Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749836
C. Su, Chia-Min Huang
Microwave plasma techniques offered many advantages over conventional fabricating methods. However, few studies have used microwave plasma energy to sinter traditional ceramics. Thus, the aim of this work is microwave plasma Jet sintering system (MPJSS) and simulate analyze the electric field of ZnO films on quartz substrates. Ansoft HFSS consists of MPJSS modules for the calculation of ZnO films electromagnetic field. Sinter of ZnO films occurs at approximately 50% N2/50% O2 with a 10 sccm gas flow rate for a process pressure of 35 Torr and 1200W applied power. Optical emission spectroscopic (OES) studies of N2/O2 microwave plasmas, the average gas temperature of the plasma to be 1809 K. X-ray diffraction (XRD), Micro-Raman, FE-SEM and UV-Vis spectrometry were used to characterize the produced ZnO films. The results of XRD and Micro-Raman showed that the synthesized ZnO films had a high crystalline wurzite structure. Intensity of diffraction peak for (101)-plane of ZnO films increases with increasing treated times in MPJSS. The highest measured regular optical transmittance of the ZnO films treated was 20% at 580–730 nm (including quartz absorption), whereas that of the ZnO films no-treated was 5% at 200–800nm (including quartz absorption).
{"title":"Grain growth of Zinc Oxide films on quartz GlassTreated in N2/O2 atmosphere using microwave plasma Jet sintering system","authors":"C. Su, Chia-Min Huang","doi":"10.1109/NANOMED.2010.5749836","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749836","url":null,"abstract":"Microwave plasma techniques offered many advantages over conventional fabricating methods. However, few studies have used microwave plasma energy to sinter traditional ceramics. Thus, the aim of this work is microwave plasma Jet sintering system (MPJSS) and simulate analyze the electric field of ZnO films on quartz substrates. Ansoft HFSS consists of MPJSS modules for the calculation of ZnO films electromagnetic field. Sinter of ZnO films occurs at approximately 50% N2/50% O2 with a 10 sccm gas flow rate for a process pressure of 35 Torr and 1200W applied power. Optical emission spectroscopic (OES) studies of N2/O2 microwave plasmas, the average gas temperature of the plasma to be 1809 K. X-ray diffraction (XRD), Micro-Raman, FE-SEM and UV-Vis spectrometry were used to characterize the produced ZnO films. The results of XRD and Micro-Raman showed that the synthesized ZnO films had a high crystalline wurzite structure. Intensity of diffraction peak for (101)-plane of ZnO films increases with increasing treated times in MPJSS. The highest measured regular optical transmittance of the ZnO films treated was 20% at 580–730 nm (including quartz absorption), whereas that of the ZnO films no-treated was 5% at 200–800nm (including quartz absorption).","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114684832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749826
Sun Ho Lee, Yoon-Jung Cha, Shin Sik Choi, Sang-Hyub Ha, Hyun Ho Lee
Poly Dimethyl Siloxane (PDMS) microneedle mold having tapered cone tips for a potential nanoparticle-based drug delivery was introduced and investigated. The fabrication of PDMS mold was performed with laser writer, which has great efficiency in repeatability and simplicity. Nanoparticles, such as polystyrene, was drop-casted at the tip of biocompatible polymers of carboxy methylcellulose (CMC) and agarose microneedle. The results demonstrated a high feasibility of successful application to a simple manufacturing of microneedle in addition to a new functionality of the microneedle for the transport of nanoparticle-conjugated drugs.
