A. Tekinalp, T. U. Kars, H. Z. Dikici, Sinan Demircioğlu, Özcan Çeneli
Objective: The study aims to determine the frequency and clinical features of COVID-19 during the long-term follow-up of patients with hematological malignancies. Methods: Patients with hematological malignancies followed in our center were evaluated retrospectively. The patients were divided into two groups with having COVID-19 between April 01, 2020, and July 01, 2021: those who had COVID-19 [COVID (+)] and those who didn’t have COVID-19 [COVID (-)]. Results: 1258 patients were evaluated. Of these, 288 (22.9%) were found to have had COVID-19. The most common and least common diagnoses in the COVID (+) group were non-Hodgkin lymphoma (NHL) (21.7%) and Hodgkin lymphoma (HL) (6.9%), respectively. The malignancies with the highest and lowest rates of COVID-19 (+) were multiple myeloma (MM) (35.6%) and chronic myeloid leukemia (CML) patients (17.8%), respectively. The median age was higher in COVID (+) chronic lymphocytic leukemia (CLL) patients than in COVID (-) patients (73 vs. 66; p= 0.001). All deaths were due to COVID in COVID (+) patients. The mortality rate for all patients was found to be significantly higher in the COVID (+) group than in the COVID (-) group (22.8% vs. 11.9%; p<0.001). Myelodysplastic syndrome (MDS) (39.5%) and acute leukemia (AL) (35.7%) had the highest mortality rates in the COVID (+) group. The mortality rates in COVID (+) CLL (26% vs. 7%), AL (35.7% vs. 17.7%) and MM (28.6% vs. 9.2%) were significantly higher than in the COVID (-) group. There were no deaths due to COVID-19 in CML patients. 79.8% of COVID (+) patients were hospitalized, and the mortality rate in these patients was significantly higher than in outpatients (34.6% vs. 2.8%; p<0.001). The patients with the highest need for mechanic ventilation had MDS (44.8%) and AL (36%). Conclusion: Our study provides important data to the literature comparing the effect of SARS-CoV-2 on all hematological malignancies with malignant patients who do not have COVID-19. KEYWORDS COVID-19, hematological malignancies, pandemic, SARS-CoV-2
{"title":"The Long-Term Analysis of Hematological Malignancies: Patients with COVID-19 versus without COVID-19","authors":"A. Tekinalp, T. U. Kars, H. Z. Dikici, Sinan Demircioğlu, Özcan Çeneli","doi":"10.36519/kd.2022.4182","DOIUrl":"https://doi.org/10.36519/kd.2022.4182","url":null,"abstract":"Objective: The study aims to determine the frequency and clinical features of COVID-19 during the long-term follow-up of patients with hematological malignancies.\u0000\u0000Methods: Patients with hematological malignancies followed in our center were evaluated retrospectively. The patients were divided into two groups with having COVID-19 between April 01, 2020, and July 01, 2021: those who had COVID-19 [COVID (+)] and those who didn’t have COVID-19 [COVID (-)].\u0000\u0000Results: 1258 patients were evaluated. Of these, 288 (22.9%) were found to have had COVID-19. The most common and least common diagnoses in the COVID (+) group were non-Hodgkin lymphoma (NHL) (21.7%) and Hodgkin lymphoma (HL) (6.9%), respectively. The malignancies with the highest and lowest rates of COVID-19 (+) were multiple myeloma (MM) (35.6%) and chronic myeloid leukemia (CML) patients (17.8%), respectively. The median age was higher in COVID (+) chronic lymphocytic leukemia (CLL) patients than in COVID (-) patients (73 vs. 66; p= 0.001). All deaths were due to COVID in COVID (+) patients. The mortality rate for all patients was found to be significantly higher in the COVID (+) group than in the COVID (-) group (22.8% vs. 11.9%; p<0.001). Myelodysplastic syndrome (MDS) (39.5%) and acute leukemia (AL) (35.7%) had the highest mortality rates in the COVID (+) group. The mortality rates in COVID (+) CLL (26% vs. 7%), AL (35.7% vs. 17.7%) and MM (28.6% vs. 9.2%) were significantly higher than in the COVID (-) group. There were no deaths due to COVID-19 in CML patients. 79.8% of COVID (+) patients were hospitalized, and the mortality rate in these patients was significantly higher than in outpatients (34.6% vs. 2.8%; p<0.001). The patients with the highest need for mechanic ventilation had MDS (44.8%) and AL (36%).\u0000\u0000Conclusion: Our study provides important data to the literature comparing the effect of SARS-CoV-2 on all hematological malignancies with malignant patients who do not have COVID-19.\u0000\u0000KEYWORDS\u0000COVID-19, hematological malignancies, pandemic, SARS-CoV-2","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48628592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This research was conducted to determine the effects of nurses’ fear of COVID-19 on their dietary habits and use of supplements. Methods: The research, which is descriptive and cross-sectional, was shared as an online survey over the social networking site and social networking with the snowball sampling method. It was carried out between December 2020 and March 2021 with 485 nurses who worked actively during the pandemic and agreed to participate in the study. The data were obtained with the questionnaire in line with the relevant literature and the “COVID -19 Fear Scale”. The data were used to evaluate the number, percentage, mean, standard deviation, median, minimum, maximum, t-test, ANOVA test, and x² test. Results: Fear levels were found to be higher in nurses who regularly took food supplements during the pandemic and didn’t have adequate or balanced nutrition, who couldn’t eat most of the time due to working conditions, who took the food supplements to help in the prevention and treatment of COVID-19 and who recommended them to the individuals around them (p<0.05). Conclusion: It was determined that there was an increase in nurses’ use of food supplements before and during the pandemic, and this increase was statistically significant (p<0.001). Keywords: Pandemic, nutrition, supplementary food, fear of COVID-19
