首页 > 最新文献

"Medical & pharmaceutical journal "Pulse"最新文献

英文 中文
PATIENT SELECTION FOR THE LASER TREATMENT BY ESTIMATION OF THE THERAPEUTIC FAILURE PROBABILITY OF SURGICAL TREATMENT 通过估计手术治疗失败的概率来选择激光治疗的患者
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-122-128
Vyrmaskin S.I., Trunin D.A., Afanasev V.V.
The study is dedicated to the study of inflammatory and destructive periodontal diseases. Predicting the probability of a favorable outcome or treatment failure is one of the most important doctor’s tasks when choosing a particular method. This problem could not be solved without using a large amount of data characterizing the patient's condition at a particular point in time. The empirical approach to this problem depends largely on individual experience and does not imply obtaining any formalized (numerical) probability estimates of successful or, on the contrary, unsuccessful end of treatment. Correct and effective using of dental lasers in clinical practice requires knowledge of their effects on tissues of the oral cavity. Each type of laser has its properties that are used to solve clinical cases. Laser radiation requires an approach that is significantly different from the traditional use of dental instruments. To determine lasers therapeutic indications for the treatment of inflammatory and destructive periodontal diseases, we applied biometric approaches to the development of mathematical models using multidimensional analysis, allowing to obtain qualitative assessments for optimization of method and treatment strategy selection. The development of predictive models was carried out in several stages. Each of the generally accepted dental signs characterizing periodontal disease could not be a reliable criterion for the effectiveness or ineffectiveness of surgical treatment. Comprehensive assessment using a logistic (exponential) model of the probability of a particular treatment outcome with a high degree statistical reliability makes it possible to select patients for whom treatment with laser technologies is recommended.
该研究致力于研究炎症性和破坏性牙周病。在选择一种特定的方法时,预测良好结果或治疗失败的可能性是医生最重要的任务之一。如果不使用大量的数据来描述患者在特定时间点的状况,就无法解决这个问题。这个问题的经验方法在很大程度上取决于个人经验,并不意味着获得任何形式化的(数值)概率估计成功或相反,不成功的治疗结束。在临床实践中正确有效地使用牙科激光需要了解其对口腔组织的影响。每种类型的激光都有其用于解决临床病例的特性。激光辐射需要的方法与传统的牙科器械使用有很大的不同。为了确定激光治疗炎症性和破坏性牙周病的适应症,我们应用生物识别方法开发了多维分析的数学模型,从而获得了优化方法和治疗策略选择的定性评估。预测模型的开发分几个阶段进行。每一个普遍接受的表征牙周病的牙齿体征都不能作为手术治疗有效或无效的可靠标准。使用具有高度统计可靠性的特定治疗结果概率的逻辑(指数)模型进行综合评估,可以选择推荐使用激光技术治疗的患者。
{"title":"PATIENT SELECTION FOR THE LASER TREATMENT BY ESTIMATION OF THE THERAPEUTIC FAILURE PROBABILITY OF SURGICAL TREATMENT","authors":"Vyrmaskin S.I., Trunin D.A., Afanasev V.V.","doi":"10.26787/nydha-2686-6838-2021-23-6-122-128","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-122-128","url":null,"abstract":"The study is dedicated to the study of inflammatory and destructive periodontal diseases. Predicting the probability of a favorable outcome or treatment failure is one of the most important doctor’s tasks when choosing a particular method. This problem could not be solved without using a large amount of data characterizing the patient's condition at a particular point in time. The empirical approach to this problem depends largely on individual experience and does not imply obtaining any formalized (numerical) probability estimates of successful or, on the contrary, unsuccessful end of treatment. Correct and effective using of dental lasers in clinical practice requires knowledge of their effects on tissues of the oral cavity. Each type of laser has its properties that are used to solve clinical cases. Laser radiation requires an approach that is significantly different from the traditional use of dental instruments. To determine lasers therapeutic indications for the treatment of inflammatory and destructive periodontal diseases, we applied biometric approaches to the development of mathematical models using multidimensional analysis, allowing to obtain qualitative assessments for optimization of method and treatment strategy selection. The development of predictive models was carried out in several stages. Each of the generally accepted dental signs characterizing periodontal disease could not be a reliable criterion for the effectiveness or ineffectiveness of surgical treatment. Comprehensive assessment using a logistic (exponential) model of the probability of a particular treatment outcome with a high degree statistical reliability makes it possible to select patients for whom treatment with laser technologies is recommended.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128150943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFICACY OF ACNE THERAPY IN PATIENTS WITH OVARIAN HYPERANDROGENISM 痤疮治疗卵巢高雄激素症的疗效观察
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-35-42
K. O.B., Tezikov Yu.V., L. I.S., A. O.R.
The aim of the study was to show the effectiveness of treatment of acne with moderate severity in women with ovarian hyperandrogenism. A total of 25 female reproductive voerast patients with moderate acne and ovarian hyperandrogenism who were not planning pregnancy were examined. All patients were examined, which included a consultation with a gynecologist with a gynecological examination, ultrasound examination of the pelvic organs, a study of the hormonal status, a biochemical blood test, as well as a dermatological examination with the determination of the dermatological index of acne (DIA). After the examination, the patients underwent complex therapy using the external treatment recommended by the dermatovenerologist (skin cleansing, gel with azelaic acid and / or gel with adapalene), as well as the appointment of a combined oral contraceptive (COC) Jes Plus. Based on this study, it can be concluded that complex therapy, including local treatment and taking Jes Plus, is the first choice in the treatment of androgen-dependent dermopathy, manifested by moderate acne, in patients with ovarian hyperandrogenism due to PCOS. Such therapy contributes not only to the formation of a pronounced clinical result, but also causes a low probability of side effects. The administration of COC containing drospirenon and the active form of folate, in the form of the calcium salt levomefolate, allows a favorable effect on the metabolic processes in the body as a whole, and in particular, provides a positive effect on the skin, the cardiovascular system, reduces the risk of systemic and local inflammation, relieving the state of hyperhomocysteinemia, providing prevention of cardiometabolic risks.
