Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-122-128
Vyrmaskin S.I., Trunin D.A., Afanasev V.V.
The study is dedicated to the study of inflammatory and destructive periodontal diseases. Predicting the probability of a favorable outcome or treatment failure is one of the most important doctor’s tasks when choosing a particular method. This problem could not be solved without using a large amount of data characterizing the patient's condition at a particular point in time. The empirical approach to this problem depends largely on individual experience and does not imply obtaining any formalized (numerical) probability estimates of successful or, on the contrary, unsuccessful end of treatment. Correct and effective using of dental lasers in clinical practice requires knowledge of their effects on tissues of the oral cavity. Each type of laser has its properties that are used to solve clinical cases. Laser radiation requires an approach that is significantly different from the traditional use of dental instruments. To determine lasers therapeutic indications for the treatment of inflammatory and destructive periodontal diseases, we applied biometric approaches to the development of mathematical models using multidimensional analysis, allowing to obtain qualitative assessments for optimization of method and treatment strategy selection. The development of predictive models was carried out in several stages. Each of the generally accepted dental signs characterizing periodontal disease could not be a reliable criterion for the effectiveness or ineffectiveness of surgical treatment. Comprehensive assessment using a logistic (exponential) model of the probability of a particular treatment outcome with a high degree statistical reliability makes it possible to select patients for whom treatment with laser technologies is recommended.
{"title":"PATIENT SELECTION FOR THE LASER TREATMENT BY ESTIMATION OF THE THERAPEUTIC FAILURE PROBABILITY OF SURGICAL TREATMENT","authors":"Vyrmaskin S.I., Trunin D.A., Afanasev V.V.","doi":"10.26787/nydha-2686-6838-2021-23-6-122-128","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-122-128","url":null,"abstract":"The study is dedicated to the study of inflammatory and destructive periodontal diseases. Predicting the probability of a favorable outcome or treatment failure is one of the most important doctor’s tasks when choosing a particular method. This problem could not be solved without using a large amount of data characterizing the patient's condition at a particular point in time. The empirical approach to this problem depends largely on individual experience and does not imply obtaining any formalized (numerical) probability estimates of successful or, on the contrary, unsuccessful end of treatment. Correct and effective using of dental lasers in clinical practice requires knowledge of their effects on tissues of the oral cavity. Each type of laser has its properties that are used to solve clinical cases. Laser radiation requires an approach that is significantly different from the traditional use of dental instruments. To determine lasers therapeutic indications for the treatment of inflammatory and destructive periodontal diseases, we applied biometric approaches to the development of mathematical models using multidimensional analysis, allowing to obtain qualitative assessments for optimization of method and treatment strategy selection. The development of predictive models was carried out in several stages. Each of the generally accepted dental signs characterizing periodontal disease could not be a reliable criterion for the effectiveness or ineffectiveness of surgical treatment. Comprehensive assessment using a logistic (exponential) model of the probability of a particular treatment outcome with a high degree statistical reliability makes it possible to select patients for whom treatment with laser technologies is recommended.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128150943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-35-42
K. O.B., Tezikov Yu.V., L. I.S., A. O.R.
The aim of the study was to show the effectiveness of treatment of acne with moderate severity in women with ovarian hyperandrogenism. A total of 25 female reproductive voerast patients with moderate acne and ovarian hyperandrogenism who were not planning pregnancy were examined. All patients were examined, which included a consultation with a gynecologist with a gynecological examination, ultrasound examination of the pelvic organs, a study of the hormonal status, a biochemical blood test, as well as a dermatological examination with the determination of the dermatological index of acne (DIA). After the examination, the patients underwent complex therapy using the external treatment recommended by the dermatovenerologist (skin cleansing, gel with azelaic acid and / or gel with adapalene), as well as the appointment of a combined oral contraceptive (COC) Jes Plus. Based on this study, it can be concluded that complex therapy, including local treatment and taking Jes Plus, is the first choice in the treatment of androgen-dependent dermopathy, manifested by moderate acne, in patients with ovarian hyperandrogenism due to PCOS. Such therapy contributes not only to the formation of a pronounced clinical result, but also causes a low probability of side effects. The administration of COC containing drospirenon and the active form of folate, in the form of the calcium salt levomefolate, allows a favorable effect on the metabolic processes in the body as a whole, and in particular, provides a positive effect on the skin, the cardiovascular system, reduces the risk of systemic and local inflammation, relieving the state of hyperhomocysteinemia, providing prevention of cardiometabolic risks.
