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The role for cochlear implants in microtia and congenital aural atresia: A case report and a review of literature 人工耳蜗在先天性小耳聋和先天性耳锁中的作用:1例报告及文献复习
IF 0.5 Q3 Medicine Pub Date : 2023-02-27 DOI: 10.1177/20101058231160603
W. L. Neo, B. Tan, Adam Ping Meng Tan, Olivia May Ling Wee, J. Thong
Sensorineural hearing loss resulting from microtia and aural atresia is rare due to different embryologic origins of the external and inner ear. Consequently, cochlear implants are seldom performed in patients with microtia and/or aural atresia. Herein we discuss an 8 year-old boy with congenital aural atresia and microtia who underwent cochlear implant surgery for profound hearing loss with good results. A literature review was performed and discussed. Pre-operative planning with high resolution computed tomography and facial nerve monitoring are crucial in identification and preservation of the facial nerve due to the high rate of aberrant anatomy. Careful incision placement is required particularly if pinna reconstruction is considered. Literature review highlighted various surgical approaches as well as different modalities used for intra-operative facial nerve monitoring. Only one patient had intra-operative complications. Cochlear implant is a viable solution in patients with external ear malformations and severe-profound sensorineural hearing loss. Adequate planning and counselling are essential due to the challenges that may occur in microtia and aural atresia.
由于外耳和内耳的胚胎起源不同,由小耳和闭耳引起的感音神经性听力损失是罕见的。因此,耳蜗植入很少用于小耳畸形和/或耳闭锁患者。我们在此讨论一位患有先天性耳闭锁和小耳症的8岁男孩,他接受人工耳蜗手术治疗重度听力损失,效果良好。进行了文献综述并进行了讨论。由于面神经解剖异常率高,术前计划与高分辨率计算机断层扫描和面神经监测对于识别和保存面神经至关重要。尤其考虑耳廓重建时,需要小心切口的放置。文献回顾强调了术中面神经监测的各种手术入路和不同方式。仅有1例患者出现术中并发症。人工耳蜗是外耳畸形和重度感音神经性听力损失患者的一种可行的解决方案。由于小耳症和耳闭锁可能出现的挑战,适当的规划和咨询是必不可少的。
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引用次数: 0
An overview of neurocognitive impairment in older people living with HIV 老年艾滋病毒感染者神经认知障碍的概述
IF 0.5 Q3 Medicine Pub Date : 2023-02-24 DOI: 10.1177/20101058231160605
Rachel QM Ng, KF Yip, YE Teh
With improved survival among People Living with HIV (PLHIV), many are confronted with age associated comorbidities and geriatric syndromes. Neurocognitive impairment is one of the three most frequent conditions that affects quality of life of PLHIV despite achieving viral suppression. Healthcare providers face challenges in early identification of neurocognitive impairment, performing comprehensive assessment and managing older PLHIV. This paper aims to review available evidence regarding aetiology and management of older PLHIV who develop neurocognitive impairment, suggest improvements on current management and postulate future study direction. A PubMed search for original articles and Clinical Guidelines was conducted from September 2021 to August 2022 using a combination of keywords related to neurocognitive impairment in PLHIV. The citations from all selected articles were reviewed for additional studies. Older PLHIV tend to be frailer than their uninfected counterparts, are plagued with multi-morbidity and are at increased risk of cognitive impairment. The aetiologies for neurocognitive impairment are multifactorial, multi-dimensional and complex. The management of neurocognitive impairment in older PLHIV involves identifying and optimizing predisposing factors, physical function, social and psychological health with appropriate care navigation. Identification and management of neurocognitive impairment in older PLHIV through interdisciplinary collaboration among stakeholders is important. This exemplifies an integrated model of care for older PLHIV and promotes the notion of living well beyond viral suppression.