{"title":"Fabricaction of nanoparticle-based microneedle for potential drug delivery","authors":"Sun Ho Lee, Yoon-Jung Cha, Shin Sik Choi, Sang-Hyub Ha, Hyun Ho Lee","doi":"10.1109/NANOMED.2010.5749826","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749826","url":null,"abstract":"Poly Dimethyl Siloxane (PDMS) microneedle mold having tapered cone tips for a potential nanoparticle-based drug delivery was introduced and investigated. The fabrication of PDMS mold was performed with laser writer, which has great efficiency in repeatability and simplicity. Nanoparticles, such as polystyrene, was drop-casted at the tip of biocompatible polymers of carboxy methylcellulose (CMC) and agarose microneedle. The results demonstrated a high feasibility of successful application to a simple manufacturing of microneedle in addition to a new functionality of the microneedle for the transport of nanoparticle-conjugated drugs.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"392 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133546536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749820
Nicky F. C. Ho, B. Chan
Actin filament, one type of cytoskeletons, plays a central role in mediating cellular in responses to mechanical loading. Many mechanorgulation studies are restricted to 2D models using isolated cells or monolayer cultures, even though it is know that cells behave differently in term of cell morphology, cell matrix adhesion composition and matrix mediated force transmission when they are in 3D configuration. This current study investigates the temporal change of actin network of hMSCs entrapped in 3D collagen construct upon cyclic compression. Human bone marrow mesenchymal stem cells were encapsulated in cylindrical collagen construct. A micromanipulator based loading device coupled to fluorescent microscope was used to deliver compression loading to the construct with 10% strain at 1Hz for different period of time. Rhodamine phalloidin was used to stain for the actin filament network to hMSC in the construct at different time points postcompression. An optimized loading protocol with 5hrs of continuous loading was delivered. Actin network concentrated at the cell periphery of cells exhibiting round morphology was observed immediately while elongated and polarized actin network was found after 24 hours. Detailed characterization of actin filament organization and their association with cell-matrix interaction molecules are warrented before the mechanisms of compression-induced hMSC alignment can be delineated
{"title":"Effect of dynamic mechanical compression on actin cytoskeleton network of human mesenchymal stem cells (hMSCs in three dimensional collagen constructs","authors":"Nicky F. C. Ho, B. Chan","doi":"10.1109/NANOMED.2010.5749820","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749820","url":null,"abstract":"Actin filament, one type of cytoskeletons, plays a central role in mediating cellular in responses to mechanical loading. Many mechanorgulation studies are restricted to 2D models using isolated cells or monolayer cultures, even though it is know that cells behave differently in term of cell morphology, cell matrix adhesion composition and matrix mediated force transmission when they are in 3D configuration. This current study investigates the temporal change of actin network of hMSCs entrapped in 3D collagen construct upon cyclic compression. Human bone marrow mesenchymal stem cells were encapsulated in cylindrical collagen construct. A micromanipulator based loading device coupled to fluorescent microscope was used to deliver compression loading to the construct with 10% strain at 1Hz for different period of time. Rhodamine phalloidin was used to stain for the actin filament network to hMSC in the construct at different time points postcompression. An optimized loading protocol with 5hrs of continuous loading was delivered. Actin network concentrated at the cell periphery of cells exhibiting round morphology was observed immediately while elongated and polarized actin network was found after 24 hours. Detailed characterization of actin filament organization and their association with cell-matrix interaction molecules are warrented before the mechanisms of compression-induced hMSC alignment can be delineated","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"374 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122435350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749828
F. Rao, Zheng Fan, Lixin Dong, Wen Li
This paper presents the design, fabrication, and characterization of a novel high-performance molecule sensor using the inter-sheet tunneling effect of a bilayer graphene. Nanosensors for ethanol molecules have been fabricated based on mechanical exfoliation and e-beam lithography for demonstrating the feasibility. Experiments reveled that by making electric contacts to different sheets of a bilayer graphene, inter-sheet effects can be exposed. As a result, the “inter-layer” sensor has a much higher (a typical result showed more than 8 times higher) sensitivity than that of an “intra-layer” sensor, in which the electric contacts are placed on the same layer. The adoption of the inter-sheet effects remarkably enriched the applicable transduction mechanisms. These include the enhanced edge effects due to the extra sides, inter-sheet tunneling due to the spacing change caused by molecule adsorption/desorption, force/displacement, pressure, surface tension, and heating, and potentially inter-sheet doping due to the open step.