{"title":"EFFICACY OF ACNE THERAPY IN PATIENTS WITH OVARIAN HYPERANDROGENISM","authors":"K. O.B., Tezikov Yu.V., L. I.S., A. O.R.","doi":"10.26787/nydha-2686-6838-2021-23-6-35-42","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-35-42","url":null,"abstract":"The aim of the study was to show the effectiveness of treatment of acne with moderate severity in women with ovarian hyperandrogenism. A total of 25 female reproductive voerast patients with moderate acne and ovarian hyperandrogenism who were not planning pregnancy were examined. All patients were examined, which included a consultation with a gynecologist with a gynecological examination, ultrasound examination of the pelvic organs, a study of the hormonal status, a biochemical blood test, as well as a dermatological examination with the determination of the dermatological index of acne (DIA). After the examination, the patients underwent complex therapy using the external treatment recommended by the dermatovenerologist (skin cleansing, gel with azelaic acid and / or gel with adapalene), as well as the appointment of a combined oral contraceptive (COC) Jes Plus. Based on this study, it can be concluded that complex therapy, including local treatment and taking Jes Plus, is the first choice in the treatment of androgen-dependent dermopathy, manifested by moderate acne, in patients with ovarian hyperandrogenism due to PCOS. Such therapy contributes not only to the formation of a pronounced clinical result, but also causes a low probability of side effects. The administration of COC containing drospirenon and the active form of folate, in the form of the calcium salt levomefolate, allows a favorable effect on the metabolic processes in the body as a whole, and in particular, provides a positive effect on the skin, the cardiovascular system, reduces the risk of systemic and local inflammation, relieving the state of hyperhomocysteinemia, providing prevention of cardiometabolic risks.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125201689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-185-192
Margity M.M., Marzhokhova M.Y., Hadzegova S.B.
Endogenous intoxication syndrome is an important link in the pathogenesis of many infectious diseases. The role of low and medium molecular weight substances and oligopeptides acting as indicators of endogenous intoxication syndrome in the pathogenesis of varicella was studied, depending on the period of the disease, the severity of the course and the presence of complications. Based on this goal, 125 patients with varicella aged 18 to 49 years were examined. Determination of the content of substances of low and medium molecular weight in biological body fluids (blood plasma, red blood cells and urine) was carried out by the method of M. Ya.Malakhova (1995) on a spectrophotometer SF-46. The Lowru (1951) method was used to determine the level of oligopeptides in body fluids. The maximum level of substances of low and medium molecular weight was observed in patients with a complicated course of varicella during the height of the disease, as well as in patients with a severe course of the disease during the height. When determining the oligopeptides, the highest values were also obtained at the height of the disease in the severe course, as well as in the complicated course at admission. During the examination, the dependence of the studied indicators on the period of the disease, the severity, as well as the presence of complications was revealed. Thus, the most pronounced changes in the level of low and medium molecular weight substances and oligopeptides were observed in severe, and the least – in the mild course of varicella in all the studied media. In patients with developed complications, the disease was more severe, while the changes in the studied parameters were more pronounced.
{"title":"THE SIGNIFICANCE OF THE CONTENT OF LOW AND MEDIUM MOLECULAR WEIGHT SUBSTANCES AND OLIGOPEPTIDES IN THE PATHOGENESIS OF VARICELLA","authors":"Margity M.M., Marzhokhova M.Y., Hadzegova S.B.","doi":"10.26787/nydha-2686-6838-2021-23-6-185-192","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-185-192","url":null,"abstract":"Endogenous intoxication syndrome is an important link in the pathogenesis of many infectious diseases. The role of low and medium molecular weight substances and oligopeptides acting as indicators of endogenous intoxication syndrome in the pathogenesis of varicella was studied, depending on the period of the disease, the severity of the course and the presence of complications. Based on this goal, 125 patients with varicella aged 18 to 49 years were examined. Determination of the content of substances of low and medium molecular weight in biological body fluids (blood plasma, red blood cells and urine) was carried out by the method of M. Ya.Malakhova (1995) on a spectrophotometer SF-46. The Lowru (1951) method was used to determine the level of oligopeptides in body fluids. The maximum level of substances of low and medium molecular weight was observed in patients with a complicated course of varicella during the height of the disease, as well as in patients with a severe course of the disease during the height. When determining the oligopeptides, the highest values were also obtained at the height of the disease in the severe course, as well as in the complicated course at admission. During the examination, the dependence of the studied indicators on the period of the disease, the severity, as well as the presence of complications was revealed. Thus, the most pronounced changes in the level of low and medium molecular weight substances and oligopeptides were observed in severe, and the least – in the mild course of varicella in all the studied media. In patients with developed complications, the disease was more severe, while the changes in the studied parameters were more pronounced.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"358 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120966742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-43-50
Kovalevsky A.M., Vorobieva Yu.B., M. D.D.
