Pub Date : 2022-12-31DOI: 10.23937/2469-5807/1510141
Jacob Sheba SK, Krishnan Elankumaran
{"title":"Sinus Histiocytosis with Massive Lymphadenopathy (Rosai Dorfman Disease) of the Liver Masquerading as a Metastatic Malignancy","authors":"Jacob Sheba SK, Krishnan Elankumaran","doi":"10.23937/2469-5807/1510141","DOIUrl":"https://doi.org/10.23937/2469-5807/1510141","url":null,"abstract":"","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124531034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.23937/2469-5807/1510126
M. Sajin, Florina Almarii, Iona Eliza Gaianu, G. Simion
{"title":"Lung Abscess as a Complication of SARS-CoV-2 Infection Associated with Mucormycosis in a Romanian Patient","authors":"M. Sajin, Florina Almarii, Iona Eliza Gaianu, G. Simion","doi":"10.23937/2469-5807/1510126","DOIUrl":"https://doi.org/10.23937/2469-5807/1510126","url":null,"abstract":"","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125321076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.23937/2469-5807/1510127
M. Celik, Y. Arıcı
{"title":"Evaluation of Pathological Parameters of Two-Year Bladder Urothelial Carcinomas in Association with Literature","authors":"M. Celik, Y. Arıcı","doi":"10.23937/2469-5807/1510127","DOIUrl":"https://doi.org/10.23937/2469-5807/1510127","url":null,"abstract":"","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115977428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-25DOI: 10.23937/2469-5807/1510125
Singh Gurmukh
{"title":"Criteria for Presumptive Diagnosis of IgD Multiple Myeloma","authors":"Singh Gurmukh","doi":"10.23937/2469-5807/1510125","DOIUrl":"https://doi.org/10.23937/2469-5807/1510125","url":null,"abstract":"","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114434845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-19DOI: 10.23937/2469-5807/1510124
K. Hussein, Mansour Josiane, Khana Layla Abou, F. Rosy, A. Georges
Intestinal ganglioneuromatosis is a rare neoplastic disease characterized by an important proliferation of Schwann cells, nerve fibers and ganglion cells in the intestinal wall. We present a case of 36-years-old male who presented with abdominal pain, constipation and vomiting of several days duration. On admission, intestinal occlusion was suspected and urgent laparotomy was done during which numerous nodules were found in the small bowel. Eventually, a segment of the bowel was resected and histopathological examination revealed a diffuse intestinal ganglioneuromatosis. Despite its rarity, this disease should always be considered in the differential diagnosis of intestinal mass in any adult patient.
{"title":"Diffuse Intestinal Ganglioneuromatosis: A Case Report with Review of Literature","authors":"K. Hussein, Mansour Josiane, Khana Layla Abou, F. Rosy, A. Georges","doi":"10.23937/2469-5807/1510124","DOIUrl":"https://doi.org/10.23937/2469-5807/1510124","url":null,"abstract":"Intestinal ganglioneuromatosis is a rare neoplastic disease characterized by an important proliferation of Schwann cells, nerve fibers and ganglion cells in the intestinal wall. We present a case of 36-years-old male who presented with abdominal pain, constipation and vomiting of several days duration. On admission, intestinal occlusion was suspected and urgent laparotomy was done during which numerous nodules were found in the small bowel. Eventually, a segment of the bowel was resected and histopathological examination revealed a diffuse intestinal ganglioneuromatosis. Despite its rarity, this disease should always be considered in the differential diagnosis of intestinal mass in any adult patient.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134578881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-07DOI: 10.23937/2469-5807/1510123
Tekabe Yared, Saqi Anjali, Zhang Geping, Goldklang Monica, Johnson Lynne L
{"title":"High Expression of RAGE and HMGB1 in Lung Tissue of Decedents with COVID-19 and Diabetes","authors":"Tekabe Yared, Saqi Anjali, Zhang Geping, Goldklang Monica, Johnson Lynne L","doi":"10.23937/2469-5807/1510123","DOIUrl":"https://doi.org/10.23937/2469-5807/1510123","url":null,"abstract":"","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133013677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.23937/2469-5807/1510122
B. Rekha, Gaur Dushyant Singh, Kotwal Aarti, K. Anuradha
