Pub Date : 2021-07-30DOI: 10.26787/nydha-2686-6838-2021-23-7-25-30
N. E.B., Davitavyan N.A., Gordienko M.V.
Damage to the skin is quite common in everyday life of a person and represents a loss of the integrity of the protective barrier of the skin, which can create conditions for the development of a local inflammatory process, as well as for the penetration of pathogens of various diseases into the human body. In order to more quickly restore the damaged area of the skin, it is important to accelerate wound healing through the use of combined drugs, including antiseptics and biologically active substances of natural origin, stimulating the natural local regenerative process. One of such rational combinations is the combination of chlorhexidine bigluconate and Japanese Sophora fruit liquid extract in the composition of the wound-healing preparation. Medicinal sticks are presented as the most rational dosage form for a wound-healing drug of the specified composition. The application of this dosage form to the treated surface leads to the formation of a thin, firmly adhering film, which evenly releases the active substances and protects the wound from external influences. The indicated positive properties of medicinal pencils are achieved due to the selection of a rational component composition of excipients with a set of necessary characteristics, among which the most significant is the ability to provide optimal release of active substances. In this regard, the purpose of this study was to conduct comparative biopharmaceutical studies to optimize the component composition of medicinal pencils with wound healing action containing chlorhexidine bigluconate and liquid extract of sophora fruit. The objects of research were Japanese Sophora fruits harvested in 2020 in the Krasnodar Territory that meet the requirements of regulatory documents; substance-solution of chlorhexidine bigluconate 20%; auxiliary substances of lipophilic and hydrophilic nature: solid paraffin, beeswax, cocoa butter, anhydrous lanolin, polyethylene oxide-400, polyethylene oxide-1500. To assess the degree of release of active substances from experimental compositions, the method of diffusion into agar was used, based on the diffusion of active substances from the dosage form into an agar gel containing a solution of ferric chloride as an indicator. It was found that the most suitable combination of auxiliary components of the dosage form, providing the best release of active substances, is a combination including solid paraffin (20 parts), beeswax (20 parts), anhydrous lanolin (20 parts), polyethylene oxide-1500 (10 parts), polyethylene oxide-400 (20 parts).
{"title":"BIOPHARMACEUTICAL ASPECTS OF CHOOSING THE BASIS OF PENCILS OF MEDICINAL WOUND-HEALING ACTION","authors":"N. E.B., Davitavyan N.A., Gordienko M.V.","doi":"10.26787/nydha-2686-6838-2021-23-7-25-30","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-7-25-30","url":null,"abstract":"Damage to the skin is quite common in everyday life of a person and represents a loss of the integrity of the protective barrier of the skin, which can create conditions for the development of a local inflammatory process, as well as for the penetration of pathogens of various diseases into the human body. In order to more quickly restore the damaged area of the skin, it is important to accelerate wound healing through the use of combined drugs, including antiseptics and biologically active substances of natural origin, stimulating the natural local regenerative process. One of such rational combinations is the combination of chlorhexidine bigluconate and Japanese Sophora fruit liquid extract in the composition of the wound-healing preparation. Medicinal sticks are presented as the most rational dosage form for a wound-healing drug of the specified composition. The application of this dosage form to the treated surface leads to the formation of a thin, firmly adhering film, which evenly releases the active substances and protects the wound from external influences. The indicated positive properties of medicinal pencils are achieved due to the selection of a rational component composition of excipients with a set of necessary characteristics, among which the most significant is the ability to provide optimal release of active substances. In this regard, the purpose of this study was to conduct comparative biopharmaceutical studies to optimize the component composition of medicinal pencils with wound healing action containing chlorhexidine bigluconate and liquid extract of sophora fruit. The objects of research were Japanese Sophora fruits harvested in 2020 in the Krasnodar Territory that meet the requirements of regulatory documents; substance-solution of chlorhexidine bigluconate 20%; auxiliary substances of lipophilic and hydrophilic nature: solid paraffin, beeswax, cocoa butter, anhydrous lanolin, polyethylene oxide-400, polyethylene oxide-1500. To assess the degree of release of active substances from experimental compositions, the method of diffusion into agar was used, based on the diffusion of active substances from the dosage form into an agar gel containing a solution of ferric chloride as an indicator. It was found that the most suitable combination of auxiliary components of the dosage form, providing the best release of active substances, is a combination including solid paraffin (20 parts), beeswax (20 parts), anhydrous lanolin (20 parts), polyethylene oxide-1500 (10 parts), polyethylene oxide-400 (20 parts).","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134154892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study: to study the influence of the level of education on the behavioral patterns associated with medical care of the population of older age groups. Materials and methods of research. The results of an anonymous survey of 1,045 people of both sexes aged 60 years and older were analyzed. The questionnaire included a question about the reasons for visiting medical organizations. The results were evaluated separately for men and women in two age groups of 60–74 years and 75 years and older. Results. There were no significant gender differences in the characteristics of medical activity among the studied cohorts of older age groups. The most common form of behavior regardless of gender was the reactive type, when seeking medical help occurred as a result of health problems. A high level of education contributes to a change in behavior towards a greater prevalence of active behavior in relation to the reasons for seeking medical help. These patterns are observed regardless of gender and are more pronounced in the age group of 75 years and older. Men and women with a low level of education are more likely to choose a reactive type of behavior when seeking medical help occurs after the appearance of health problems. The frequency of passive behavior does not depend on the level of education and is more often recorded in the age group of 60–74 years.
