Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130614
S. Jayarathna, M. Ahmed, S. Cho
The motivation of this study was to develop a Geant4-based novel three dimensional (3D) digital mouse model derived from in vivo cone-beam computed tomography (CBCT) images of a mouse injected with gold nanoparticles (GNPs) for x-ray tomography simulation studies. Pixel-by-pixel CT numbers from axial CBCT images of a mouse, obtained before and after injecting GNPs, were converted into material densities and then transformed into identical 3D voxels using a custom Geant4 application. The consecutive materialized slices were then stacked along the longitudinal axis to build the whole-body mouse models. The first mouse model showed no GNPs inside any organs of interest or the skeleton, whereas the second model showed the actual GNP biodistributions inside the kidneys along with the anatomical features. The applicability of the mouse models for x-ray imaging was investigated by a whole-body CBCT and x-ray fluorescence computed tomography (XFCT) Monte Carlo (MC) simulations. The current investigation showed the feasibility of developing digital mouse models using CBCT images of a mouse injected with GNPs and their application to simulation studies of preclinical CBCT or XFCT or multimodal CBCT+XFCT imaging.
{"title":"Geant4-based Model of a Mouse Injected with Gold Nanoparticles for X-Ray Tomography Simulation Studies","authors":"S. Jayarathna, M. Ahmed, S. Cho","doi":"10.1109/NANOMED49242.2019.9130614","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130614","url":null,"abstract":"The motivation of this study was to develop a Geant4-based novel three dimensional (3D) digital mouse model derived from in vivo cone-beam computed tomography (CBCT) images of a mouse injected with gold nanoparticles (GNPs) for x-ray tomography simulation studies. Pixel-by-pixel CT numbers from axial CBCT images of a mouse, obtained before and after injecting GNPs, were converted into material densities and then transformed into identical 3D voxels using a custom Geant4 application. The consecutive materialized slices were then stacked along the longitudinal axis to build the whole-body mouse models. The first mouse model showed no GNPs inside any organs of interest or the skeleton, whereas the second model showed the actual GNP biodistributions inside the kidneys along with the anatomical features. The applicability of the mouse models for x-ray imaging was investigated by a whole-body CBCT and x-ray fluorescence computed tomography (XFCT) Monte Carlo (MC) simulations. The current investigation showed the feasibility of developing digital mouse models using CBCT images of a mouse injected with GNPs and their application to simulation studies of preclinical CBCT or XFCT or multimodal CBCT+XFCT imaging.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132131163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130625
Neda Sharifi, Yifan Chen, Geoffrey Holmes, U. Cheang, Zheng Gong
In this paper, for the first time, a novel method of controlling nanoswimmers in blood vessels with a square lattice of discrete points that represent potential paths of vascular growth is proposed. The objective function of the proposed model predictive control (MPC) algorithm is comprised of the target cost function and the repulsive boundary function. The former is used to measure the Manhattan distance between the current position of the nanoswimmers and the targeted location to simulate the lattice-like vascular patterns inside the human body. Blood flow velocity may cause nanoswimmers to pass the target point where backward movement is not possible. Therefore, we introduce a repulsive boundary function which plays a crucial role in terms of avoiding nanoswimmers from getting too close to the boundaries. This new formulation, based on the Manhattan distance, is particularly successful in controlling and steering nanoswimmers while avoiding boundaries by taking into account realistic in vivo nanoswimmers' propagation. The proposed feedback control is validated through simulation.
