Pub Date : 2022-06-01DOI: 10.1177/20101058221117891
Tomoki Nakagawa, R. Masuda, Hiraiwa Shinichiro, S. Yamada, M. Iwazaki
An 81-year-old man was admitted for resection of an asymptomatic left anterior mediastinal tumor. Chest computed tomography showed that a small, homogeneous lesion had grown to a large, cystic lesion (80 mm) over a 5-year period. The cystic tumor was removed with adherent structures such as the left upper pulmonary parenchyma and lower part of the left innominate vein via median sternotomy with assistance from a left thoracoscopic procedure. Macroscopically, a solid tumor was located within the large multilocular cyst. The pathological diagnosis was cystic squamous cell carcinoma (12 mm), which had not infiltrated any surrounding organs. The patient has remained well without recurrence as of 4 years postoperatively.
{"title":"Thymic squamous cell carcinoma lurking in a growing large cyst: A case report","authors":"Tomoki Nakagawa, R. Masuda, Hiraiwa Shinichiro, S. Yamada, M. Iwazaki","doi":"10.1177/20101058221117891","DOIUrl":"https://doi.org/10.1177/20101058221117891","url":null,"abstract":"An 81-year-old man was admitted for resection of an asymptomatic left anterior mediastinal tumor. Chest computed tomography showed that a small, homogeneous lesion had grown to a large, cystic lesion (80 mm) over a 5-year period. The cystic tumor was removed with adherent structures such as the left upper pulmonary parenchyma and lower part of the left innominate vein via median sternotomy with assistance from a left thoracoscopic procedure. Macroscopically, a solid tumor was located within the large multilocular cyst. The pathological diagnosis was cystic squamous cell carcinoma (12 mm), which had not infiltrated any surrounding organs. The patient has remained well without recurrence as of 4 years postoperatively.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45278142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/20101058221147755
A. Masnammany, Wendy Lau, P. Wong, N. Manolios
Tumour necrosis factor inhibitors (TNFis) can trigger autoantibody formation and, in a small proportion of patients, result in symptomatic autoimmune diseases, including polymyositis and dermatomyositis. Focal myositis presents with localized muscle pain and is diagnosed based on magnetic resonance imaging (MRI), electromyography (EMG) and muscle histopathology. We report the first case of TNFi-induced focal myositis in the left thigh of a patient with ulcerative colitis on infliximab. A 30-year-old lady presented with left thigh pain with no other systemic manifestation or muscle weakness. The immunology profile showed positivity of antinuclear antibody (ANA), high titre of anti-ds-DNA, and anti-Mi-2 without any features of systemic lupus erythematosus or dermatomyositis. Discontinuation of the TNFi and commencement of glucocorticoids resulted in the resolution of the myositis.
{"title":"Anti tumor necrosis factor induced focal myositis","authors":"A. Masnammany, Wendy Lau, P. Wong, N. Manolios","doi":"10.1177/20101058221147755","DOIUrl":"https://doi.org/10.1177/20101058221147755","url":null,"abstract":"Tumour necrosis factor inhibitors (TNFis) can trigger autoantibody formation and, in a small proportion of patients, result in symptomatic autoimmune diseases, including polymyositis and dermatomyositis. Focal myositis presents with localized muscle pain and is diagnosed based on magnetic resonance imaging (MRI), electromyography (EMG) and muscle histopathology. We report the first case of TNFi-induced focal myositis in the left thigh of a patient with ulcerative colitis on infliximab. A 30-year-old lady presented with left thigh pain with no other systemic manifestation or muscle weakness. The immunology profile showed positivity of antinuclear antibody (ANA), high titre of anti-ds-DNA, and anti-Mi-2 without any features of systemic lupus erythematosus or dermatomyositis. Discontinuation of the TNFi and commencement of glucocorticoids resulted in the resolution of the myositis.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48276889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/20101058221144113
M. Jahanbakhsh, M. Amini-Rarani, Shahram Tahmasebian, Masoumeh Shahbazi
Objective The Bring Your Own Device (BYOD) approach has promoted the usage of personal mobile devices for organizational and carrier purposes. Applying a BYOD approach might provide various challenges for healthcare organizations. This study endeavored to identify the attributes of hospitals readiness in applying BYOD and to rank these attributes in order to develop appropriate policies for dealing with challenges. Materials and methods This study is an explanatory sequential mixed method design that was carried out in two qualitative and quantitative phases for identifying the BYOD attributes and ranking them, respectively. Semi-structured interviews with 15 experts in the BYOD field were performed through in the qualitative phase. Purposive and snowball sampling approaches were used to choose experts. Thematic analysis was used to analyze qualitative data. The identified attributes were ranked in a quantitative phase by asking 10 experts using fuzzy hierarchical analysis. Results Six main themes and 23 subthemes were identified. The findings of hierarchical analysis showed that ethical considerations, management principles, human resources, legislation considerations, cost, and technical infrastructure as the six main themes, respectively, have priority in hospitals readiness for BYOD. Conclusion Addressing the highlighted priorities, from ethical considerations to technical infrastructure, in the formulation and implementation of formal programs and policies by health managers and authorities will prepare hospitals for the use of BYOD while decreasing the challenges associated with it.
