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VOLUNTARY BEHAVIOR OF STUDENTS STUDYING MEDICAL SPECIALTIES IN THE CONTEXT OF A PANDEMIC 大流行背景下医学专业学生的自愿行为
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-16 DOI: 10.5272/jimab.2023294.5163
Rozalina Yordanova, Silvia Kyuchukova, Albena Andonova, Mima Nikolova, Magdalena Platikanova
By training young people a range of practical medical skills and engaging them in volunteer activity, they are expected to express themselves and achieve outcomes that have an impact on their own lives and the lives of others in society. Purpose: to determine the attitudes and motivations of students studying medical specialties who want to volunteer using their professional training received at Higher Medical School during the pandemic. Material and Methods: A survey; Mathematical and statistical processing of the obtained data; Applying an established methodology for selection of willing and motivated students; Non-formal education. Results: Total surveyed students 282 - the largest number are those studying the Nurse specialty (48.2%). 57.4% of study participants had experience volunteering. 52.7% would work as a volunteer with Covid-19 patients. 11% were already volunteering Covid-19 at healthcare facilities. The main reason why students are most likely to volunteer in the Covid-19 sectors is personal moral principles (49.2%). The main way students would spread information in society about the nature and principles of voluntary student work is through social networks (75.2%). Conclusions: More than half of the respondents had experience as volunteers. Students are motivated and willing to help Covid-19 patients. Personal motivation and opportunities to improve skills and acquire new knowledge and competencies are the main reasons students prefer volunteering during a pandemic. Volunteer work has a positive influence on the professional development of students, a good impact on their professional identity creation and is essential for their future work as healthcare professionals.
通过培训年轻人一系列实用医疗技能并让他们参与志愿活动,期望他们能够表达自己的想法并取得对他们自己和社会上其他人的生活产生影响的成果。目的:确定希望利用大流行期间在高等医学院接受的专业培训进行志愿服务的医学专业学生的态度和动机。材料与方法:调查;对所得数据进行数学和统计处理;采用既定的方法选择有意愿和积极进取的学生;非正规教育。结果:受访学生282人,其中以护理专业学生最多,占48.2%。57.4%的研究参与者有过志愿服务的经历。52.7%的人会作为志愿者与Covid-19患者一起工作。11%的人已经在医疗机构志愿服务Covid-19。学生在新冠疫情领域做志愿者的主要原因是个人道德原则(49.2%)。学生在社会上传播学生志愿工作性质和原则信息的主要方式是通过社交网络(75.2%)。结论:超过一半的受访者有志愿者的经历。学生有动力并愿意帮助Covid-19患者。个人动机以及提高技能和获得新知识和能力的机会是学生更愿意在大流行期间志愿服务的主要原因。志愿者工作对学生的专业发展有积极的影响,对他们的职业认同产生良好的影响,对他们未来作为医疗专业人员的工作至关重要。
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引用次数: 0
VISION OF NURSES WORKING. VISION WITH DISABLED CHILDREN ABOUT THEIR PROFESSIONAL COMPETENCE 护士工作的景象。视力与残疾儿童有关他们的专业能力
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-12 DOI: 10.5272/jimab.2023294.5158
Monika Obreykova, Albena Andonova
The nurse's work with children with disabilities requires narrowly profiled knowledge to ensure adequate medical and health care for children in the process of deinstitutionalization. Purpose: The purpose of the research is to establish the attitudes of nurses regarding the increase of their professional competence for working with children with disabilities in the process of deinstitutionalization. Methods: An anonymous survey was conducted of 109 nurses working in medical and social care homes (HMSCC) in the cities of Burgas and Stara Zagora. For this purpose, a questionnaire consisting of 34 questions of open and closed type was developed. Results: The survey found 68% of respondents believed that a nurse should have a continuous drive to learn new knowledge about caring for children with disabilities. The respondents (75%) indicate that dealing with emergency situations is a mandatory professional competence for those working with children with disabilities, another 55% consider that the ability to emotionally assess the child's condition is very important when performing their professional activity. The respondents considered that a personal contribution of the nurse (outside of professional duties) is necessary for the improvement of care for children with disabilities [t(107) = 5.814; p-level < 0.001]. Conclusion: The survey found a positive attitude of the respondents to participate in postgraduate studies. The respondents express a desire to become involved as trainers of parents to provide real knowledge and skills in order to deal with and solve the child's health problems that arise at home.