该研究的目的是显示治疗中度严重痤疮对卵巢高雄激素症妇女的有效性。本文对25例未计划妊娠的中度痤疮伴卵巢雄激素过多的女性生殖卵巢患者进行了检查。所有患者均接受检查,包括妇科医生妇科检查,盆腔器官超声检查,激素状态研究,血液生化检查,以及皮肤病检查,确定痤疮皮肤病指数(DIA)。检查后,患者接受皮肤性学家推荐的外部治疗(皮肤清洁、壬二酸凝胶和/或阿达帕烯凝胶)以及联合口服避孕药(COC) Jes Plus的综合治疗。本研究认为,对于PCOS所致卵巢雄激素分泌过多患者,以中度痤疮为表现的雄激素依赖性皮肤病,综合治疗包括局部治疗和服用Jes Plus是首选。这样的治疗不仅可以形成明显的临床效果,而且副作用的可能性也很低。服用含有降螺烯农和叶酸活性形式的COC(以钙盐左旋甲叶酸的形式),可以对整个身体的代谢过程产生有利影响,特别是对皮肤、心血管系统产生积极影响,降低全身和局部炎症的风险,缓解高同型半胱氨酸血症的状态,提供心脏代谢风险的预防。
{"title":"EFFICACY OF ACNE THERAPY IN PATIENTS WITH OVARIAN HYPERANDROGENISM","authors":"K. O.B., Tezikov Yu.V., L. I.S., A. O.R.","doi":"10.26787/nydha-2686-6838-2021-23-6-35-42","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-35-42","url":null,"abstract":"The aim of the study was to show the effectiveness of treatment of acne with moderate severity in women with ovarian hyperandrogenism. A total of 25 female reproductive voerast patients with moderate acne and ovarian hyperandrogenism who were not planning pregnancy were examined. All patients were examined, which included a consultation with a gynecologist with a gynecological examination, ultrasound examination of the pelvic organs, a study of the hormonal status, a biochemical blood test, as well as a dermatological examination with the determination of the dermatological index of acne (DIA). After the examination, the patients underwent complex therapy using the external treatment recommended by the dermatovenerologist (skin cleansing, gel with azelaic acid and / or gel with adapalene), as well as the appointment of a combined oral contraceptive (COC) Jes Plus. Based on this study, it can be concluded that complex therapy, including local treatment and taking Jes Plus, is the first choice in the treatment of androgen-dependent dermopathy, manifested by moderate acne, in patients with ovarian hyperandrogenism due to PCOS. Such therapy contributes not only to the formation of a pronounced clinical result, but also causes a low probability of side effects. The administration of COC containing drospirenon and the active form of folate, in the form of the calcium salt levomefolate, allows a favorable effect on the metabolic processes in the body as a whole, and in particular, provides a positive effect on the skin, the cardiovascular system, reduces the risk of systemic and local inflammation, relieving the state of hyperhomocysteinemia, providing prevention of cardiometabolic risks.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125201689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE SIGNIFICANCE OF THE CONTENT OF LOW AND MEDIUM MOLECULAR WEIGHT SUBSTANCES AND OLIGOPEPTIDES IN THE PATHOGENESIS OF VARICELLA 低、中分子量物质及寡肽含量在水痘发病机制中的意义
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-185-192
Margity M.M., Marzhokhova M.Y., Hadzegova S.B.
Endogenous intoxication syndrome is an important link in the pathogenesis of many infectious diseases. The role of low and medium molecular weight substances and oligopeptides acting as indicators of endogenous intoxication syndrome in the pathogenesis of varicella was studied, depending on the period of the disease, the severity of the course and the presence of complications. Based on this goal, 125 patients with varicella aged 18 to 49 years were examined. Determination of the content of substances of low and medium molecular weight in biological body fluids (blood plasma, red blood cells and urine) was carried out by the method of M. Ya.Malakhova (1995) on a spectrophotometer SF-46. The Lowru (1951) method was used to determine the level of oligopeptides in body fluids. The maximum level of substances of low and medium molecular weight was observed in patients with a complicated course of varicella during the height of the disease, as well as in patients with a severe course of the disease during the height. When determining the oligopeptides, the highest values were also obtained at the height of the disease in the severe course, as well as in the complicated course at admission. During the examination, the dependence of the studied indicators on the period of the disease, the severity, as well as the presence of complications was revealed. Thus, the most pronounced changes in the level of low and medium molecular weight substances and oligopeptides were observed in severe, and the least – in the mild course of varicella in all the studied media. In patients with developed complications, the disease was more severe, while the changes in the studied parameters were more pronounced.
内源性中毒综合征是许多传染病发病的重要环节。根据疾病的病程、病程的严重程度和并发症的存在,研究了作为内源性中毒综合征指标的低分子量和中分子量物质和寡肽在水痘发病机制中的作用。基于这一目标,125例18至49岁的水痘患者接受了检查。采用M. Ya法测定生物体液(血浆、红细胞和尿液)中低分子量物质的含量。Malakhova(1995)在分光光度计SF-46上。采用Lowru(1951)方法测定体液中寡肽的水平。在水痘病程复杂的患者以及病程严重的患者中,观察到低分子量和中等分子量物质的最高水平。在测定寡肽时,在重症病程的疾病高度以及入院时的复杂病程中也获得了最高值。在检查过程中,揭示了所研究的指标对病程、严重程度以及是否存在并发症的依赖性。因此,在所有研究介质中,在严重水痘病程中观察到的低分子量和中分子量物质和寡肽水平的变化最为显著,而在轻度水痘病程中观察到的变化最少。在出现并发症的患者中,疾病更为严重,而研究参数的变化更为明显。
{"title":"THE SIGNIFICANCE OF THE CONTENT OF LOW AND MEDIUM MOLECULAR WEIGHT SUBSTANCES AND OLIGOPEPTIDES IN THE PATHOGENESIS OF VARICELLA","authors":"Margity M.M., Marzhokhova M.Y., Hadzegova S.B.","doi":"10.26787/nydha-2686-6838-2021-23-6-185-192","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-185-192","url":null,"abstract":"Endogenous intoxication syndrome is an important link in the pathogenesis of many infectious diseases. The role of low and medium molecular weight substances and oligopeptides acting as indicators of endogenous intoxication syndrome in the pathogenesis of varicella was studied, depending on the period of the disease, the severity of the course and the presence of complications. Based on this goal, 125 patients with varicella aged 18 to 49 years were examined. Determination of the content of substances of low and medium molecular weight in biological body fluids (blood plasma, red blood cells and urine) was carried out by the method of M. Ya.Malakhova (1995) on a spectrophotometer SF-46. The Lowru (1951) method was used to determine the level of oligopeptides in body fluids. The maximum level of substances of low and medium molecular weight was observed in patients with a complicated course of varicella during the height of the disease, as well as in patients with a severe course of the disease during the height. When determining the oligopeptides, the highest values were also obtained at the height of the disease in the severe course, as well as in the complicated course at admission. During the examination, the dependence of the studied indicators on the period of the disease, the severity, as well as the presence of complications was revealed. Thus, the most pronounced changes in the level of low and medium molecular weight substances and oligopeptides were observed in severe, and the least – in the mild course of varicella in all the studied media. In patients with developed complications, the disease was more severe, while the changes in the studied parameters were more pronounced.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"358 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120966742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
RESTORATION OF TEETH BASED ON THE CONCEPT OF «PRE-POLISHING OF THE COMPOSITE DENTIN LAYER” 基于“复合牙本质层预抛光”概念的牙齿修复
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-43-50
Kovalevsky A.M., Vorobieva Yu.B., M. D.D.