{"title":"Identifying and ranking the attributes of hospitals readiness to apply bring your own device: An explanatory sequential mixed study","authors":"M. Jahanbakhsh, M. Amini-Rarani, Shahram Tahmasebian, Masoumeh Shahbazi","doi":"10.1177/20101058221144113","DOIUrl":"https://doi.org/10.1177/20101058221144113","url":null,"abstract":"Objective The Bring Your Own Device (BYOD) approach has promoted the usage of personal mobile devices for organizational and carrier purposes. Applying a BYOD approach might provide various challenges for healthcare organizations. This study endeavored to identify the attributes of hospitals readiness in applying BYOD and to rank these attributes in order to develop appropriate policies for dealing with challenges. Materials and methods This study is an explanatory sequential mixed method design that was carried out in two qualitative and quantitative phases for identifying the BYOD attributes and ranking them, respectively. Semi-structured interviews with 15 experts in the BYOD field were performed through in the qualitative phase. Purposive and snowball sampling approaches were used to choose experts. Thematic analysis was used to analyze qualitative data. The identified attributes were ranked in a quantitative phase by asking 10 experts using fuzzy hierarchical analysis. Results Six main themes and 23 subthemes were identified. The findings of hierarchical analysis showed that ethical considerations, management principles, human resources, legislation considerations, cost, and technical infrastructure as the six main themes, respectively, have priority in hospitals readiness for BYOD. Conclusion Addressing the highlighted priorities, from ethical considerations to technical infrastructure, in the formulation and implementation of formal programs and policies by health managers and authorities will prepare hospitals for the use of BYOD while decreasing the challenges associated with it.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43048533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/20101058221094864
Xiaomei Zheng, Mei En Joy Yeo, Charles Chin Han Lew
Background: In patients who underwent lower limb amputation (LLA), the prevalence of malnutrition and its association with clinical outcomes are unclear. Objectives: This systematic review aims to identify literature and summarise existing information on (1) the prevalence of malnutrition in the patients with LLA and (2) the association between pre-operative nutritional status and post-surgery clinical outcomes in patients who require amputation. Methods: A search was conducted in four electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, CINAHL and Scopus) to identify eligible studies. The search strategy was based on keywords – amputation, malnutrition and undernutrition. Article were included regardless of the study design; and if they were written in English; included adult patients with lower limb or foot amputation; and performed pre-amputation nutrition assessments. Results: Seven articles met the eligibility criteria. Malnutrition was assessed by biochemistry and/or anthropometry – none of which are validated nutrition assessment tools. Nevertheless, abnormal biochemistry and/or anthropometry results were associated with delayed wound healing, complications and failed amputation compared to normal ranges. The association between abnormal biochemistry and/or anthropometry parameters and mortality was less consistent. Only one study used a validated nutrition screen tool and found half of the population with LLA were at risk of malnutrition, but no association was reported. Conclusions: The association between malnutrition and clinical outcomes in patients who underwent LLA remains unclear as all the eligible studies that investigated association used unvalidated nutrition assessment tools. There is an urgent need to address this knowledge gap in future research.
