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Role of conjunctival imprint cytology in detecting vitamin A deficiency in cancer patients: A case-control study 结膜印迹细胞学在检测癌症患者维生素A缺乏中的作用:一项病例对照研究
Pub Date : 2014-07-01 DOI: 10.4103/2278-019X.131960
C. Padmini, P. A. Kumari, D. R. Rao
Context: Conjunctival Imprint cytology is widely used to detect vitamin A deficiency in field studies. Vitamin A deficiency is known to be associated with malignancies. Aims: To assess the vitamin-A status in cancer patients using conjunctival impression cytology technique (CICT) and to correlate the results with serum levels of the vitamin. Settings and Design: To study CICT in freshly detected cancer patients. To compare with normal controls, and to correlate the results obtained by the cytology technique with a serum retinol by HPLC method. Materials and Methods: Patients and their family members accompanying the patients were taken as subjects for the study and after an informed consent. Conjunctival imprint cytology samples and venous blood for serum retinol were collected from both groups. Statistical Analysis Used: Odds ratio, Pearson Chi-square test, Fisher exact test, analysis of variable, independent and dependent sample t test, mean and standard deviation. Data: Of 1551 subjects analyzed, vitamin A level Conclusions: CICT is a reliable technique to detect vitamin A deficiency in cancer patients.
背景:结膜印迹细胞学在实地研究中广泛用于检测维生素A缺乏症。众所周知,维生素A缺乏与恶性肿瘤有关。目的:应用结膜印象细胞学技术(CICT)评价肿瘤患者的维生素a水平,并探讨其与血清维生素水平的相关性。设置与设计:研究新发现的癌症患者的CICT。与正常对照进行比较,并将细胞学技术所得结果与高效液相色谱法测定血清视黄醇进行比较。材料与方法:选取患者及其家属为研究对象,经知情同意后进行研究。采集结膜印迹细胞学标本和静脉血血清视黄醇含量。统计学分析:比值比、Pearson卡方检验、Fisher精确检验、变量分析、独立样本和依赖样本t检验、均值和标准差。结论:CICT是检测癌症患者维生素A缺乏症的可靠技术。
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引用次数: 0
Metabolic abnormalities and body composition in Human Immunodeficiency Virus-infected patients receiving highly active anti-retroviral therapy 接受高活性抗逆转录病毒治疗的人类免疫缺陷病毒感染患者的代谢异常和身体组成
Pub Date : 2014-07-01 DOI: 10.4103/2278-019X.131961
I. Ali, Reetu Keisam, Avinash Keisam, L. Prasad, R. Salam, Premchand Singh Thangjam
Background: With the advent of highly active antiretroviral therapy (HAART) metabolic abnormalities such as dyslipidaemia, changes in fat distribution and insulin resistance have been observed with increasing frequency in patients with Human Immunodeficiency Virus (HIV) infection. Aims: This study was undertaken to (i) assess body composition and the metabolic effects of HAART in HIV infected patients and (ii) compare the above variables between different 1 st and 2 nd ART regimens of National AIDS Control Organization of India. Methods and Material: 201 HIV patients receiving HAART for more than 3 months were studied. Body mass composition was measured using TANITA segmental body composition monitor. The metabolic parameters measured included blood glucose, serum cholesterol and serum triglycerides. Results: Lipodystrophy was observed in 21.40% patients. The mean body mass index (BMI) was 18.24 ± 3.18 and mean visceral fat mass was 4.16 kg. Altered lipid profile was observed in 26.86% patients (25.55% on 1 st line and 38.09% on 2 nd line) and impaired glucose tolerance was seen in 7.96% (6.66% on 1 st line and 19.04% on 2 nd line). Conclusions: HAART has significant effect on the body mass composition and metabolic parameters.
背景:随着高效抗逆转录病毒治疗(HAART)的出现,代谢异常如血脂异常、脂肪分布改变和胰岛素抵抗在人类免疫缺陷病毒(HIV)感染患者中越来越常见。目的:本研究旨在(i)评估艾滋病毒感染患者的身体成分和HAART的代谢影响,(ii)比较印度国家艾滋病控制组织不同的第1和第2 ART方案之间的上述变量。方法与材料:201例接受HAART治疗3个月以上的HIV患者。采用TANITA节段性体成分监测仪测量体质量组成。测量的代谢参数包括血糖、血清胆固醇和血清甘油三酯。结果:21.40%的患者出现脂肪营养不良。平均体重指数(BMI)为18.24±3.18,平均内脏脂肪量为4.16 kg。26.86%的患者出现血脂改变(第1组为25.55%,第2组为38.09%),7.96%的患者出现糖耐量受损(第1组为6.66%,第2组为19.04%)。结论:HAART对机体质量组成和代谢参数有显著影响。
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引用次数: 3
Reversible MRI changes of prolonged hypoglycemia 长期低血糖的可逆性MRI改变
Pub Date : 2014-07-01 DOI: 10.4103/2278-019X.131963
S. Thakur, N. Babu, J. Mokta, Sanjeev Sharma
Hypoglycemia is most commonly caused by drugs used to treat diabetes mellitus or by exposure to other drugs, including alcohol. Diverse neurologic manifestations of hypoglycemia have been reported frequently. These neurologic symptoms range from focal neurologic deficits to permanent dysfunction or death. Here, we report a case of prolonged hypoglycemia in an alcoholic who was unconscious and in whom there were reversible changes on magnetic resonance imaging.
