Abstract An 18-month-old miniature donkey was presented for evaluation and treatment of a left carpal valgus present since birth. Clinical examination confirmed the severe and unstable carpal valgus. Radiographs and computed tomography revealed a caudally luxated ulnar carpal bone, malformation of the distal radial epiphysis, as well as a complete collapse of the lateral part of the radiocarpal joint. Outward rotation of the limb distal to the joint collapse was also visible. Surgical treatment was elected and a pancarpal arthrodesis performed using two short 3.5 mm locking compression plates. Ten months later, the donkey was pasture sound and radiographs showed complete fusion of the carpal joints.
{"title":"Congenital Ulnar Carpal Bone Luxation in a Miniature Donkey Treated by Pancarpal Arthrodesis","authors":"M. Robert, Y. Smit","doi":"10.1055/s-0040-1710503","DOIUrl":"https://doi.org/10.1055/s-0040-1710503","url":null,"abstract":"Abstract An 18-month-old miniature donkey was presented for evaluation and treatment of a left carpal valgus present since birth. Clinical examination confirmed the severe and unstable carpal valgus. Radiographs and computed tomography revealed a caudally luxated ulnar carpal bone, malformation of the distal radial epiphysis, as well as a complete collapse of the lateral part of the radiocarpal joint. Outward rotation of the limb distal to the joint collapse was also visible. Surgical treatment was elected and a pancarpal arthrodesis performed using two short 3.5 mm locking compression plates. Ten months later, the donkey was pasture sound and radiographs showed complete fusion of the carpal joints.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129262729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Crovace, L. Lacitignola, F. Staffieri, E. Francioso, G. Rossi, A. Crovace
Abstract Objective In the present study, we report our results of the use of autologous bone marrow mononuclear cells (BMMCs) as a minimally invasive treatment for Legg-Calvé-Perthes in dogs. Study Design In accordance with Ljunggren's scale, inclusion criteria were determined by clinical condition and radiographic features of the disease, resulting in 32 dogs enrolled in this retrospective study from 2007 to 2019. Bone marrow was collected from each dog from the iliac crest and the mononuclear fraction was separated with density gradient centrifugation. The mean number of BMMCs was 104.7 ± 46.5 × 106 cells. The mean BMMC colony-forming units were 71.6 ± 51.9 × 102/mL. Cells were suspended in fibrin glue before BMMC administration and implanted via transcutaneous injection under computed tomography or radiographic guidance, using a Jamshidi needle inserted through the femoral head and neck. Results A progressive reduction of pain within 3 weeks after BMMC administration was observed in 28 patients, with gradually increased weight bearing on the affected limb. In four dogs, however, pain and lameness persisted and at 3 months post-BMMC injection, femoral head and neck resection was performed. Histological and immunohistochemical studies were done on samples from those four dogs, which showed evidence of formation of new cartilage and subchondral bone in the area where cells were implanted. Clinical Significance Based on these results, BMMC therapy may be considered as effective and minimally invasive treatment option for LCPD in dogs.
{"title":"Treatment of Monolateral Legg-Calvé-Perthes Disease with Autologous Bone Marrow Mononuclear Cells in 32 Dogs","authors":"A. Crovace, L. Lacitignola, F. Staffieri, E. Francioso, G. Rossi, A. Crovace","doi":"10.1055/s-0040-1701470","DOIUrl":"https://doi.org/10.1055/s-0040-1701470","url":null,"abstract":"Abstract Objective In the present study, we report our results of the use of autologous bone marrow mononuclear cells (BMMCs) as a minimally invasive treatment for Legg-Calvé-Perthes in dogs. Study Design In accordance with Ljunggren's scale, inclusion criteria were determined by clinical condition and radiographic features of the disease, resulting in 32 dogs enrolled in this retrospective study from 2007 to 2019. Bone marrow was collected from each dog from the iliac crest and the mononuclear fraction was separated with density gradient centrifugation. The mean number of BMMCs was 104.7 ± 46.5 × 106 cells. The mean BMMC colony-forming units were 71.6 ± 51.9 × 102/mL. Cells were suspended in fibrin glue before BMMC administration and implanted via transcutaneous injection under computed tomography or radiographic guidance, using a Jamshidi needle inserted through the femoral head and neck. Results A progressive reduction of pain within 3 weeks after BMMC administration was observed in 28 patients, with gradually increased weight bearing on the affected limb. In four dogs, however, pain and lameness persisted and at 3 months post-BMMC injection, femoral head and neck resection was performed. Histological and immunohistochemical studies were done on samples from those four dogs, which showed evidence of formation of new cartilage and subchondral bone in the area where cells were implanted. Clinical Significance Based on these results, BMMC therapy may be considered as effective and minimally invasive treatment option for LCPD in dogs.