背景：在接受下肢截肢（LLA）的患者中，营养不良的患病率及其与临床结果的关系尚不清楚。目的：本系统综述旨在确定文献并总结现有信息：（1）LLA患者营养不良的患病率；（2）需要截肢的患者术前营养状况与术后临床结果之间的关系。方法：在四个电子数据库（Cochrane Central Register of Controlled Trials（Central）、PubMed、CINAHL和Scopus）中进行搜索，以确定符合条件的研究。搜索策略基于关键词——截肢、营养不良和营养不良。无论研究设计如何，均包括文章；如果它们是用英语写的；包括下肢或足部截肢的成年患者；并进行截肢前营养评估。结果：7篇文章符合资格标准。营养不良通过生物化学和/或人体测量法进行评估——这些都不是经过验证的营养评估工具。然而，与正常范围相比，异常的生物化学和/或人体测量结果与伤口愈合延迟、并发症和截肢失败有关。异常生物化学和/或人体测量参数与死亡率之间的相关性不太一致。只有一项研究使用了经过验证的营养筛查工具，发现半数LLA患者有营养不良的风险，但没有相关报告。结论：LLA患者的营养不良与临床结果之间的相关性尚不清楚，因为所有调查相关性的合格研究都使用了未经验证的营养评估工具。在未来的研究中，迫切需要解决这一知识差距。
{"title":"The association between pre-operative malnutrition and post-amputation clinical outcomes: A systematic review","authors":"Xiaomei Zheng, Mei En Joy Yeo, Charles Chin Han Lew","doi":"10.1177/20101058221094864","DOIUrl":"https://doi.org/10.1177/20101058221094864","url":null,"abstract":"Background: In patients who underwent lower limb amputation (LLA), the prevalence of malnutrition and its association with clinical outcomes are unclear. Objectives: This systematic review aims to identify literature and summarise existing information on (1) the prevalence of malnutrition in the patients with LLA and (2) the association between pre-operative nutritional status and post-surgery clinical outcomes in patients who require amputation. Methods: A search was conducted in four electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, CINAHL and Scopus) to identify eligible studies. The search strategy was based on keywords – amputation, malnutrition and undernutrition. Article were included regardless of the study design; and if they were written in English; included adult patients with lower limb or foot amputation; and performed pre-amputation nutrition assessments. Results: Seven articles met the eligibility criteria. Malnutrition was assessed by biochemistry and/or anthropometry – none of which are validated nutrition assessment tools. Nevertheless, abnormal biochemistry and/or anthropometry results were associated with delayed wound healing, complications and failed amputation compared to normal ranges. The association between abnormal biochemistry and/or anthropometry parameters and mortality was less consistent. Only one study used a validated nutrition screen tool and found half of the population with LLA were at risk of malnutrition, but no association was reported. Conclusions: The association between malnutrition and clinical outcomes in patients who underwent LLA remains unclear as all the eligible studies that investigated association used unvalidated nutrition assessment tools. There is an urgent need to address this knowledge gap in future research.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44095563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/20101058221144111
Kuan Yau Yeh, Asyif Fairus Ahmad, A. Alaga
Phantom tumour, vanishing tumour, and pseudotumour of the lung are terms used to describe the tumour appearance on a chest radiograph of a decompensated heart failure patient, which typically disappears after appropriate treatment of their underlying condition. It is a loculated pleural effusion in the fissures that gives rise to the tumour appearance on the chest radiograph of a patient with heart failure. Its existence might mislead the diagnosis, resulting in unnecessary invasive diagnostic investigations done on the patient. We present a case of a 64 year-old male with multiple co-morbidities presenting with dyspnea, loss of weight, and loss of appetite. A chest radiograph showed homogenous opacity over the right lower zone with cardiomegaly, raising the suspicion of a lung mass apart from heart failure. It disappeared after appropriate diuretic treatment. The computed tomography (CT) thorax, which was planned by the primary team, subsequently showed no lung mass. Hence, a high index of suspicion of phantom tumour is important when a lung mass is noted on a chest radiograph of a patient clinically presented with heart failure. This is because exposure to ionising radiation from CT is completely avoidable with just appropriate treatment of fluid overload. However, CT is still the best modality for assisting physicians in a doubtful case.