Introduction: Early diagnosis of tuberculosis is important for therapeutic reasons and to control the spread of infection [1,2]. Culture of M. tuberculosis is the gold standard method for the diagnosis of TB [3]. However, culture is a slow process requiring specialized laboratories and skilled staff. Hence there is a need for a rapid, cheaper and effective technique for the detection of the tubercle bacilli. Material and methods: A total of 200 clinically suspected cases of tuberculosis were included in the study. All the cytological specimens procured were smeared and stained for both ZN and FL staining. A part of the sample was used for Lowenstein Jensen (LJ) culture. Patients on ATT were excluded from the study. Results: The maximum cases were in the age group of 2130 years. In 57% cases, patients were male with M:F ratio of 1.3:1. The sensitivity of FL (95.83%) was more as compared to ZN (91.67%). The difference in the case detection rate was statistically significant with p value 0.001. The average time taken to screen per slide by ZN was more (4.32 mins) as compared to that by FL (2.28 mins), reflecting a time saving by 47%. Conclusion: FL staining has an upper edge in respect to efficacy, time saving and less observer fatigue. Hence replacement of the age old ZN technique and using FL microscopy may be considered as alternative for diagnosis of tuberculosis.
{"title":"Comparison of Ziehl - Neelsen (ZN) Staining and Fluorescent (FL) Staining in Suspected Cases of Tuberculosis","authors":"B. Rekha, Gaur Dushyant Singh, Kotwal Aarti, K. Anuradha","doi":"10.23937/2469-5807/1510122","DOIUrl":"https://doi.org/10.23937/2469-5807/1510122","url":null,"abstract":"Introduction: Early diagnosis of tuberculosis is important for therapeutic reasons and to control the spread of infection [1,2]. Culture of M. tuberculosis is the gold standard method for the diagnosis of TB [3]. However, culture is a slow process requiring specialized laboratories and skilled staff. Hence there is a need for a rapid, cheaper and effective technique for the detection of the tubercle bacilli. Material and methods: A total of 200 clinically suspected cases of tuberculosis were included in the study. All the cytological specimens procured were smeared and stained for both ZN and FL staining. A part of the sample was used for Lowenstein Jensen (LJ) culture. Patients on ATT were excluded from the study. Results: The maximum cases were in the age group of 2130 years. In 57% cases, patients were male with M:F ratio of 1.3:1. The sensitivity of FL (95.83%) was more as compared to ZN (91.67%). The difference in the case detection rate was statistically significant with p value 0.001. The average time taken to screen per slide by ZN was more (4.32 mins) as compared to that by FL (2.28 mins), reflecting a time saving by 47%. Conclusion: FL staining has an upper edge in respect to efficacy, time saving and less observer fatigue. Hence replacement of the age old ZN technique and using FL microscopy may be considered as alternative for diagnosis of tuberculosis.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115552961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pregnancy and the postpartum period carry high risk of thromboembolic phenomenon which increases manifold postpartally. Multiple predisposing risk factors, usually acting in combination, add up to this risk. All three of the Virchow’s triad conditions predisposing to vascular thrombosis, i.e., endothelial injury, venous stasis and hypercoagulability, are present in pregnancy. The deaths caused by pulmonary embolism may become the subject of medicolegal investigation due a sudden and unexpected fatal outcome. A thorough dissection, documentation and ancillary investigations pertaining to pulmonary emboli are important components of evaluating such fatalities. The investigation requires a dependable protocol that should include a proper evaluation of the timing of the embolus along with the residual and other thrombi, whenever discovered. Because of the pathophysiology and propagation of thrombus over a range of time period, one may see a broad histological range of thrombosis and organization. The present case pertains to the sudden death of a young female in the postpartum period who suffered a massive pulmonary embolism about 6 weeks after delivery. An extensive dissection of the lower limbs showed multiple deep venous thrombi in the calf and femoral regions while moderate to large coiled emboli were found in the pulmonary arterial vasculature. An additional histopathological dating of the thrombi as well as pulmonary embolus was performed that helped in elucidating the time range of their development.