{"title":"Relationship Between Nutrition and Supplementary Food Use and Fear of COVID-19 in Nurses Who Worked Actively During the Pandemic","authors":"Fatma Zingiloglu, K. Beydağ","doi":"10.36519/kd.2022.4167","DOIUrl":"https://doi.org/10.36519/kd.2022.4167","url":null,"abstract":"Objectives: This research was conducted to determine the effects of nurses’ fear of COVID-19 on their dietary habits and use of supplements. Methods: The research, which is descriptive and cross-sectional, was shared as an online survey over the social networking site and social networking with the snowball sampling method. It was carried out between December 2020 and March 2021 with 485 nurses who worked actively during the pandemic and agreed to participate in the study. The data were obtained with the questionnaire in line with the relevant literature and the “COVID -19 Fear Scale”. The data were used to evaluate the number, percentage, mean, standard deviation, median, minimum, maximum, t-test, ANOVA test, and x² test. Results: Fear levels were found to be higher in nurses who regularly took food supplements during the pandemic and didn’t have adequate or balanced nutrition, who couldn’t eat most of the time due to working conditions, who took the food supplements to help in the prevention and treatment of COVID-19 and who recommended them to the individuals around them (p<0.05). Conclusion: It was determined that there was an increase in nurses’ use of food supplements before and during the pandemic, and this increase was statistically significant (p<0.001). Keywords: Pandemic, nutrition, supplementary food, fear of COVID-19","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48841942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Multiple factors have been studied in association with disease severity in COVID-19. The cycle threshold (Ct) value of polymerase chain reaction (PCR) can reflect viral load in the specimens. In this study, we aimed to evaluate the effect of the Ct value on clinical course and mortality in COVID-19 patients. Methods: Adult patients who tested positive for SARS-CoV-2 with PCR test and who were hospitalized with COVID-19-related symptoms between August 1, 2020, and November 30, 2020, were included in the study. In addition, Ct value, demographic and clinical data (length of hospital stay, need for admission to intensive care unit (ICU), need for mechanical ventilation (MV), and mortality) were reviewed retrospectively. Results: 117 patients were included in the study. The mean Ct value was 22.37±4.72 (11.07-34.06). There was no significant difference in the mean Ct values between the patients who needed ICU admission and those who did not. When the patients were evaluated by dividing them into three groups according to their Ct values, as < 20, between 20-24 and >24; there was no significant difference between these three groups in terms of severity of pneumonia, laboratory parameters (D-dimer, Neutrophil/Lymphocyte ratio, C-reactive protein, lymphocyte count), length of hospital stay, need for ICU admission, need for MV and mortality. When the patients were divided into two groups with Ct values as <23.3 and ≥23.3, no significant difference was found between the groups regarding ICU need, MV need, and 28-day mortality rates. Conclusion: Most of the studies in the literature about Ct value and its effect on clinical course indicate that lower Ct values are potentially associated with worse outcomes in COVID-19. However, there are also studies reporting that the Ct value does not reflect the severity of the disease. We did not find a correlation between Ct value and laboratory markers, length of hospital stay, the severity of pneumonia, need for ICU admission or MV, and mortality in COVID-19 patients in this presented study. Keywords: Ct value, cycle threshold, COVID-19, clinical course, mortality