{"title":"Model Predictive Control Strategy for Navigating Nanoswimmers in Blood Vessels Using Taxicab Geometry","authors":"Neda Sharifi, Yifan Chen, Geoffrey Holmes, U. Cheang, Zheng Gong","doi":"10.1109/NANOMED49242.2019.9130625","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130625","url":null,"abstract":"In this paper, for the first time, a novel method of controlling nanoswimmers in blood vessels with a square lattice of discrete points that represent potential paths of vascular growth is proposed. The objective function of the proposed model predictive control (MPC) algorithm is comprised of the target cost function and the repulsive boundary function. The former is used to measure the Manhattan distance between the current position of the nanoswimmers and the targeted location to simulate the lattice-like vascular patterns inside the human body. Blood flow velocity may cause nanoswimmers to pass the target point where backward movement is not possible. Therefore, we introduce a repulsive boundary function which plays a crucial role in terms of avoiding nanoswimmers from getting too close to the boundaries. This new formulation, based on the Manhattan distance, is particularly successful in controlling and steering nanoswimmers while avoiding boundaries by taking into account realistic in vivo nanoswimmers' propagation. The proposed feedback control is validated through simulation.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121189138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130606
H. Feng, W. Lou, F. Zheng, Zi Ye, Yi Sun
Aiming at the irregular distribution of kidney stones inside the body, traditional clinical surgery can not achieve complete resection of the lesion, the targeted drug damage to the affected body is too large, can not effectively identify the target information of the lesion, and the probability of recurrence is high, In this paper, an enhanced energizing module microsystem with lesion target recognition and cutting is developed. The system mainly includes: a neural network signal extraction module for target recognition, a logic control target chip for lesion resection, and a targeted drug with jet ability. The overall structure of the micro-system is micro/mesoscopic size, and the sensitive structure is an execution probe of “small grain size”. After the enhanced energizing module enters the patient from the vein, it begins to extract the cell growth and reproduction information of the surrounding environment and the echo information of the stone lesions. enhanced energizing module set treatment mode selection, each of the enhanced energizing module has two or more targeted drug heads, which can be set according to the characteristics of the lesions. The targeted drug head with jet function bombards the surface of the affected area, which can produce a local high temperature of 1500 °C, which can reliably destroy the lesions of the affected area.
{"title":"Micro-system design of enhanced energizing module for targeted targets","authors":"H. Feng, W. Lou, F. Zheng, Zi Ye, Yi Sun","doi":"10.1109/NANOMED49242.2019.9130606","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130606","url":null,"abstract":"Aiming at the irregular distribution of kidney stones inside the body, traditional clinical surgery can not achieve complete resection of the lesion, the targeted drug damage to the affected body is too large, can not effectively identify the target information of the lesion, and the probability of recurrence is high, In this paper, an enhanced energizing module microsystem with lesion target recognition and cutting is developed. The system mainly includes: a neural network signal extraction module for target recognition, a logic control target chip for lesion resection, and a targeted drug with jet ability. The overall structure of the micro-system is micro/mesoscopic size, and the sensitive structure is an execution probe of “small grain size”. After the enhanced energizing module enters the patient from the vein, it begins to extract the cell growth and reproduction information of the surrounding environment and the echo information of the stone lesions. enhanced energizing module set treatment mode selection, each of the enhanced energizing module has two or more targeted drug heads, which can be set according to the characteristics of the lesions. The targeted drug head with jet function bombards the surface of the affected area, which can produce a local high temperature of 1500 °C, which can reliably destroy the lesions of the affected area.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126329213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130608
V. Sirdeshmukh, Harshika R. Apte, Anup A. Kale
There is an increasing need for the rapid detection of S. aureus owing to the health concerns it raises worldwide. Electrochemical detection methods have proved to be rapid and capable of offering Point-Of-Care diagnosis. Recently, graphene-based materials have emerged as most promising nanomaterials for electrochemical analysis. They have shown improved sensitivity and stability when used as transducer matrices in electrochemical sensing. The latest entrant in this class of materials is Graphene Quantum Dots (GQDs) which, apart from their optical properties possess excellent electrical conductivity and electro-catalytic properties. In this contribution, we explored GQD as electrochemical probe in a sandwich immunoassay designed to detect pathogenic strain of S. aureus. Our results show that GQDs, when used as immuno-labels, improved the sensitivity of the assay by more than 100%. The limit of detection (LOD) was less than 1 CFU/mL. Moreover, it offers rapid detection of pathogens in less than an hour.
