Pub Date : 2019-07-11DOI: 10.23937/2469-5807/1510094
M. Tena-Suck, M. E. Hernández-Campos, Alma Ortiz Plataa, Carlos Sánchez Garibay, Citlaltepetl Salinas Lara, Carlos Peñafiel
Background: Craniopharyngiomas constitute 2 to 4% of intracranial neoplasms. Although this tumors exhibit a benign histopathological pattern, recurrence is commonly reported by cerebrospinal fluid seeding and direct brain invasion. The aim of this study was to analyses and recognizes craniopharyngioma pathological features in relationship to brain invasion as a prognostic factor. Methods: One hundred patients who were surgically treated for Craniopharyngiomas extending outside the sellar and suprasellar regions were evaluated. Clinical, pathological and immunohistochemistry profile correlations were done. Results: The age of the patients varied from 15 to 87 years (mean 49.4 yrs); 41 (41%) patients were males and 59 (59%) were females. Brain invasion was found in 51 cases, recurrence occurred in 45 patients and 11 died. The follow-up was for 30.12 ± 13.82 months. The arrange mean of KI67-Li in tumoral nest cell invasion was 32.04 ± 6.57 vs. 16.68 ± 4.0 for non tumoral invasion (p = 0.000). The intratumoral MVD-Li (CD34) mean range in invasive tumors was 4.84 ± 1.06 vs. 4.88 ± 1.01 in non-invasive tumors (p = 0.462). The amount of MVD-li in peritumoral area was 17.98 ± 4.67 vs. 14.84 ± 5.16 of non peritumoral (p = 0.017). Higher Ki67-Li in neoplastic nest cells, were correlated with higher peritumoral MVD-Li (p = 0.033), and E-Cadherin, β-tubulin, NFG and D2DR intratumoral positive immnunoexpression. Conclusion: Invasion in craniopharyngioma is a common event that it is associated, to neuronal differentiation in tumoral cells and hypoxic chances. The neoplastic nest cells in the adjacent brain tissue showed a higher labelling index, higher peritumoral microvascular density, but not always it was associated to recurrence.
{"title":"Craniopharyngioma Brain Invasion Forms","authors":"M. Tena-Suck, M. E. Hernández-Campos, Alma Ortiz Plataa, Carlos Sánchez Garibay, Citlaltepetl Salinas Lara, Carlos Peñafiel","doi":"10.23937/2469-5807/1510094","DOIUrl":"https://doi.org/10.23937/2469-5807/1510094","url":null,"abstract":"Background: Craniopharyngiomas constitute 2 to 4% of intracranial neoplasms. Although this tumors exhibit a benign histopathological pattern, recurrence is commonly reported by cerebrospinal fluid seeding and direct brain invasion. The aim of this study was to analyses and recognizes craniopharyngioma pathological features in relationship to brain invasion as a prognostic factor. Methods: One hundred patients who were surgically treated for Craniopharyngiomas extending outside the sellar and suprasellar regions were evaluated. Clinical, pathological and immunohistochemistry profile correlations were done. Results: The age of the patients varied from 15 to 87 years (mean 49.4 yrs); 41 (41%) patients were males and 59 (59%) were females. Brain invasion was found in 51 cases, recurrence occurred in 45 patients and 11 died. The follow-up was for 30.12 ± 13.82 months. The arrange mean of KI67-Li in tumoral nest cell invasion was 32.04 ± 6.57 vs. 16.68 ± 4.0 for non tumoral invasion (p = 0.000). The intratumoral MVD-Li (CD34) mean range in invasive tumors was 4.84 ± 1.06 vs. 4.88 ± 1.01 in non-invasive tumors (p = 0.462). The amount of MVD-li in peritumoral area was 17.98 ± 4.67 vs. 14.84 ± 5.16 of non peritumoral (p = 0.017). Higher Ki67-Li in neoplastic nest cells, were correlated with higher peritumoral MVD-Li (p = 0.033), and E-Cadherin, β-tubulin, NFG and D2DR intratumoral positive immnunoexpression. Conclusion: Invasion in craniopharyngioma is a common event that it is associated, to neuronal differentiation in tumoral cells and hypoxic chances. The neoplastic nest cells in the adjacent brain tissue showed a higher labelling index, higher peritumoral microvascular density, but not always it was associated to recurrence.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126276432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-31DOI: 10.23937/2469-5807/1510091
D. A. Steenblock, Taruna Ikrar
Heavy metal toxicity has been conjectured as a possible risk factor for and player in amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. To test for a correlational relationship or linkage, we conducted a retrospective study of 54 sALS and 26 healthy volunteers who agreed to serve as controls, all of whom were seen at the Personalized Regenerative Medicine Clinic (San Clemente, California USA) between 2011 and 2016. We evaluated clinical laboratory findings including heavy metal content in blood and urine samples, along with serum creatinine, ferritin and haptoglobin levels, by means of inductively coupled plasma optical spectrometry and instrumental activation analysis. Disease progression, assessed using the Revised ALS Functional Rating Scale (ALS-FRS-R), was generally associated with mercury, lead, cadmium, arsenic and nickel burden. In our analysis, we found evidence of an association between ALS morbidity risk and elevated levels of mercury, lead, cadmium, arsenic, and nickel. Our findings implicate and support a linkage between relatively high levels of heavy metals, elevated serum ferritin and haptoglobin levels, and reduced urine creatinine level and sporadic amyotrophic lateral sclerosis. By virtue of this the authors argue that these may serve as a biomarker to help distinguish clinically ALS from other, symptom similar neurogenerative conditions.