{"title":"Lung mass in patient with congestive heart failure – Now you see it, now you don’t !","authors":"Kuan Yau Yeh, Asyif Fairus Ahmad, A. Alaga","doi":"10.1177/20101058221144111","DOIUrl":"https://doi.org/10.1177/20101058221144111","url":null,"abstract":"Phantom tumour, vanishing tumour, and pseudotumour of the lung are terms used to describe the tumour appearance on a chest radiograph of a decompensated heart failure patient, which typically disappears after appropriate treatment of their underlying condition. It is a loculated pleural effusion in the fissures that gives rise to the tumour appearance on the chest radiograph of a patient with heart failure. Its existence might mislead the diagnosis, resulting in unnecessary invasive diagnostic investigations done on the patient. We present a case of a 64 year-old male with multiple co-morbidities presenting with dyspnea, loss of weight, and loss of appetite. A chest radiograph showed homogenous opacity over the right lower zone with cardiomegaly, raising the suspicion of a lung mass apart from heart failure. It disappeared after appropriate diuretic treatment. The computed tomography (CT) thorax, which was planned by the primary team, subsequently showed no lung mass. Hence, a high index of suspicion of phantom tumour is important when a lung mass is noted on a chest radiograph of a patient clinically presented with heart failure. This is because exposure to ionising radiation from CT is completely avoidable with just appropriate treatment of fluid overload. However, CT is still the best modality for assisting physicians in a doubtful case.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":"31 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41557630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/20101058221138840
Kamalesh Anbalakan, K. Chew, J. Loh, D. Sim, S. Lai, Louis Teo Loon Yee
Background Survival after heart transplantation (HT) has improved considerably since the first HT was performed in 1967 in Cape Town, South Africa. Understanding immunology behind organ rejection has paved way for advances in the assessment of pre-transplant compatibility, development of newer and more specific immunosuppressive drugs, and management of rejection. Objectives Unlike medical therapy for heart failure, transplant protocols vary considerably between different centers. These variations in protocols generally reflect unique population characteristics and the availability of resources. This review article aims to provide a consolidated update on contemporary cardiac transplant medicine. We also aim to highlight local practice and its difference from our international counterparts. Methods A literature search was performed on Pubmed and Cochrane Central Register of Controlled Trials to identify trials and review articles that discussed heart transplant immunology and protocols. The International Society for Heart and Lung Transplant (ISHLT) guidelines were also reviewed. We focused on risk factors, prevention strategies, and treatment of cardiac rejection. Results A total of 48 articles were selected to provide a comprehensive overview of the contemporary practice of cardiac transplant immunosuppressive therapy. Comparisons were made with local data and practice protocols to highlight key differences. Conclusion Heart transplant covers a small subset of cardiac patients and much of the evidence is derived from empirical observations and retrospective analysis. This accounts for the heterogeneity in care and treatment protocols. More studies are needed to select best practices from around the world to further improve outcomes.
{"title":"Contemporary review of heart transplant immunology and immunosuppressive therapy","authors":"Kamalesh Anbalakan, K. Chew, J. Loh, D. Sim, S. Lai, Louis Teo Loon Yee","doi":"10.1177/20101058221138840","DOIUrl":"https://doi.org/10.1177/20101058221138840","url":null,"abstract":"Background Survival after heart transplantation (HT) has improved considerably since the first HT was performed in 1967 in Cape Town, South Africa. Understanding immunology behind organ rejection has paved way for advances in the assessment of pre-transplant compatibility, development of newer and more specific immunosuppressive drugs, and management of rejection. Objectives Unlike medical therapy for heart failure, transplant protocols vary considerably between different centers. These variations in protocols generally reflect unique population characteristics and the availability of resources. This review article aims to provide a consolidated update on contemporary cardiac transplant medicine. We also aim to highlight local practice and its difference from our international counterparts. Methods A literature search was performed on Pubmed and Cochrane Central Register of Controlled Trials to identify trials and review articles that discussed heart transplant immunology and protocols. The International Society for Heart and Lung Transplant (ISHLT) guidelines were also reviewed. We focused on risk factors, prevention strategies, and treatment of cardiac rejection. Results A total of 48 articles were selected to provide a comprehensive overview of the contemporary practice of cardiac transplant immunosuppressive therapy. Comparisons were made with local data and practice protocols to highlight key differences. Conclusion Heart transplant covers a small subset of cardiac patients and much of the evidence is derived from empirical observations and retrospective analysis. This accounts for the heterogeneity in care and treatment protocols. More studies are needed to select best practices from around the world to further improve outcomes.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45383361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/20101058221111575
Andy Sing Ong Tang, Kok Choon Cheah, T. S. Leong, L. Chew
The literature on methaemoglobinaemia in pregnancy is scarce, imposing clinical challenges to both obstetricians and haematologists. We report a total of nine pregnancies with methaemoglobinaemia treated in our centre. Their methaemoglobin levels, mode of delivery, pregnancy management and outcome were summarized.