{"title":"Graphene Quantum Dots as promising probes in electrochemical immunoassay for rapid and sensitive detection of pathogenic Staphylococcus aureus","authors":"V. Sirdeshmukh, Harshika R. Apte, Anup A. Kale","doi":"10.1109/NANOMED49242.2019.9130608","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130608","url":null,"abstract":"There is an increasing need for the rapid detection of S. aureus owing to the health concerns it raises worldwide. Electrochemical detection methods have proved to be rapid and capable of offering Point-Of-Care diagnosis. Recently, graphene-based materials have emerged as most promising nanomaterials for electrochemical analysis. They have shown improved sensitivity and stability when used as transducer matrices in electrochemical sensing. The latest entrant in this class of materials is Graphene Quantum Dots (GQDs) which, apart from their optical properties possess excellent electrical conductivity and electro-catalytic properties. In this contribution, we explored GQD as electrochemical probe in a sandwich immunoassay designed to detect pathogenic strain of S. aureus. Our results show that GQDs, when used as immuno-labels, improved the sensitivity of the assay by more than 100%. The limit of detection (LOD) was less than 1 CFU/mL. Moreover, it offers rapid detection of pathogens in less than an hour.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132255587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130615
Yuxiang Pan, Yonglian Qiu, Deming Jiang, Xin Liu, Chenlei Gu, H. Wan, Ping Wang
Drug screening is traditionally based on the pharmacodynamic models from 2D cell culture or animal experiments. Recently, three-dimensional (3D) tumor cell models have attracted increasing interest due to their great advantages in simulating more accurately the heterogeneous tumor behavior in vivo. Drug screening based on 3D cells can provide more accurate efficacy results. However, it is difficult to realize real-time and label-free monitoring of 3D cell viability by common imaging techniques. To solve this technical difficulty, a novel micro-groove impedance sensor (MGIS) was specially developed for 3D cell viability real-time monitoring. Precultured 3D spheroids cells are trapped in the micro-cavity with opposite gold electrodes for the in-situ impedance measurement. The presence of 3D spheroid cells will lead to the change of electron transfer efficiency on the electrode surface, which will lead to the change of impedance. When antitumor drugs act on the spheroid cells, the spheroids will cleave and the impedance will decrease. In order to verify the accuracy of MGIS chip, we adopted standard live/dead fluorescence staining to validate the activity of 3D cells. Furthermore, anti-tumor drug sensitivity tests were conducted to validate the drug screening ability of MGIS plat-form. All the results demonstrate that the MGIS is able to monitoring 3D cell viability and drug screening.
{"title":"A novel micro-groove impedance sensor for 3D cell viability monitoring and high-throughput drug screening","authors":"Yuxiang Pan, Yonglian Qiu, Deming Jiang, Xin Liu, Chenlei Gu, H. Wan, Ping Wang","doi":"10.1109/NANOMED49242.2019.9130615","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130615","url":null,"abstract":"Drug screening is traditionally based on the pharmacodynamic models from 2D cell culture or animal experiments. Recently, three-dimensional (3D) tumor cell models have attracted increasing interest due to their great advantages in simulating more accurately the heterogeneous tumor behavior in vivo. Drug screening based on 3D cells can provide more accurate efficacy results. However, it is difficult to realize real-time and label-free monitoring of 3D cell viability by common imaging techniques. To solve this technical difficulty, a novel micro-groove impedance sensor (MGIS) was specially developed for 3D cell viability real-time monitoring. Precultured 3D spheroids cells are trapped in the micro-cavity with opposite gold electrodes for the in-situ impedance measurement. The presence of 3D spheroid cells will lead to the change of electron transfer efficiency on the electrode surface, which will lead to the change of impedance. When antitumor drugs act on the spheroid cells, the spheroids will cleave and the impedance will decrease. In order to verify the accuracy of MGIS chip, we adopted standard live/dead fluorescence staining to validate the activity of 3D cells. Furthermore, anti-tumor drug sensitivity tests were conducted to validate the drug screening ability of MGIS plat-form. All the results demonstrate that the MGIS is able to monitoring 3D cell viability and drug screening.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130400249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130607
S. Jayarathna, M. Ahmed, S. Cho
We previously reported the development of direct x-ray fluorescence (XRF) imaging system for quantitative imaging of gold nanoparticles (GNPs) on a benchtop setting. This system is implemented with an ordinary polychromatic x-ray source and, by detecting gold $L$-shell XRF photons, is capable of detecting/imaging trace amounts of gold nanoparticles (GNPs), on the order of parts-per-million (ppm), under the calibration conditions. For routine XRF imaging of biological samples (e.g., explanted tumors) containing ppm-level GNPs, this system needs to be tested further under more realistic imaging conditions. Thus, we developed a GNP-loaded tissue-mimicking phantom and performed a phantom imaging study using our benchtop XRF imaging system. For the tissue-mimicking phantom construction, the GNP-filled capillary tubes with known GNP concentrations were placed in an “E” shaped pattern and sandwiched between three layers of cheese. The results (i.e., XRF map) from the scanning of this phantom showed that the “E” shape of the phantom was well visible in the XRF map and all three arms and the stem of “E” were spatially resolved within ∼2 mm. The measured GNP concentrations were in good agreement with the known GNP concentrations.