After studying various methods of restoring teeth in the oral cavity, we came to the conclusion that no one technique is perfect. This article describes clinical cases, as well as laboratory studies that allow us to judge the effectiveness of dental restoration based on the concept of "pre-polishing of the dentin layer of the composite". The quality of the surface characteristics of the restorations of the anterior group of teeth made of pre-polymerization composite materials was analyzed. The aesthetic restoration of teeth was performed using the classical method of layer-by-layer application and photopolymerization of the composite, as well as the proposed method based on the concept of pre-polishing of the dentin layer of the composite material. After adequate anesthesia and odontopreparation, a portion of the composite material that recreates the dentine layer is introduced into a pre-prepared and isolated from the oral fluid cavity, adapted to the hard tissues of the tooth, and then photopolymerized with a dental lamp. Next, the created layer is polished to a mirror shine and re-adhesive treatment with a self-etching adhesive system, photopolymerization. The next transparent layer of the composite material, imitating enamel, is applied to the "petal" of the polished dentine (inner) layer of the material to the enamel-dentine border with the obligatory imitation of mamelon and the surface structure of the restored tooth and its cutting edge is formed in a generally accepted way. After the final photopolymerization, the final grinding and polishing is carried out. The proposed method of aesthetic restoration of teeth, based on the concept of pre-polishing the dentine layer of the composite material, allows you to achieve a higher quality of restoration, and guarantees long-term preservation of color, gloss and edge fit of the restoration of the frontal group of teeth.
{"title":"RESTORATION OF TEETH BASED ON THE CONCEPT OF «PRE-POLISHING OF THE COMPOSITE DENTIN LAYER”","authors":"Kovalevsky A.M., Vorobieva Yu.B., M. D.D.","doi":"10.26787/nydha-2686-6838-2021-23-6-43-50","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-43-50","url":null,"abstract":"After studying various methods of restoring teeth in the oral cavity, we came to the conclusion that no one technique is perfect. This article describes clinical cases, as well as laboratory studies that allow us to judge the effectiveness of dental restoration based on the concept of \"pre-polishing of the dentin layer of the composite\". The quality of the surface characteristics of the restorations of the anterior group of teeth made of pre-polymerization composite materials was analyzed. The aesthetic restoration of teeth was performed using the classical method of layer-by-layer application and photopolymerization of the composite, as well as the proposed method based on the concept of pre-polishing of the dentin layer of the composite material. After adequate anesthesia and odontopreparation, a portion of the composite material that recreates the dentine layer is introduced into a pre-prepared and isolated from the oral fluid cavity, adapted to the hard tissues of the tooth, and then photopolymerized with a dental lamp. Next, the created layer is polished to a mirror shine and re-adhesive treatment with a self-etching adhesive system, photopolymerization. The next transparent layer of the composite material, imitating enamel, is applied to the \"petal\" of the polished dentine (inner) layer of the material to the enamel-dentine border with the obligatory imitation of mamelon and the surface structure of the restored tooth and its cutting edge is formed in a generally accepted way. After the final photopolymerization, the final grinding and polishing is carried out. The proposed method of aesthetic restoration of teeth, based on the concept of pre-polishing the dentine layer of the composite material, allows you to achieve a higher quality of restoration, and guarantees long-term preservation of color, gloss and edge fit of the restoration of the frontal group of teeth.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127796880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-51-57