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116749366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract This study aimed to describe a staged bilateral z-tenotomy and anastomosis procedure of flexor carpi ulnaris and superficial digital flexor tendons for the correction of carpal valgus and flexural deformity in a 1-year-old male-neutered Akita dog. Bilateral carpal valgus and flexural deformity were observed with palpably taut flexor carpi ulnaris tendons. The dog had a mild, weight-bearing bilateral forelimb lameness with the left forelimb more severely affected. Both forelimbs were treated with staged z-tenotomy and anastomosis procedure of both flexor carpi ulnaris and superficial digital flexor tendons. Successful tendon lengthening and correction of carpal valgus were achieved via z-tenotomy and anastomosis of affected tendons. No complications were observed. An 18-month follow-up revealed no evidence of lameness or carpal valgus. Though tendon injuries commonly occur in small animal patients, there is a shortage of reported cases, especially involving musculotendinous contractures. There are even fewer reports of successful tenotomy procedures. This case report supports successful outcome of the z-tenotomy procedure in a canine patient.
{"title":"Correction of Carpal Valgus and Flexural Deformity with z-Tenotomy and Anastomosis Procedure in a Dog","authors":"Mikaela Gondolfe, M. Garneau","doi":"10.1055/s-0040-1710069","DOIUrl":"https://doi.org/10.1055/s-0040-1710069","url":null,"abstract":"Abstract This study aimed to describe a staged bilateral z-tenotomy and anastomosis procedure of flexor carpi ulnaris and superficial digital flexor tendons for the correction of carpal valgus and flexural deformity in a 1-year-old male-neutered Akita dog. Bilateral carpal valgus and flexural deformity were observed with palpably taut flexor carpi ulnaris tendons. The dog had a mild, weight-bearing bilateral forelimb lameness with the left forelimb more severely affected. Both forelimbs were treated with staged z-tenotomy and anastomosis procedure of both flexor carpi ulnaris and superficial digital flexor tendons. Successful tendon lengthening and correction of carpal valgus were achieved via z-tenotomy and anastomosis of affected tendons. No complications were observed. An 18-month follow-up revealed no evidence of lameness or carpal valgus. Though tendon injuries commonly occur in small animal patients, there is a shortage of reported cases, especially involving musculotendinous contractures. There are even fewer reports of successful tenotomy procedures. This case report supports successful outcome of the z-tenotomy procedure in a canine patient.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132081233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Objective The aim of this study was to report an unusual case of an iatrogenic foreign body within the stifle joint, removed 6 years after distal femoral fracture repair in a small dog. Acute lameness was caused by a migrating screwdriver fragment, which had been lost during initial fracture repair and which did not cause clinical signs for years until dislodged inside the joint. Case Report A male Jack Russell, 7 years of age, underwent plate and screws fixation to treat a Salter-Harris type I fracture at the age of 9 months. Seven months after surgery, partial implant removal was performed. Six years after fracture repair, the dog presented for a non-weight-bearing lameness and pain on the previously operated stifle joint, which occurred suddenly while walking on the leash. Radiographs revealed a small intra-articular metallic radiodense foreign body. Arthroscopy was used to remove the migrating broken-tip of a screwdriver from the medial aspect of the tibiofemoral joint. Retrieving the foreign body led to the immediate resolution of clinical signs without complications. Conclusion By reporting this case of a forgotten foreign body retained inside a stifle joint for 6 years, we aim to illustrate the potential risk of leaving a piece of metal inside the body. A high index of suspicion for such complications should be kept a long time after surgery. Arthroscopy was a useful first-line tool for efficiently and mini-invasively treating this unusual problem.