随着艾滋病毒感染者(PLHIV)存活率的提高,许多人面临着与年龄相关的合并症和老年综合征。神经认知障碍是影响PLHIV患者生活质量的三种最常见的情况之一,尽管病毒得到了抑制。医疗保健提供者在早期识别神经认知障碍、进行全面评估和管理老年hiv方面面临挑战。本文旨在回顾有关老年PLHIV发生神经认知障碍的病因和管理方面的现有证据,提出改进当前管理的建议,并设想未来的研究方向。从2021年9月到2022年8月,使用与PLHIV神经认知障碍相关的关键词组合,对PubMed的原始文章和临床指南进行了搜索。对所有入选文章的引用进行了审查,以进行进一步的研究。老年PLHIV感染者往往比未感染的感染者更脆弱,患有多种疾病,认知障碍的风险更高。神经认知障碍的病因是多因素、多维度和复杂的。老年hiv患者神经认知功能障碍的管理包括识别和优化易感因素、身体功能、社会和心理健康以及适当的护理导航。通过利益相关者之间的跨学科合作来识别和管理老年PLHIV患者的神经认知障碍是很重要的。这体现了对老年艾滋病毒感染者的综合护理模式,并促进了生活在病毒抑制之外的概念。
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引用次数: 2
Resting metabolic rate in healthy Singaporeans: Performance of the Harris-Benedict equation and a new predictive model 健康新加坡人的静息代谢率:Harris-Benedict方程的性能和一个新的预测模型
IF 0.5 Q3 Medicine Pub Date : 2023-02-11 DOI: 10.1177/20101058231156628
Natalie Tan, K. Tham, Chun Keong Eric Ho, C. Ng
Prediction equations for resting metabolic rate (RMR) are valuable in managing patients’ weight; however, no accurate equation exists for Singaporeans. To develop and cross-validate a predictive regression equation for RMR in Singaporeans, using indirect calorimetry as the reference method. 104 healthy Singaporeans (34.3 ± 12.2 years) participated, comprising 34 men and 70 women. Anthropometric measurements and demographics information were obtained from participants. RMR was measured via indirect calorimetry (TrueOne 2400 system). Stepwise regression analysis was used to develop the most parsimonious predictive equation. Performance of the equation was evaluated using ordinary least products (OLP) regression and Bland–Altman analysis, whilst internal cross-validation was performed by use of the predicted residual sum of squares (PRESS) method. To compare the new equation with existing ones, the performance of the Harris-Benedict equation was also evaluated. The best predictive equation takes the form RMR(kcal) = 918 + 16.5(weight)-135.7(gender) - 1152(Waist-to-height-ratio) +0.014(International Physical Activity Questionnaire Score), where gender = 1 (female) or 0 (male). OLP regression revealed no systematic bias for the new equation. Bland–Altman analysis showed that its total (systematic and random) error was 212 kcal. Internal model validation using the PRESS method revealed minimal reduction in predictive accuracy. In contrast, OLP regression showed a significant pattern of over-prediction by the Harris-Benedict equation (y-intercept = −280 kcal; 95%CI, −100 to −461 kcal). Our new equation outperformed the Harris-Benedict equation in accurately predicting RMR in Singaporeans. Comprising easily obtained anthropometric and self-reported measures, we envisage its potential relevance in clinical and epidemiological settings.