{"title":"THE INFLUENCE OF THE LEVEL OF EDUCATION ON THE BEHAVIORAL PATTERNS ASSOCIATED WITH THE ACCESS TO MEDICAL CARE OF THE POPULATION OF OLDER AGE GROUPS","authors":"Cherkasov S.N., Polozkov O.I., Fedyaeva A.V., Kamaev Yu.O.","doi":"10.26787/nydha-2686-6838-2021-23-7-31-37","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-7-31-37","url":null,"abstract":"The purpose of the study: to study the influence of the level of education on the behavioral patterns associated with medical care of the population of older age groups. Materials and methods of research. The results of an anonymous survey of 1,045 people of both sexes aged 60 years and older were analyzed. The questionnaire included a question about the reasons for visiting medical organizations. The results were evaluated separately for men and women in two age groups of 60–74 years and 75 years and older. Results. There were no significant gender differences in the characteristics of medical activity among the studied cohorts of older age groups. The most common form of behavior regardless of gender was the reactive type, when seeking medical help occurred as a result of health problems. A high level of education contributes to a change in behavior towards a greater prevalence of active behavior in relation to the reasons for seeking medical help. These patterns are observed regardless of gender and are more pronounced in the age group of 75 years and older. Men and women with a low level of education are more likely to choose a reactive type of behavior when seeking medical help occurs after the appearance of health problems. The frequency of passive behavior does not depend on the level of education and is more often recorded in the age group of 60–74 years.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127400792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article presents the results of evaluating the prototyping of metal-ceramic structures made by casting and selective laser sintering. To achieve this goal, 27 patients with fabricated metal-ceramic crowns and bridgeworks were examined. Two study groups were created. The first group included 14 patients for whom dental prosthesis frameworks were made by casting. The second group consisted of 13 people, for whom the frames of dentures were made by the method of selective laser sintering. The analysis of clinical effectiveness was carried out according to the following criteria: 1- precision of the felling of prosthesis frame to solid tissues of abutment teeth; 2- the condition of the marginal periodontium; 3- the integrity of the ceramic cladding. The results of the study showed that the precision to solid tooth tissues of metal-ceramic dental prostheses made by laser selective sintering is higher than of frames made by casting. In accordance to the second criteria the best results were also shown by the participants of the second group. No chipping of the ceramic veneer from the metal-ceramic denture frameworks made by laser selective sintering was found. Thus, dentures which frameworks are made by the method of selective laser sintering are characterized by a higher objective assessment of their precision to the solid tissues of the abutment teeth. Lesions of the marginal periodontium both inflammatory and dystrophic were less in the participants of the second group. The frequency of defects in the coating of metal-ceramic dentures was significantly lower in the case of fabrication frameworks by laser selective sintering.