{"title":"Molecular nanosensors based on the inter-sheet tunneling effect of a bilayer graphene","authors":"F. Rao, Zheng Fan, Lixin Dong, Wen Li","doi":"10.1109/NANOMED.2010.5749828","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749828","url":null,"abstract":"This paper presents the design, fabrication, and characterization of a novel high-performance molecule sensor using the inter-sheet tunneling effect of a bilayer graphene. Nanosensors for ethanol molecules have been fabricated based on mechanical exfoliation and e-beam lithography for demonstrating the feasibility. Experiments reveled that by making electric contacts to different sheets of a bilayer graphene, inter-sheet effects can be exposed. As a result, the “inter-layer” sensor has a much higher (a typical result showed more than 8 times higher) sensitivity than that of an “intra-layer” sensor, in which the electric contacts are placed on the same layer. The adoption of the inter-sheet effects remarkably enriched the applicable transduction mechanisms. These include the enhanced edge effects due to the extra sides, inter-sheet tunneling due to the spacing change caused by molecule adsorption/desorption, force/displacement, pressure, surface tension, and heating, and potentially inter-sheet doping due to the open step.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122968676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749825
H. Vu-Quang, M. Yoo, C. Cho, H. Jeong, Y. Jeong, I. Park
Detection of lymph node (LN) metastasis by magnetic resonance imaging (MRI) has obtained clinical significance for treating cancer patients. LN metastasis often happens through regional lymphatic system, leading to distal tumor formation including lungs, liver and bones. Successful imaging of small and microscopic LN metastasis provides the helpful information in deciding the therapeutic option of cancer. Mannan is a water-soluble polysaccharide having high content of D-mannose residues which can be recognized by mannose receptors on activated macrophages and dendritic cells. Mannan-coated superparamagnetic iron oxide nanoparticles (Mannan-SPION) were developed to be specifically delivered to immune cells in lymph node by receptor-mediated endocytosis. Mannan-SPION was proven to be suitable for MR imaging due to small size, excellent stability in ferrofluid, and low cytotoxicity. From the Prussian blue staining, Mannan-SPION was showed their ability to be taken up by immune cells such as macrophage and dendritic cell. In addition mannan-SPION exhibited enhanced targeted delivery efficiency to macrophages in lymph nodes in vivo compared with PVA-SPION. Especially, LN enhancement of Mannan-SPION on MRI was dramatically increased at the later stage after intravenous injection compared with PVA-SPION control, indicative of the potential to successfully detect micrometastasis in LN.
{"title":"Immune cells-specific delivery of mannan-coated superparamagnetic iron oxide nanoparticles for the detection of metastatic lymph node","authors":"H. Vu-Quang, M. Yoo, C. Cho, H. Jeong, Y. Jeong, I. Park","doi":"10.1109/NANOMED.2010.5749825","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749825","url":null,"abstract":"Detection of lymph node (LN) metastasis by magnetic resonance imaging (MRI) has obtained clinical significance for treating cancer patients. LN metastasis often happens through regional lymphatic system, leading to distal tumor formation including lungs, liver and bones. Successful imaging of small and microscopic LN metastasis provides the helpful information in deciding the therapeutic option of cancer. Mannan is a water-soluble polysaccharide having high content of D-mannose residues which can be recognized by mannose receptors on activated macrophages and dendritic cells. Mannan-coated superparamagnetic iron oxide nanoparticles (Mannan-SPION) were developed to be specifically delivered to immune cells in lymph node by receptor-mediated endocytosis. Mannan-SPION was proven to be suitable for MR imaging due to small size, excellent stability in ferrofluid, and low cytotoxicity. From the Prussian blue staining, Mannan-SPION was showed their ability to be taken up by immune cells such as macrophage and dendritic cell. In addition mannan-SPION exhibited enhanced targeted delivery efficiency to macrophages in lymph nodes in vivo compared with PVA-SPION. Especially, LN enhancement of Mannan-SPION on MRI was dramatically increased at the later stage after intravenous injection compared with PVA-SPION control, indicative of the potential to successfully detect micrometastasis in LN.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117061214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749813
N. Kotagiri, Jin-Woo Kim
Single walled carbon nanotubes (SWNT) have shown tremendous promise as agents for diagnostic and therapeutic intervention in vivo. We demonstrate how Dextran sulfate (DS) can render SWNT transparent to macrophages, a vital component of the innate immunity. We also demonstrate a site specific attachment strategy to conjugate antibodies to DS for downstream applications. DS was compared to Polyethylene Glycol (PEG) coated SWNT, a trusted standard for rendering nanoparticles immune to opsonization.