After studying various methods of restoring teeth in the oral cavity, we came to the conclusion that no one technique is perfect. This article describes clinical cases, as well as laboratory studies that allow us to judge the effectiveness of dental restoration based on the concept of "pre-polishing of the dentin layer of the composite". The quality of the surface characteristics of the restorations of the anterior group of teeth made of pre-polymerization composite materials was analyzed. The aesthetic restoration of teeth was performed using the classical method of layer-by-layer application and photopolymerization of the composite, as well as the proposed method based on the concept of pre-polishing of the dentin layer of the composite material. After adequate anesthesia and odontopreparation, a portion of the composite material that recreates the dentine layer is introduced into a pre-prepared and isolated from the oral fluid cavity, adapted to the hard tissues of the tooth, and then photopolymerized with a dental lamp. Next, the created layer is polished to a mirror shine and re-adhesive treatment with a self-etching adhesive system, photopolymerization. The next transparent layer of the composite material, imitating enamel, is applied to the "petal" of the polished dentine (inner) layer of the material to the enamel-dentine border with the obligatory imitation of mamelon and the surface structure of the restored tooth and its cutting edge is formed in a generally accepted way. After the final photopolymerization, the final grinding and polishing is carried out. The proposed method of aesthetic restoration of teeth, based on the concept of pre-polishing the dentine layer of the composite material, allows you to achieve a higher quality of restoration, and guarantees long-term preservation of color, gloss and edge fit of the restoration of the frontal group of teeth.
在研究了口腔内修复牙齿的各种方法后,我们得出结论,没有一种技术是完美的。本文介绍了临床病例和实验室研究,使我们能够根据“预抛光复合材料的牙本质层”的概念来判断牙齿修复的有效性。对预聚合复合材料制备的前牙组修复体的表面特性进行了质量分析。采用传统的逐层应用和光聚合复合材料的方法,以及基于预抛光复合材料牙本质层的概念的方法进行牙齿的美学修复。经过充分的麻醉和牙齿修复后,将一部分重建牙本质层的复合材料引入预先准备好的、从口腔液腔中分离出来的、与牙齿硬组织相适应的材料中,然后用牙科灯进行光聚合。接下来,将所创建的层抛光至镜面光泽,并使用自蚀刻粘合剂系统进行重新粘合处理,即光聚合。复合材料的下一层透明层,即仿牙釉质,将材料抛光后的牙本质(内)层的“花瓣”涂在牙釉质-牙本质边界上,并强制性地模仿mamelon,以普遍接受的方式形成修复牙齿的表面结构及其切削刃。在最终光聚合后,进行最后的研磨和抛光。提出的牙齿美学修复方法,基于复合材料的牙本质层预抛光的概念,使您可以实现更高质量的修复,并保证修复的正面组牙齿的颜色,光泽和边缘贴合的长期保存。
{"title":"RESTORATION OF TEETH BASED ON THE CONCEPT OF «PRE-POLISHING OF THE COMPOSITE DENTIN LAYER”","authors":"Kovalevsky A.M., Vorobieva Yu.B., M. D.D.","doi":"10.26787/nydha-2686-6838-2021-23-6-43-50","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-43-50","url":null,"abstract":"After studying various methods of restoring teeth in the oral cavity, we came to the conclusion that no one technique is perfect. This article describes clinical cases, as well as laboratory studies that allow us to judge the effectiveness of dental restoration based on the concept of \"pre-polishing of the dentin layer of the composite\". The quality of the surface characteristics of the restorations of the anterior group of teeth made of pre-polymerization composite materials was analyzed. The aesthetic restoration of teeth was performed using the classical method of layer-by-layer application and photopolymerization of the composite, as well as the proposed method based on the concept of pre-polishing of the dentin layer of the composite material. After adequate anesthesia and odontopreparation, a portion of the composite material that recreates the dentine layer is introduced into a pre-prepared and isolated from the oral fluid cavity, adapted to the hard tissues of the tooth, and then photopolymerized with a dental lamp. Next, the created layer is polished to a mirror shine and re-adhesive treatment with a self-etching adhesive system, photopolymerization. The next transparent layer of the composite material, imitating enamel, is applied to the \"petal\" of the polished dentine (inner) layer of the material to the enamel-dentine border with the obligatory imitation of mamelon and the surface structure of the restored tooth and its cutting edge is formed in a generally accepted way. After the final photopolymerization, the final grinding and polishing is carried out. The proposed method of aesthetic restoration of teeth, based on the concept of pre-polishing the dentine layer of the composite material, allows you to achieve a higher quality of restoration, and guarantees long-term preservation of color, gloss and edge fit of the restoration of the frontal group of teeth.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127796880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
PERIPHERAL HEMODYNAMICS PECULIARITIES IN YOUNG AND MIDDLE-AGED MEN WITH A RECIDIVATING MYOCARDIAL INFARCTION 青年和中年男性心肌梗死复发的外周血流动力学特征