{"title":"PROSPECTS FOR MANUFACTURING FRAMES OF METAL CERAMIC STRUCTURES OF DENTAL PROSTHESES BY THE METHOD OF SELECTIVE LASER SINTERING","authors":"Stepanov V.A., Shemonaev V.I., Buyanov E.A., Grachev D.V., Parkhomenko A.N., Zubreva I.A.","doi":"10.26787/nydha-2686-6838-2021-23-6-232-239","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-232-239","url":null,"abstract":"The article presents the results of evaluating the prototyping of metal-ceramic structures made by casting and selective laser sintering. To achieve this goal, 27 patients with fabricated metal-ceramic crowns and bridgeworks were examined. Two study groups were created. The first group included 14 patients for whom dental prosthesis frameworks were made by casting. The second group consisted of 13 people, for whom the frames of dentures were made by the method of selective laser sintering. The analysis of clinical effectiveness was carried out according to the following criteria: 1- precision of the felling of prosthesis frame to solid tissues of abutment teeth; 2- the condition of the marginal periodontium; 3- the integrity of the ceramic cladding. The results of the study showed that the precision to solid tooth tissues of metal-ceramic dental prostheses made by laser selective sintering is higher than of frames made by casting. In accordance to the second criteria the best results were also shown by the participants of the second group. No chipping of the ceramic veneer from the metal-ceramic denture frameworks made by laser selective sintering was found. Thus, dentures which frameworks are made by the method of selective laser sintering are characterized by a higher objective assessment of their precision to the solid tissues of the abutment teeth. Lesions of the marginal periodontium both inflammatory and dystrophic were less in the participants of the second group. The frequency of defects in the coating of metal-ceramic dentures was significantly lower in the case of fabrication frameworks by laser selective sintering.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124024500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-193-199
Lebedev M.V., Kerimova K.I., Zakharova I.Yu.
This article presents the most well-known research methods that have been applied in practice, which make it possible to assess the state and indicators of public health and health care. The above methods contribute to obtaining the necessary data on the current activities of the subjects of the health care system and assessing the health and quality of life of the population. Modern medical science is characterized by an increase in the number of ongoing scientific research. Research is a necessary component of dissertation work, only they introduce new information into the health care system, allow one to acquire new skills, and contribute to the development of new technologies. The research results are certainly of interest to both healthcare professionals and patients. The requirements for the methodology of scientific research and the quality of the data provided by the researcher are becoming unambiguously more stringent. The implementation and implementation of scientific research in the field of medicine is associated with the need and obligation to comply with various standards and regulations. The published data must be scientifically new and presented in accordance with international standards. Undoubtedly, a certain role is played by the competent presentation of research and analysis methods, which allow the researcher and specialists studying the research data to correctly interpret the data obtained and put them into practice. Thus, selective planning of prospective research in the field of public health and health care, correct formulation of goals and objectives, concretization of research design, definition of modern research methodology and data analysis are the basis of its effectiveness. The use of a set of interacting medical and sociological research methods, focused on the result, contributes to the achievement of the set goals at the proper level.
{"title":"THE IMPORTANCE OF SOCIAL AND HYGIENIC RESEARCH METHODS IN THE DISSERTATION WORK ON THE SPECIALTY \"PUBLIC HEALTH AND HEALTHCARE\".","authors":"Lebedev M.V., Kerimova K.I., Zakharova I.Yu.","doi":"10.26787/nydha-2686-6838-2021-23-6-193-199","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-193-199","url":null,"abstract":"This article presents the most well-known research methods that have been applied in practice, which make it possible to assess the state and indicators of public health and health care. The above methods contribute to obtaining the necessary data on the current activities of the subjects of the health care system and assessing the health and quality of life of the population. Modern medical science is characterized by an increase in the number of ongoing scientific research. Research is a necessary component of dissertation work, only they introduce new information into the health care system, allow one to acquire new skills, and contribute to the development of new technologies. The research results are certainly of interest to both healthcare professionals and patients. The requirements for the methodology of scientific research and the quality of the data provided by the researcher are becoming unambiguously more stringent. The implementation and implementation of scientific research in the field of medicine is associated with the need and obligation to comply with various standards and regulations. The published data must be scientifically new and presented in accordance with international standards. Undoubtedly, a certain role is played by the competent presentation of research and analysis methods, which allow the researcher and specialists studying the research data to correctly interpret the data obtained and put them into practice. Thus, selective planning of prospective research in the field of public health and health care, correct formulation of goals and objectives, concretization of research design, definition of modern research methodology and data analysis are the basis of its effectiveness. The use of a set of interacting medical and sociological research methods, focused on the result, contributes to the achievement of the set goals at the proper level.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132857278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-8-12
Akhmadeeva L.R., Bulyakova G.A., Khairullin A.T.