低血糖最常见的原因是治疗糖尿病的药物或接触其他药物,包括酒精。低血糖的多种神经系统表现已被频繁报道。这些神经系统症状的范围从局灶性神经功能缺损到永久性功能障碍或死亡。在此,我们报告一例长期低血糖的酗酒者,他是无意识的,在磁共振成像上有可逆的变化。
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引用次数: 2
Vitamins at the Nobels 诺贝尔奖上的维生素
Pub Date : 2013-07-01 DOI: 10.4103/2278-019X.114727
B. Kalra, S. Kalra
The Nobel Prize is the pinnacle of success in medical research. An analysis of the Nobel Prize winning discoveries gives an idea of the evolution of modern medical science. This brief communication focuses on the vitamins that made it to the Nobel high table, i.e., the vitamin-related discoveries that won the Prize in Physiology or Medicine, and in Chemistry. The authors trace the history of vitamins at the Nobel Prize, from 1903, when Niels Finsen won the prize for his work on heliotherapy, till date. The discoveries of various researchers are explained, as is their importance.
诺贝尔奖是医学研究成功的顶峰。对诺贝尔奖获奖发现的分析使人们对现代医学的发展有了一个了解。这篇简短的交流主要集中在那些进入诺贝尔奖高台上的维生素,即获得生理学或医学奖和化学奖的与维生素相关的发现。作者追溯了维生素获得诺贝尔奖的历史,从1903年尼尔斯·芬森(Niels Finsen)因其在日光疗法方面的工作获得诺贝尔奖开始,一直到现在。书中解释了不同研究人员的发现及其重要性。
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引用次数: 0
The underestimated nutritional aspects of micronutrients supplementation in intensive care 在重症监护中微量营养素补充的被低估的营养方面
Pub Date : 2013-07-01 DOI: 10.4103/2278-019X.114730
Sukhminder Jit Bajwa
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引用次数: 3
Garlic supplement, probiotics enriched fermented milk, and their combination: Effect on glycemia, dyslipidemia and oxidative status in STZ-diabetic rats 大蒜补充剂、益生菌发酵乳及其组合:对stz -糖尿病大鼠血糖、血脂异常和氧化状态的影响
Pub Date : 2013-07-01 DOI: 10.4103/2278-019X.114720
M. Badkook
Background: Oxidative stress associated with hyperglycemia is a key factor in the development of diabetic complications. The organosulfur compounds in garlic have been shown to possess antioxidative, antidiabetic and immunological potency. Probiotics in fermented milk (FM) also enhance antioxidant and hypoglycemic therapy through the modulation of gut microbes in type 2 diabetes. Aim : To examine the effects of administration of garlic supplement, probiotics, and their combination on glycemic, lipid, and antioxidant status in type 2 diabetes. Materials and Methods : Diabetes was induced by STZ-injection in thirty male albino rats. Animals were equally divided to 5 groups: garlic (G) (20 mg/kgBW/Allicin), probiotics (Prob) (0.5 ml/kg/BW), garlic with probiotics (G + Prob), oral hypoglycemic drug (OGD), diabetic control (DM). After 45 days of treatment, tests were conducted for fasting glucose, glycated hemoglobin (GHbA1c), insulin, malondialdehyde (MDA), total antioxidant capacity (TOAC), total cholesterol (TC), LDL-C, HDL-C, and TG. Results: Glucose and GHbA1c were significantly reduced with all treatments. GHbA1c was significantly lower in the G and G + P groups compared to DM and OGD. No significant difference was observed for insulin. Garlic reduced TC and TG compared to DM, and reduced LDL-C compared to OGD. G + Prob treatment raised LDL-C compared to G, Prob, and OGD groups. HDL-C significantly increased in the P and G + Prob groups compared to DM, OGD, and G groups. MDA decreased with all treatments, while TOAC increased with G and G + P groups compared to DM and OGD. Conclusion: G arlic, or its combination with probiotics might promote beneficial effects in controlling glycemia, dyslipidemia, and oxidative stress. Probiotics was not as efficient as G and G + Prob treatments.