重金属中毒已被推测为肌萎缩侧索硬化症(ALS)和其他神经退行性疾病的可能危险因素和参与者。为了测试相关关系或联系，我们对54名als患者和26名健康志愿者进行了回顾性研究，这些志愿者同意作为对照组，所有人都在2011年至2016年期间在个性化再生医学诊所(San Clemente, California USA)就诊。我们评估了临床实验室结果，包括血液和尿液样本中的重金属含量，以及血清肌酐、铁蛋白和触珠蛋白水平，采用电感耦合等离子体光学光谱法和仪器激活分析。使用修订的ALS功能评定量表(ALS- frs - r)评估的疾病进展通常与汞、铅、镉、砷和镍负担相关。在我们的分析中，我们发现了ALS发病风险与汞、铅、镉、砷和镍含量升高之间存在关联的证据。我们的研究结果暗示并支持相对较高的重金属水平、血清铁蛋白和接触球蛋白水平升高、尿肌酐水平降低与散发性肌萎缩性侧索硬化症之间的联系。鉴于此，作者认为这些可以作为一种生物标志物，帮助区分临床ALS与其他症状类似的神经生成疾病。
{"title":"Atypical Levels of Heavy Metals, Creatinine, Haptoglobin, and Ferritin Found in Amyotrophic Lateral Sclerosis Outpatients vs. Healthy Controls: Possible Utility as a Diagnostic Biomarker","authors":"D. A. Steenblock, Taruna Ikrar","doi":"10.23937/2469-5807/1510091","DOIUrl":"https://doi.org/10.23937/2469-5807/1510091","url":null,"abstract":"Heavy metal toxicity has been conjectured as a possible risk factor for and player in amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. To test for a correlational relationship or linkage, we conducted a retrospective study of 54 sALS and 26 healthy volunteers who agreed to serve as controls, all of whom were seen at the Personalized Regenerative Medicine Clinic (San Clemente, California USA) between 2011 and 2016. We evaluated clinical laboratory findings including heavy metal content in blood and urine samples, along with serum creatinine, ferritin and haptoglobin levels, by means of inductively coupled plasma optical spectrometry and instrumental activation analysis. Disease progression, assessed using the Revised ALS Functional Rating Scale (ALS-FRS-R), was generally associated with mercury, lead, cadmium, arsenic and nickel burden. In our analysis, we found evidence of an association between ALS morbidity risk and elevated levels of mercury, lead, cadmium, arsenic, and nickel. Our findings implicate and support a linkage between relatively high levels of heavy metals, elevated serum ferritin and haptoglobin levels, and reduced urine creatinine level and sporadic amyotrophic lateral sclerosis. By virtue of this the authors argue that these may serve as a biomarker to help distinguish clinically ALS from other, symptom similar neurogenerative conditions.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131951062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-29DOI: 10.23937/2469-5807/1510088
M ArafahMaha
The correlation between glomerular podocytes and renal tubular cells involved in handling of leaked proteins and the level of proteinuria was evaluated. Retrospective 22 cases of clinical proteinuria in patients with various glomerulopathies were retrieved and analyzed. Glomerulopathies in the concerned patients were pathologically diagnosed through light and electron microscopic examination of the submitted renal biopsies. Three cases with protein levels in urine within the acceptable normal range were additionally analyzed as controls. Electron microscopic examination of the glomerular podocytes and immunofluorescence of the renal tubular epithelium in the relevant cases constituted the base for the present study. Among the studied cases, it was found that the greater the number of glomerular podocytes with reabsorbed intracytoplasmic proteins and the higher score of tubular protein immunofluorescence, the lower the level of proteinuria. Comparatively, cases with fewer number of podocytes with reabsorbed proteins and lower score of tubular protein immunofluorescence had higher levels of proteinuria. The present study aims to pay the attention to the correlation between morphologically recognizable glomerular podocytes and renal tubular epithelium with reabsorbed proteins and the level of proteinuria in patients with various glomerulopathies. The current study may serve as a base for the future research work concerned with the structural changes of glomerular podocytes and renal tubular epithelium as a compensative mechanism in cases of proteinuria.