静息代谢率(RMR)预测方程在管理患者体重方面是有价值的;然而,对于新加坡人来说,没有准确的公式。以间接量热法为参考方法,建立并交叉验证新加坡人RMR预测回归方程。104名健康新加坡人(34.3±12.2岁)参与研究,其中男性34人,女性70人。从参与者那里获得了人体测量数据和人口统计信息。RMR采用间接量热法(TrueOne 2400系统)测量。采用逐步回归分析建立了最简洁的预测方程。使用普通最小积(OLP)回归和Bland-Altman分析对方程的性能进行评估,同时使用预测残差平方和(PRESS)方法进行内部交叉验证。为了将新方程与现有方程进行比较,还对Harris-Benedict方程的性能进行了评价。最佳预测方程为RMR(kcal) = 918 + 16.5(体重)-135.7(性别)- 1152(腰高比)+0.014(国际体育活动问卷得分),其中性别= 1(女性)或0(男性)。OLP回归显示新方程没有系统偏差。Bland-Altman分析显示其总(系统和随机)误差为212千卡。使用PRESS方法的内部模型验证显示预测准确性的最小降低。相比之下,OLP回归显示出哈里斯-本尼迪克特方程(y-截距= - 280 kcal;95%CI,−100 ~−461 kcal)。我们的新方程在准确预测新加坡人的RMR方面优于哈里斯-本尼迪克特方程。包括容易获得的人体测量和自我报告的测量,我们设想其在临床和流行病学设置的潜在相关性。
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引用次数: 0
A pilot study to validate AMTAS in a specialist outpatient clinic at a public restructured hospital in Singapore 在新加坡一家公立重组医院的专科门诊验证AMTAS的试点研究
IF 0.5 Q3 Medicine Pub Date : 2023-02-04 DOI: 10.1177/20101058231154667
Hazel Yeo Kai Hui, Kenneth Chua Wei De, S. Kamath, Steven Lock Hey Lee
The prevalence of age-related hearing loss is expected to increase with the ageing population in Singapore resulting in increased demand for pure tone audiometry (PTA). One way of meeting the increased demand for PTA is the Automated Method of Testing Auditory Sensitivity (AMTAS). Nonetheless, before AMTAS may be implemented, it is important to validate its results by comparing them against those of conventional PTA for the diverse Singaporean population. 100 participants were recruited from the Otorhinolaryngology clinic at a public hospital. PTA was conducted for participants via the conventional method and AMTAS. The hearing thresholds obtained via the two methods were then compared. A feedback questionnaire on the use of AMTAS was also completed by all participants. Air and bone conduction threshold results from 80 participants were analysed. The absolute mean difference in air conduction thresholds obtained via the two methods ranged from 3.30 to 9.62 dB. The absolute mean difference in bone conduction thresholds obtained via the two methods ranged from 8.16 to 9.38 dB. Most participants indicated that the machine was easy to use. Other feedback collected indicated that the AMTAS testing environment was noisy and that testing was fast. This study finds that despite differences in hearing thresholds obtained via AMTAS and manual PTA, these differences are within the acceptable 10 dB test-retest variation. Nonetheless, existing issues related to the AMTAS software and noise levels in the testing environment will need to be addressed before it can be used in the clinic.
随着新加坡人口的老龄化,年龄相关听力损失的患病率预计将增加,从而导致对纯音听力计(PTA)的需求增加。满足PTA日益增长的需求的一种方法是测试听觉灵敏度的自动化方法(AMTAS)。尽管如此,在实施AMTAS之前,重要的是通过将其结果与针对不同新加坡人口的传统PTA进行比较来验证其结果。从一家公立医院的耳鼻喉科诊所招募了100名参与者。通过传统方法和AMTAS对参与者进行PTA。然后比较通过这两种方法获得的听力阈值。所有参与者还完成了关于使用AMTAS的反馈调查表。对80名参与者的空气和骨传导阈值结果进行了分析。通过这两种方法获得的空气传导阈值的绝对平均差在3.30到9.62 dB之间。通过这两个方法获得的骨传导阈值的平均差在8.16到9.38 dB之间。大多数参与者表示该机器易于使用。收集到的其他反馈表明,AMTAS测试环境嘈杂,测试速度快。本研究发现,尽管通过AMTAS和手动PTA获得的听力阈值存在差异,但这些差异在可接受的10dB重测变化范围内。尽管如此,在临床使用之前,仍需要解决与AMTAS软件和测试环境中噪声水平相关的现有问题。
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引用次数: 0
Review of outcomes of combination therapy using yttrium 90 radioembolization and sorafenib/nivolumab for HCC with hepatic vein or IVC invasion 钇90放射栓塞和索拉非尼/纳武单抗联合治疗肝静脉或下腔静脉浸润的HCC的结果综述
IF 0.5 Q3 Medicine Pub Date : 2023-01-28 DOI: 10.1177/20101058231154666
Shiqi Chung, A. Gogna, S. Chandramohan, R. Lo, F. Irani, N. Venkatanarasimha