护士照顾残疾儿童的工作需要狭义的知识,以确保在去机构化过程中为儿童提供适当的医疗和保健。目的:本研究的目的是了解护士对在去机构化过程中提高其与残疾儿童工作的专业能力的态度。方法:对布尔加斯市和斯塔拉扎戈拉市医疗和社会养老院(HMSCC)的109名护士进行匿名调查。为此,编制了一份由34个开放性和封闭性问题组成的问卷。结果:调查发现68%的受访者认为护士应该不断学习照顾残疾儿童的新知识。答复者(75%)指出,处理紧急情况是从事残疾儿童工作的人必须具备的专业能力,另有55%的人认为,在从事专业活动时,从情感上评估儿童状况的能力非常重要。受访者认为,护士的个人贡献(在专业职责之外)对于改善残疾儿童的护理是必要的[t(107) = 5.814;逐行扫描& lt;0.001]。结论:调查发现受访者对参加研究生学习持积极态度。答复者表示希望作为父母的培训人员参与其中,提供真正的知识和技能,以便处理和解决儿童在家中出现的健康问题。
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引用次数: 0
HYPERBARIC OXYGEN THERAPY (HBOT) AS THE TREATMENT OF PROLONGED HYPOXEMIA DUE TO COVID-19 高压氧疗法(hbot)治疗COVID-19所致长期低氧血症
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-09 DOI: 10.5272/jimab.2023294.5150
Diana Paskaleva, Vasilka Gyurova-Kancheva, Slavka Kacarova, Bozhidar Pilichev, Okean Kostov, Maria Bozhkova, Dimitar Penkov
Background - hyperbaric oxygen therapy (HBOT) is a clinical method of treatment with oxygen while under increased atmospheric pressure. It has been proven as an independent therapeutic factor for a number of diseases, and in the case of COVID-19, its potential as an adjuvant therapy is still being studied. Case report – in the case of a 61-year-old man with severe pneumonia resulting from infection with COVID-19 and persisting hypoxemia and dyspnea after the acute phase. Prescribed continuous oxygenation in home conditions due to deteriorating general condition and quality of life. Undertaken additional hyperbaric oxygen therapy resulting in significant improvement after the 20th session. Conclusion - the connection between HBOT and improved paraclinical and imaging indicators, in this case, suggests conclusions of a therapeutic effect of HBOT in hypoxemia as a post-COVID symptom.
背景-高压氧治疗(HBOT)是一种在增加大气压力下用氧气进行治疗的临床方法。它已被证明是许多疾病的独立治疗因素,就COVID-19而言,其作为辅助治疗的潜力仍在研究中。病例报告-一名61岁男子因感染COVID-19并在急性期后持续低氧血症和呼吸困难而患有严重肺炎。由于一般情况和生活质量恶化,在家庭条件下规定持续氧合。在第20次会议后进行了额外的高压氧治疗,结果显著改善。结论:在本病例中,HBOT与临床旁和影像学指标的改善之间的联系,提示HBOT作为covid后症状对低氧血症的治疗作用。
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引用次数: 0
ALLERGIC CONTACT DERMATITIS WITH AN UNUSUAL CONFIGURATION AFTER PREOPERATIVE POVIDONE-IODINE DISINFECTION. A CLINICAL CASE 术前聚维酮碘消毒后异常形态的过敏性接触性皮炎。1例临床病例
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-09 DOI: 10.5272/jimab.2023294.5154
Yoanna Velevska-Vatova, Filka Georgieva
Contact dermatitis is an inflammatory skin reaction resulting from skin contact with exogenous substances that act as allergens and/or irritants. Epicutaneous testing is the gold standard for diagnosing allergic contact dermatitis and differentiating it from irritant contact dermatitis. We present a clinical case of allergic contact dermatitis after preoperative povidone-iodine disinfection.