{"title":"Arthroscopic Removal of a Screwdriver Fragment in a Dog 6 Years after Femoral Fracture Repair","authors":"M. Petazzoni","doi":"10.1055/s-0040-1709451","DOIUrl":"https://doi.org/10.1055/s-0040-1709451","url":null,"abstract":"Abstract Objective The aim of this study was to report an unusual case of an iatrogenic foreign body within the stifle joint, removed 6 years after distal femoral fracture repair in a small dog. Acute lameness was caused by a migrating screwdriver fragment, which had been lost during initial fracture repair and which did not cause clinical signs for years until dislodged inside the joint. Case Report A male Jack Russell, 7 years of age, underwent plate and screws fixation to treat a Salter-Harris type I fracture at the age of 9 months. Seven months after surgery, partial implant removal was performed. Six years after fracture repair, the dog presented for a non-weight-bearing lameness and pain on the previously operated stifle joint, which occurred suddenly while walking on the leash. Radiographs revealed a small intra-articular metallic radiodense foreign body. Arthroscopy was used to remove the migrating broken-tip of a screwdriver from the medial aspect of the tibiofemoral joint. Retrieving the foreign body led to the immediate resolution of clinical signs without complications. Conclusion By reporting this case of a forgotten foreign body retained inside a stifle joint for 6 years, we aim to illustrate the potential risk of leaving a piece of metal inside the body. A high index of suspicion for such complications should be kept a long time after surgery. Arthroscopy was a useful first-line tool for efficiently and mini-invasively treating this unusual problem.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124054020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Parés-Casanova, R. Crosby-Granados, Fabián Muñoz, Arcesio Salamanca-Carreño
Abstract Background Deviations from the perfect symmetry of normally bilateral symmetrical characters occur during individual development due to the influence of multiple factors. Fluctuating asymmetry (FA) is the random developmental variation of a trait (or character) that is perfectly symmetrical, on average, across a population. Directional asymmetry (DA) occurs when one side of the pair of body sides is strongly more marked. Objective We investigated the presence and level of skull FA and DA in the Araucan horse, a breed from East Colombia. Study Design A sample of 21 skulls belonging to adult animals was studied by means of standard geometric–morphometric methods using 16 landmarks on the dorsal aspect of the crania. Results Measurements showed a significant DA with a consistent rightward shift of the splanchnocrania. Conclusions The results of this study raise questions about the influence of masticatory biomechanics on the asymmetric development of the skull, and also about how management and ingesta-specific properties (such as abrasiveness) may influence this asymmetry.
{"title":"Marked Directional Skull Asymmetry in the Araucan Horse","authors":"P. Parés-Casanova, R. Crosby-Granados, Fabián Muñoz, Arcesio Salamanca-Carreño","doi":"10.1055/s-0040-1702986","DOIUrl":"https://doi.org/10.1055/s-0040-1702986","url":null,"abstract":"Abstract Background Deviations from the perfect symmetry of normally bilateral symmetrical characters occur during individual development due to the influence of multiple factors. Fluctuating asymmetry (FA) is the random developmental variation of a trait (or character) that is perfectly symmetrical, on average, across a population. Directional asymmetry (DA) occurs when one side of the pair of body sides is strongly more marked. Objective We investigated the presence and level of skull FA and DA in the Araucan horse, a breed from East Colombia. Study Design A sample of 21 skulls belonging to adult animals was studied by means of standard geometric–morphometric methods using 16 landmarks on the dorsal aspect of the crania. Results Measurements showed a significant DA with a consistent rightward shift of the splanchnocrania. Conclusions The results of this study raise questions about the influence of masticatory biomechanics on the asymmetric development of the skull, and also about how management and ingesta-specific properties (such as abrasiveness) may influence this asymmetry.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"03 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129945812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandros Bourbos, F. Cinti, Fabiana Sergiampietri, G. Pisani
Abstract Two large-breed dogs underwent delayed surgical repair of pelvic fractures with the aid of a skeletal traction device. Distraction and reduction in the fractures using the skeletal traction device were monitored by direct visualization and intraoperative fluoroscopy. Postoperative radiographs revealed good to near-anatomical bone reduction and fracture alignment without narrowing of the pelvic canal. Both dogs had complete functional recovery with no evidence of neurological deficits. The use of a skeletal traction device should be considered for reduction and fixation of delayed pelvic fractures.