G. A.V., Epifanov S.Yu., Reiza V.A.
Relevance. Hemodynamics changes in recidivating myocardial infarction and early postinfarction angina are not well understood. In recent years, the frequency of these complications has been increasing. Aim. To evaluate peripheral hemodynamics changes in men under 60 years old with recurrent myocardial infarction and early postinfarction angina to improve prevention and outcomes. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent myocardial infarction - 102 patients; II - control, without it - 541 patients. A comparative assessment of hemodynamics changes in first 48 hours (1) and the end of third week disease (2), also risk analysis of recurrent ischemia and poor outcome in selected groups were performed. Results. The study group was distinguished by a high level of total peripheral resistance1 (2055.5±965.2 (dyn×sec×cm-5)) from the control (2055.5± 965.2 (dyn×sec×cm-5); p=0.02). In both groups, a decrease in the values of all indicators was noted (p<0.05). A more pronounced decrease in total peripheral resistance was found in the study group, and in the parameters of blood pressure and heart rate - in the control group. The values of total peripheral resistance1 ≥1600 dyne×sec×cm-5 were the markers of the risk of ischemia recurrence. Predictors of poor outcome are blood pressure levels1 (systolic <97; diastolic <70; mean <93.3 (mm Hg)); total peripheral resistance1 <1746.2 dyne×sec×cm-5 and heart rate (˃92 per min). Conclusions. Patients with recurrent ischemia are characterized by higher levels of total peripheral resistance in the first hours of myocardial infarction. For both groups, a decrease in all studied indicators is determined. The above values of hemodynamic parameters should be used in the formation of groups with a high risk of early recurrence of ischemia and an unfavorable outcome, as well as for prognostic modeling of these complications.
{"title":"PERIPHERAL HEMODYNAMICS PECULIARITIES IN YOUNG AND MIDDLE-AGED MEN WITH A RECIDIVATING MYOCARDIAL INFARCTION","authors":"G. A.V., Epifanov S.Yu., Reiza V.A.","doi":"10.26787/nydha-2686-6838-2021-23-6-51-57","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-51-57","url":null,"abstract":"Relevance. Hemodynamics changes in recidivating myocardial infarction and early postinfarction angina are not well understood. In recent years, the frequency of these complications has been increasing.\u0000Aim. To evaluate peripheral hemodynamics changes in men under 60 years old with recurrent myocardial infarction and early postinfarction angina to improve prevention and outcomes.\u0000Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent myocardial infarction - 102 patients; II - control, without it - 541 patients. A comparative assessment of hemodynamics changes in first 48 hours (1) and the end of third week disease (2), also risk analysis of recurrent ischemia and poor outcome in selected groups were performed.\u0000Results. The study group was distinguished by a high level of total peripheral resistance1 (2055.5±965.2 (dyn×sec×cm-5)) from the control (2055.5± 965.2 (dyn×sec×cm-5); p=0.02). In both groups, a decrease in the values of all indicators was noted (p<0.05). A more pronounced decrease in total peripheral resistance was found in the study group, and in the parameters of blood pressure and heart rate - in the control group. The values of total peripheral resistance1 ≥1600 dyne×sec×cm-5 were the markers of the risk of ischemia recurrence. Predictors of poor outcome are blood pressure levels1 (systolic <97; diastolic <70; mean <93.3 (mm Hg)); total peripheral resistance1 <1746.2 dyne×sec×cm-5 and heart rate (˃92 per min).\u0000Conclusions. Patients with recurrent ischemia are characterized by higher levels of total peripheral resistance in the first hours of myocardial infarction. For both groups, a decrease in all studied indicators is determined. The above values of hemodynamic parameters should be used in the formation of groups with a high risk of early recurrence of ischemia and an unfavorable outcome, as well as for prognostic modeling of these complications.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"36 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129967008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-143-156
Baykova O.A., Nikolaeva N.N., Grishchenko E.G., N. L.V.
This review covers the incidence of opisthorchiasis caused by Opisthorchis viverrini in South-East Asia countries: Thailand, Laos, Cambodia, and Vietnam. We analyzed the history of Opisthorchiidae representative’s discovery and cultural aspects of opisthorchiasis in South-East Asia. The most prevalent cancer type in Thailand is cholangiocarcinoma that is caused by Opisthorchiidae invasion. These parasites are transmitted to humans through raw fish consumption. Sociological studies demonstrated that raw fish food is the part of national traditions and identity of South-East Asian people. Tourism and population movement lead to the spreading of “Asian” Opisthorchiidae in Russia. The high prevalence of Opisthorchis felineus invasion in Russia may both simplify or complicate the clinical recognition of “Asian” opisthorchiasis. Molecular and genetic characteristics of the parasites determine their adaptivity, medication resistance, and finally, the clinical manifestations of opisthorchiasis. It contributes to the further understanding of chronic opisthorchiasis treatment.