A systematic review of the outcomes of combination therapy using Yttrium 90 radioembolization (Y90) and sorafenib/nivolumab for patients with hepatocellular carcinoma (HCC), with hepatic vein (HV) or inferior vena cava (IVC) invasion. The aim of this study is to summarise the results of different studies that used the combination therapy for HCC patients with tumor thrombosis involving the HV or IVC. A literature search was performed using keywords in Medline and Google Scholar limited to publications from 2010 to 2021. There were 173 articles identified during the initial literature search. During abstract screening, 81 articles were excluded. Another 83 did not contain information on hepatic vein or IVC invasion. Therefore, 9 articles met the eligibility criteria and were included in the synthesis. In total, 37 patients with hepatic vein or IVC invasion were identified. There were 31 patients who were given sorafenib, 7 were given nivolumab and 1 was given both sorafenib and nivolumab. Among the 37 patients, 21 had hepatic vein invasion, 22 had IVC invasion and 6 had both HV and IVC invasion. The median OS was 20.55 months and median PFS was 8.18 months. For the results, 23 patients were evaluated via modified RECIST (mRECIST) criteria and 14 were evaluated via RECIST 1.1. The combination of local and systemic therapies demonstrated potential results for increased response rates, OS and PFS benefits. Further studies are required to determine the long-term outcomes of the combination therapy for this group of patients.
对肝静脉(HV)或下腔静脉(IVC)侵犯的肝细胞癌(HCC)患者使用钇90放射栓塞(Y90)和索拉非尼/尼武单抗联合治疗的结果进行了系统回顾。本研究的目的是总结不同研究的结果,这些研究使用联合治疗HCC患者合并肿瘤血栓形成累及HV或IVC。使用Medline和谷歌Scholar中的关键词进行文献检索,限于2010年至2021年的出版物。在最初的文献检索中发现了173篇文章。在摘要筛选中,81篇文章被排除。另外83例没有肝静脉或下腔静脉侵犯的信息。因此,有9篇文章符合入选标准,被纳入综合研究。共发现37例肝静脉或下腔静脉侵犯。31例患者接受索拉非尼治疗,7例接受纳武单抗治疗,1例同时接受索拉非尼和纳武单抗治疗。37例患者中,肝静脉侵犯21例,下腔静脉侵犯22例,HV和下腔静脉同时侵犯6例。中位OS为20.55个月,中位PFS为8.18个月。结果,23例患者通过改良的RECIST (mRECIST)标准进行评估,14例患者通过RECIST 1.1进行评估。局部和全身联合治疗显示出提高缓解率、OS和PFS益处的潜在结果。需要进一步的研究来确定这组患者联合治疗的长期结果。
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引用次数: 1
Impact of pharmacist-led collaborative gout clinic on timely achievement of serum uric acid goals 药剂师领导的合作痛风诊所对及时实现血清尿酸目标的影响
IF 0.5 Q3 Medicine Pub Date : 2023-01-19 DOI: 10.1177/20101058231152048
Kah Mun Cheong, M. Sriranganathan, E. Lee
The concept of a pharmacist-led collaborative gout clinic is relatively new in Singapore. This study examined the impact of this pilot shared care model on providing dose titration of urate lowering therapy, gout education and patient support to achieve target serum uric acid (sUA) levels. A retrospective pre-post study was undertaken to compare outcomes in patients who were started on either allopurinol or febuxostat in the 24 months prior to (Group A: Pre implementation) or 33 months following launch of the collaborative gout clinic (Group B: Post implementation). The collaborative gout clinic comprises of a clinical pharmacist under the supervision of a rheumatologist. Of 98 eligible subjects enrolled in our study, there were 50 patients (all prescribed allopurinol) for Group A and 48 patients for Group B (allopurinol n = 29, febuxostat n = 19). Among patients who achieved target sUA level of 360 μmol/L or less at 1 year of drug initiation with use of allopurinol, the median [interquartile range, IQR] time taken to attain target sUA was shorter in Group B than Group A (111 [82–308] days vs. 293 [265–414] days, p = 0.016). As compared to Group A, Group B had lesser patients experiencing gout flare (41.3% vs. 70.0%, p = 0.018) and more patients achieving target sUA (75.9% vs. 22.0%, p < 0.001). Mean ± [standard deviation, SD] daily allopurinol dose to achieve target sUA levels was 276 mg ± [138 mg]. Our results demonstrate the use of a pharmacist-led collaborative gout clinic may help to achieve better clinical outcomes in gout management.