There is a big number of patients with chronic brain ischemia both among in-patients and out-patients seen by neurologists. This is a typical clinical situation. Retino-cochleo-cerebral vasculopathy (also called Susac syndrome) is a rare autoimmune disorder affecting brain vessels, the 8th cranial nerve and retina. Chronic brain ischemia usually manifests as cognitive decline, affective (emotional) disorders and focal neurological signs. We studied a “portrait” of patients with chronic brain ischemia, admitted to the hospital As in-patient of rehabilitation unit. Here we present the typical case using as an example cerebral ischemic conditions and unusual ones describing retino-cochleo-cerebral vasculopathy as one of the conditions from the group of primary angiitis of central nervous system in adults. All the case were observed by us in neurological and neurorehabilitation wards. It is a pilot project with 43 patients as the total number of patients included into this study. Their mean age was 62.8 years. The mean duration of in-patient observation was 14 days at the hospital. In this paper we discuss the clinical characteristics of our cohort of patients. The least affected here was the short-term memory for numbers. The most affected domain included emotions, anxiety, and depression. We followed this situation in most of our cases. The unusual clinical case of Susac syndrome in a male patient of 59 years is described. The diagnosis was confirmed using modern instrumental tests such as magnetic-resonance tomography and fluorescent angiography of eye retina.
{"title":"CEREBROVASCULAR DISORDERS: TYPICAL AND UNUSUAL CLINICAL PROBLEMS","authors":"Akhmadeeva L.R., Bulyakova G.A., Khairullin A.T.","doi":"10.26787/nydha-2686-6838-2021-23-6-8-12","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-8-12","url":null,"abstract":"There is a big number of patients with chronic brain ischemia both among in-patients and out-patients seen by neurologists. This is a typical clinical situation. Retino-cochleo-cerebral vasculopathy (also called Susac syndrome) is a rare autoimmune disorder affecting brain vessels, the 8th cranial nerve and retina. Chronic brain ischemia usually manifests as cognitive decline, affective (emotional) disorders and focal neurological signs. We studied a “portrait” of patients with chronic brain ischemia, admitted to the hospital As in-patient of rehabilitation unit. Here we present the typical case using as an example cerebral ischemic conditions and unusual ones describing retino-cochleo-cerebral vasculopathy as one of the conditions from the group of primary angiitis of central nervous system in adults. All the case were observed by us in neurological and neurorehabilitation wards. It is a pilot project with 43 patients as the total number of patients included into this study. Their mean age was 62.8 years. The mean duration of in-patient observation was 14 days at the hospital. In this paper we discuss the clinical characteristics of our cohort of patients. The least affected here was the short-term memory for numbers. The most affected domain included emotions, anxiety, and depression. We followed this situation in most of our cases. The unusual clinical case of Susac syndrome in a male patient of 59 years is described. The diagnosis was confirmed using modern instrumental tests such as magnetic-resonance tomography and fluorescent angiography of eye retina.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121853281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-20-27
Bochkarev B.G., Goryachev A.B., Samko G.N., Kabakova T.I., Bochkareva E.B.
Improving the availability of medical and medicinal care is the most important task of all levels of government and especially relevant in the context of modernization of the health system. The purpose of the work was to analyze the peculiarities of the functioning of the Drug Provision System of the Rural Population of the Republic of Adygea to identify reserves for its development and substantiate directions for further improvement, taking into account regional conditions. It was established that in the Republic of Adygea out of 160 units of medical organizations, the right of retail trade in drugs, 112 medical and obstetric items that have licenses for pharmaceutical activities are used by drug trading. A feature of the implementation of pharmaceutical activities in rural areas is the absence in most places of modern transport highways, which creates logistics problems and significantly complicates the regular delivery of drugs to the population. Among the positive points, the appearance of an additional way of delivering drugs to the feldsher-obstetric items located in hard-to-reach (mountainous) areas implemented in the federal population to ensure the necessary drugs is noted. The inclusion of pharmacies of partners in the system of ensuring the population did not require additional agreements and expenditures on their services, since this function does not carry additional costs, but at the same time increases their image. It has been established that over the past 2 years, the quality of drugs in the countryside residents decreased significantly. In the region, the number of current pharmaceutical activities has decreased by 21%, the number of operating paramedic-obstetric items has also decreased by 18%, and the number of pharmacies of the program has decreased by 2.8 times. Currently, unresolved problems of the organizational nature came to the fore, among which: the absence of working capital organizations for the acquisition of drugs, in the presence of extrabudgetary funds received from the implementation of paid medical services; insufficient legal training of individual officials of medical organizations in state procurement issues; the absence from the overwhelming number of retail trade licenses for transportation of goods of pharmacy assortment and others. The identified problems are based on the basis of the work plan of health authorities, pharmaceutical activities, medical and pharmaceutical organizations of the Republic of Adygea to improve the forms and working methods for the provision of agricultural drugs.