{"title":"OPISTORCHIASIS IN SOUTH-WEST ASIA: HISTORY, GEOGRAPHY, EPIDEMIOLOGY, AND SOCIOLOGY. TOURISM AND POPULATION MOVEMENT INCREASE THE RISK OF THAI LIVER FLUKE SPREADING IN RUSSIA","authors":"Baykova O.A., Nikolaeva N.N., Grishchenko E.G., N. L.V.","doi":"10.26787/nydha-2686-6838-2021-23-6-143-156","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-143-156","url":null,"abstract":"This review covers the incidence of opisthorchiasis caused by Opisthorchis viverrini in South-East Asia countries: Thailand, Laos, Cambodia, and Vietnam. We analyzed the history of Opisthorchiidae representative’s discovery and cultural aspects of opisthorchiasis in South-East Asia. The most prevalent cancer type in Thailand is cholangiocarcinoma that is caused by Opisthorchiidae invasion. These parasites are transmitted to humans through raw fish consumption. Sociological studies demonstrated that raw fish food is the part of national traditions and identity of South-East Asian people. Tourism and population movement lead to the spreading of “Asian” Opisthorchiidae in Russia. The high prevalence of Opisthorchis felineus invasion in Russia may both simplify or complicate the clinical recognition of “Asian” opisthorchiasis. Molecular and genetic characteristics of the parasites determine their adaptivity, medication resistance, and finally, the clinical manifestations of opisthorchiasis. It contributes to the further understanding of chronic opisthorchiasis treatment.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115576865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-99-106
Obukhov Yu.A., Zhukovskaya E.V., Karelin A.F.
Annotation. The authors' study highlights the urgent problem of the development of toxic damage to the dentition under the influence of anticancer therapy in children and adolescents. The aim of the study was to study the violation of the homeostasis of the oral fluid and the severity of the carious process. Materials and methods. As part of a pilot study at the Russian Field Treatment and Rehabilitation Center, 63 children were studied the severity of mineral homeostasis disorders and damage to the dentoalveolar system. Results. In 67% of patients in the main group, there was an increased tendency to form carious cavities. 54.5% of them have complicated caries. One third of patients had more than five carious teeth. In the control group, carious lesions of the teeth in only three patients (20%), with the involvement of 1-3 teeth in the pathological process. Violation of enamel formation was diagnosed in 36% of children of the main group. There is a tendency for the accumulation of the studied microelements in the oral fluid, while in the blood serum there is a normal or insignificant decrease in their content. According to the literature, this may indicate destruction in the oral cavity. Deviations in the homeostasis of chemical elements in children who completed the treatment of malignant neoplasms and children in the control group were revealed. An increased content of osteotrophic microelements was found to correlate with the destructive processes of the teeth. Conclusion. It seems appropriate to study the severity of morphological changes in hard tissues of teeth and the electrolyte composition of mixed saliva in children and adolescents who have been cured of malignant neoplasms. The results of studies of gastric cancer, as an indicator of metabolic disorders, will make it possible not only to reveal the imbalance of macro- and microelements, but also to establish the effectiveness of adaptation mechanisms aimed at normalizing the elemental composition of the oral fluid.
