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A Different Scintigraphic Perspective on the Systolic Function of the Left Ventricle-1. 左心室收缩功能的不同闪烁透视图-1。
IF 0.9 Q3 Medicine Pub Date : 2023-10-20 DOI: 10.4274/mirt.galenos.2023.75046
Alper Özgür Karaçalıoğlu, Alev Çınar

Objectives: The aim of this study was to analyze the systolic part of the left ventricular (LV) volume curve obtained by gated myocardial perfusion imaging with the formula used in exponential decay and to investigate the clinical value of the results.

Methods: One hundred fifty eight patients were retrospectively enrolled in the study. The study group was divided into three groups as normal, ischemia, and infarct. The systolic portion of the LV volume curve was also analyzed using the exponential decay formula. The scintigraphic parameter obtained using this formula is called the ejection constant (Ec).

Results: The Ec results were 1.8±0.8, 2.7±0.9, 3.5±1 in infarct, ischemia, and normal groups, respectively, and the difference in Ec results between the groups was statistically significant (p≤0.001).

Conclusion: It appears that Ec may play a clinical role as a scintigraphic parameter in the evaluation of systolic functions of the left ventricle.

目的:本研究的目的是用指数衰减公式分析门控心肌灌注成像获得的左心室(LV)容积曲线的收缩部分,并探讨其临床价值。方法:对158例患者进行回顾性研究。研究组分为正常组、缺血组和梗死组。左心室容积曲线的收缩部分也使用指数衰减公式进行分析。使用该公式获得的闪烁扫描参数称为射血常数(Ec)。结果:梗死组、缺血组和正常组的Ec结果分别为1.8±0.8、2.7±0.9、3.5±1,Ec结果两组间差异有统计学意义(p≤0.001)。结论:Ec可能作为评价左心室收缩功能的闪烁扫描参数在临床上发挥作用。
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引用次数: 0
A Rare Case of "Periportal Cuffing" as an Incidental Finding on 18F-FDG PET/CT. 在18F-FDG PET/CT上偶然发现的罕见“门周翻边”病例。
IF 0.9 Q3 Medicine Pub Date : 2023-10-20 DOI: 10.4274/mirt.galenos.2023.53254
Burak Demir, Elgin Özkan, Seda Kaynak Şahap, Gizem Sütçü, Ceyda Tuna Kırsaçlıoğlu, Çiğdem Soydal, Ömer Suat Fitoz, Aydan Kansu Tanca, Emel Ünal

A 7-year-old boy with known diagnosis of hereditary spherocytosis and ulcerative colitis was referred for 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography after detection of a 28 mm lesion suspicious for malignancy in spleen on upper abdomen magnetic resonance imaging (MRI). As an incidental finding, a moderately increased uptake of 18F-FDG was observed in periportal region with no definable mass. MRI revealed compatible findings with "periportal cuffing" as described on ultrasonography.

一名已知诊断为遗传性球细胞增多症和溃疡性结肠炎的7岁男孩,在上腹部磁共振成像(MRI)上发现脾脏有28毫米可疑恶性病变后,被转诊接受18F-氟脱氧葡萄糖(18F-FDG)正电子发射断层扫描/计算机断层扫描。偶然发现,在门周区域观察到18F-FDG的摄取适度增加,但没有明确的肿块。MRI显示与超声所述的“门周铐”一致。
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引用次数: 0
Isolated Castrate-resistant Prostate Cancer Metastasis to Both Adrenal Glands Detected on 68Ga PSMA PET/CT. 68Ga PSMA PET/CT检测到孤立的耐Castrate前列腺癌症双侧肾上腺转移。
IF 0.9 Q3 Medicine Pub Date : 2023-10-20 DOI: 10.4274/mirt.galenos.2023.03780
Osman Kanatsız, Filiz Özülker, Tamer Aydın, Tamer Özülker

A 61-year-old male patient, who had undergone radical prostatectomy, underwent 68Ga labeled prostate-specific membrane antigen (PSMA) positron emission tomography/computerized tomography (PET/CT) for evaluation of suspected biochemical recurrence of prostate cancer (PCa). PET/CT scan showed increased 68Ga PSMA expressions in hypodense mass lesions in both adrenal gland localizations. An adrenal gland tru-cut biopsy was performed for the right side, which showed poor-differentiated carcinoma metastases associated with the patient's high-grade PCa. As far as we could determine based on an extensive literature search, this is the second case in which isolated adrenal metastasis was detected by 68Ga PSMA PET/CT study in a patient with PCa.