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-51-57
G. A.V., Epifanov S.Yu., Reiza V.A.
Relevance. Hemodynamics changes in recidivating myocardial infarction and early postinfarction angina are not well understood. In recent years, the frequency of these complications has been increasing.Aim. To evaluate peripheral hemodynamics changes in men under 60 years old with recurrent myocardial infarction and early postinfarction angina to improve prevention and outcomes.Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent myocardial infarction - 102 patients; II - control, without it - 541 patients. A comparative assessment of hemodynamics changes in first 48 hours (1) and the end of third week disease (2), also risk analysis of recurrent ischemia and poor outcome in selected groups were performed.Results. The study group was distinguished by a high level of total peripheral resistance1 (2055.5±965.2 (dyn×sec×cm-5)) from the control (2055.5± 965.2 (dyn×sec×cm-5); p=0.02). In both groups, a decrease in the values of all indicators was noted (p<0.05). A more pronounced decrease in total peripheral resistance was found in the study group, and in the parameters of blood pressure and heart rate - in the control group. The values of total peripheral resistance1 ≥1600 dyne×sec×cm-5 were the markers of the risk of ischemia recurrence. Predictors of poor outcome are blood pressure levels1 (systolic <97; diastolic <70; mean <93.3 (mm Hg)); total peripheral resistance1 <1746.2 dyne×sec×cm-5 and heart rate (˃92 per min).Conclusions. Patients with recurrent ischemia are characterized by higher levels of total peripheral resistance in the first hours of myocardial infarction. For both groups, a decrease in all studied indicators is determined. The above values of hemodynamic parameters should be used in the formation of groups with a high risk of early recurrence of ischemia and an unfavorable outcome, as well as for prognostic modeling of these complications.
的相关性。再发心肌梗死和梗死后早期心绞痛的血流动力学变化尚不清楚。近年来,这些并发症的发生频率一直在增加。评估60岁以下男性复发性心肌梗死及梗死后早期心绞痛患者外周血动力学变化,以改善预防和预后。材料和方法。该研究包括19-60岁患有I型心肌梗死的男性。患者被分为两个年龄相当的组:I -研究组,复发性心肌梗死- 102例;II -对照,不加- 541例。比较评估了前48小时(1)和疾病第三周结束时(2)的血流动力学变化,并对选定组的复发性缺血和不良预后进行了风险分析。研究组的特点是总外周电阻1(2055.5±965.2 (dyn×sec×cm-5))高于对照组(2055.5±965.2 (dyn×sec×cm-5));p = 0.02)。两组患者各项指标均下降(p<0.05)。在研究组中发现了更明显的外周总阻力下降,在对照组中发现了血压和心率参数的下降。外周血总阻力1≥1600 dyne×sec×cm-5为缺血复发危险的标志。预后不良的预测因子为血压水平1(收缩压<97;舒张期< 70;平均值<93.3 (mm Hg));总外周电阻1 <1746.2 dyne×sec×cm-5,心率(≤92 / min)。复发性缺血患者的特点是在心肌梗死的最初几个小时内总外周抵抗水平较高。对于这两组,所有研究指标都有所下降。上述血流动力学参数值应用于早期缺血复发风险高和预后不良的组,以及这些并发症的预后建模。
{"title":"PERIPHERAL HEMODYNAMICS PECULIARITIES IN YOUNG AND MIDDLE-AGED MEN WITH A RECIDIVATING MYOCARDIAL INFARCTION","authors":"G. A.V., Epifanov S.Yu., Reiza V.A.","doi":"10.26787/nydha-2686-6838-2021-23-6-51-57","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-51-57","url":null,"abstract":"Relevance. Hemodynamics changes in recidivating myocardial infarction and early postinfarction angina are not well understood. In recent years, the frequency of these complications has been increasing.\u0000Aim. To evaluate peripheral hemodynamics changes in men under 60 years old with recurrent myocardial infarction and early postinfarction angina to improve prevention and outcomes.\u0000Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with recurrent myocardial infarction - 102 patients; II - control, without it - 541 patients. A comparative assessment of hemodynamics changes in first 48 hours (1) and the end of third week disease (2), also risk analysis of recurrent ischemia and poor outcome in selected groups were performed.\u0000Results. The study group was distinguished by a high level of total peripheral resistance1 (2055.5±965.2 (dyn×sec×cm-5)) from the control (2055.5± 965.2 (dyn×sec×cm-5); p=0.02). In both groups, a decrease in the values of all indicators was noted (p<0.05). A more pronounced decrease in total peripheral resistance was found in the study group, and in the parameters of blood pressure and heart rate - in the control group. The values of total peripheral resistance1 ≥1600 dyne×sec×cm-5 were the markers of the risk of ischemia recurrence. Predictors of poor outcome are blood pressure levels1 (systolic <97; diastolic <70; mean <93.3 (mm Hg)); total peripheral resistance1 <1746.2 dyne×sec×cm-5 and heart rate (˃92 per min).\u0000Conclusions. Patients with recurrent ischemia are characterized by higher levels of total peripheral resistance in the first hours of myocardial infarction. For both groups, a decrease in all studied indicators is determined. The above values of hemodynamic parameters should be used in the formation of groups with a high risk of early recurrence of ischemia and an unfavorable outcome, as well as for prognostic modeling of these complications.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"36 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129967008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OPISTORCHIASIS IN SOUTH-WEST ASIA: HISTORY, GEOGRAPHY, EPIDEMIOLOGY, AND SOCIOLOGY. TOURISM AND POPULATION MOVEMENT INCREASE THE RISK OF THAI LIVER FLUKE SPREADING IN RUSSIA 西南亚的蛇耳管虫病:历史、地理、流行病学和社会学。旅游业和人口流动增加了泰国肝吸虫在俄罗斯传播的风险
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-143-156
Baykova O.A., Nikolaeva N.N., Grishchenko E.G., N. L.V.