{"title":"Fabrication and Testing of a Gold Nanoparticle-loaded Tissue-mimicking Phantom for Validation of Gold $L$-shell X-ray Fluorescence Imaging Results","authors":"S. Jayarathna, M. Ahmed, S. Cho","doi":"10.1109/NANOMED49242.2019.9130607","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130607","url":null,"abstract":"We previously reported the development of direct x-ray fluorescence (XRF) imaging system for quantitative imaging of gold nanoparticles (GNPs) on a benchtop setting. This system is implemented with an ordinary polychromatic x-ray source and, by detecting gold $L$-shell XRF photons, is capable of detecting/imaging trace amounts of gold nanoparticles (GNPs), on the order of parts-per-million (ppm), under the calibration conditions. For routine XRF imaging of biological samples (e.g., explanted tumors) containing ppm-level GNPs, this system needs to be tested further under more realistic imaging conditions. Thus, we developed a GNP-loaded tissue-mimicking phantom and performed a phantom imaging study using our benchtop XRF imaging system. For the tissue-mimicking phantom construction, the GNP-filled capillary tubes with known GNP concentrations were placed in an “E” shaped pattern and sandwiched between three layers of cheese. The results (i.e., XRF map) from the scanning of this phantom showed that the “E” shape of the phantom was well visible in the XRF map and all three arms and the stem of “E” were spatially resolved within ∼2 mm. The measured GNP concentrations were in good agreement with the known GNP concentrations.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"1142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133842902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130617
Prakash Rewatkar, Avinash Kothuru, S. Goel
Herein, a cost-efficient, easy realizable and customized laser-induced flexible graphene (LIFG) have been explored as Enzymatic Biofuel Cell (EBFC) bioelectrodes. These LIFG bioelectrodes were created on a polyamide substrate directly by irradiation with a CO2 laser at optimized laser properties (speed and power). The bioelectrodes were rigorously characterized using Raman spectroscopic technique. Further, the surface morphological study of polyamide film, LIFG, and LIFG with the relevant enzymes modified bioelectrodes has been accomplished using Scanning Electron Microscope (SEM) and Energy Dispersive Spectroscopy (EDS). Subsequently, the voltammetric electrochemical analysis of modified bioelectrodes has been carried out using Linear Sweep Voltammetry (LSV), Cyclic Voltammetry (CV) and Open Circuit Potential (OCP). Such electrochemical characterizations have shown excellent performance and further motivate us towards future studies at the microfluidics level.
{"title":"Laser-induced Flexible Graphene Bioelectrodes for Enzymatic Biofuel Cell","authors":"Prakash Rewatkar, Avinash Kothuru, S. Goel","doi":"10.1109/NANOMED49242.2019.9130617","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130617","url":null,"abstract":"Herein, a cost-efficient, easy realizable and customized laser-induced flexible graphene (LIFG) have been explored as Enzymatic Biofuel Cell (EBFC) bioelectrodes. These LIFG bioelectrodes were created on a polyamide substrate directly by irradiation with a CO2 laser at optimized laser properties (speed and power). The bioelectrodes were rigorously characterized using Raman spectroscopic technique. Further, the surface morphological study of polyamide film, LIFG, and LIFG with the relevant enzymes modified bioelectrodes has been accomplished using Scanning Electron Microscope (SEM) and Energy Dispersive Spectroscopy (EDS). Subsequently, the voltammetric electrochemical analysis of modified bioelectrodes has been carried out using Linear Sweep Voltammetry (LSV), Cyclic Voltammetry (CV) and Open Circuit Potential (OCP). Such electrochemical characterizations have shown excellent performance and further motivate us towards future studies at the microfluidics level.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130935830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130605
K. Dixit, N. Sinha
In this work, functionally graded scaffolds of nanofiber reinforced bioactive glass have been fabricated using additive manufacturing technique. The bioactive glass was synthesized using sol-gel method. Pluronic F-127 was used as ink carrier for fabricating the scaffolds. The reinforced nanofibers are uniformly dispersed in the bioactive glass matrix. The inclusion of nanofiber showed 94% enhancement in the compressive strength of the fabricated scaffolds demonstrating their potential for bone tissue engineering applications.