一名61岁的男性患者接受了根治性前列腺切除术,接受了68Ga标记的前列腺特异性膜抗原(PSMA)正电子发射断层扫描/计算机断层扫描(PET/CT),以评估癌症(PCa)的疑似生化复发。PET/CT扫描显示68Ga-PSMA在两个肾上腺定位的低密度肿块中的表达增加。右侧肾上腺tru-cut活检显示与患者的高级别前列腺癌相关的低分化癌转移。根据广泛的文献检索,我们可以确定,这是68Ga-PSMA PET/CT研究在前列腺癌患者中检测到的第二例孤立的肾上腺转移。
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引用次数: 0
Cutaneous Metastase of Rectal Neuroendocrine Carcinoma Revealed on 18F-FDG PET/CT. 18F-FDG PET/CT显示的直肠神经内分泌癌皮肤转移。
IF 0.9 Q3 Medicine Pub Date : 2023-06-20 DOI: 10.4274/mirt.galenos.2022.99266
Ömer Faruk Şahin, Rahime Şahin, Mehmet Can Baloğlu, Tevfik Fikret Çermik, Nurhan Ergül

Rectal neuroendocrine carcinomas constitute <1% of all neuroendocrine carcinomas and <1% of all gastrointestinal tract malignancies. Cutaneous metastases of rectal neuroendocrine carcinoma are rarer than visceral metastases. We represent a 71-year-old man who was diagnosed with neuroendocrine tumor grade 3 originating from the rectum 1 year ago. He was referred for 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography for restaging after 6 cycles of chemotherapy and radiotherapy. Intensely increased 18F-FDG uptake in the right cutaneous inguinal region was consistent with neuroendocrine carcinoma metastasis with biopsy from the same region.

直肠神经内分泌癌采用18f -氟脱氧葡萄糖(FDG)正电子发射断层扫描/计算机断层扫描,经过6个周期的化疗和放疗后重新分期。右侧皮肤腹股沟区18F-FDG摄取强烈增加与同一区域活检的神经内分泌癌转移一致。
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引用次数: 0
Unusual Case of Pseudomembranous Colitis Presenting as Fever of Unknown Origin Diagnosed by Tc-99m-HMPAO-labeled Leukocytes SPECT/CT. 以tc -99m- hpao标记白细胞SPECT/CT诊断不明原因发热的假膜性结肠炎罕见病例。
IF 0.9 Q3 Medicine Pub Date : 2023-06-20 DOI: 10.4274/mirt.galenos.2022.59354
Rosanna Del Carmen Zambrano-Infantino, Jean Félix Piñerúa-Gonsálvez, Noelia Alvarez-Mena, Sandra Izquierdo-Santervás, Noelia Alcaide, Maria Garcia-Aragon, Ricardo Ruano-Pérez

The fever of unknown origin (FUO) represents a complex diagnostic challenge due to the wide range of etiologies that could cause it, including neoplastic, infectious, rheumatic/inflammatory, and miscellaneous disorders. Several nuclear medicine techniques have proven to be valuable tools for guiding etiologic diagnosis in the setting of FUO. One of these is technetium-99m (Tc-99m)-hexamethylpropylene amine oxime (HMPAO)-labeled leukocyte scintigraphy, which is a diagnosis method that allows in most cases the localization and evaluation of the extension of an occult infection. This paper presents an uncommon case of pseudomembranous colitis without diarrhea as etiology of FUO diagnosed by Tc-99m-HMPAO-labeled leukocytes.

不明原因发热(FUO)是一项复杂的诊断挑战,因为可能引起不明原因发热的病因范围很广,包括肿瘤、感染性、风湿病/炎症和各种疾病。一些核医学技术已被证明是指导FUO病因诊断的宝贵工具。其中之一是锝-99m (Tc-99m)-六甲基丙烯胺肟(HMPAO)标记的白细胞闪烁成像,这是一种诊断方法,在大多数情况下可以定位和评估隐匿感染的扩展。本文报告一罕见的假性膜性结肠炎无腹泻的病因诊断为FUO的tc -99m- hpao标记的白细胞。
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引用次数: 0
Testicular Metastasis of Jejunal Neuroendocrine Tumor on 68Ga-DOTATATE PET/CT. 空肠神经内分泌肿瘤睾丸转移的68Ga-DOTATATE PET/CT分析。
IF 0.9 Q3 Medicine Pub Date : 2023-06-20 DOI: 10.4274/mirt.galenos.2022.06926
Ömer Faruk Şahin, Özge Erol Fenercioğlu, Ediz Beyhan, Tevfik Fikret Çermik, Nurhan Ergül

Neuroendocrine tumors are slow-growing tumors originating from neuroendocrine cells and capable of metastasis. Most of them are found in the gastrointestinal tract; however, they can also be rarely seen in other organs. Testicular neuroendocrine tumors account for less than 1% of all testicular neoplasms. They may present as primary testicular or secondary tumors from extratesticular sources. Jejunal neuroendocrine tumor metastasis to the testis is extremely rare. We present the case of a 61-year-old man with a jejunal neuroendocrine tumor and metastases to bilateral testicles revealed on Gallium-68-DOTATATE positron emission tomography/computed tomography.