接触性皮炎是由于皮肤接触作为过敏原和/或刺激物的外源性物质而引起的皮肤炎症反应。表皮试验是诊断过敏性接触性皮炎和鉴别刺激性接触性皮炎的金标准。我们报告一例术前聚维酮碘消毒后的过敏性接触性皮炎。
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引用次数: 0
FRACTURE RISK AND OBSTRUCTIVE SLEEP APNOEA 骨折风险和阻塞性睡眠呼吸暂停
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-02 DOI: 10.5272/jimab.2023294.5145
Daniela Krasimirova, Blagovest Stoimenov, Sevda Naydenska, Kiril Genov, Ventsislava Pencheva
Obstructive Sleep Apnoea (OSA) with hypoxemia, oxidative stress, low-grade inflammation and multiple hormonal metabolic changes affect the bone metabolism. This leads to an increased fracture risk in patients with OSA. Purpose: The aim of the study was to explore the connection between fracture risk and newly-diagnosed OSA. Materials/methods: 130 patients with newly diagnosed OSA and 67 controls without OSA were included in the study. Anthropometric, laboratory, instrumental and study tests and fracture risk assessment under the FRAX program were performed. Results: There isn’t a statistical difference in the age and gender in the OSA group compared to the controls (p>0.05). A statistically significant difference between the OSA group and the control group was found with regard to the body mass index (BMI), visceral fat mass ratio (VFR), neck circumference, Epworth sleepiness scale (ESS), Vitamin D levels, beta-crosslaps and osteocalcin (р<0.0001 for all). Reduction of bone mineral density (BMD) was found in patients with OSA. On average, three risk factors for fracture were found in patients with OSA compared to an absence or only one risk factor in the control group (р<0.0001). Conclusion: Patients with OSA are at an increased fracture risk due to disturbed bone metabolism. They have lower Vitamin D levels, reduction of BMD and 3 risk factors for high FR. This requiresan assessment of fracture risk and its eventual reduction in patients with OSA.
阻塞性睡眠呼吸暂停(OSA)伴低氧血症、氧化应激、低度炎症及多种激素代谢变化影响骨代谢。这导致OSA患者骨折风险增加。目的:探讨骨折风险与新诊断OSA之间的关系。材料/方法:纳入130例新诊断OSA患者和67例非OSA对照。在FRAX程序下进行人体测量、实验室、仪器和研究测试以及骨折风险评估。结果:OSA组患者年龄、性别与对照组比较,差异无统计学意义(p>0.05)。OSA组与对照组在体重指数(BMI)、内脏脂肪质量比(VFR)、颈围、Epworth嗜睡量表(ESS)、维生素D水平、β交叉指数和骨钙素方面存在统计学差异(均为0.0001)。发现OSA患者骨密度(BMD)降低。平均而言,OSA患者中有3个骨折危险因素,而对照组中没有或只有1个危险因素(0.001)。结论:由于骨代谢紊乱,OSA患者骨折风险增加。他们有较低的维生素D水平,骨密度降低和高FR的3个危险因素。这需要评估OSA患者的骨折风险并最终降低其风险。
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引用次数: 0
SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY 皮肤鳞状细胞癌:预测复发、转移和死亡率的临床组织病理学相关性研究
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-10-02 DOI: 10.5272/jimab.2023294.5139
Preslav Vasilev, Savelina Popovska, Milen Karaivanov, Dobromir Dimitrov, Ivelina Yordanova
Introduction: The incidence of Squamous cell carcinoma of the skin (SCCs) increases annually, and this process will likely be continued because of sun exposure, outdoor activities and the aging population. Objectives: The aim of our study is to analyse clinicohistopathological features, recurrence, metastasis and mortality rates of SCCs in Pleven, Lovech region, Bulgaria. Methods: We investigated 355 patients with histologically confirmed SCCs for the period 2016 – 2022 and carried out a detailed histopathological analysis of 100 tumors. They were divided into two groups according to their macroscopic diameter: with low risk for recurrence and metastases (<20mm) and high – risk (>20mm). We studied the localisation, histological subtype, tumor cell differentiation, microscopic depth of invasion, perineural and lymphovascular invasion, stromal lymphocyte infiltration. Results: We revealed that 73,3% of the patients with SCCs reported severe sunburns, and 1,13% of them underwent immunosuppressive treatment. Head and Neck localisation is the most common – 72,7%. We established a mean histological depth of SCCs of 5,92mm, lymphovascular invasion in 7% and perineural invasion in 5% of the cases. We found that tumors with a macroscopic diameter >20mm have a greater depth of invasion in comparison to SCCs with a smaller diameter. We found an incidence of local recurrence of 4,8%, lymph node metastases at 5,1%, far metastases in internal organs at 2,25% and mortality at 1,97%. Conclusion: Clinicohistopathological features of SCCs with related to recurrence, metastasis and mortality are localisation on the scalp, ears or lips, tumor size >20mm, depth of invasion >6mm, poor tumor cell differentiation, perineural and lymphovascular invasion, low or absent stromal lymphocyte infiltration.