{"title":"MINERAL HOMEOSTASIS OF THE ORAL FLUID IN CHILDREN AND ADOLESCENTS WHO HAVE UNDERGONE TREATMENT OF MALIGNANT NEOPLASMS","authors":"Obukhov Yu.A., Zhukovskaya E.V., Karelin A.F.","doi":"10.26787/nydha-2686-6838-2021-23-6-99-106","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-99-106","url":null,"abstract":"Annotation. The authors' study highlights the urgent problem of the development of toxic damage to the dentition under the influence of anticancer therapy in children and adolescents. The aim of the study was to study the violation of the homeostasis of the oral fluid and the severity of the carious process. Materials and methods. As part of a pilot study at the Russian Field Treatment and Rehabilitation Center, 63 children were studied the severity of mineral homeostasis disorders and damage to the dentoalveolar system. Results. In 67% of patients in the main group, there was an increased tendency to form carious cavities. 54.5% of them have complicated caries. One third of patients had more than five carious teeth. In the control group, carious lesions of the teeth in only three patients (20%), with the involvement of 1-3 teeth in the pathological process. Violation of enamel formation was diagnosed in 36% of children of the main group. There is a tendency for the accumulation of the studied microelements in the oral fluid, while in the blood serum there is a normal or insignificant decrease in their content. According to the literature, this may indicate destruction in the oral cavity. Deviations in the homeostasis of chemical elements in children who completed the treatment of malignant neoplasms and children in the control group were revealed. An increased content of osteotrophic microelements was found to correlate with the destructive processes of the teeth. Conclusion. It seems appropriate to study the severity of morphological changes in hard tissues of teeth and the electrolyte composition of mixed saliva in children and adolescents who have been cured of malignant neoplasms. The results of studies of gastric cancer, as an indicator of metabolic disorders, will make it possible not only to reveal the imbalance of macro- and microelements, but also to establish the effectiveness of adaptation mechanisms aimed at normalizing the elemental composition of the oral fluid.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"715 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121999246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chamomilla recutita is used in scientific medicine. Tripleurospermum inodorum (L.) Sch. Bip. is widely spread among possible impurities of Chamomilla recutita (L.) Rauschert. This plant is perspective for establishment into scientific medicine but it can’t change Chamomilla recutita (L.) Rauschert. Purpose of research: development of a method for the quantitative determination of the amount of flavonoids in terms of rutin in Tripleurospermum inodorum’s flowers using differential spectrophotometry. Materials and methods. The samples prepared in different parts of Russia were used as objects of research. (2017 – 2020). Spectral studies were carried out in the wavelength range of 350-430 nm with a step of 1 nm using a spectrophotometer SF-2000. Results. To determine the analytical wavelength, the UV spectra of alcohol extraction of Tripleurospermum inodorum’s flowers were studied. Maximum of absorption was noticed at wavelength 370 nm. The differential spectrum of the same extraction with an aluminum chloride solution of 2% in 96% alcohol has a maximum at a length of 410±2 nm, which coincides with the maximum of the Standard Sample (SS) of rutin. The largest number of flavonoids is extracted by 70% alcohol. The maximum optical density and the highest output of the number of flavonoids from the raw material is observed at a degree of grinding of 2 mm with a single extraction for 60 minutes. In the conditions of complexation, the optimal ratio of the volume of the test solution and aluminum chloride with a solution of 2% in 96% alcohol is the ratio of 1:1. The stability of the complex with an aluminum chloride solution of 2% in 96% alcohol is observed in 40 minutes after the start of the reaction and retains it for 30 minutes. Findings. The method is developed and the parameters of the quantitative determination of the amount of flavonoids in Tripleurospermum inodorum flores are determined in terms of rutin using differential spectrophotometry.
{"title":"DEVELOPMENT OF A METHOD FOR QUANTITATIVE DETERMINATION OF THE AMOUNT OF FLAVONOIDS IN TRIPLEUROSPERMUM INODORUM’S FLOWERS","authors":"Blinova O.L., Gileva A.A., Hlebnikov A.V., Belonogova V.D., Turyshev A.Y.","doi":"10.26787/nydha-2686-6838-2021-23-6-157-166","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-157-166","url":null,"abstract":"Chamomilla recutita is used in scientific medicine. Tripleurospermum inodorum (L.) Sch. Bip. is widely spread among possible impurities of Chamomilla recutita (L.) Rauschert. This plant is perspective for establishment into scientific medicine but it can’t change Chamomilla recutita (L.) Rauschert. \u0000Purpose of research: development of a method for the quantitative determination of the amount of flavonoids in terms of rutin in Tripleurospermum inodorum’s flowers using differential spectrophotometry.\u0000Materials and methods. The samples prepared in different parts of Russia were used as objects of research. (2017 – 2020). Spectral studies were carried out in the wavelength range of 350-430 nm with a step of 1 nm using a spectrophotometer SF-2000.\u0000Results. To determine the analytical wavelength, the UV spectra of alcohol extraction of Tripleurospermum inodorum’s flowers were studied. Maximum of absorption was noticed at wavelength 370 nm. The differential spectrum of the same extraction with an aluminum chloride solution of 2% in 96% alcohol has a maximum at a length of 410±2 nm, which coincides with the maximum of the Standard Sample (SS) of rutin. The largest number of flavonoids is extracted by 70% alcohol. The maximum optical density and the highest output of the number of flavonoids from the raw material is observed at a degree of grinding of 2 mm with a single extraction for 60 minutes. In the conditions of complexation, the optimal ratio of the volume of the test solution and aluminum chloride with a solution of 2% in 96% alcohol is the ratio of 1:1. The stability of the complex with an aluminum chloride solution of 2% in 96% alcohol is observed in 40 minutes after the start of the reaction and retains it for 30 minutes.\u0000Findings. The method is developed and the parameters of the quantitative determination of the amount of flavonoids in Tripleurospermum inodorum flores are determined in terms of rutin using differential spectrophotometry.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123163577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-261-267
Lebedev M.V., Zakharova I.Yu.