药剂师主导的合作痛风诊所的概念在新加坡相对较新。本研究考察了这种试点共享护理模式对提供降低尿酸盐治疗的剂量滴定、痛风教育和患者支持以达到目标血清尿酸(sUA)水平的影响。进行了一项回顾性前后研究,以比较在合作痛风诊所启动前24个月(A组:实施前)或启动后33个月(B组:实施后)开始服用别嘌呤醇或非布索坦的患者的结果。合作痛风诊所由一名临床药剂师在风湿病学家的监督下组成。在我们研究的98名符合条件的受试者中,A组有50名患者(均为处方别嘌醇),B组有48名患者(别嘌酚n=29,非布索坦n=19)。在使用别嘌醇开始用药1年时达到360μmol/L或更低的sUA目标水平的患者中,B组达到sUA目标所需的中位[四分位间距,IQR]时间比A组短(111[82-308]天对293[265-414]天,p=0.016)。与A组相比,B组发生痛风发作的患者较少(41.3%对70.0%,p=0.018),达到sUA目标的患者较多(75.9%对22.0%,p<0.001)。达到sUA水平的平均值±[标准差,SD]日别嘌醇剂量为276 mg±[138 mg]。我们的研究结果表明,使用药剂师领导的合作痛风诊所可能有助于在痛风管理中取得更好的临床结果。
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引用次数: 0
Atypical fibrous histiocytomas and pleomorphic fibroma-type lesions in a patient with li-fraumeni syndrome 非典型纤维组织细胞瘤和多形性纤维瘤型病变1例li- frameni综合征
IF 0.5 Q3 Medicine Pub Date : 2023-01-18 DOI: 10.1177/20101058231152047
Logaswari M, M. Koh, K. Sittampalam
Atypical fibrous histiocytomas are an uncommon but benign variant of dermatofibroma where the neoplastic cells can feature cytological atypia constituted by prominent nuclear enlargement, pleomorphism and multinucleated giant cells. Though these can have a degree of atypia, they have a benign course and a failure to recognize these tumors as benign can lead to misdiagnosis and overtreatment, particularly in patients with Li-Fraumeni syndrome who are known to be predisposed to various malignancies. Here, we report a patient with atypical fibrous histiocytomas and multiple pleomorphic fibroma-type lesions in the setting of Li-Fraumeni syndrome.
非典型纤维组织细胞瘤是一种罕见但良性的皮肤纤维瘤,其肿瘤细胞具有细胞学上的非典型性,由明显的核增大、多形性和多核巨细胞组成。虽然这些可能有一定程度的非典型性,但它们具有良性病程,未能识别这些肿瘤为良性可能导致误诊和过度治疗,特别是对于已知易患各种恶性肿瘤的Li-Fraumeni综合征患者。在此,我们报告一位患有非典型纤维组织细胞瘤和多发性多形性纤维瘤型病变的Li-Fraumeni综合征患者。
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引用次数: 0
What lies beneath: A case report of Morel-Lavallée lesion 下面是:morel - lavallsamac病变1例报告
IF 0.5 Q3 Medicine Pub Date : 2023-01-17 DOI: 10.1177/20101058231152046
Udayan Joseph, J. R. Thangayah
A Morel-Lavallée lesion is a rare internal degloving injury that patients present with to the Emergency Department (ED) typically following high impact trauma. The diagnosis is often missed due to its uncommon presentation and emphasis on other concomitant injuries that may have occurred as a result of polytrauma. Potential long-term complications from these closed soft-tissue injuries highlight the need for early recognition. We present one such case encountered in our ED and aim to familiarize readers with the presentation, diagnostic and treatment modalities, and challenges emergency physicians might face when encountering patients with such lesions.