{"title":"FEATURES OF THE DRUG ENFORCEMENT OF THE RURAL POPULATION OF THE REPUBLIC OF ADYGEA","authors":"Bochkarev B.G., Goryachev A.B., Samko G.N., Kabakova T.I., Bochkareva E.B.","doi":"10.26787/nydha-2686-6838-2021-23-6-20-27","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-20-27","url":null,"abstract":"Improving the availability of medical and medicinal care is the most important task of all levels of government and especially relevant in the context of modernization of the health system. The purpose of the work was to analyze the peculiarities of the functioning of the Drug Provision System of the Rural Population of the Republic of Adygea to identify reserves for its development and substantiate directions for further improvement, taking into account regional conditions. It was established that in the Republic of Adygea out of 160 units of medical organizations, the right of retail trade in drugs, 112 medical and obstetric items that have licenses for pharmaceutical activities are used by drug trading. A feature of the implementation of pharmaceutical activities in rural areas is the absence in most places of modern transport highways, which creates logistics problems and significantly complicates the regular delivery of drugs to the population. Among the positive points, the appearance of an additional way of delivering drugs to the feldsher-obstetric items located in hard-to-reach (mountainous) areas implemented in the federal population to ensure the necessary drugs is noted. The inclusion of pharmacies of partners in the system of ensuring the population did not require additional agreements and expenditures on their services, since this function does not carry additional costs, but at the same time increases their image. It has been established that over the past 2 years, the quality of drugs in the countryside residents decreased significantly. In the region, the number of current pharmaceutical activities has decreased by 21%, the number of operating paramedic-obstetric items has also decreased by 18%, and the number of pharmacies of the program has decreased by 2.8 times. Currently, unresolved problems of the organizational nature came to the fore, among which: the absence of working capital organizations for the acquisition of drugs, in the presence of extrabudgetary funds received from the implementation of paid medical services; insufficient legal training of individual officials of medical organizations in state procurement issues; the absence from the overwhelming number of retail trade licenses for transportation of goods of pharmacy assortment and others. The identified problems are based on the basis of the work plan of health authorities, pharmaceutical activities, medical and pharmaceutical organizations of the Republic of Adygea to improve the forms and working methods for the provision of agricultural drugs.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114491579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-58-65
Balabanov A.S., Epifanov S.Yu., Reiza V.A.
Relevance. Heart arrhythmia in early postinfarction angina and recurrent myocardial infarction is negatively affected the prognosis of the disease. Aim. To evaluate the peculiarities of heart rhythm and conduction disturbances and electrocardiographic (ECG) changes in men under 60 years old with early postinfarction angina and recurrent myocardial infarction for improve prevention and outcomes. Material and methods. The study included men aged 19-60 years old with myocardial infarction type I. Patients were divided into two age-comparable groups: I - study group with recurrent episodes of ischemia (early postinfarction angina pectoris and / or recurrent MI) - 110 patients; II - control, without them - 555 patients. A comparative assessment of heart arrhythmias and electrocardiographic changes observation frequency in the selected groups was performed. Results. In the patients of the study group more often than among all other patients, ventricular fibrillation was observed (8.5 and 3.9%, respectively; p = 0.04), paroxysmal supraventricular tachycardia (5.7 and 1.8%; p = 0.02) and electrocardiographic signs of the right atrium enlargement (9.4 and 1.6%; p ˂ 0.0001). In group I, among the deceased, electrocardiographic signs of left ventricular hypertrophy were more often detected (93.3 and 57.9%; p = 0.02). Arrhythmias that started in the subacute period of myocardial infarction were recorded with the same frequency in both groups of patients (1.4 and 1.6%; p = 0.9). Conclusions. Men under 60 years old with recurrent episodes of ischemia in myocardial infarction are characterized by potentially curable ventricular fibrillation and supraventricular tachycardias. Electrocardiographic signs of left ventricular enlargement were an additional marker of a poor prognosis for these patients. The frequency of occurrence of "late" arrhythmias in this pathology is 1.4%, and the methods of their possible correction require clarification depending on the mechanism of their development.