Every year there is a significant increase in combined anomalies and deformities of the maxillofacial region, congenital pathologies, malignant tumors, severe inflammatory diseases of the face and neck. Almost every patient who underwent surgery on the maxillofacial region develops secondary deformities of the maxillofacial region, adentia of the teeth of the jaws, impaired occlusion and speech, skeletal anomalies, which requires a comprehensive interdisciplinary approach of doctors of different profiles. The aim of the work was to improve the provision of specialized care to patients with pathology of the maxillofacial region through the introduction of an interdisciplinary approach in the treatment of patients in the center of maxillofacial surgery at the N.N. Burdenko Penza Regional Clinical Hospital (N.N. Burdenko ). Material and methods. The study was carried out on the basis of the Center for Maxillofacial Surgery of the State Budgetary Healthcare Institution "Penza Regional Clinical Hospital named after V.I. NN Burdenko ". A retrospective analysis of outpatient patient records, case histories, electronic databases, regulatory and legal documentation from 2010-2020 was carried out. Results and its discussion. Until November 2020, in the Penza region, medical care for patients with diseases of the maxillofacial region was provided in the department of maxillofacial surgery of the N.N. Burdenko State Budgetary Clinical Hospital. When analyzing the reporting and regulatory documents, it was concluded that it is necessary to improve the quality of specialized care in the field of maxillofacial surgery. We propose to employ the following specialists on the staff of the department: dentist-therapist for adults and children, gnathologist, dentist-orthodontist, otorhinolaryngologist, speech therapist. Conclusion. The materials presented in the article reflect the need for an integrated approach and close interaction between the doctors of the center. This stage begins during the preoperative preparation and planning of the operation. Rehabilitation of patients with pathology of the maxillofacial region is aimed at maximum aesthetic and anatomical recovery and requires an individual approach. To solve this problem, it is necessary to introduce interdisciplinary interaction of specialists in the center of maxillofacial surgery.