{"title":"The Use of an Intraoperative Skeletal Traction Device for Delayed Reduction in Pelvic Fractures in Two Dogs","authors":"Alexandros Bourbos, F. Cinti, Fabiana Sergiampietri, G. Pisani","doi":"10.1055/s-0040-1713124","DOIUrl":"https://doi.org/10.1055/s-0040-1713124","url":null,"abstract":"Abstract Two large-breed dogs underwent delayed surgical repair of pelvic fractures with the aid of a skeletal traction device. Distraction and reduction in the fractures using the skeletal traction device were monitored by direct visualization and intraoperative fluoroscopy. Postoperative radiographs revealed good to near-anatomical bone reduction and fracture alignment without narrowing of the pelvic canal. Both dogs had complete functional recovery with no evidence of neurological deficits. The use of a skeletal traction device should be considered for reduction and fixation of delayed pelvic fractures.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123410762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pantarsal Arthrodesis to Treat a Full-Thickness Lateral Trochlear Ridge Osteochondritis Dissecans in a Dog","authors":"M. Petazzoni, Michela Buiatti","doi":"10.1055/s-0039-1694702","DOIUrl":"https://doi.org/10.1055/s-0039-1694702","url":null,"abstract":"","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132707175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cathleen A. Mochal-King, A. Rashmir, Lowella V. Fortuno, M. Grzanna, A. Au, J. Dougherty, C. Frondoza
Abstract Objectives The aim of this study was to evaluate the effect of amikacin (AK) and enrofloxacin (EF) at concentrations consistent with those obtained by intra-articular and intravenous regional limb perfusion on both cytotoxicity and prostaglandin E2 (PGE2) production by equine chondrocytes. This study also determines if PGE2 production could be reduced by avocado/soybean unsaponifiables (ASU), glucosamine (GLU) and chondroitin sulphate (CS). Study Design Chondrocytes were grown in monolayer from the articular cartilage of 12 horses and treated with clinically relevant concentrations of AK and EF, with or without the combination of ASU + GLU + CS. Positive controls consisted of chondrocytes that were activated with lipopolysaccharide (LPS). Chondrocyte response was evaluated using both MTT cytotoxicity assay and immunoassay for PGE2 production. Results Amikacin and EF generated a dose-dependent cytotoxicity. Amikacin induced 90% cell death at a concentration of 25 mg/mL. Enrofloxacin induced 90% cell death at 1.0 mg/mL and 98% cell death at 10 mg/mL (p < 0.05). Amikacin failed to induce PGE2 production at any of the concentrations studied. In contrast, EF and the positive control (LPS) induced PGE2 production at all concentrations. Induction of PGE2 by EF at all concentrations was significantly reduced (p < 0.05) by pre-treatment with ASU + GLU + CS. Conclusions and Clinical Relevance Horses receiving commonly used dosages of AK and EF may benefit from administration of ASU + GLU + CS.
{"title":"Mitigation of Antibiotic-Inducted Toxicity in Equine Chondrocytes by Soybean/Glucosamine/Chondroitin Combination","authors":"Cathleen A. Mochal-King, A. Rashmir, Lowella V. Fortuno, M. Grzanna, A. Au, J. Dougherty, C. Frondoza","doi":"10.1055/s-0039-1693441","DOIUrl":"https://doi.org/10.1055/s-0039-1693441","url":null,"abstract":"Abstract Objectives The aim of this study was to evaluate the effect of amikacin (AK) and enrofloxacin (EF) at concentrations consistent with those obtained by intra-articular and intravenous regional limb perfusion on both cytotoxicity and prostaglandin E2 (PGE2) production by equine chondrocytes. This study also determines if PGE2 production could be reduced by avocado/soybean unsaponifiables (ASU), glucosamine (GLU) and chondroitin sulphate (CS). Study Design Chondrocytes were grown in monolayer from the articular cartilage of 12 horses and treated with clinically relevant concentrations of AK and EF, with or without the combination of ASU + GLU + CS. Positive controls consisted of chondrocytes that were activated with lipopolysaccharide (LPS). Chondrocyte response was evaluated using both MTT cytotoxicity assay and immunoassay for PGE2 production. Results Amikacin and EF generated a dose-dependent cytotoxicity. Amikacin induced 90% cell death at a concentration of 25 mg/mL. Enrofloxacin induced 90% cell death at 1.0 mg/mL and 98% cell death at 10 mg/mL (p < 0.05). Amikacin failed to induce PGE2 production at any of the concentrations studied. In contrast, EF and the positive control (LPS) induced PGE2 production at all concentrations. Induction of PGE2 by EF at all concentrations was significantly reduced (p < 0.05) by pre-treatment with ASU + GLU + CS. Conclusions and Clinical Relevance Horses receiving commonly used dosages of AK and EF may benefit from administration of ASU + GLU + CS.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122325714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Oginska, R. Whitelock, K. Hausler, Amy Stelman, M. Allen
Abstract The use of extracorporeal shock wave therapy (ESWT) for the treatment of delayed or non-union of long bone fractures has been described in human patients with encouraging results. This case report describes the successful treatment of a mandibular fracture non-union with ESWT. To authors' knowledge, this is the first report of the clinical use of ESWT for the management of a non-union in a dog.