This review covers the incidence of opisthorchiasis caused by Opisthorchis viverrini in South-East Asia countries: Thailand, Laos, Cambodia, and Vietnam. We analyzed the history of Opisthorchiidae representative’s discovery and cultural aspects of opisthorchiasis in South-East Asia. The most prevalent cancer type in Thailand is cholangiocarcinoma that is caused by Opisthorchiidae invasion. These parasites are transmitted to humans through raw fish consumption. Sociological studies demonstrated that raw fish food is the part of national traditions and identity of South-East Asian people. Tourism and population movement lead to the spreading of “Asian” Opisthorchiidae in Russia. The high prevalence of Opisthorchis felineus invasion in Russia may both simplify or complicate the clinical recognition of “Asian” opisthorchiasis. Molecular and genetic characteristics of the parasites determine their adaptivity, medication resistance, and finally, the clinical manifestations of opisthorchiasis. It contributes to the further understanding of chronic opisthorchiasis treatment.
本文综述了泰国、老挝、柬埔寨和越南等东南亚国家由毒舌绦虫引起的阿片绦虫病的发病率。本文分析了东南亚地区恙虫科代表的发现历史和恙虫病的文化方面。在泰国,最常见的癌症类型是胆管癌,这是由拟蚊入侵引起的。这些寄生虫通过食用生鱼传染给人类。社会学研究表明,生鱼食是东南亚人民民族传统和身份的一部分。旅游和人口流动导致“亚洲”蠓科在俄罗斯的传播。俄罗斯的高流行率可能简化或复杂化了“亚洲”蛇胸虫病的临床认识。寄生虫的分子和遗传特征决定了它们的适应性、耐药性,最终决定了蛇胸蚴病的临床表现。有助于加深对慢性蛇胸腺病治疗的认识。
{"title":"OPISTORCHIASIS IN SOUTH-WEST ASIA: HISTORY, GEOGRAPHY, EPIDEMIOLOGY, AND SOCIOLOGY. TOURISM AND POPULATION MOVEMENT INCREASE THE RISK OF THAI LIVER FLUKE SPREADING IN RUSSIA","authors":"Baykova O.A., Nikolaeva N.N., Grishchenko E.G., N. L.V.","doi":"10.26787/nydha-2686-6838-2021-23-6-143-156","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-143-156","url":null,"abstract":"This review covers the incidence of opisthorchiasis caused by Opisthorchis viverrini in South-East Asia countries: Thailand, Laos, Cambodia, and Vietnam. We analyzed the history of Opisthorchiidae representative’s discovery and cultural aspects of opisthorchiasis in South-East Asia. The most prevalent cancer type in Thailand is cholangiocarcinoma that is caused by Opisthorchiidae invasion. These parasites are transmitted to humans through raw fish consumption. Sociological studies demonstrated that raw fish food is the part of national traditions and identity of South-East Asian people. Tourism and population movement lead to the spreading of “Asian” Opisthorchiidae in Russia. The high prevalence of Opisthorchis felineus invasion in Russia may both simplify or complicate the clinical recognition of “Asian” opisthorchiasis. Molecular and genetic characteristics of the parasites determine their adaptivity, medication resistance, and finally, the clinical manifestations of opisthorchiasis. It contributes to the further understanding of chronic opisthorchiasis treatment.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115576865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MINERAL HOMEOSTASIS OF THE ORAL FLUID IN CHILDREN AND ADOLESCENTS WHO HAVE UNDERGONE TREATMENT OF MALIGNANT NEOPLASMS 接受过恶性肿瘤治疗的儿童和青少年口服液的矿物质稳态
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-99-106
Obukhov Yu.A., Zhukovskaya E.V., Karelin A.F.
Annotation. The authors' study highlights the urgent problem of the development of toxic damage to the dentition under the influence of anticancer therapy in children and adolescents. The aim of the study was to study the violation of the homeostasis of the oral fluid and the severity of the carious process. Materials and methods. As part of a pilot study at the Russian Field Treatment and Rehabilitation Center, 63 children were studied the severity of mineral homeostasis disorders and damage to the dentoalveolar system. Results. In 67% of patients in the main group, there was an increased tendency to form carious cavities. 54.5% of them have complicated caries. One third of patients had more than five carious teeth. In the control group, carious lesions of the teeth in only three patients (20%), with the involvement of 1-3 teeth in the pathological process. Violation of enamel formation was diagnosed in 36% of children of the main group. There is a tendency for the accumulation of the studied microelements in the oral fluid, while in the blood serum there is a normal or insignificant decrease in their content. According to the literature, this may indicate destruction in the oral cavity. Deviations in the homeostasis of chemical elements in children who completed the treatment of malignant neoplasms and children in the control group were revealed. An increased content of osteotrophic microelements was found to correlate with the destructive processes of the teeth. Conclusion. It seems appropriate to study the severity of morphological changes in hard tissues of teeth and the electrolyte composition of mixed saliva in children and adolescents who have been cured of malignant neoplasms. The results of studies of gastric cancer, as an indicator of metabolic disorders, will make it possible not only to reveal the imbalance of macro- and microelements, but also to establish the effectiveness of adaptation mechanisms aimed at normalizing the elemental composition of the oral fluid.