背景:氧化应激与高血糖相关是糖尿病并发症发生的关键因素。大蒜中的有机硫化合物已被证明具有抗氧化、抗糖尿病和免疫功效。发酵乳中的益生菌也通过调节2型糖尿病患者的肠道微生物来增强抗氧化和降糖治疗。目的:探讨大蒜补充剂、益生菌及其联合使用对2型糖尿病患者血糖、血脂和抗氧化状态的影响。材料与方法:用stz注射液诱导30只雄性白化大鼠患糖尿病。动物平均分为5组:大蒜(G)组(20 mg/kgBW/蒜素)、益生菌(Prob)组(0.5 ml/kg/BW)、大蒜加益生菌(G + Prob)组、口服降糖药(OGD)组、糖尿病对照组(DM)组。治疗45天后,检测空腹血糖、糖化血红蛋白(GHbA1c)、胰岛素、丙二醛(MDA)、总抗氧化能力(TOAC)、总胆固醇(TC)、LDL-C、HDL-C和TG。结果:各治疗组血糖、GHbA1c均显著降低。与DM和OGD相比,G组和G + P组的GHbA1c显著降低。胰岛素组无显著差异。与DM相比,大蒜降低了TC和TG,与OGD相比,大蒜降低了LDL-C。与G、Prob和OGD组相比,G + Prob组LDL-C升高。与DM、OGD和G组相比,P组和G + Prob组HDL-C显著升高。与DM和OGD相比,G和G + P组MDA降低,TOAC升高。结论:大蒜或其与益生菌联合使用可能对控制血糖、血脂异常和氧化应激具有有益作用。益生菌治疗效果不如G和G + Prob治疗。
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引用次数: 0
Controversies, principles and essentials of enteral and parenteral nutrition in critically ill-patients 危重病人肠内和肠外营养的争议、原则和要点
Pub Date : 2013-07-01 DOI: 10.4103/2278-019X.114731
Sukhminder Jit Bajwa, Sachin Gupta
Nutritional management in critically ill-patients is always a challenging task as malnutrition can have a direct impact on the prognosis. Besides assessing for nutritional requirement, the underlying severe illness and co-morbidities have to be given due consideration. Nutritional assessment has to be individualized, and nutritional plan should be formulated by involving a dedicated nutritionist. Early initiation of nutrition definitely improves the outcome in critically ill patients. Facts and principles of enteral and parenteral nutrition must be disseminated among all physicians and nursing staff working in intensive care units. Majority of old controversies related to parenteral and enteral nutrition have been settled with the intervention of various national and international committees such as Alliance and Espen. Nutritional disorders such as malnutrition, overfeeding and negative energy balance are highly associated with increased morbidity and mortality. Enteral nutrition though always preferred can always be supplemented with parenteral nutrition so as to optimize nutrition and energy status in critically ill patients.
危重病人的营养管理一直是一项具有挑战性的任务,因为营养不良可以直接影响预后。除了评估营养需求外,还必须适当考虑潜在的严重疾病和合并症。营养评估必须个体化,营养计划应由专门的营养师制定。早期开始营养治疗肯定能改善危重病人的预后。必须向在重症监护病房工作的所有医生和护理人员宣传肠内和肠外营养的事实和原则。大多数与肠外营养和肠内营养有关的旧争论已经解决了各种国家和国际委员会的干预,如联盟和Espen。营养失调,如营养不良、过度喂养和负能量平衡,与发病率和死亡率增加高度相关。虽然肠内营养一直是首选,但在危重患者中,肠外营养总是可以补充的,以优化营养和能量状况。
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引用次数: 4
Nutrition, energy intake- output, exercise, and fluid homeostasis during fasting in Ramadan 斋月禁食期间的营养、能量摄入-输出、运动和体液平衡
Pub Date : 2013-07-01 DOI: 10.4103/2278-019X.114722
M. Jaleel, F. Fathima, B. Jaleel
The month long ritual fasting undertaken by Muslims in Ramadan though intermittent in that they abstain from eating and drinking from dawn till dusk only, it is absolute during the span of fasting as they are forbidden from taking anything by mouth be it water, fruits or even oral medications. There are bound to be changes in their life style, sleep hours, physical activities, food consumption, meals frequencies, and dietary habits for different reasons. Proper management of food and fluid intake and exercise activity regulation is essential so that the spiritual fasting of Ramadan becomes an enjoyable experience free from avoidable hardships for all those who are found fit to undertake Ramadan fasting. Controlled studies are required to unravel the mysteries surrounding the complete understanding of the physiological states of satiety, hunger and fasting, and the role of both internal and external factors of orexigenic and anorexogenic nature and the scientific basis of the relative ease with which millions of Muslims the world over are able to observe the month-long Ramadan fast.
