Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89373382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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