{"title":"HEART RATE AND CONDUCTIVITY DISORDERS FEATURES IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION AND RECURRENT ISCHEMIA","authors":"Balabanov A.S., Epifanov S.Yu., Reiza V.A.","doi":"10.26787/nydha-2686-6838-2021-23-6-58-65","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-58-65","url":null,"abstract":"Relevance. Heart arrhythmia in early postinfarction angina and recurrent myocardial infarction is negatively affected the prognosis of the disease.\u0000Aim. To evaluate the peculiarities of heart rhythm and conduction disturbances and electrocardiographic (ECG) changes in men under 60 years old with early postinfarction angina and recurrent myocardial infarction for improve prevention and outcomes.\u0000Material and methods. The study included men aged 19-60 years old with myocardial infarction type I. Patients were divided into two age-comparable groups: I - study group with recurrent episodes of ischemia (early postinfarction angina pectoris and / or recurrent MI) - 110 patients; II - control, without them - 555 patients. A comparative assessment of heart arrhythmias and electrocardiographic changes observation frequency in the selected groups was performed.\u0000Results. In the patients of the study group more often than among all other patients, ventricular fibrillation was observed (8.5 and 3.9%, respectively; p = 0.04), paroxysmal supraventricular tachycardia (5.7 and 1.8%; p = 0.02) and electrocardiographic signs of the right atrium enlargement (9.4 and 1.6%; p ˂ 0.0001). In group I, among the deceased, electrocardiographic signs of left ventricular hypertrophy were more often detected (93.3 and 57.9%; p = 0.02). Arrhythmias that started in the subacute period of myocardial infarction were recorded with the same frequency in both groups of patients (1.4 and 1.6%; p = 0.9).\u0000Conclusions. Men under 60 years old with recurrent episodes of ischemia in myocardial infarction are characterized by potentially curable ventricular fibrillation and supraventricular tachycardias. Electrocardiographic signs of left ventricular enlargement were an additional marker of a poor prognosis for these patients. The frequency of occurrence of \"late\" arrhythmias in this pathology is 1.4%, and the methods of their possible correction require clarification depending on the mechanism of their development.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129828243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Relevance. In modern publications, sufficient attention is paid to the study of the cellular composition of peripheral blood and the immune status of athletes. These studies are carried out at various stages of the training process in order to establish a connection between the registered changes and the nature and severity of muscle loads. The available literature data mainly relate to the indicators of the immunity of adult athletes involved in various sports, recorded at various stages of training and characterizing the adaptation to muscular load. The state of the immune system largely determines the success of a sports career in modern sports. Aim of the study: to assess the immune profile (cellular and humoral link) of pubertal hockey players at the beginning of the preparatory stage of the training period. Materials and methods. To assess the immune profile (cellular and humoral link) of pubertal hockey players at the beginning of the preparatory stage of the training period, the relative and absolute content of lymphocytes was studied by the method of immunophenotyping with the determination of their subpopulation composition (CD3 +, CD3 + CD4 +, CD3 + CD8 +; CD3- CD16 + CD56 +, CD19 +, CD4 + / CD8 +), and by turbidimetry - specific proteins (immunoglobulins A, G, M). Results. The obtained values of the studied indicators did not differ from those of adolescents who do not go in for sports, and generally fit into the age norms. Isolated cases of deviations are associated with the characteristics of the morbidity of the examined adolescents. The recorded immune profile of athletes will be used as reference values during the continuation of the study (at the end of the pre-competition and post-competition periods), the purpose of which is to monitor the impact of the training process on the immunity of athletes of puberty. The obtained values of the studied indicators do not differ from those in the control and, fit into the age norms. In conclusion, the authors come to the conclusion that it is possible to use the recorded immune profile of athletes as reference values during the continuation of the study (at the end of the preparatory stage and at the end of the competitive period), the purpose of which will be to assess the impact of the training process on the immunity of athletes of puberty.