{"title":"Methaemoglobinaemia in pregnancy: Real world experience in a single centre in Malaysia","authors":"Andy Sing Ong Tang, Kok Choon Cheah, T. S. Leong, L. Chew","doi":"10.1177/20101058221111575","DOIUrl":"https://doi.org/10.1177/20101058221111575","url":null,"abstract":"The literature on methaemoglobinaemia in pregnancy is scarce, imposing clinical challenges to both obstetricians and haematologists. We report a total of nine pregnancies with methaemoglobinaemia treated in our centre. Their methaemoglobin levels, mode of delivery, pregnancy management and outcome were summarized.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48178751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Inpatient sleep quality is influenced by multiple factors including medical conditions, use of medication and the ward environment. Without adequate rest, detrimental effects on patients’ physical and psychological performances may persist, inhibiting recovery and increasing length of stay. Objective This study examined the sleep quality of adult inpatients and its’ associations with sociodemographic, clinical and environmental factors. Methods An observational study was conducted in the medical wards of an acute care hospital in Singapore from July to December 2018. Patients completed the Pittsburgh Sleep Quality Index (PSQI) to establish baseline sleeping habits and the Richards-Campbell Sleep Questionnaire (RCSQ) to assess perception of sleep quality during hospitalisation. Noise levels were measured using the SL-4023SD sound level meter. Environmental factors affecting sleep were also recorded. Results 52 patients were recruited reported a mean RCSQ score of 5.83 (SD = 2.31) and mean Global PSQI score was 6.06 (SD = 3.33), indicative of poor baseline sleep. The highest mean noise level presented with an average reading of 80 dB, surpassing the WHO recommended noise levels by two times. Subjective sleep quality was not affected by demographic, clinical factors and bed locations. Patients exposed to night lamps reported a reduction in sleep quality (p = .04). Conclusions Recognising the importance of overall sleep quality and the identification of external factors influencing patients’ sleep quality during hospitalisation is a vital step towards developing successful interventions to promote good sleep hygiene in the general wards of the Asian context.
{"title":"Subjective sleep quality among hospitalised adult patients: An observational, cross-sectional study","authors":"Siti Nadiah Binte Arman, YingHui Lee, Violeta Lopez, Siew Hoon Lim","doi":"10.1177/20101058221111664","DOIUrl":"https://doi.org/10.1177/20101058221111664","url":null,"abstract":"Background Inpatient sleep quality is influenced by multiple factors including medical conditions, use of medication and the ward environment. Without adequate rest, detrimental effects on patients’ physical and psychological performances may persist, inhibiting recovery and increasing length of stay. Objective This study examined the sleep quality of adult inpatients and its’ associations with sociodemographic, clinical and environmental factors. Methods An observational study was conducted in the medical wards of an acute care hospital in Singapore from July to December 2018. Patients completed the Pittsburgh Sleep Quality Index (PSQI) to establish baseline sleeping habits and the Richards-Campbell Sleep Questionnaire (RCSQ) to assess perception of sleep quality during hospitalisation. Noise levels were measured using the SL-4023SD sound level meter. Environmental factors affecting sleep were also recorded. Results 52 patients were recruited reported a mean RCSQ score of 5.83 (SD = 2.31) and mean Global PSQI score was 6.06 (SD = 3.33), indicative of poor baseline sleep. The highest mean noise level presented with an average reading of 80 dB, surpassing the WHO recommended noise levels by two times. Subjective sleep quality was not affected by demographic, clinical factors and bed locations. Patients exposed to night lamps reported a reduction in sleep quality (p = .04). Conclusions Recognising the importance of overall sleep quality and the identification of external factors influencing patients’ sleep quality during hospitalisation is a vital step towards developing successful interventions to promote good sleep hygiene in the general wards of the Asian context.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48239493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/20101058221111576
Hajime Watanabe, A. Wada, Tomoki Nakagawa, R. Masuda, S. Yamada, M. Iwazaki
We report on a rare case of thoracoscopic surgery for a patient with an aberrant pulmonary artery of the inferior lobar branch (A7) in the right lower lobe. A 69-year-old woman presented with a chief complaint of an abnormal shadow on chest radiography. Computed tomography (CT) revealed a 14-mm solid nodule in the right lower lobe. The patient was diagnosed with lung cancer by bronchoscopic biopsy, and a surgery was planned. Preoperative thin-slice CT and three-dimensional CT showed an aberrant A7 branching from the right main pulmonary artery. The right lower lobe and lymph node dissection was performed safely under a video view. Preoperative evaluation of this anomaly is important for a safe surgery.