注释。作者的研究强调了儿童和青少年在抗癌治疗的影响下牙列毒性损伤发展的紧迫问题。该研究的目的是研究口腔体液平衡的破坏和龋齿过程的严重程度。材料和方法。作为俄罗斯野外治疗和康复中心试点研究的一部分,研究了63名儿童体内矿物质平衡失调和牙槽系统损伤的严重程度。结果。在主组67%的患者中,形成龋齿的倾向增加。54.5%的人患有复杂的龋齿。三分之一的患者龋齿超过五颗。对照组仅3例(20%)出现牙齿龋齿病变,病理过程中涉及1-3颗牙齿。主组中有36%的儿童被诊断为牙釉质形成破坏。所研究的微量元素有在口服液中积累的趋势,而在血清中其含量则有正常或不显著的下降。根据文献,这可能表明口腔受到破坏。结果显示,完成恶性肿瘤治疗的儿童与对照组儿童体内化学元素平衡存在差异。骨营养微量元素含量的增加被发现与牙齿的破坏过程有关。结论。研究恶性肿瘤治愈后的儿童和青少年牙齿硬组织形态变化的严重程度和混合唾液的电解质组成似乎是合适的。作为代谢紊乱的指标,胃癌的研究结果不仅可以揭示宏观和微量元素的失衡,还可以建立旨在使口服液元素组成正常化的适应机制的有效性。
{"title":"MINERAL HOMEOSTASIS OF THE ORAL FLUID IN CHILDREN AND ADOLESCENTS WHO HAVE UNDERGONE TREATMENT OF MALIGNANT NEOPLASMS","authors":"Obukhov Yu.A., Zhukovskaya E.V., Karelin A.F.","doi":"10.26787/nydha-2686-6838-2021-23-6-99-106","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-99-106","url":null,"abstract":"Annotation. The authors' study highlights the urgent problem of the development of toxic damage to the dentition under the influence of anticancer therapy in children and adolescents. The aim of the study was to study the violation of the homeostasis of the oral fluid and the severity of the carious process. Materials and methods. As part of a pilot study at the Russian Field Treatment and Rehabilitation Center, 63 children were studied the severity of mineral homeostasis disorders and damage to the dentoalveolar system. Results. In 67% of patients in the main group, there was an increased tendency to form carious cavities. 54.5% of them have complicated caries. One third of patients had more than five carious teeth. In the control group, carious lesions of the teeth in only three patients (20%), with the involvement of 1-3 teeth in the pathological process. Violation of enamel formation was diagnosed in 36% of children of the main group. There is a tendency for the accumulation of the studied microelements in the oral fluid, while in the blood serum there is a normal or insignificant decrease in their content. According to the literature, this may indicate destruction in the oral cavity. Deviations in the homeostasis of chemical elements in children who completed the treatment of malignant neoplasms and children in the control group were revealed. An increased content of osteotrophic microelements was found to correlate with the destructive processes of the teeth. Conclusion. It seems appropriate to study the severity of morphological changes in hard tissues of teeth and the electrolyte composition of mixed saliva in children and adolescents who have been cured of malignant neoplasms. The results of studies of gastric cancer, as an indicator of metabolic disorders, will make it possible not only to reveal the imbalance of macro- and microelements, but also to establish the effectiveness of adaptation mechanisms aimed at normalizing the elemental composition of the oral fluid.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"715 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121999246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DEVELOPMENT OF A METHOD FOR QUANTITATIVE DETERMINATION OF THE AMOUNT OF FLAVONOIDS IN TRIPLEUROSPERMUM INODORUM’S FLOWERS 建立了一种测定三胸草花中总黄酮含量的方法
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-157-166
Blinova O.L., Gileva A.A., Hlebnikov A.V., Belonogova V.D., Turyshev A.Y.
Chamomilla recutita is used in scientific medicine. Tripleurospermum inodorum (L.) Sch. Bip. is widely spread among possible impurities of Chamomilla recutita (L.) Rauschert. This plant is perspective for establishment into scientific medicine but it can’t change Chamomilla recutita (L.) Rauschert. Purpose of research: development of a method for the quantitative determination of the amount of flavonoids in terms of rutin in Tripleurospermum inodorum’s flowers using differential spectrophotometry.Materials and methods. The samples prepared in different parts of Russia were used as objects of research. (2017 – 2020). Spectral studies were carried out in the wavelength range of 350-430 nm with a step of 1 nm using a spectrophotometer SF-2000.Results. To determine the analytical wavelength, the UV spectra of alcohol extraction of Tripleurospermum inodorum’s flowers were studied. Maximum of absorption was noticed at wavelength 370 nm. The differential spectrum of the same extraction with an aluminum chloride solution of 2% in 96% alcohol has a maximum at a length of 410±2 nm, which coincides with the maximum of the Standard Sample (SS) of rutin. The largest number of flavonoids is extracted by 70% alcohol. The maximum optical density and the highest output of the number of flavonoids from the raw material is observed at a degree of grinding of 2 mm with a single extraction for 60 minutes. In the conditions of complexation, the optimal ratio of the volume of the test solution and aluminum chloride with a solution of 2% in 96% alcohol is the ratio of 1:1. The stability of the complex with an aluminum chloride solution of 2% in 96% alcohol is observed in 40 minutes after the start of the reaction and retains it for 30 minutes.Findings. The method is developed and the parameters of the quantitative determination of the amount of flavonoids in Tripleurospermum inodorum flores are determined in terms of rutin using differential spectrophotometry.
洋甘菊被用于科学医学。三胸精(L.)毕普原理图。广泛分布于茶甘菊(L.)的可能杂质中。Rauschert。该植物具有建立科学医学的前景,但不能改变洋甘菊(Chamomilla recutta)。Rauschert。研究目的:建立差示分光光度法定量测定三胸草花中以芦丁为单位的黄酮类化合物含量的方法。材料和方法。在俄罗斯不同地区制备的样品被用作研究对象。(2017 - 2020)。用sf -2000分光光度计在350-430 nm波长范围内进行光谱研究,步长为1 nm。为确定分析波长,研究了三棱香花醇提物的紫外光谱。在波长370nm处观察到最大吸收。以2%氯化铝溶液(96%乙醇)为溶剂提取芦丁时,差异谱在410±2 nm处有最大值,与芦丁标准样品(SS)的最大值一致。用70%的酒精提取的黄酮类化合物最多。在2 mm的研磨度下,单次提取60分钟,观察到原料的最大光密度和黄酮类化合物的最高产量。在络合条件下,以2%的浓度在96%的酒精中配制的试验溶液与氯化铝的最佳体积比为1:1。反应开始后40分钟,用2%的氯化铝溶液(96%乙醇)观察配合物的稳定性,并保持30分钟。建立了以芦丁为主要成分的差示分光光度法测定三棱香花中总黄酮含量的方法。
{"title":"DEVELOPMENT OF A METHOD FOR QUANTITATIVE DETERMINATION OF THE AMOUNT OF FLAVONOIDS IN TRIPLEUROSPERMUM INODORUM’S FLOWERS","authors":"Blinova O.L., Gileva A.A., Hlebnikov A.V., Belonogova V.D., Turyshev A.Y.","doi":"10.26787/nydha-2686-6838-2021-23-6-157-166","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-157-166","url":null,"abstract":"Chamomilla recutita is used in scientific medicine. Tripleurospermum inodorum (L.) Sch. Bip. is widely spread among possible impurities of Chamomilla recutita (L.) Rauschert. This plant is perspective for establishment into scientific medicine but it can’t change Chamomilla recutita (L.) Rauschert. \u0000Purpose of research: development of a method for the quantitative determination of the amount of flavonoids in terms of rutin in Tripleurospermum inodorum’s flowers using differential spectrophotometry.\u0000Materials and methods. The samples prepared in different parts of Russia were used as objects of research. (2017 – 2020). Spectral studies were carried out in the wavelength range of 350-430 nm with a step of 1 nm using a spectrophotometer SF-2000.\u0000Results. To determine the analytical wavelength, the UV spectra of alcohol extraction of Tripleurospermum inodorum’s flowers were studied. Maximum of absorption was noticed at wavelength 370 nm. The differential spectrum of the same extraction with an aluminum chloride solution of 2% in 96% alcohol has a maximum at a length of 410±2 nm, which coincides with the maximum of the Standard Sample (SS) of rutin. The largest number of flavonoids is extracted by 70% alcohol. The maximum optical density and the highest output of the number of flavonoids from the raw material is observed at a degree of grinding of 2 mm with a single extraction for 60 minutes. In the conditions of complexation, the optimal ratio of the volume of the test solution and aluminum chloride with a solution of 2% in 96% alcohol is the ratio of 1:1. The stability of the complex with an aluminum chloride solution of 2% in 96% alcohol is observed in 40 minutes after the start of the reaction and retains it for 30 minutes.\u0000Findings. The method is developed and the parameters of the quantitative determination of the amount of flavonoids in Tripleurospermum inodorum flores are determined in terms of rutin using differential spectrophotometry.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123163577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