{"title":"Autopsy and Medicolegal Evaluation in a Case of Sudden Maternal Death from Pulmonary Embolism","authors":"Mittal Pawan, Karagwal Prateek, Gilotra Meenu, Kulhria Amrita, Saini Abhishek, Juneja Saurabh","doi":"10.23937/2469-5807/1510121","DOIUrl":"https://doi.org/10.23937/2469-5807/1510121","url":null,"abstract":"Pregnancy and the postpartum period carry high risk of thromboembolic phenomenon which increases manifold postpartally. Multiple predisposing risk factors, usually acting in combination, add up to this risk. All three of the Virchow’s triad conditions predisposing to vascular thrombosis, i.e., endothelial injury, venous stasis and hypercoagulability, are present in pregnancy. The deaths caused by pulmonary embolism may become the subject of medicolegal investigation due a sudden and unexpected fatal outcome. A thorough dissection, documentation and ancillary investigations pertaining to pulmonary emboli are important components of evaluating such fatalities. The investigation requires a dependable protocol that should include a proper evaluation of the timing of the embolus along with the residual and other thrombi, whenever discovered. Because of the pathophysiology and propagation of thrombus over a range of time period, one may see a broad histological range of thrombosis and organization. The present case pertains to the sudden death of a young female in the postpartum period who suffered a massive pulmonary embolism about 6 weeks after delivery. An extensive dissection of the lower limbs showed multiple deep venous thrombi in the calf and femoral regions while moderate to large coiled emboli were found in the pulmonary arterial vasculature. An additional histopathological dating of the thrombi as well as pulmonary embolus was performed that helped in elucidating the time range of their development.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"79 2-3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116586221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-25DOI: 10.23937/2469-5807/1510120
Chepkorir Cynthia Chemonges, N. Joshua, Joseph Ndungu Rugumu
Background: Lymphadenopathy is common in both adult and paediatric patients in Kenya. It has a broad differential diagnosis, the most common being non-specific reactive lymphoid hyperplasia. Prevalence and morbidity of malignancies in early stages, such as micro lymphoma in reactive lymphadenitis remains poorly investigated. Objective: This study evaluated the histopathologic patterns of lymph node biopsies reported as reactive lymphadenitis at Kenyatta National Hospital between 2013-2019. Methods: Formalin fixed paraffin embedded tissue blocks were used. Consent to conduct the study was obtained from KNH/UoN ERC. Demographic and clinical data were retrieved from the records. Haematoxylin and eosin was performed to confirm the initial diagnosis, followed with immunophenotyping in cases suspicious of lymphomas. Data was analysed using SPSS version 20. Results: We analysed 86 cases, 64(73%) adults and 22(27%) paediatrics. Age range was 1 year 3 months to 76 years. Males were 49(57%), and females 37(43%). Follicular hyperplasia 63(73%), sinusoidal 16(19%) and PTGC 1(1%) were the histopathological patterns reported. No diffuse or mixed patterns, and no micro lymphomas were found. However, immunophenotyping confirmed 6(7%) cases to be DLBCL (1 case), high grade round blue cell tumour of childhood (1 case), and 4(3SLL and 1MCL) cases. Discussion: Diagnosis of reactive lymphadenitis is a major challenge, especially in settings with limited utilization of immunophenotyping and molecular analyses. It has a broad differential diagnosis, the most common being nonspecific reactive lymphoid hyperplasia, which often disguises malignancy. In this study, follicular hyperplasia was the more common sub-classification. Conclusion: Sub-classifications of reactive lymphadenitis may help in diagnosis of underlying pathologic conditions.