morel - lavallsamade病变是一种罕见的内部脱手套损伤,患者通常在高冲击力创伤后出现在急诊科。由于其不常见的表现和强调其他可能因多发创伤而发生的伴发损伤,常被误诊。这些闭合性软组织损伤的潜在长期并发症强调了早期识别的必要性。我们将介绍一个在急诊科遇到的此类病例,目的是让读者熟悉其表现、诊断和治疗方式,以及急诊医生在遇到此类病变患者时可能面临的挑战。
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引用次数: 0
Outcomes of a “hospital at home” programme for the supervised home recovery of COVID-19 patients in Singapore 新加坡为COVID-19患者提供在家康复监督的“家庭医院”计划的结果
IF 0.5 Q3 Medicine Pub Date : 2023-01-15 DOI: 10.1177/20101058231152049
M. Tan, Mary Grace Aller Arciga, Juweita Binte Arba’in, Rachel Marie Towle, S. Lim, Woon Hoe Tang, L. Low
Background The Singapore General Hospital COVID-19 Virtual Ward is a “hospital at home” (HaH) programme for the supervised home recovery of higher-acuity COVID-19 patients from the hospital and the community. Objective To describe how an existing HaH programme was redesigned so that COVID-19 patients could be remotely monitored at home and report the outcomes of the first 100 patients in this Virtual Ward. Methods Patients received an admission package comprising instructions and equipment for home monitoring, and uploaded their parameters into a clinical dashboard via a secure messaging app. Medical staff conducted video or telephone consultations daily. Patients were discharged according to time-based criteria, although some required SARS-CoV-2 PCR testing, which were conducted at home by a third-party medical provider. De-identified data of the first 100 patients were analysed by demographic details, indication for enrolment into the Virtual Ward, and the need for subsequent inpatient readmission. Results Of the first 100 patients admitted into the Virtual Ward, 58 were female, mean age was 63.1 years old (23–95 years), and 76 were fully vaccinated. There were 77 hospital referrals and 23 community referrals. The number of days of inpatient hospitalisation avoided was 717 days (average of 7.9 days per patient). Three hospital referrals (3.9%) were readmitted, while seven community referrals (30.4%) required subsequent hospitalisation. Conclusion The Virtual Ward programme demonstrates that selected COVID-19 patient can safely recover at home with remote medical support and monitoring, thereby expanding hospital capacity.