{"title":"Evaluation of the Association Between Ct Value of SARS-CoV-2 PCR with Disease Progression and Mortality","authors":"Kübra Demir-Önder, Aysegul Seremet-Keskin, Aylin Erman-Daloglu, Umay Balcı, Ülkü Üser","doi":"10.36519/kd.2022.4190","DOIUrl":"https://doi.org/10.36519/kd.2022.4190","url":null,"abstract":"Objective: Multiple factors have been studied in association with disease severity in COVID-19. The cycle threshold (Ct) value of polymerase chain reaction (PCR) can reflect viral load in the specimens. In this study, we aimed to evaluate the effect of the Ct value on clinical course and mortality in COVID-19 patients.\u0000\u0000Methods: Adult patients who tested positive for SARS-CoV-2 with PCR test and who were hospitalized with COVID-19-related symptoms between August 1, 2020, and November 30, 2020, were included in the study. In addition, Ct value, demographic and clinical data (length of hospital stay, need for admission to intensive care unit (ICU), need for mechanical ventilation (MV), and mortality) were reviewed retrospectively.\u0000\u0000Results: 117 patients were included in the study. The mean Ct value was 22.37±4.72 (11.07-34.06). There was no significant difference in the mean Ct values between the patients who needed ICU admission and those who did not. When the patients were evaluated by dividing them into three groups according to their Ct values, as < 20, between 20-24 and >24; there was no significant difference between these three groups in terms of severity of pneumonia, laboratory parameters (D-dimer, Neutrophil/Lymphocyte ratio, C-reactive protein, lymphocyte count), length of hospital stay, need for ICU admission, need for MV and mortality. When the patients were divided into two groups with Ct values as <23.3 and ≥23.3, no significant difference was found between the groups regarding ICU need, MV need, and 28-day mortality rates.\u0000\u0000Conclusion: Most of the studies in the literature about Ct value and its effect on clinical course indicate that lower Ct values are potentially associated with worse outcomes in COVID-19. However, there are also studies reporting that the Ct value does not reflect the severity of the disease. We did not find a correlation between Ct value and laboratory markers, length of hospital stay, the severity of pneumonia, need for ICU admission or MV, and mortality in COVID-19 patients in this presented study.\u0000\u0000Keywords: Ct value, cycle threshold, COVID-19, clinical course, mortality","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49245916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Akdogan, D. Yapar, E. Demir, Pinar Tuncel-Ozturk, Aysel Kocagul-Celikbas, N. Baykam
{"title":"Are We Ready to Follow HIV/AIDS Patients?","authors":"O. Akdogan, D. Yapar, E. Demir, Pinar Tuncel-Ozturk, Aysel Kocagul-Celikbas, N. Baykam","doi":"10.36519/kd.2022.3798","DOIUrl":"https://doi.org/10.36519/kd.2022.3798","url":null,"abstract":"","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69624919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although PCR is the most reliable test for the diagnosis of Covid-19 infection, false negative and positive results can also occur. Our case is a 32-year-old laboratory technician who applied with headache and malaise and her first Covid-19 PCR test was negative. It was repeated two days later, and the result was positive. Additional tests were also performed, and Parvovirus IgM antibody was also found to be positive. Four weeks later, while Covid-19 IgM and IgG test results were negative, the Parvovirus B19 IgG and IgM test results were positive. The Covid-19 PCR test was evaluated as false positive. We aimed to emphasize the need to consider other viral infections in the differential diagnosis even under pandemic conditions.
{"title":"A Case of Parvovirus B19 Infection Diagnosed as COVID-19 due to False PCR Positivity","authors":"G. Şenol, Ferhat Demirci","doi":"10.36519/kd.2022.3872","DOIUrl":"https://doi.org/10.36519/kd.2022.3872","url":null,"abstract":"Although PCR is the most reliable test for the diagnosis of Covid-19 infection, false negative and positive results can also occur. Our case is a 32-year-old laboratory technician who applied with headache and malaise and her first Covid-19 PCR test was negative. It was repeated two days later, and the result was positive. Additional tests were also performed, and Parvovirus IgM antibody was also found to be positive. Four weeks later, while Covid-19 IgM and IgG test results were negative, the Parvovirus B19 IgG and IgM test results were positive. The Covid-19 PCR test was evaluated as false positive. We aimed to emphasize the need to consider other viral infections in the differential diagnosis even under pandemic conditions.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42622598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Diagnostic Performance of Culture, Rapid Urease Test and Histopathology in the Diagnosis of Helicobacter pylori Infection, and In Vitro Susceptibility of Various Antimicrobials Against Helicobacter pylori","authors":"R. Kesli, H. Bilgin, Yasar Unlu, G. Gungor","doi":"10.36519/kd.2022.3573","DOIUrl":"https://doi.org/10.36519/kd.2022.3573","url":null,"abstract":"","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43880052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Healthcare professionals taking care of COVID-19 patients are considered to be at high risk for acquiring infection, and the protection of healthcare professionals is one of the top priorities. Inadequate knowledge of the disease by healthcare professionals and their inability to access or use personal protective equipment (PPE) required for protection may cause rapidly spreading of infection. In this study, we aimed to evaluate the knowledge levels of healthcare professionals regarding COVID-19 and PPE use.