导读:皮肤鳞状细胞癌(SCCs)的发病率每年都在增加,由于日晒、户外活动和人口老龄化,这一过程可能会持续下去。目的:我们研究的目的是分析保加利亚Pleven, Lovech地区SCCs的临床组织病理学特征,复发,转移和死亡率。方法:我们调查了2016 - 2022年期间355例组织学证实的SCCs患者,并对100例肿瘤进行了详细的组织病理学分析。根据其肉眼直径分为两组:复发转移风险低(>20mm)和高风险(>20mm)。我们研究了肿瘤的定位、组织学亚型、肿瘤细胞分化、显微浸润深度、神经和淋巴血管浸润、间质淋巴细胞浸润。结果:我们发现73.3%的SCCs患者报告了严重的晒伤,其中1.13%的患者接受了免疫抑制治疗。头颈部定位是最常见的,占72.7%。我们确定SCCs的平均组织学深度为5,92mm,淋巴血管浸润占7%,神经周围浸润占5%。我们发现,与直径较小的SCCs相比,肉眼直径为20mm的肿瘤侵袭深度更大。我们发现局部复发率为4.8%,淋巴结转移率为5.1%,内脏远端转移率为2.25%,死亡率为1.97%。结论:SCCs与复发、转移及死亡相关的临床组织病理学特征为头皮、耳部或唇部病变,肿瘤大小约20mm,浸润深度约6mm,肿瘤细胞分化差,浸润神经周围及淋巴血管,间质淋巴细胞浸润低或无浸润。
{"title":"SQUAMOUS CELL CARCINOMA OF THE SKIN: A STUDY OF CLINICOHISTOPATHOLOGICAL CORRELATIONS PREDICTIVE FOR RECURRENCE, METASTASIS AND MORTALITY","authors":"Preslav Vasilev, Savelina Popovska, Milen Karaivanov, Dobromir Dimitrov, Ivelina Yordanova","doi":"10.5272/jimab.2023294.5139","DOIUrl":"https://doi.org/10.5272/jimab.2023294.5139","url":null,"abstract":"Introduction: The incidence of Squamous cell carcinoma of the skin (SCCs) increases annually, and this process will likely be continued because of sun exposure, outdoor activities and the aging population. Objectives: The aim of our study is to analyse clinicohistopathological features, recurrence, metastasis and mortality rates of SCCs in Pleven, Lovech region, Bulgaria. Methods: We investigated 355 patients with histologically confirmed SCCs for the period 2016 – 2022 and carried out a detailed histopathological analysis of 100 tumors. They were divided into two groups according to their macroscopic diameter: with low risk for recurrence and metastases (<20mm) and high – risk (>20mm). We studied the localisation, histological subtype, tumor cell differentiation, microscopic depth of invasion, perineural and lymphovascular invasion, stromal lymphocyte infiltration. Results: We revealed that 73,3% of the patients with SCCs reported severe sunburns, and 1,13% of them underwent immunosuppressive treatment. Head and Neck localisation is the most common – 72,7%. We established a mean histological depth of SCCs of 5,92mm, lymphovascular invasion in 7% and perineural invasion in 5% of the cases. We found that tumors with a macroscopic diameter >20mm have a greater depth of invasion in comparison to SCCs with a smaller diameter. We found an incidence of local recurrence of 4,8%, lymph node metastases at 5,1%, far metastases in internal organs at 2,25% and mortality at 1,97%. Conclusion: Clinicohistopathological features of SCCs with related to recurrence, metastasis and mortality are localisation on the scalp, ears or lips, tumor size >20mm, depth of invasion >6mm, poor tumor cell differentiation, perineural and lymphovascular invasion, low or absent stromal lymphocyte infiltration.","PeriodicalId":44393,"journal":{"name":"Journal of IMAB","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135895249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LONG-STEMMED HEMIARTHROPLASTY WITH CERCLAGE WIRING FOR THE TREATMENT OF PROXIMAL HUMERAL FRACTURE: A CASE REPORT OF THE MULTIMORBID PATIENT 长柄半关节置换术加环系钢丝治疗肱骨近端骨折1例
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.5272/jimab.2023293.5120
Emil Simeonov
Introduction: Complex multi-fragmentary fractures of the proximal humerus are a rare type of injury, which represent a major challenge, even to the most experienced shoulder surgeons. Hemiarthroplasty is commonly accepted as the first surgical choice of treatment for three or four-part fractures of the proximal humerus. Case Report: A 62-year-old female who has sustained complex multi-fragmentary trauma of the proximal humerus presented to the clinic after a low-energy trauma. The patient was managed with a long-stemmed shoulder hemiarthroplasty and cerclage wiring of the fracture area. A good clinical and radiological outcome was observed 5 months post-operatively. Conclusion: We report the functional, anatomical and radiological outcome of a case of a rare type of proximal humeral fracture that was managed with a long-stemmed hemiarthroplasty and cerclage wire and has shown a good early clinical outcome.