背景:淋巴结病在肯尼亚的成人和儿科患者中都很常见。它有广泛的鉴别诊断，最常见的是非特异性反应性淋巴样增生。早期恶性肿瘤的患病率和发病率，如反应性淋巴结炎中的微淋巴瘤，仍然缺乏调查。目的:本研究评估了2013-2019年肯雅塔国家医院报告的反应性淋巴结炎淋巴结活检的组织病理学模式。方法:采用福尔马林固定石蜡包埋组织块。已从KNH/ un ERC获得开展该研究的同意。从记录中检索人口统计学和临床数据。采用血红素和伊红进行初步诊断，随后对疑似淋巴瘤的病例进行免疫表型分析。数据分析采用SPSS version 20。结果:我们分析了86例病例，其中成人64例(73%)，儿科22例(27%)。年龄1岁3个月至76岁。男性49例(57%)，女性37例(43%)。报告的组织病理学类型为滤泡增生63例(73%)，窦状增生16例(19%)和PTGC 1例(1%)。未见弥漫性或混合性淋巴瘤，未见微淋巴瘤。然而，免疫分型证实6例(7%)为DLBCL(1例)，儿童高级别圆形蓝细胞瘤(1例)，4例(3SLL和1MCL)。讨论:诊断反应性淋巴结炎是一个主要的挑战，特别是在免疫表型和分子分析应用有限的情况下。它具有广泛的鉴别诊断，最常见的是非特异性反应性淋巴样增生，通常掩盖恶性肿瘤。在本研究中，滤泡增生是更常见的亚分类。结论:反应性淋巴结炎的亚分类有助于基础病理条件的诊断。
{"title":"A Review of the Sub-Classification of Lymph Node Biopsies Reported as Reactive Lymphadenitis at Kenyatta National Hospital, Kenya","authors":"Chepkorir Cynthia Chemonges, N. Joshua, Joseph Ndungu Rugumu","doi":"10.23937/2469-5807/1510120","DOIUrl":"https://doi.org/10.23937/2469-5807/1510120","url":null,"abstract":"Background: Lymphadenopathy is common in both adult and paediatric patients in Kenya. It has a broad differential diagnosis, the most common being non-specific reactive lymphoid hyperplasia. Prevalence and morbidity of malignancies in early stages, such as micro lymphoma in reactive lymphadenitis remains poorly investigated. Objective: This study evaluated the histopathologic patterns of lymph node biopsies reported as reactive lymphadenitis at Kenyatta National Hospital between 2013-2019. Methods: Formalin fixed paraffin embedded tissue blocks were used. Consent to conduct the study was obtained from KNH/UoN ERC. Demographic and clinical data were retrieved from the records. Haematoxylin and eosin was performed to confirm the initial diagnosis, followed with immunophenotyping in cases suspicious of lymphomas. Data was analysed using SPSS version 20. Results: We analysed 86 cases, 64(73%) adults and 22(27%) paediatrics. Age range was 1 year 3 months to 76 years. Males were 49(57%), and females 37(43%). Follicular hyperplasia 63(73%), sinusoidal 16(19%) and PTGC 1(1%) were the histopathological patterns reported. No diffuse or mixed patterns, and no micro lymphomas were found. However, immunophenotyping confirmed 6(7%) cases to be DLBCL (1 case), high grade round blue cell tumour of childhood (1 case), and 4(3SLL and 1MCL) cases. Discussion: Diagnosis of reactive lymphadenitis is a major challenge, especially in settings with limited utilization of immunophenotyping and molecular analyses. It has a broad differential diagnosis, the most common being nonspecific reactive lymphoid hyperplasia, which often disguises malignancy. In this study, follicular hyperplasia was the more common sub-classification. Conclusion: Sub-classifications of reactive lymphadenitis may help in diagnosis of underlying pathologic conditions.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133090794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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