{"title":"Evaluation of Healthcare Professionals’ Knowledge Level, Attitude and Use of Personal Protective Equipment about COVID-19","authors":"Tuba Duman-Karakus, E. Tanyel, A. Deveci","doi":"10.36519/kd.2022.4036","DOIUrl":"https://doi.org/10.36519/kd.2022.4036","url":null,"abstract":"Objective: Healthcare professionals taking care of COVID-19 patients are considered to be at high risk for acquiring infection, and the protection of healthcare professionals is one of the top priorities. Inadequate knowledge of the disease by healthcare professionals and their inability to access or use personal protective equipment (PPE) required for protection may cause rapidly spreading of infection. In this study, we aimed to evaluate the knowledge levels of healthcare professionals regarding COVID-19 and PPE use.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44980327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ç. Kader, A. Erbay, Mehmet Samet Demirel, Osman Kocabiyik, Elif Ciftci, Nuriye Yalcın-Colak, Guleser Unsal, Sebnem Eren-Gok
Objective: Healthcare professionals will be key to the success of COVID-19 vaccination programs because they are in the primary vaccination group. This study aims to measure and evaluate the acceptance, attitudes, and behaviors of healthcare professionals towards the COVID-19 vaccine.
{"title":"Evaluation of Attitudes and Behaviors of Healthcare Professionals towards COVID-19 Vaccination","authors":"Ç. Kader, A. Erbay, Mehmet Samet Demirel, Osman Kocabiyik, Elif Ciftci, Nuriye Yalcın-Colak, Guleser Unsal, Sebnem Eren-Gok","doi":"10.36519/kd.2022.3799","DOIUrl":"https://doi.org/10.36519/kd.2022.3799","url":null,"abstract":"Objective: Healthcare professionals will be key to the success of COVID-19 vaccination programs because they are in the primary vaccination group. This study aims to measure and evaluate the acceptance, attitudes, and behaviors of healthcare professionals towards the COVID-19 vaccine.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44107251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ozlem Altuntas-Aydin, A. Gunduz, A. Inan, Hayat Kumbasar-Karaosmanoglu, B. Mete, S. Tekin, Dilek Sevgi Yildiz, F. Tabak
{"title":"Initiation of Rapid Antiretroviral Therapy in HIV Infection","authors":"Ozlem Altuntas-Aydin, A. Gunduz, A. Inan, Hayat Kumbasar-Karaosmanoglu, B. Mete, S. Tekin, Dilek Sevgi Yildiz, F. Tabak","doi":"10.36519/kd.2022.3699","DOIUrl":"https://doi.org/10.36519/kd.2022.3699","url":null,"abstract":"","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69624875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve Sefa Sayar, A. Acar, D. Bulut, S. Çelik, E. Oguz
Objective: Immunosuppressive drugs are included in the treatment protocols of severe COVID-19 cases that may present with cytokine storm. In this study, we aimed to examine the characteristics of COVID-19 patients who received immunosuppressive therapy Methods: Patients diagnosed with COVID-19 and followed in the quarantine wards of our hospital between 01.03.2020-24.05.2020 were included in the study. Patient information was obtained retrospectively from patient files and discharge reports, and 263 COVID-19 patients -aged 18 and over- were included in the study.
{"title":"Evaluation of COVID-19 Cases Who Received Immunosuppressive Therapy at a Tertiary Care Hospital","authors":"Merve Sefa Sayar, A. Acar, D. Bulut, S. Çelik, E. Oguz","doi":"10.36519/kd.2022.3538","DOIUrl":"https://doi.org/10.36519/kd.2022.3538","url":null,"abstract":"Objective: Immunosuppressive drugs are included in the treatment protocols of severe COVID-19 cases that may present with cytokine storm. In this study, we aimed to examine the characteristics of COVID-19 patients who received immunosuppressive therapy Methods: Patients diagnosed with COVID-19 and followed in the quarantine wards of our hospital between 01.03.2020-24.05.2020 were included in the study. Patient information was obtained retrospectively from patient files and discharge reports, and 263 COVID-19 patients -aged 18 and over- were included in the study.","PeriodicalId":44309,"journal":{"name":"Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44370019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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