神经内分泌肿瘤是起源于神经内分泌细胞的生长缓慢的肿瘤,具有转移能力。它们大多存在于胃肠道;然而,它们在其他器官中也很少见。睾丸神经内分泌肿瘤占所有睾丸肿瘤的不到1%。它们可能表现为原发性睾丸肿瘤或来自睾丸外的继发性肿瘤。空肠神经内分泌肿瘤转移至睾丸极为罕见。我们报告一例61岁男性空肠神经内分泌肿瘤并转移到双侧睾丸,镓-68- dotatate正电子发射断层扫描/计算机断层扫描显示。
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引用次数: 1
Urinary Bladder Carcinoma Demonstrated on Bone Scintigraphy and SPECT/CT Images. 骨显像和SPECT/CT图像显示膀胱癌。
IF 0.9 Q3 Medicine Pub Date : 2023-06-20 DOI: 10.4274/mirt.galenos.2023.27037
Sotiria Alexiou, Xanthi Xourgia, Pavlos Raptis, Dimitrios Baltogiannis, Chrissa Sioka

Bone scintigraphy with Tc-99m-diphosphonate analogs are widely used in staging, restaging, and monitoring the therapy effectiveness of various cancer types. Bone-seeking agents are excreted through urination, resulting in the visualization of either anatomical abnormalities or pathological conditions of the kidneys and bladder. We present a case of a 63-year-old man with urinary bladder carcinoma depicted on whole body planar and single-photon emission computed tomography/computed tomography images.

tc -99m-二膦酸盐类似物骨显像广泛应用于各种类型癌症的分期、再分期和治疗效果监测。寻骨剂通过尿液排出,导致肾脏和膀胱的解剖异常或病理状况的可视化。我们报告一例63岁男性膀胱癌的全身平面和单光子发射计算机断层扫描/计算机断层扫描图像。
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引用次数: 0
I-131 Avid Tumor Thrombus in a Case of Poorly Differentiated Thyroid Cancer. 低分化甲状腺癌1例I-131肿瘤血栓。
IF 0.9 Q3 Medicine Pub Date : 2023-06-20 DOI: 10.4274/mirt.galenos.2023.81567
Sana Munir Gill, Aamna Hassan, Humayun Bashir, Waqas Shafiq

Intravenous tumor extension is a well-recognized phenomenon occurring in various malignancies but is a relatively rare entity in thyroid carcinoma. In patients with poorly differentiated thyroid cancer (pDTC), I-131 avid superior vena cava tumor (SVC) thrombus at initial presentation is infrequent and potential life threatening. Tumor thrombus can form either due to direct vascular extension of the primary mass or by hematogenous spread. Hybrid nuclear imaging can differentiate the two entities, which can impact the treatment plan of the patient. We present images of an interesting case of evolution of SVC thrombus in a 46-year-old woman with diagnosed pDTC over the span of two years.

静脉肿瘤扩展是发生在各种恶性肿瘤中的一种公认的现象,但在甲状腺癌中相对罕见。在低分化甲状腺癌(pDTC)患者中,最初出现I-131上腔静脉肿瘤(SVC)血栓的情况并不常见,而且可能危及生命。肿瘤血栓既可由原发肿块的直接血管扩张形成,也可由血液扩散形成。混合核成像可以区分两种实体,从而影响患者的治疗计划。我们提出的图像一个有趣的情况下演变的SVC血栓在一个46岁的妇女诊断为pDTC超过两年的跨度。
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引用次数: 0
Gastric Emptying Scintigraphy: Diagnostic Value of Delayed Imaging and the Impact on Reclassification of Diagnosis. 胃排空显像:延迟成像的诊断价值及对重新分类诊断的影响。
IF 0.9 Q3 Medicine Pub Date : 2023-06-20 DOI: 10.4274/mirt.galenos.2021.65902
Mohsen Qutbi, Reyhane Ahmadi, Elinaz Hosseinzadeh, Ali Asadi

Objectives: To investigate the added diagnostic value of delayed imaging at 3 and 4 h compared to 2 h imaging as well as scanning up to 4 h compared to 3, and by this means, diagnosis reclassification or changes in diagnosis across various time points.