新加坡总医院COVID-19虚拟病房是一项“家庭医院”(HaH)计划,旨在监督医院和社区的高敏锐度COVID-19患者在家中康复。目的描述如何重新设计现有的HaH方案,以便在家中远程监测COVID-19患者,并报告该虚拟病房前100名患者的结果。方法患者收到入院说明书和家庭监测设备包,并通过安全消息应用程序将入院参数上传到临床仪表板。医务人员每天进行视频或电话咨询。患者根据基于时间的标准出院,尽管有些人需要在家中由第三方医疗提供者进行SARS-CoV-2 PCR检测。前100名患者的去识别数据通过人口学细节、进入虚拟病房的指征以及随后住院患者再入院的需要进行分析。结果虚拟病房前100例患者中,女性58例,平均年龄63.1岁(23 ~ 95岁),接种疫苗76例。医院转诊77例,社区转诊23例。避免住院的天数为717天(平均每名患者7.9天)。3例医院转诊(3.9%)再次入院,而7例社区转诊(30.4%)需要后续住院。结论虚拟病房项目表明,通过远程医疗支持和监测,选定的COVID-19患者可以在家中安全康复,从而扩大医院容量。
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引用次数: 0
Voriconazole-induced arthritis, enthesitis and periostitis 伏立康唑引起的关节炎、附着点炎和骨膜炎
IF 0.5 Q3 Medicine Pub Date : 2023-01-03 DOI: 10.1177/20101058221149575
A. Masnammany, Wendy Lau, P. Wong, N. Manolios
Voriconazole is a fluoride-containing anti-fungal. Prolonged exposure can result in fluoride deposition within the bone extracellular matrix, resulting in periostitis and arthritis. We report a patient who developed widespread bony pain and polyarthralgia while on voriconazole therapy for COVID-19-associated pulmonary aspergillosis. No associated autoimmune rheumatic disease or alternative cause was noted. Blood investigations showed elevated total serum alkaline phosphatase, bone-specific ALP and fluoride levels, with normal serum voriconazole levels. A whole body nuclear bone scan showed multifocal periostitis. A diagnosis of voriconazole-induced periostitis and arthritis was made. Complete resolution of clinical symptoms with normalisation of the serum ALP occurred within four weeks of voriconazole cessation. While voriconazole-induced periostitis/arthritis is a recognised phenomenon in solid organ and haematopoietic stem cell transplant patients on long-term voriconazole, this case highlights the importance of having a high index of suspicion in other settings including CAPA. Clinical presentation can be mistaken for bony metastatic disease or other inflammatory arthritis.
伏立康唑是一种含氟的抗真菌药物。长期暴露会导致氟沉积在骨细胞外基质中,导致骨膜炎和关节炎。我们报告了一名患者,他在接受伏立康唑治疗COVID-19相关肺曲膜炎时出现广泛的骨痛和多关节痛。没有发现相关的自身免疫性风湿性疾病或其他原因。血液检查显示血清总碱性磷酸酶、骨特异性碱性磷酸酶和氟化物水平升高,血清伏立康唑水平正常。全身核骨扫描显示多灶性骨膜炎。诊断为伏立康唑引起的骨膜炎和关节炎。伏立康唑停用后四周内,临床症状完全缓解,血清ALP正常化。虽然伏立康唑诱导的骨膜炎/关节炎在长期服用伏立康唑的实体器官和造血干细胞移植患者中是一种公认的现象,但该病例突出了在包括CAPA在内的其他情况下具有高怀疑指数的重要性。临床表现可能被误认为是骨转移性疾病或其他炎性关节炎。
{"title":"Voriconazole-induced arthritis, enthesitis and periostitis","authors":"A. Masnammany, Wendy Lau, P. Wong, N. Manolios","doi":"10.1177/20101058221149575","DOIUrl":"https://doi.org/10.1177/20101058221149575","url":null,"abstract":"Voriconazole is a fluoride-containing anti-fungal. Prolonged exposure can result in fluoride deposition within the bone extracellular matrix, resulting in periostitis and arthritis. We report a patient who developed widespread bony pain and polyarthralgia while on voriconazole therapy for COVID-19-associated pulmonary aspergillosis. No associated autoimmune rheumatic disease or alternative cause was noted. Blood investigations showed elevated total serum alkaline phosphatase, bone-specific ALP and fluoride levels, with normal serum voriconazole levels. A whole body nuclear bone scan showed multifocal periostitis. A diagnosis of voriconazole-induced periostitis and arthritis was made. Complete resolution of clinical symptoms with normalisation of the serum ALP occurred within four weeks of voriconazole cessation. While voriconazole-induced periostitis/arthritis is a recognised phenomenon in solid organ and haematopoietic stem cell transplant patients on long-term voriconazole, this case highlights the importance of having a high index of suspicion in other settings including CAPA. Clinical presentation can be mistaken for bony metastatic disease or other inflammatory arthritis.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47189440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Proceedings of Singapore Healthcare
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