{"title":"Proteinuria Level and Associated Changes in Glomerular Podocytes and Renal Tubular Epithelium","authors":"M ArafahMaha","doi":"10.23937/2469-5807/1510088","DOIUrl":"https://doi.org/10.23937/2469-5807/1510088","url":null,"abstract":"The correlation between glomerular podocytes and renal tubular cells involved in handling of leaked proteins and the level of proteinuria was evaluated. Retrospective 22 cases of clinical proteinuria in patients with various glomerulopathies were retrieved and analyzed. Glomerulopathies in the concerned patients were pathologically diagnosed through light and electron microscopic examination of the submitted renal biopsies. Three cases with protein levels in urine within the acceptable normal range were additionally analyzed as controls. Electron microscopic examination of the glomerular podocytes and immunofluorescence of the renal tubular epithelium in the relevant cases constituted the base for the present study. Among the studied cases, it was found that the greater the number of glomerular podocytes with reabsorbed intracytoplasmic proteins and the higher score of tubular protein immunofluorescence, the lower the level of proteinuria. Comparatively, cases with fewer number of podocytes with reabsorbed proteins and lower score of tubular protein immunofluorescence had higher levels of proteinuria. The present study aims to pay the attention to the correlation between morphologically recognizable glomerular podocytes and renal tubular epithelium with reabsorbed proteins and the level of proteinuria in patients with various glomerulopathies. The current study may serve as a base for the future research work concerned with the structural changes of glomerular podocytes and renal tubular epithelium as a compensative mechanism in cases of proteinuria.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130175506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-20DOI: 10.23937/2469-5807/1510087
Tena-Suck Martha Lilia, R. Armando, Chávez-Macías Laura, Peñafiel-Salgado Carlos, Sánchez-Garibay Carlos
Cellular Ependymoma is a term losing in the new WHO 2016 criteria, actually are classified as classical or anaplastic or associated to RELA fusion. We presented a rare case report of classical cellular ependymoma in supratentorial location, which presented a neuronal differentiation and desmoplasia in a young man of 29-yr-old, Immunohistochemistry tumor cells expressed Neu-N, Synaptophysin, SNE, α-synuclein, beta tubulin, ubiquitin, neurofilament, D2DR, and GFAP and vimentin. This rare tumor is a very controversial. It was classified as intermediated grade and recently is named as anaplastic or associated to RELA fusion with neuronal differentiation and with dense and diffuse desmoplastic stroma. Genetic expression of RELA gene was required to make a better diagnostic according with the new classification of Central Nervous System classification according with the WHO.