肱骨近端复杂的多碎片性骨折是一种罕见的损伤类型,即使对最有经验的肩部外科医生来说,也是一个重大的挑战。半关节置换术通常被认为是肱骨近端三或四部分骨折的首选手术治疗方法。病例报告:一个62岁的女性谁持续复杂的多碎片性创伤的肱骨近端提出了低能量创伤后的诊所。患者采用长柄肩关节置换术和骨折区环扎钢丝进行治疗。术后5个月临床及影像学表现良好。结论:我们报告了一例罕见的肱骨近端骨折的功能、解剖和放射学结果,该病例采用长柄半关节置换术和环扎金属丝进行治疗,并显示出良好的早期临床结果。
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引用次数: 0
ANALYSIS OF MEDIUM-TERM RESULTS ACHIEVED AFTER MICROFRACTURES AND PERFORATIONS (DRILLING) IN LOCALIZED CHONDRAL LESIONS IN THE KNEE JOINT 膝关节局部软骨病变微骨折和穿孔(钻孔)后中期疗效分析
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-28 DOI: 10.5272/jimab.2023293.5125
Emil Simeonov
Introduction: The main advantage of perforative techniques is their atraumatic, non-invasiveness and possibly being done under arthroscopic control. Purpose: This study aims to compare two methods of operative techniques in the treatment of chondral lesions of the knee. Materials and methods: The clinical study included 237 symptomatic patients with chondral defects from the period of 2010 – 2018. Patients were divided into 2 groups. The first group included 49 (32.11%) patients with arthroscopic micro-fractures. The second group included 54 (35.49%) patients with arthroscopic subchondral perforation (drilling). The term of follow-up was 36 months. Each patient had at least 4 documented follow-up visits. Results: Results from grading scales – Lysholm, KOS, MRI – scales, as well as our own scale for evaluating knee function (PS) scale, were documented in each patient's separate file. The average pre-operative Lysholm score was 41.5 ± 6.6 in the microfracture group and 43.0 ± 5.6 in the perforation group. At the 36th-month average, Lysholm's score increased to 86.9 ± 7.3 in the microfracture group and to 86.1 ± 6.6 in the perforation group. During the study, it was also found that a correlation exists between the received results and the age of the patient, the size of the chondral defect, and the tracking period. Conclusion: The effectiveness of osteoperforative techniques relies on many factors: the age of the patient, the size of the defect, and the tracking period. In the end, mesenchymal stimulation of chondrogenesis results in positive mid-term results in patients with small-sized chondral lesion.
简介:穿孔技术的主要优点是其无伤性、无创性和可能在关节镜控制下进行。目的:比较两种治疗膝关节软骨病变的手术方法。材料与方法:选取2010 - 2018年237例有症状的软骨缺损患者作为临床研究对象。患者分为两组。第一组49例(32.11%)关节镜下微骨折患者。第二组包括54例(35.49%)关节镜下软骨下穿孔(钻孔)患者。随访时间36个月。每位患者至少有4次记录在案的随访。结果:分级量表- Lysholm, KOS, MRI -量表,以及我们自己的评估膝关节功能量表(PS)量表的结果记录在每个患者的单独文件中。术前Lysholm评分微骨折组平均为41.5±6.6分,穿孔组平均为43.0±5.6分。36个月时,微骨折组Lysholm评分为86.9±7.3,穿孔组Lysholm评分为86.1±6.6。在研究过程中,我们还发现收到的结果与患者的年龄、软骨缺损的大小和跟踪时间存在相关性。结论:骨手术技术的有效性取决于许多因素:患者的年龄、缺损的大小和跟踪时间。最终,间充质细胞刺激软骨形成导致小软骨病变患者中期结果阳性。
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引用次数: 0
PROBLEMATIC ASPECTS AND CHALLENGES AHEAD OF THE MEDICAL PROFESSIONALS WORKING IN EMERGENCY MEDICAL CARE IN BULGARIA 在保加利亚从事紧急医疗护理的医疗专业人员面临的问题和挑战
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-25 DOI: 10.5272/jimab.2023293.5116
Deyana Todorova, Albena Andonova
PURPOSE: The article aims to determine the most common problematic aspects and challenges ahead of the medical professionals working in emergency medical care in the Republic of Bulgaria. For that reason, scientific developments, reports and publications of researchers and experts have been studied and analyzed. MATERIALS AND METHODS: A survey was conducted via an interview and direct anonymous questionnaire throughout the first quarter of 2019 amongst 325 respondents. RESULTS: The medical professionals providing emergency medical care face numerous challenges that require instant and adequate measures. Options for overcoming the difficulties that medical professionals face daily are sought at all levels of the hierarchy. A lot of work is done in the direction of a real interaction between all the subjects. CONCLUSIONS: The issues of the EMC require complex, radical measures.