{"title":"Additively Manufactured Nanofiber Reinforced Bioactive Glass Based Functionally Graded Scaffolds for Bone Tissue Engineering","authors":"K. Dixit, N. Sinha","doi":"10.1109/NANOMED49242.2019.9130605","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130605","url":null,"abstract":"In this work, functionally graded scaffolds of nanofiber reinforced bioactive glass have been fabricated using additive manufacturing technique. The bioactive glass was synthesized using sol-gel method. Pluronic F-127 was used as ink carrier for fabricating the scaffolds. The reinforced nanofibers are uniformly dispersed in the bioactive glass matrix. The inclusion of nanofiber showed 94% enhancement in the compressive strength of the fabricated scaffolds demonstrating their potential for bone tissue engineering applications.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123661367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/nanomed49242.2019.9130602
Jin-Woo Kim, Yong Yeon Jeong
{"title":"Welcome","authors":"Jin-Woo Kim, Yong Yeon Jeong","doi":"10.1109/nanomed49242.2019.9130602","DOIUrl":"https://doi.org/10.1109/nanomed49242.2019.9130602","url":null,"abstract":"","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"2674 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115898047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.1109/NANOMED49242.2019.9130611
Yulin Lei, Hong Hu, Junlong Han, Qingyun Huang, Xiaoqing Yang
Single droplet jetting is investigated in this paper. Jetting was induced by parallel travelling surface acoustic wave (PTRSAW) devices with straight inter-digital transducers (SIDTs), which were fabricated on a double-sided polished, 0.5 mm-thick, 128° Y-X single-crystal LiNbO3 substrate. The PTRSAW device was mainly composed of two sets of symmetrically distributed SIDTs connected in parallel, which induced two columns of 29.1 MHz PTRSAWs simultaneously. A single droplet jetting phenomenon with $0.8 mumathrm{L}$ of deionised water was captured by a microscope with a high-speed camera. The experimental results show that this method has the advantages of strong driving ability, simple device structure, instant reaction and high ejection efficiency. A complete mathematical model of droplet jetting based on RSAW technology is established and realised by COMSOL finite element simulation software with a multi-physics interface of laminar two-phase flow and level set. The droplet jetting mechanism was analysed from the liquid volume fraction distribution, pressure and velocity evolution during the jetting process. The characteristics of the jetting droplets is strongly dependent on the SAW streaming force, which is well supported the experimental results.
本文对单液滴喷射进行了研究。射流是由平行传播表面声波(PTRSAW)器件引起的，该器件具有直数字间换能器(SIDTs)，该换能器制作在双面抛光，0.5 mm厚，128°Y-X单晶LiNbO3衬底上。PTRSAW器件主要由两组对称分布的sidt并联组成，可同时产生两列29.1 MHz的PTRSAW。用高速相机显微镜捕捉到$0.8 mu mathm {L}$去离子水的单滴喷射现象。实验结果表明，该方法具有驱动能力强、装置结构简单、反应迅速、弹射效率高等优点。建立了基于RSAW技术的完整的液滴喷射数学模型，并利用COMSOL有限元仿真软件实现了层流两相流和水平集的多物理场界面。从液滴喷射过程中液体体积分数分布、压力和速度变化等方面分析了液滴喷射机理。射流液滴的特性与SAW的流动力密切相关，这与实验结果相吻合。
{"title":"Single Droplet Jetting Mechanism Based on Parallel Travelling Rayleigh Surface Acoustic Waves","authors":"Yulin Lei, Hong Hu, Junlong Han, Qingyun Huang, Xiaoqing Yang","doi":"10.1109/NANOMED49242.2019.9130611","DOIUrl":"https://doi.org/10.1109/NANOMED49242.2019.9130611","url":null,"abstract":"Single droplet jetting is investigated in this paper. Jetting was induced by parallel travelling surface acoustic wave (PTRSAW) devices with straight inter-digital transducers (SIDTs), which were fabricated on a double-sided polished, 0.5 mm-thick, 128° Y-X single-crystal LiNbO3 substrate. The PTRSAW device was mainly composed of two sets of symmetrically distributed SIDTs connected in parallel, which induced two columns of 29.1 MHz PTRSAWs simultaneously. A single droplet jetting phenomenon with $0.8 mumathrm{L}$ of deionised water was captured by a microscope with a high-speed camera. The experimental results show that this method has the advantages of strong driving ability, simple device structure, instant reaction and high ejection efficiency. A complete mathematical model of droplet jetting based on RSAW technology is established and realised by COMSOL finite element simulation software with a multi-physics interface of laminar two-phase flow and level set. The droplet jetting mechanism was analysed from the liquid volume fraction distribution, pressure and velocity evolution during the jetting process. The characteristics of the jetting droplets is strongly dependent on the SAW streaming force, which is well supported the experimental results.","PeriodicalId":443566,"journal":{"name":"2019 IEEE 13th International Conference on Nano/Molecular Medicine & Engineering (NANOMED)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133751806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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