细胞室管膜瘤是WHO 2016年新标准中的一个术语，实际上被归类为经典或间变性或与RELA融合相关。我们报告一例罕见的膜上位置的经典细胞室管膜瘤，在29岁的年轻男性中表现为神经元分化和结缔组织增生，免疫组化肿瘤细胞表达new - n, Synaptophysin, SNE， α-synuclein， β微管蛋白，泛素，神经丝，D2DR, GFAP和vimentin。这种罕见的肿瘤是非常有争议的。它被归类为中度，最近被命名为间变性或与RELA融合与神经元分化和密集和弥漫性间质有关。根据WHO的中枢神经系统分类的新分类，需要RELA基因的遗传表达来更好地进行诊断。
{"title":"Cellular Desmoplastic or Anaplastic Supratentorial Ependymoma with Neuronal Differentiation in Probable Associated to RELA Fusion? Case Report","authors":"Tena-Suck Martha Lilia, R. Armando, Chávez-Macías Laura, Peñafiel-Salgado Carlos, Sánchez-Garibay Carlos","doi":"10.23937/2469-5807/1510087","DOIUrl":"https://doi.org/10.23937/2469-5807/1510087","url":null,"abstract":"Cellular Ependymoma is a term losing in the new WHO 2016 criteria, actually are classified as classical or anaplastic or associated to RELA fusion. We presented a rare case report of classical cellular ependymoma in supratentorial location, which presented a neuronal differentiation and desmoplasia in a young man of 29-yr-old, Immunohistochemistry tumor cells expressed Neu-N, Synaptophysin, SNE, α-synuclein, beta tubulin, ubiquitin, neurofilament, D2DR, and GFAP and vimentin. This rare tumor is a very controversial. It was classified as intermediated grade and recently is named as anaplastic or associated to RELA fusion with neuronal differentiation and with dense and diffuse desmoplastic stroma. Genetic expression of RELA gene was required to make a better diagnostic according with the new classification of Central Nervous System classification according with the WHO.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117344548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-08DOI: 10.23937/2469-5807/1510086
Va Аliev, V. Semenyutin, G. Panuntsev
The choice of treatment of carotid artery stenosis is firstly based on assessment of the degree of stenosis and embologeneity of the atherosclerotic plaque. But even in “good-risk” population it is still difficult to identify the patients who are particularly at high threat of stroke and would most benefit from carotid reconstruction. Along with common criteria numerous studies also focus on a prognostic role of a cerebrovascular reserve (CVR) and its state which allows to carry out more objective and pathogenetically substantiated selection of cases for surgical and medical treatment. The present study is a literature review of CVR assessment with different methods in relation to the clinical course of disease, severity of stenosis, the state of collateral circulation, its dynamics after operative procedures. Questions are discussed about the informative value of CVR indices in predicting ischemic strokes and postoperative hyperperfusion complications. It was concluded there is a great need for carrying out multicenter randomized studies to determine the prognostic role of CVR in the choice of treatment strategy, to clarify the indications and evaluate the effectiveness of surgical intervention in patients with stenotic lesions of the internal carotid arteries.
{"title":"Predictive Value of Cerebrovascular Reserve in Patients with Carotid Artery Stenosis for Choosing Treatment Strategy","authors":"Va Аliev, V. Semenyutin, G. Panuntsev","doi":"10.23937/2469-5807/1510086","DOIUrl":"https://doi.org/10.23937/2469-5807/1510086","url":null,"abstract":"The choice of treatment of carotid artery stenosis is firstly based on assessment of the degree of stenosis and embologeneity of the atherosclerotic plaque. But even in “good-risk” population it is still difficult to identify the patients who are particularly at high threat of stroke and would most benefit from carotid reconstruction. Along with common criteria numerous studies also focus on a prognostic role of a cerebrovascular reserve (CVR) and its state which allows to carry out more objective and pathogenetically substantiated selection of cases for surgical and medical treatment. The present study is a literature review of CVR assessment with different methods in relation to the clinical course of disease, severity of stenosis, the state of collateral circulation, its dynamics after operative procedures. Questions are discussed about the informative value of CVR indices in predicting ischemic strokes and postoperative hyperperfusion complications. It was concluded there is a great need for carrying out multicenter randomized studies to determine the prognostic role of CVR in the choice of treatment strategy, to clarify the indications and evaluate the effectiveness of surgical intervention in patients with stenotic lesions of the internal carotid arteries.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130354542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-14DOI: 10.23937/2469-5807/1510085
Jr Lineu Perrone, Daltoé Felipe Perozzo, Araújo Luiz Carlos Areas, Nunes Fabio Daumas, Gallottini Marina Helena Cury, M. Andrea
{"title":"Clinical and Genetics Findings in Möbius Syndrome: Role of Hoxa1 and Hoxb1 Mutations","authors":"Jr Lineu Perrone, Daltoé Felipe Perozzo, Araújo Luiz Carlos Areas, Nunes Fabio Daumas, Gallottini Marina Helena Cury, M. Andrea","doi":"10.23937/2469-5807/1510085","DOIUrl":"https://doi.org/10.23937/2469-5807/1510085","url":null,"abstract":"","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130783475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.23937/2469-5807/1510073
Panwar Hemlata, T. Santosh, Kumar Bharti, Singh Vandita, Ramchandani Rk
Background: Tubercular mastitis is a great masquerader and is an extremely rare entity as extra-pulmonary tuberculosis even in endemic countries like India and incidence accounts for 4% of breast lesions. Case report: We report a case of primary TB of breast in a elderly female presenting as diffuse upper left breast lump with indurated and ulcerated overlying skin along with retraction of nipple. Clinically suspicion was of abscess and duct ectasia. Fine needle aspiration cytology (FNAC) of breast lump with touch imprint smears was done. FNAC showed epithelioid cell granulomas, Langhans type of giant cells with the presence of acid-fast bacilli on Ziehl Neelsen (ZN) stains. Conclusion: FNAC diagnosis of tubercular mastitis is a useful tool for the proper management and treatment of patient thus avoiding unnecessary surgery.