穆斯林在斋月期间进行的长达一个月的仪式禁食,虽然间歇性地从黎明到黄昏都不吃不喝,但在禁食期间是绝对的,因为他们禁止口服任何东西,无论是水、水果,甚至是口服药物。由于不同的原因,他们的生活方式、睡眠时间、体育活动、食物消耗、用餐频率和饮食习惯必然会发生变化。适当管理食物和液体的摄入以及运动活动的调节是必不可少的,这样斋月的精神斋戒才会成为所有适合斋月斋戒的人的一种愉快的经历,而不会有可避免的困难。需要对照研究来揭开围绕着对饱腹、饥饿和禁食的生理状态的完整理解的奥秘,以及厌氧和厌食性质的内部和外部因素的作用,以及世界各地数百万穆斯林能够相对轻松地遵守长达一个月的斋月禁食的科学基础。
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引用次数: 7
Impact of nutritional counseling on dietary practices and body mass index among people living with HIV/AIDS at a tertiary care teaching hospital in Mumbai 孟买一家三级保健教学医院的营养咨询对艾滋病毒/艾滋病感染者饮食习惯和体重指数的影响
Pub Date : 2013-07-01 DOI: 10.4103/2278-019X.114721
Sushma S. Gaikwad, P. Giri, S. R. Suryawanshi, S. Garg, M. Singh, V. Gupta
Background: In India, human immunodeficiency virus (HIV) epidemic occurs in the population in which malnutrition is already endemic. The relationship between HIV and nutrition is multi-faceted and multi-directional. HIV can cause or worsen malnutrition due to decreased food intake, increased energy requirements, and poor nutrient absorption. Malnutrition in turn further weakens the immune system, increasing susceptibility to infections and worsening the disease impact. Materials and Methods: This interventional study was carried out in the antiretroviral therapy (ART) Centre of Topiwala National Medical College and BYL Nair Ch. Hospital, Mumbai during the period of July 2011 to February 2012. A total of 123 patients during the study period were included and a pre-designed and pre-tested questionnaire was used to collect data. Data were analyzed using Statistical Package of Social Sciences (SPSS) 16.0. Results: In the present study, out of 123 study participants taken into consideration, 47.15% were males and 52.85% were females. After nutritional counseling, the percentage of participants practice of using boiled or clean water for drinking purpose increased significantly from 30.90% to 82.12% ( P Conclusion: Effects of nutritional counselling in our study groups were favourable. There were improvements in dietary practices about nutrition in people living with HIV/AIDS.
背景:在印度,人类免疫缺陷病毒(HIV)的流行发生在营养不良已经流行的人群中。艾滋病毒与营养之间的关系是多方面的、多方位的。由于食物摄入减少、能量需求增加和营养吸收不良,艾滋病毒可引起或加重营养不良。营养不良反过来又进一步削弱免疫系统,增加对感染的易感性,使疾病的影响恶化。材料和方法:本介入研究于2011年7月至2012年2月在孟买Topiwala国立医学院抗逆转录病毒治疗(ART)中心和BYL Nair总医院进行。研究期间共纳入123例患者,采用预先设计和预先测试的问卷收集数据。数据采用SPSS 16.0统计软件包进行分析。结果:本研究纳入的123名研究对象中,男性占47.15%,女性占52.85%。在接受营养咨询后,使用开水或清水饮用的比例从30.90%显著增加到82.12% (P结论:营养咨询在我们的研究组中效果良好。艾滋病毒/艾滋病感染者的营养饮食习惯有所改善。
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引用次数: 8
Nutritional risk factors in endocrine diseases 内分泌疾病的营养危险因素
Pub Date : 2013-07-01 DOI: 10.4103/2278-019X.114732
S. Bajwa, Randeep Kaur, Esha Sethi
Nutrition plays a role of great magnitude in the pathogenesis and progress of endocrine diseases. Traditionally, the nutritional risk factors such as over- and under-nutrition in the context of endocrine diseases have been described alone in their individual capacity. However, the current subject of interest is how these risk factors interact with genetic variations and affect nutritional programming. Also, the role of endocrine disrupter chemicals that are consistently being ingested in routine diet is being evaluated in the causation of current epidemic of endocrine disorders such as diabetes and obesity. The present review aims at highlighting the important nutritional risk factors that have impacts on various endocrine disorders.
营养在内分泌疾病的发病和发展过程中起着重要的作用。传统上,营养风险因素,如内分泌疾病中的营养过剩和营养不足,都是单独以其个人能力来描述的。然而,目前感兴趣的主题是这些风险因素如何与遗传变异相互作用并影响营养规划。此外,正在评估日常饮食中不断摄入的内分泌干扰化学物质在导致糖尿病和肥胖等内分泌失调疾病流行方面的作用。本综述的目的是强调重要的营养危险因素对各种内分泌失调的影响。
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引用次数: 7
期刊
Journal of Medical Nutrition and Nutraceuticals
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