目的:本文旨在确定在保加利亚共和国从事紧急医疗护理工作的医疗专业人员面临的最常见问题方面和挑战。为此,研究和分析了研究人员和专家的科学发展、报告和出版物。材料和方法:在2019年第一季度,通过访谈和直接匿名问卷对325名受访者进行了调查。结果:提供紧急医疗服务的医务人员面临着许多挑战,需要及时和充分的措施。各级医务人员都在寻求各种办法来克服医疗专业人员每天面临的困难。很多工作都是在所有主体之间的真正互动的方向上完成的。结论:EMC问题需要采取复杂、彻底的措施。
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引用次数: 0
ISOTRETINOIN INDUCED PSYCHOTIC SYMPTOMS 异维甲酸引起精神病症状
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-09-20 DOI: 10.5272/jimab.2023293.5112
Tatyana Telbizova, Svetlin Varbanov
Isotretinoin is an effective treatment for severe and resistant forms of acne. It has proven potential for inducing dose-dependent psychiatric side effects, especially in some vulnerable groups of patients. Objective: The aim of the present article is to report a case of a 22-year-old woman with a family history of schizophrenia who was diagnosed with acne. After unsuccessful antibiotic treatment of acne, a panic disorder accompanied by depressive symptoms manifested. Isotretinoin 20 mg/day was used as а second step of the dermatological treatment for a period of four months, along with psychotropic treatment for panic disorder – sertraline 50 mg/day and flupentixol 1,5 mg/day. When the dose of Isotretinoin was increased to 40 mg/day, paranoid delusions occurred. The manifestation of psychotic symptoms required discontinuation of all medications and initiation of antipsychotic therapy with quetiapine. The psychotic symptoms completely disappeared when the dose of quetiapine was increased to 300 mg/day. Conclusion: The presented case emphasizes the need for increased vigilance about the manifestation of psychiatric symptoms, especially in patients with a family history, current or past medical history of mental disorder. In such cases, consultation with a psychiatrist before starting treatment with Isotretinoin is recommended in order to better clarify the benefits and the risks of the treatment. The endogenous origin of the psychosis was discussed in the differential diagnostic plan, which requires long-term monitoring of the mental state.
异维甲酸是一种有效的治疗严重和抵抗形式的痤疮。它已被证明有可能引起剂量依赖的精神副作用,特别是在一些脆弱的患者群体中。目的:本文的目的是报告一例22岁的女性精神分裂症家族史谁被诊断为痤疮。在抗生素治疗痤疮失败后,出现了伴随抑郁症状的恐慌症。异维甲酸20毫克/天作为皮肤病治疗的第二步,为期四个月,同时使用精神药物治疗惊恐障碍-舍曲林50毫克/天和氟哌噻醇1.5毫克/天。当异维甲酸剂量增加到40 mg/d时,出现偏执妄想。精神病症状的表现需要停止所有药物并开始用喹硫平进行抗精神病治疗。当喹硫平剂量增加到300 mg/d时,精神病症状完全消失。结论:本病例强调需要提高对精神症状表现的警惕,特别是对有精神障碍家族史、当前或既往病史的患者。在这种情况下,建议在开始异维a酸治疗之前咨询精神科医生,以便更好地阐明治疗的益处和风险。在鉴别诊断方案中讨论了精神病的内源性起源,这需要长期监测精神状态。
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引用次数: 1
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