INTERDISCIPLINARY APPROACH IN ASSISTING PATIENTS WITH PATHOLOGY OF THE MAXILLOFACIAL REGION IN THE CENTER OF MAXILLOFACIAL SURGERY 在颌面外科的中心,以跨学科的方法协助患者处理颌面区域的病理
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-261-267
Lebedev M.V., Zakharova I.Yu.
Every year there is a significant increase in combined anomalies and deformities of the maxillofacial region, congenital pathologies, malignant tumors, severe inflammatory diseases of the face and neck. Almost every patient who underwent surgery on the maxillofacial region develops secondary deformities of the maxillofacial region, adentia of the teeth of the jaws, impaired occlusion and speech, skeletal anomalies, which requires a comprehensive interdisciplinary approach of doctors of different profiles.The aim of the work was to improve the provision of specialized care to patients with pathology of the maxillofacial region through the introduction of an interdisciplinary approach in the treatment of patients in the center of maxillofacial surgery at the N.N. Burdenko Penza Regional Clinical Hospital (N.N. Burdenko ).Material and methods. The study was carried out on the basis of the Center for Maxillofacial Surgery of the State Budgetary Healthcare Institution "Penza Regional Clinical Hospital named after V.I. NN Burdenko ". A retrospective analysis of outpatient patient records, case histories, electronic databases, regulatory and legal documentation from 2010-2020 was carried out.Results and its discussion. Until November 2020, in the Penza region, medical care for patients with diseases of the maxillofacial region was provided in the department of maxillofacial surgery of the N.N. Burdenko State Budgetary Clinical Hospital. When analyzing the reporting and regulatory documents, it was concluded that it is necessary to improve the quality of specialized care in the field of maxillofacial surgery. We propose to employ the following specialists on the staff of the department: dentist-therapist for adults and children, gnathologist, dentist-orthodontist, otorhinolaryngologist, speech therapist.Conclusion. The materials presented in the article reflect the need for an integrated approach and close interaction between the doctors of the center. This stage begins during the preoperative preparation and planning of the operation. Rehabilitation of patients with pathology of the maxillofacial region is aimed at maximum aesthetic and anatomical recovery and requires an individual approach. To solve this problem, it is necessary to introduce interdisciplinary interaction of specialists in the center of maxillofacial surgery.
每年,颌面畸形、先天性病变、恶性肿瘤、面部和颈部严重炎症性疾病的合并异常和畸形都有显著增加。几乎每个在颌面区域接受手术的患者都会出现继发性颌面畸形、颌齿缺失、咬合和言语障碍、骨骼异常,这需要不同背景的医生综合跨学科的方法。这项工作的目的是通过在nn Burdenko Penza地区临床医院(nn Burdenko)的颌面外科中心采用跨学科方法治疗患者,改善对颌面区域病理患者的专业护理。材料和方法。这项研究是在国家预算保健机构颌面外科中心"奔萨地区临床医院"的基础上进行的,该医院以v.i.n. Burdenko命名。回顾性分析2010-2020年门诊病历、病例史、电子数据库、法规和法律文件。结果及其讨论。截至2020年11月,奔萨地区颌面疾病患者的医疗服务由布尔登科国家预算临床医院颌面外科提供。通过对相关报告和规范性文件的分析,认为有必要提高颌面外科专科护理质量。本科拟聘请以下专家:成人及儿童牙科治疗师、牙科医生、牙科正畸医生、耳鼻喉科医生、语言治疗师。在文章中提出的材料反映了需要一个综合的方法和中心的医生之间的密切互动。这一阶段从术前准备和手术计划开始。患者的康复与颌面区域的病理是旨在最大限度的审美和解剖恢复,需要一个单独的方法。为了解决这一问题,有必要在颌面外科中心引入专家的跨学科互动。
{"title":"INTERDISCIPLINARY APPROACH IN ASSISTING PATIENTS WITH PATHOLOGY OF THE MAXILLOFACIAL REGION IN THE CENTER OF MAXILLOFACIAL SURGERY","authors":"Lebedev M.V., Zakharova I.Yu.","doi":"10.26787/nydha-2686-6838-2021-23-6-261-267","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-261-267","url":null,"abstract":"Every year there is a significant increase in combined anomalies and deformities of the maxillofacial region, congenital pathologies, malignant tumors, severe inflammatory diseases of the face and neck. Almost every patient who underwent surgery on the maxillofacial region develops secondary deformities of the maxillofacial region, adentia of the teeth of the jaws, impaired occlusion and speech, skeletal anomalies, which requires a comprehensive interdisciplinary approach of doctors of different profiles.\u0000The aim of the work was to improve the provision of specialized care to patients with pathology of the maxillofacial region through the introduction of an interdisciplinary approach in the treatment of patients in the center of maxillofacial surgery at the N.N. Burdenko Penza Regional Clinical Hospital (N.N. Burdenko ).\u0000Material and methods. The study was carried out on the basis of the Center for Maxillofacial Surgery of the State Budgetary Healthcare Institution \"Penza Regional Clinical Hospital named after V.I. NN Burdenko \". A retrospective analysis of outpatient patient records, case histories, electronic databases, regulatory and legal documentation from 2010-2020 was carried out.\u0000Results and its discussion. Until November 2020, in the Penza region, medical care for patients with diseases of the maxillofacial region was provided in the department of maxillofacial surgery of the N.N. Burdenko State Budgetary Clinical Hospital. When analyzing the reporting and regulatory documents, it was concluded that it is necessary to improve the quality of specialized care in the field of maxillofacial surgery. We propose to employ the following specialists on the staff of the department: dentist-therapist for adults and children, gnathologist, dentist-orthodontist, otorhinolaryngologist, speech therapist.\u0000Conclusion. The materials presented in the article reflect the need for an integrated approach and close interaction between the doctors of the center. This stage begins during the preoperative preparation and planning of the operation. Rehabilitation of patients with pathology of the maxillofacial region is aimed at maximum aesthetic and anatomical recovery and requires an individual approach. To solve this problem, it is necessary to introduce interdisciplinary interaction of specialists in the center of maxillofacial surgery.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"138 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116379869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
TOXIC EFFECTS OF ANTICANCER THERAPY 抗癌治疗的毒性作用
Pub Date : 2021-06-30 DOI: 10.26787/nydha-2686-6838-2021-23-6-28-34
Gelfer S.A., Semenova V.V.