{"title":"Sugar coated stealth carbon nanotubes","authors":"N. Kotagiri, Jin-Woo Kim","doi":"10.1109/NANOMED.2010.5749813","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749813","url":null,"abstract":"Single walled carbon nanotubes (SWNT) have shown tremendous promise as agents for diagnostic and therapeutic intervention in vivo. We demonstrate how Dextran sulfate (DS) can render SWNT transparent to macrophages, a vital component of the innate immunity. We also demonstrate a site specific attachment strategy to conjugate antibodies to DS for downstream applications. DS was compared to Polyethylene Glycol (PEG) coated SWNT, a trusted standard for rendering nanoparticles immune to opsonization.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126058640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749842
Jeong-Hwan Kim, Jin-Woo Kim
We propose mono-, di-, or tri-probe functionalized water-soluble gold nanoparticles (AuNPs) (∼ 2 nm) based on our aqueous-phase serial solid-phase monofunctionalization (monof-) approach. They exhibit both electrical and optical sensing capabilities when specifically coupled with distinctive one- or diametric-functionality. Using ferrocene redox derivative for electrical detection scheme, the monof-, bif-, and trif-NPs show distinctively proportionated current peaks, which could allow quantitative biosensing as well as precise bioconjugation. TEM images verified the covalent bond-directed assembly of 1D and 2D structures. While typical individual AuNPs are not NIR responsive, the assembled nanosensing units exhibit longitudinal surface plasmon resonance, indicating their high promises for the high functional NIR-based medical applications. These exemplify a significant stride towards ‘multiplex’ nanosensors with enhanced functionality, selectivity, and complexity.
{"title":"Controlled chemical functionalization of water-soluble nanoprobes for site-specific biomedical diagnosis","authors":"Jeong-Hwan Kim, Jin-Woo Kim","doi":"10.1109/NANOMED.2010.5749842","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749842","url":null,"abstract":"We propose mono-, di-, or tri-probe functionalized water-soluble gold nanoparticles (AuNPs) (∼ 2 nm) based on our aqueous-phase serial solid-phase monofunctionalization (monof-) approach. They exhibit both electrical and optical sensing capabilities when specifically coupled with distinctive one- or diametric-functionality. Using ferrocene redox derivative for electrical detection scheme, the monof-, bif-, and trif-NPs show distinctively proportionated current peaks, which could allow quantitative biosensing as well as precise bioconjugation. TEM images verified the covalent bond-directed assembly of 1D and 2D structures. While typical individual AuNPs are not NIR responsive, the assembled nanosensing units exhibit longitudinal surface plasmon resonance, indicating their high promises for the high functional NIR-based medical applications. These exemplify a significant stride towards ‘multiplex’ nanosensors with enhanced functionality, selectivity, and complexity.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121865870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749819
Yongping Zhai, Dongxiang Zhou, Shun Liu, Yunhui Liu, W. Fung
Auto-focusing is one of the key issues in motorized biological microscopes as it strongly affects the quality of the microscopic images. Auto-focusing is a difficult problem because the size of biological objects is as small as a few micrometers, and the problem is even more challenging when the density of the image content is low. In this paper, we propose a content based focus measure for guiding automatic search of the optimal focal plane with different image content densities. The proposed method adaptively assigns different weights to pixels based on the image content in the focus measure computation. Larger weights are assigned to pixels that represent interested objects, while smaller weights are given to debris and background pixels. Experimental investigation has been conducted to demonstrate superior performance of the proposed method over existing methods.