{"title":"Thoracoscopic lobectomy for an aberrant pulmonary artery of mediastinal inferior lobar branch: A case report","authors":"Hajime Watanabe, A. Wada, Tomoki Nakagawa, R. Masuda, S. Yamada, M. Iwazaki","doi":"10.1177/20101058221111576","DOIUrl":"https://doi.org/10.1177/20101058221111576","url":null,"abstract":"We report on a rare case of thoracoscopic surgery for a patient with an aberrant pulmonary artery of the inferior lobar branch (A7) in the right lower lobe. A 69-year-old woman presented with a chief complaint of an abnormal shadow on chest radiography. Computed tomography (CT) revealed a 14-mm solid nodule in the right lower lobe. The patient was diagnosed with lung cancer by bronchoscopic biopsy, and a surgery was planned. Preoperative thin-slice CT and three-dimensional CT showed an aberrant A7 branching from the right main pulmonary artery. The right lower lobe and lymph node dissection was performed safely under a video view. Preoperative evaluation of this anomaly is important for a safe surgery.","PeriodicalId":44685,"journal":{"name":"Proceedings of Singapore Healthcare","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46010665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1177/20101058221144115
Bee Ling Kelly Chng, Wei Heng, Yu Ming Soon, J. S. Hon, Y. Lau, R. Tan, J. Tan
Introduction PCSK9 inhibitors demonstrated their effectiveness in reducing low-density lipoprotein cholesterol (LDL-C) and cardiovascular events in landmark trials. It remains unclear whether the results can be translated to Asian populations. This study was designed to assess the real-world safety, adherence and efficacy of PCSK9 inhibitors. Methods A retrospective review for patients newly initiated on PCSK9 inhibitors between 1st June 2017 and 31st July 2021 was conducted in a tertiary cardiology centre. Patients aged ≥ 21 years with a minimum one-month follow-up were included. Adverse drug reactions (ADRs), drug discontinuation, adherence patterns and efficacy between evolocumab and alirocumab groups were compared. Multivariable and propensity score adjusted Cox regression analyses were applied to analyse the outcomes. Results Of 87 patients screened, 80 (51 evolocumab; 29 alirocumab) were included. There were no significant differences between evolocumab and alirocumab groups in ADRs (11.8% vs 3.4%, adjusted HR, 2.97; 95% CI, 0.34 – 25.89 in multivariable analysis; adjusted HR, 3.24; 95% CI, 0.38–27.69 after propensity score adjustment) and discontinuation rates (27.5% vs 34.5%, adjusted HR, 0.89; 95% CI, 0.40–2.02 in multivariable analysis; adjusted HR, 0.88; 95% CI, 0.39–1.99 after propensity score adjustment). High medication cost was the main reason for discontinuation. One-third of patients had inadequate adherence to PCSK9 inhibitors. Both groups showed significant reductions of LDL-C compared to baseline. Conclusions PCSK9 inhibitors are efficacious, safe and well tolerated. Further studies are warranted to examine the cost-effectiveness of PCSK9 inhibitors to rationalise their sustainable use for cardiovascular prevention.
具有里程碑意义的试验表明PCSK9抑制剂在降低低密度脂蛋白胆固醇(LDL-C)和心血管事件方面具有有效性。目前尚不清楚该结果是否适用于亚洲人群。本研究旨在评估PCSK9抑制剂在现实世界中的安全性、依从性和有效性。方法回顾性分析2017年6月1日至2021年7月31日在三级心脏病中心新开始使用PCSK9抑制剂的患者。患者年龄≥21岁，随访至少1个月。比较evolocumab组和alirocumab组之间的药物不良反应(adr)、停药、依从模式和疗效。采用多变量和倾向评分校正Cox回归分析对结果进行分析。结果在87例患者中，80例(51例evolocumab;纳入29例alirocumab)。evolocumab组和alirocumab组在adr方面无显著差异(11.8% vs 3.4%，调整HR, 2.97;多变量分析95% CI为0.34 ~ 25.89;调整后的HR为3.24;倾向评分调整后95% CI, 0.38-27.69)和停药率(27.5% vs 34.5%，调整后HR, 0.89;多变量分析95% CI为0.40-2.02;调整后的HR为0.88;95% CI, 0.39-1.99后倾向评分调整)。药物费用高是导致停药的主要原因。三分之一的患者对PCSK9抑制剂的依从性不足。与基线相比，两组的LDL-C均显著降低。结论PCSK9抑制剂有效、安全、耐受性好。有必要进一步研究PCSK9抑制剂的成本效益，以使其用于心血管预防的可持续使用合理化。
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