{"title":"CHARACTERIZATION OF THE IMMUNE STATUS OF YOUNG HOCKEY PLAYERS PUBERTY","authors":"Simonova N.А., Petrushkina N.P., Zhukovskaya E.V., Kolomiets O.I.","doi":"10.26787/nydha-2686-6838-2021-23-6-114-121","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-114-121","url":null,"abstract":"Relevance. In modern publications, sufficient attention is paid to the study of the cellular composition of peripheral blood and the immune status of athletes. These studies are carried out at various stages of the training process in order to establish a connection between the registered changes and the nature and severity of muscle loads. The available literature data mainly relate to the indicators of the immunity of adult athletes involved in various sports, recorded at various stages of training and characterizing the adaptation to muscular load. The state of the immune system largely determines the success of a sports career in modern sports. Aim of the study: to assess the immune profile (cellular and humoral link) of pubertal hockey players at the beginning of the preparatory stage of the training period. Materials and methods. To assess the immune profile (cellular and humoral link) of pubertal hockey players at the beginning of the preparatory stage of the training period, the relative and absolute content of lymphocytes was studied by the method of immunophenotyping with the determination of their subpopulation composition (CD3 +, CD3 + CD4 +, CD3 + CD8 +; CD3- CD16 + CD56 +, CD19 +, CD4 + / CD8 +), and by turbidimetry - specific proteins (immunoglobulins A, G, M). Results. The obtained values of the studied indicators did not differ from those of adolescents who do not go in for sports, and generally fit into the age norms. Isolated cases of deviations are associated with the characteristics of the morbidity of the examined adolescents. The recorded immune profile of athletes will be used as reference values during the continuation of the study (at the end of the pre-competition and post-competition periods), the purpose of which is to monitor the impact of the training process on the immunity of athletes of puberty. The obtained values of the studied indicators do not differ from those in the control and, fit into the age norms. In conclusion, the authors come to the conclusion that it is possible to use the recorded immune profile of athletes as reference values during the continuation of the study (at the end of the preparatory stage and at the end of the competitive period), the purpose of which will be to assess the impact of the training process on the immunity of athletes of puberty.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129311744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-136-142
Yaborova O.V., Sosnina S.A., Turyshev A.Yu.
The search for new sources of medicinal plant raw materials for the production of drugs is one of the urgent tasks of modern pharmacy. The expansion of the range of medicinal plant raw materials is possible, first of all, due to the types systematically close to the official ones. In medical practice, wild strawberry leaves are used. Wild strawberry leaves are used in medicine as a diuretic, anti-inflammatory, antispasmodic, choleretic, hypoglycemic, antipyretic, hypolipidemic, antimicrobial and appetite-enhancing agent. Earlier studies of strawberry leaves have shown that they have a rich chemical composition and are widely cultivated in Russia, being an affordable source for mass procurement of raw materials, and are not used in scientific medicine. At the same time, in folk medicine, strawberry garden leaves are used similarly, and sometimes instead of wild strawberries. The proximity of the composition of biologically active substances of wild strawberries and garden strawberries. To expand the modern nomenclature of medicines, studies on the comparative study of the toxicity and pharmacological activity of infusions and extraction forms from medicinal plant raw materials of strawberry leaves are relevant. In this regard, the study of the toxicity, diuretic and anti-inflammatory activity of the infusion of garden strawberry leaves and the extract of dry strawberry leaves is of practical interest for the formation of a scientific justification for their use in medical practice.
{"title":"STUDY OF DIURETIC AND ANTI-INFLAMMATORY ACTIVITY OF INFUSION AND EXTRACT OF DRIED STRAWBERRY LEAVES","authors":"Yaborova O.V., Sosnina S.A., Turyshev A.Yu.","doi":"10.26787/nydha-2686-6838-2021-23-6-136-142","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-136-142","url":null,"abstract":"The search for new sources of medicinal plant raw materials for the production of drugs is one of the urgent tasks of modern pharmacy. The expansion of the range of medicinal plant raw materials is possible, first of all, due to the types systematically close to the official ones. In medical practice, wild strawberry leaves are used. Wild strawberry leaves are used in medicine as a diuretic, anti-inflammatory, antispasmodic, choleretic, hypoglycemic, antipyretic, hypolipidemic, antimicrobial and appetite-enhancing agent. Earlier studies of strawberry leaves have shown that they have a rich chemical composition and are widely cultivated in Russia, being an affordable source for mass procurement of raw materials, and are not used in scientific medicine. At the same time, in folk medicine, strawberry garden leaves are used similarly, and sometimes instead of wild strawberries. The proximity of the composition of biologically active substances of wild strawberries and garden strawberries.\u0000To expand the modern nomenclature of medicines, studies on the comparative study of the toxicity and pharmacological activity of infusions and extraction forms from medicinal plant raw materials of strawberry leaves are relevant. In this regard, the study of the toxicity, diuretic and anti-inflammatory activity of the infusion of garden strawberry leaves and the extract of dry strawberry leaves is of practical interest for the formation of a scientific justification for their use in medical practice.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116999020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-66-72