{"title":"Content based focus measure for robust auto-focusing of microscopy in biomedical applications","authors":"Yongping Zhai, Dongxiang Zhou, Shun Liu, Yunhui Liu, W. Fung","doi":"10.1109/NANOMED.2010.5749819","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749819","url":null,"abstract":"Auto-focusing is one of the key issues in motorized biological microscopes as it strongly affects the quality of the microscopic images. Auto-focusing is a difficult problem because the size of biological objects is as small as a few micrometers, and the problem is even more challenging when the density of the image content is low. In this paper, we propose a content based focus measure for guiding automatic search of the optimal focal plane with different image content densities. The proposed method adaptively assigns different weights to pixels based on the image content in the focus measure computation. Larger weights are assigned to pixels that represent interested objects, while smaller weights are given to debris and background pixels. Experimental investigation has been conducted to demonstrate superior performance of the proposed method over existing methods.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125631822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749810
M. Kaneko, Yukic Hirose, W. Fukui, Y. Sakata, Kazuhiro Yamamoto, T. Kawahara, Y. Yamanishi, F. Arai
This paper presents the first challenge for real time stiffness evaluation of red blood cell (RBC) by utilizing both a high speed vision and a micro channel. Since the passing time of cell in the micro channel whose diameter is smaller than that of cell depends upon the stiffness of cell, we can indirectly evaluate the stiffness by the passing time. With the assistance of a high speed vision system, we succeeded in evaluating the stiffness of RBCs with 5 [msec/cell]. The biggest advantage for utilizing a high speed vision is that we can know exactly what is actually happening in the channel, while it is really hard for other approaches. This paper discusses two key ideas for online sensing and shows experimental results.
{"title":"5ms-stiffness-evaluation of red blood cell","authors":"M. Kaneko, Yukic Hirose, W. Fukui, Y. Sakata, Kazuhiro Yamamoto, T. Kawahara, Y. Yamanishi, F. Arai","doi":"10.1109/NANOMED.2010.5749810","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749810","url":null,"abstract":"This paper presents the first challenge for real time stiffness evaluation of red blood cell (RBC) by utilizing both a high speed vision and a micro channel. Since the passing time of cell in the micro channel whose diameter is smaller than that of cell depends upon the stiffness of cell, we can indirectly evaluate the stiffness by the passing time. With the assistance of a high speed vision system, we succeeded in evaluating the stiffness of RBCs with 5 [msec/cell]. The biggest advantage for utilizing a high speed vision is that we can know exactly what is actually happening in the channel, while it is really hard for other approaches. This paper discusses two key ideas for online sensing and shows experimental results.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131911147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.1109/NANOMED.2010.5749824
Y. Nguyen, M. Miroir, Guillaume Kazmitcheff, E. Ferrary, O. Sterkers, A. B. Grayeli
In order to design a drug delivery system to the human cochlea, a magnetic pump driving Fe3O4 super paramagnetic nanoparticles (MNP) attachable to a drug was evaluated. Such a device could be inserted into the cochlea by a minimally invasive technique. In this study, the effect of a magnetic field generated by solenoids coiled around a 1 mm diameter catheter filled with 200 nm MNP was studied. Results showed that, particles can be concentrated at different locations of the catheter for a precise delivery at different cochlear locations. The particles could also be driven between 2 solenoids 50 mm apart with 150 mA which is compatible with current sources in available cochlear implants.
{"title":"Super paramagnetic nanoparticles delivery through a microcatheter by solenoids","authors":"Y. Nguyen, M. Miroir, Guillaume Kazmitcheff, E. Ferrary, O. Sterkers, A. B. Grayeli","doi":"10.1109/NANOMED.2010.5749824","DOIUrl":"https://doi.org/10.1109/NANOMED.2010.5749824","url":null,"abstract":"In order to design a drug delivery system to the human cochlea, a magnetic pump driving Fe3O4 super paramagnetic nanoparticles (MNP) attachable to a drug was evaluated. Such a device could be inserted into the cochlea by a minimally invasive technique. In this study, the effect of a magnetic field generated by solenoids coiled around a 1 mm diameter catheter filled with 200 nm MNP was studied. Results showed that, particles can be concentrated at different locations of the catheter for a precise delivery at different cochlear locations. The particles could also be driven between 2 solenoids 50 mm apart with 150 mA which is compatible with current sources in available cochlear implants.","PeriodicalId":446237,"journal":{"name":"2010 IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116549448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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