{"title":"INTERDISCIPLINARY APPROACH IN ASSISTING PATIENTS WITH PATHOLOGY OF THE MAXILLOFACIAL REGION IN THE CENTER OF MAXILLOFACIAL SURGERY","authors":"Lebedev M.V., Zakharova I.Yu.","doi":"10.26787/nydha-2686-6838-2021-23-6-261-267","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-261-267","url":null,"abstract":"Every year there is a significant increase in combined anomalies and deformities of the maxillofacial region, congenital pathologies, malignant tumors, severe inflammatory diseases of the face and neck. Almost every patient who underwent surgery on the maxillofacial region develops secondary deformities of the maxillofacial region, adentia of the teeth of the jaws, impaired occlusion and speech, skeletal anomalies, which requires a comprehensive interdisciplinary approach of doctors of different profiles.\u0000The aim of the work was to improve the provision of specialized care to patients with pathology of the maxillofacial region through the introduction of an interdisciplinary approach in the treatment of patients in the center of maxillofacial surgery at the N.N. Burdenko Penza Regional Clinical Hospital (N.N. Burdenko ).\u0000Material and methods. The study was carried out on the basis of the Center for Maxillofacial Surgery of the State Budgetary Healthcare Institution \"Penza Regional Clinical Hospital named after V.I. NN Burdenko \". A retrospective analysis of outpatient patient records, case histories, electronic databases, regulatory and legal documentation from 2010-2020 was carried out.\u0000Results and its discussion. Until November 2020, in the Penza region, medical care for patients with diseases of the maxillofacial region was provided in the department of maxillofacial surgery of the N.N. Burdenko State Budgetary Clinical Hospital. When analyzing the reporting and regulatory documents, it was concluded that it is necessary to improve the quality of specialized care in the field of maxillofacial surgery. We propose to employ the following specialists on the staff of the department: dentist-therapist for adults and children, gnathologist, dentist-orthodontist, otorhinolaryngologist, speech therapist.\u0000Conclusion. The materials presented in the article reflect the need for an integrated approach and close interaction between the doctors of the center. This stage begins during the preoperative preparation and planning of the operation. Rehabilitation of patients with pathology of the maxillofacial region is aimed at maximum aesthetic and anatomical recovery and requires an individual approach. To solve this problem, it is necessary to introduce interdisciplinary interaction of specialists in the center of maxillofacial surgery.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116379869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.26787/nydha-2686-6838-2021-23-6-28-34
Gelfer S.A., Semenova V.V.
The generally accepted practice of medical technology is to record the first time sick, the results of dynamic observations of patients (follow-up). The first research groups for the study of malignant neoplasms (MNO) in children appeared in the United States in 1955. The article describes the importance of early rehabilitation of patients who have undergone cancer on the example of a clinical case. Advances in the treatment of cancer patients have resulted in a higher percentage of people cured. But very early after the start of the use of anticancer therapy (POT), doctors began to observe manifestations of an iatrogenic nature due to the use of toxic drugs and radiation. At the moment, the influence of genetic factors on the development of complications of chemotherapy and radiation therapy is being actively studied. The molecular mechanisms of the development of abnormally pronounced toxic effects in most cases are associated with disorders in the DNA repair system. To minimize the risk of severe toxic effects, these factors should be taken into account when choosing a treatment strategy. On the example of patient N., 18 years old, the condition after the end of treatment for rhabdomyosarcoma of the temporal region, the duration of remission is 12 years, one can see how the treatment can iatrogenically affect the patient's life in adulthood, having undergone treatment in childhood. With an early start of rehabilitation and timely identification of the long-term consequences of anticancer therapy, it is possible to improve the patient's quality of life. With the accumulation of observation data on the domestic cohort of children and adolescents who completed therapy 15-20 years ago, it will become possible to assess the burden of national health care in the structure of morbidity, disability, and the development of second tumors.
{"title":"TOXIC EFFECTS OF ANTICANCER THERAPY","authors":"Gelfer S.A., Semenova V.V.","doi":"10.26787/nydha-2686-6838-2021-23-6-28-34","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-28-34","url":null,"abstract":"The generally accepted practice of medical technology is to record the first time sick, the results of dynamic observations of patients (follow-up). The first research groups for the study of malignant neoplasms (MNO) in children appeared in the United States in 1955. The article describes the importance of early rehabilitation of patients who have undergone cancer on the example of a clinical case. Advances in the treatment of cancer patients have resulted in a higher percentage of people cured. But very early after the start of the use of anticancer therapy (POT), doctors began to observe manifestations of an iatrogenic nature due to the use of toxic drugs and radiation. At the moment, the influence of genetic factors on the development of complications of chemotherapy and radiation therapy is being actively studied. The molecular mechanisms of the development of abnormally pronounced toxic effects in most cases are associated with disorders in the DNA repair system. To minimize the risk of severe toxic effects, these factors should be taken into account when choosing a treatment strategy. On the example of patient N., 18 years old, the condition after the end of treatment for rhabdomyosarcoma of the temporal region, the duration of remission is 12 years, one can see how the treatment can iatrogenically affect the patient's life in adulthood, having undergone treatment in childhood. With an early start of rehabilitation and timely identification of the long-term consequences of anticancer therapy, it is possible to improve the patient's quality of life. With the accumulation of observation data on the domestic cohort of children and adolescents who completed therapy 15-20 years ago, it will become possible to assess the burden of national health care in the structure of morbidity, disability, and the development of second tumors.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122441717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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