{"title":"Ambiguity in Diagnosis of Extra-Pulmonary Breast Tuberculosis as Breast Abscess/Duct Ectasia","authors":"Panwar Hemlata, T. Santosh, Kumar Bharti, Singh Vandita, Ramchandani Rk","doi":"10.23937/2469-5807/1510073","DOIUrl":"https://doi.org/10.23937/2469-5807/1510073","url":null,"abstract":"Background: Tubercular mastitis is a great masquerader and is an extremely rare entity as extra-pulmonary tuberculosis even in endemic countries like India and incidence accounts for 4% of breast lesions. Case report: We report a case of primary TB of breast in a elderly female presenting as diffuse upper left breast lump with indurated and ulcerated overlying skin along with retraction of nipple. Clinically suspicion was of abscess and duct ectasia. Fine needle aspiration cytology (FNAC) of breast lump with touch imprint smears was done. FNAC showed epithelioid cell granulomas, Langhans type of giant cells with the presence of acid-fast bacilli on Ziehl Neelsen (ZN) stains. Conclusion: FNAC diagnosis of tubercular mastitis is a useful tool for the proper management and treatment of patient thus avoiding unnecessary surgery.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127616177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.23937/2469-5807/1510076
S. Ban, Naaz Iram, C. Anne
Lymphomas of the gastrointestinal tract are very rare. Primary and secondary oesophageal lymphoma account for less than 1% of all gastrointestinal lymphomas. Secondary oesophageal involvement is by contiguous spread from the stomach or surrounding lymph nodes. Patients with oesophageal lymphoma have varying presentations and complications which include perforation with a tracheo-oesophageal fistula, mass and haemorrhage. We present a case of recurrence of Hodgkin lymphoma involving the oesophagus and the surrounding lymph nodes. A 75-year-old male presented with dysphagia. He was diagnosed three years ago with Hodgkin lymphoma stage 2A and was managed by chemotherapy. Barium swallow was performed for the present complaint which showed a 12 mm lesion situated 5 cm above the cardio-oesophageal junction. Urgent gastroscopy was done, and the lesion was biopsied. The PET scan revealed FDG avid oesophageal malignancy with probable FDG avid nodal disease around the proximal lesser curvature of the stomach.
{"title":"Hodgkin Lymphoma Involving the Oesophagus: A Case Report","authors":"S. Ban, Naaz Iram, C. Anne","doi":"10.23937/2469-5807/1510076","DOIUrl":"https://doi.org/10.23937/2469-5807/1510076","url":null,"abstract":"Lymphomas of the gastrointestinal tract are very rare. Primary and secondary oesophageal lymphoma account for less than 1% of all gastrointestinal lymphomas. Secondary oesophageal involvement is by contiguous spread from the stomach or surrounding lymph nodes. Patients with oesophageal lymphoma have varying presentations and complications which include perforation with a tracheo-oesophageal fistula, mass and haemorrhage. We present a case of recurrence of Hodgkin lymphoma involving the oesophagus and the surrounding lymph nodes. A 75-year-old male presented with dysphagia. He was diagnosed three years ago with Hodgkin lymphoma stage 2A and was managed by chemotherapy. Barium swallow was performed for the present complaint which showed a 12 mm lesion situated 5 cm above the cardio-oesophageal junction. Urgent gastroscopy was done, and the lesion was biopsied. The PET scan revealed FDG avid oesophageal malignancy with probable FDG avid nodal disease around the proximal lesser curvature of the stomach.","PeriodicalId":444147,"journal":{"name":"International Journal of Pathology and Clinical Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115608638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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