G. A.V., Epifanov S.Yu., Reiza V.A.
Relevance. Dyslipidemia is considered one of the main risk factors for the development of recurrent myocardial infarction and early postinfarction angina. Aim. To evaluate the features of lipid metabolism in acute and subacute myocardial infarction in men under 60 years old with recurrent episodes of ischemia (recurrent myocardial infarction and/or early postinfarction angina) to search for new approaches to improve prevention measures. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent myocardial infarction - 68 patients; II - control, without it - 427 patients. A comparative assessment of lipid metabolism parameters and their dynamics in selected groups were performed. Results. The study group differed in higher levels of total serum cholesterol (6.17±1.78 mmol/l) from the control group (5.56±1.28 mmol/l; p=0.02) at the end of the third week of disease, its dynamics during the observation period (I: 9.1%; p<0.0001; II: -1.8%; p<0.0001) and the dynamics of the atherogenic coefficient (I: -4.7.1; p=0.02; II: 6.3%; p<0.0001). In both groups, the group showed an increase in lipoproteins of low (I: 33.1; p=0.02; II: 45.5%; p<0.0001) and very low density (I: 275.8; p=0,0004; II: 233.4%; p<0.0001), atherogenic indices, decrease: triglycerides (I: -31.8%; p=0.02; II: -1.7%; p<0.0001) and high-density lipoproteins (I: -0.6%; p=0.02; II: -6.1%; p<0.0001). Conclusions. The group with recurrent ischemia is characterized by more pronounced hypercholesterolemia at the end of the subacute period of myocardial infarction in comparison with the control group due to an increase in the concentrations of atherogenic lipid metabolism fractions. The dynamics of indices and the coefficient of atherogenicity during this period is multidirectional, which requires additional study.
{"title":"THE LIPID METABOLISM IN YOUNG AND MEDIUM MEN AGE WITH MYOCARDIAL INFARCTION AND RECURRENT EPISODES OF ISCHEMIA","authors":"G. A.V., Epifanov S.Yu., Reiza V.A.","doi":"10.26787/nydha-2686-6838-2021-23-6-66-72","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-66-72","url":null,"abstract":"Relevance. Dyslipidemia is considered one of the main risk factors for the development of recurrent myocardial infarction and early postinfarction angina.\u0000Aim. To evaluate the features of lipid metabolism in acute and subacute myocardial infarction in men under 60 years old with recurrent episodes of ischemia (recurrent myocardial infarction and/or early postinfarction angina) to search for new approaches to improve prevention measures.\u0000Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent myocardial infarction - 68 patients; II - control, without it - 427 patients. A comparative assessment of lipid metabolism parameters and their dynamics in selected groups were performed.\u0000Results. The study group differed in higher levels of total serum cholesterol (6.17±1.78 mmol/l) from the control group (5.56±1.28 mmol/l; p=0.02) at the end of the third week of disease, its dynamics during the observation period (I: 9.1%; p<0.0001; II: -1.8%; p<0.0001) and the dynamics of the atherogenic coefficient (I: -4.7.1; p=0.02; II: 6.3%; p<0.0001). In both groups, the group showed an increase in lipoproteins of low (I: 33.1; p=0.02; II: 45.5%; p<0.0001) and very low density (I: 275.8; p=0,0004; II: 233.4%; p<0.0001), atherogenic indices, decrease: triglycerides (I: -31.8%; p=0.02; II: -1.7%; p<0.0001) and high-density lipoproteins (I: -0.6%; p=0.02; II: -6.1%; p<0.0001).\u0000Conclusions. The group with recurrent ischemia is characterized by more pronounced hypercholesterolemia at the end of the subacute period of myocardial infarction in comparison with the control group due to an increase in the concentrations of atherogenic lipid metabolism fractions. The dynamics of indices and the coefficient of atherogenicity during this period is multidirectional, which requires additional study.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115271694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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