The generally accepted practice of medical technology is to record the first time sick, the results of dynamic observations of patients (follow-up). The first research groups for the study of malignant neoplasms (MNO) in children appeared in the United States in 1955. The article describes the importance of early rehabilitation of patients who have undergone cancer on the example of a clinical case. Advances in the treatment of cancer patients have resulted in a higher percentage of people cured. But very early after the start of the use of anticancer therapy (POT), doctors began to observe manifestations of an iatrogenic nature due to the use of toxic drugs and radiation. At the moment, the influence of genetic factors on the development of complications of chemotherapy and radiation therapy is being actively studied. The molecular mechanisms of the development of abnormally pronounced toxic effects in most cases are associated with disorders in the DNA repair system. To minimize the risk of severe toxic effects, these factors should be taken into account when choosing a treatment strategy. On the example of patient N., 18 years old, the condition after the end of treatment for rhabdomyosarcoma of the temporal region, the duration of remission is 12 years, one can see how the treatment can iatrogenically affect the patient's life in adulthood, having undergone treatment in childhood. With an early start of rehabilitation and timely identification of the long-term consequences of anticancer therapy, it is possible to improve the patient's quality of life. With the accumulation of observation data on the domestic cohort of children and adolescents who completed therapy 15-20 years ago, it will become possible to assess the burden of national health care in the structure of morbidity, disability, and the development of second tumors.
医学技术上普遍接受的做法是记录患者第一次生病、动态观察的结果(随访)。1955年,美国出现了第一批研究儿童恶性肿瘤(MNO)的研究小组。本文以一个临床病例为例,说明癌症患者早期康复的重要性。癌症治疗的进步使治愈率提高了。但在开始使用抗癌治疗(POT)后很早就,医生开始观察到由于使用有毒药物和辐射而导致的医源性表现。目前,遗传因素对化疗和放疗并发症发展的影响正在积极研究中。在大多数情况下,异常明显的毒性作用的分子机制与DNA修复系统的紊乱有关。为了尽量减少严重毒性作用的风险,在选择治疗策略时应考虑这些因素。以患者N.为例,18岁,颞区横纹肌肉瘤治疗结束后的情况,缓解期为12年,可以看出治疗如何在儿童时期接受治疗的情况下对患者成年期的生活产生医源性影响。尽早开始康复治疗,及时发现抗癌治疗的长期后果,就有可能改善患者的生活质量。随着对15-20年前完成治疗的国内儿童和青少年队列观察数据的积累,将有可能评估国家卫生保健在发病率、残疾和第二肿瘤发展结构方面的负担。
{"title":"TOXIC EFFECTS OF ANTICANCER THERAPY","authors":"Gelfer S.A., Semenova V.V.","doi":"10.26787/nydha-2686-6838-2021-23-6-28-34","DOIUrl":"https://doi.org/10.26787/nydha-2686-6838-2021-23-6-28-34","url":null,"abstract":"The generally accepted practice of medical technology is to record the first time sick, the results of dynamic observations of patients (follow-up). The first research groups for the study of malignant neoplasms (MNO) in children appeared in the United States in 1955. The article describes the importance of early rehabilitation of patients who have undergone cancer on the example of a clinical case. Advances in the treatment of cancer patients have resulted in a higher percentage of people cured. But very early after the start of the use of anticancer therapy (POT), doctors began to observe manifestations of an iatrogenic nature due to the use of toxic drugs and radiation. At the moment, the influence of genetic factors on the development of complications of chemotherapy and radiation therapy is being actively studied. The molecular mechanisms of the development of abnormally pronounced toxic effects in most cases are associated with disorders in the DNA repair system. To minimize the risk of severe toxic effects, these factors should be taken into account when choosing a treatment strategy. On the example of patient N., 18 years old, the condition after the end of treatment for rhabdomyosarcoma of the temporal region, the duration of remission is 12 years, one can see how the treatment can iatrogenically affect the patient's life in adulthood, having undergone treatment in childhood. With an early start of rehabilitation and timely identification of the long-term consequences of anticancer therapy, it is possible to improve the patient's quality of life. With the accumulation of observation data on the domestic cohort of children and adolescents who completed therapy 15-20 years ago, it will become possible to assess the burden of national health care in the structure of morbidity, disability, and the development of second tumors.","PeriodicalId":445713,"journal":{"name":"\"Medical & pharmaceutical journal \"Pulse\"","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122441717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
"Medical & pharmaceutical journal "Pulse"
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1