{"title":"Extracorporeal Shock Wave Therapy for the Treatment of Non-Union of a Canine Mandibular Fracture","authors":"O. Oginska, R. Whitelock, K. Hausler, Amy Stelman, M. Allen","doi":"10.1055/s-0039-3400617","DOIUrl":"https://doi.org/10.1055/s-0039-3400617","url":null,"abstract":"Abstract The use of extracorporeal shock wave therapy (ESWT) for the treatment of delayed or non-union of long bone fractures has been described in human patients with encouraging results. This case report describes the successful treatment of a mandibular fracture non-union with ESWT. To authors' knowledge, this is the first report of the clinical use of ESWT for the management of a non-union in a dog.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126054518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Albert, S. Reese, M. Nolff, A. Meyer-Lindenberg
Abstract Objectives The aim of this study was to evaluate the systemic effect of negative pressure wound therapy (NPWT) on the treatment of complicated wounds in dogs. Materials and Methods Dogs undergoing open wound treatment were randomly assigned to one of two groups: NPWT (n = 11) or polyurethane foam dressing (n = 11). Rectal temperature, heart rate as well as haematocrit, thrombocytes, leucocyte count, band neutrophils, C-reactive protein (CrP), total protein and albumin were recorded daily from the beginning of therapy (day 0) until day 5, as well as on day 10. The effect of treatment on systemic parameters was evaluated as well as the prognostic power of the individual parameters with regard to successful wound closure. Results A more profound systemic decrease was found in total protein under NPWT. This difference was non-significant. Patients with non-successful closure displayed a non-significant trend towards lower initial leukocyte and thrombocyte counts and significantly higher CrP values on days 4, 5 and 10 (p < 0.05) compared with successfully treated patients. Receiver operating characteristic analysis revealed an optimal cutoff value of 70.2 mg/L at day 4 (sensitivity 80; specificity of 85.7). Conclusion There might be an increased loss of protein in NPWT-treated patients, which does not affect albumin levels, otherwise no systemic effects were detected compared with the control treatment. The parameter with the best sensitivity and specificity to detect serious complications (no wound closure achieved) was CrP at day 4.
{"title":"Evaluation of Systemic Effects of Negative Pressure Wound Therapy in Open Wound Treatment in Dogs","authors":"R. Albert, S. Reese, M. Nolff, A. Meyer-Lindenberg","doi":"10.1055/s-0039-1693007","DOIUrl":"https://doi.org/10.1055/s-0039-1693007","url":null,"abstract":"Abstract Objectives The aim of this study was to evaluate the systemic effect of negative pressure wound therapy (NPWT) on the treatment of complicated wounds in dogs. Materials and Methods Dogs undergoing open wound treatment were randomly assigned to one of two groups: NPWT (n = 11) or polyurethane foam dressing (n = 11). Rectal temperature, heart rate as well as haematocrit, thrombocytes, leucocyte count, band neutrophils, C-reactive protein (CrP), total protein and albumin were recorded daily from the beginning of therapy (day 0) until day 5, as well as on day 10. The effect of treatment on systemic parameters was evaluated as well as the prognostic power of the individual parameters with regard to successful wound closure. Results A more profound systemic decrease was found in total protein under NPWT. This difference was non-significant. Patients with non-successful closure displayed a non-significant trend towards lower initial leukocyte and thrombocyte counts and significantly higher CrP values on days 4, 5 and 10 (p < 0.05) compared with successfully treated patients. Receiver operating characteristic analysis revealed an optimal cutoff value of 70.2 mg/L at day 4 (sensitivity 80; specificity of 85.7). Conclusion There might be an increased loss of protein in NPWT-treated patients, which does not affect albumin levels, otherwise no systemic effects were detected compared with the control treatment. The parameter with the best sensitivity and specificity to detect serious complications (no wound closure achieved) was CrP at day 4.","PeriodicalId":443672,"journal":{"name":"VCOT Open","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133714905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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