Methods: Seventeen patients clinically suspected of gastroparesis, 8 (47.1%) men and 9 (52.9%) women, according to the standard procedural guidelines, underwent gastric emptying scintigraphy after ingesting a standard meal. One-minute static images in anterior and posterior projections were acquired immediately after ingestion and then at 1-, 2-, 3- , and 4 h time points. For image analysis, a manual region-of-interest was drawn, and then, count of stomach in each projection was used to calculate geometric mean for each time point. Decay correction was applied. At 2-, 3- and 4 h time points, percentage of retained activity was compared to standard values; therefore, each patient was labeled as normal or delayed.

Results: Pairwise correlation between time points was statistically significant. Value of hour 3 shows an extremely strong correlation with the value of hour 4 (r=0.951, p<0.001). In hour 2, of 17 participants, 11 (64.7%) were diagnosed as normal and 6 (35.3%) as delayed. In hour 3, the diagnosis made as delayed rose to 9 (52.9%), whereas normal was 8 (47.1%). Finally, in hour 4, results were 10 (58.8%) as delayed and 7 (41.2%) as normal. All subjects who were labeled as delayed in hour 3 remained with the same diagnosis and 1 out of 8 subjects categorized as normal in hour 3 changed to delayed. For testing agreement, coefficient of kappa was computed between each pair. Agreement between diagnosis in hour 2 with hours 3 or 4 was not strong (kappa <0.6 for both pairs). However, a strong agreement was found between diagnosis in hours 3 and 4 (kappa: 0.881).

Conclusion: Because of excellent correlation between values of hours 3 and 4 and strong agreement between the diagnosis in those time points, extending acquisition from 3 to 4 h adds little to the final dai gnosis and may not be noticeably meaningful, especially in the clinical setting.

目的:探讨3和4小时延迟成像与2小时成像相比,以及4小时扫描与3小时相比的附加诊断价值,并通过这种方法,在不同时间点进行诊断重分类或诊断变化。方法:17例临床疑似胃轻瘫患者,其中男性8例(47.1%),女性9例(52.9%),根据标准程序指南,在进食标准膳食后行胃排空显像检查。摄食后立即获取前后投影的1分钟静态图像,然后在1、2、3和4小时时间点获取静态图像。对图像进行分析时,首先绘制人工感兴趣区域,然后利用每个投影中的胃计数计算每个时间点的几何平均值。进行衰减校正。在第2、3和4小时时间点,将保留活性的百分比与标准值进行比较;因此,每个患者被标记为正常或延迟。结果:时间点间两两相关有统计学意义。结论:由于第3小时和第4小时的值具有极好的相关性,并且在这两个时间点的诊断结果非常一致,因此将采集时间从3小时延长到4小时对最终诊断的帮助很小,可能没有明显的意义,特别是在临床环境中。
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引用次数: 0
Polyostotic Fibrous Dysplasia in a Six-year-Old Boy. 6岁男孩多骨纤维发育不良1例。
IF 0.9 Q3 Medicine Pub Date : 2023-06-20 DOI: 10.4274/mirt.galenos.2023.79095
Nevena Manevska, Dushica Todorova-Stefanovski, Smiljana Bundovska Kocev, Sinisha Stojanoski, Tanja Makazlieva

Fibrous dysplasia (FD) is a rare congenital benign bone disease that manifests as a defect in the bone remodeling process, affecting the function, differentiation, and maturation of osteoblasts. This process is located in the bone marrow, where the normal marrow tissue is replaced with immature bone islands and fibrous stroma. The etiology is unclear so far, but it is known to be connected with a point mutation of the gene that encodes Gs α protein at the time of embryogenesis, and because of that, all of the affected somatic cells become dysplastic. It is important to determine whether the mutation occurred earlier in the process of embryogenesis so that there will be more mutant cells and the disease will appear in a more severe form. The clinical presentation of FD is variable, so there are plenty of potential differential diagnoses. The most common include Paget disease, non-ossifying fibroma, osteofibrous dysplasia, aneurysmal bone cyst, adamantinoma, giant cell tumor, fracture callus, and low-grade central osteosarcoma.

纤维结构不良(FD)是一种罕见的先天性良性骨病,表现为骨重塑过程中的缺陷,影响成骨细胞的功能、分化和成熟。这个过程发生在骨髓中,正常的骨髓组织被未成熟的骨岛和纤维间质所取代。病因目前尚不清楚,但已知与胚胎发生时编码Gs α蛋白的基因的点突变有关,因此,所有受影响的体细胞都变得发育不良。重要的是要确定突变是否发生在胚胎发生过程的早期,这样会有更多的突变细胞,疾病会以更严重的形式出现。FD的临床表现是多变的,因此有很多潜在的鉴别诊断。最常见的包括Paget病、非骨化纤维瘤、骨纤维结构不良、动脉瘤样骨囊肿、硬质瘤、巨细胞瘤、骨折骨痂和低度中枢性骨肉瘤。
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引用次数: 0
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Molecular Imaging and Radionuclide Therapy
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