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Multiple benefits of added computed tomography for myocardial perfusion imaging in patients with psoriasis. 银屑病患者心肌灌注显像增加计算机断层扫描的多重益处。
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0032
Joseph C Lee, Alaa Alghamry
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引用次数: 0
Relationship between cerebral blood flow reduction patterns on scintigraphy and nonmotor symptoms in new-onset Lewy body disease. 新发路易体病脑血流减少模式与非运动症状的关系
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0005
Yukinori Okada, Makoto Shiraishi, Koji Hori, Keiichro Yamaguchi, Yasuhiro Hasegawa

Background: This study aimed to investigate the relationship between patterns of reduced cerebral blood flow (CBF) evaluated by means of 123I-N-isopropyl-p-iodoamphetamine ([123I]IMP) scintigraphy and nonmotor symptoms in new-onset Lewy body disease (Parkinson's disease and dementia with Lewy bodies [DLB]).

Material and methods: Twenty-four patients diagnosed with new-onset Parkinson's disease or DLB underwent [123I]IMP CBF scintigraphy at St. Marianna Medical University Hospital between January 1, 2010, and March 30, 2018. The reductions in CBF in various brain regions were analyzed using the three-dimensional stereotactic surface projection method and were compared to standard database values, yielding extent values (%). The extent values were evaluated in relation to the presence/absence of motor or nonmotor symptoms such as visual hallucinations, auditory hallucinations, delirium, depression, delusions, and dementia.

Results: The extent value was 100% in the angular, supramarginal, and lingual gyri; 95% in the orbital gyri; and 92.6% in the fusiform gyri. The extent value in patients without hallucinations and those with visual hallucinations was 41.2% and 54.3%, respectively, in the frontal lobe (p = 0.02) and 33.3% and 51.0%, respectively, in the medial prefrontal gyri (p = 0.02). Age-adjusted multivariate analysis showed that extent values in the frontal lobe were associated with visual hallucinations (odds ratio: 1.09, 95% confidence interval 1.00-1.18, p = 0.04).

Conclusions: The above results show that the CBF is reduced in several areas of the cerebral cortex and suggest an association between reduced blood flow in the frontal lobe and the appearance of visual hallucinations in patients with new-onset DLB.

背景:本研究旨在探讨用123I- n -异丙基-对碘安非他明([123I]IMP)显像评估的脑血流量减少(CBF)模式与新发路易体病(帕金森病和伴路易体痴呆[DLB])非运动症状的关系。材料和方法:2010年1月1日至2018年3月30日,24例诊断为新发帕金森病或DLB的患者在St. Marianna Medical University Hospital接受了[123I]IMP CBF扫描。使用三维立体定向表面投影法分析脑CBF在不同脑区的减少,并与标准数据库值进行比较,得出幅度值(%)。评估程度值与运动或非运动症状的有无相关,如视幻觉、幻听、谵妄、抑郁、妄想和痴呆。结果:角回、缘上回和舌回的程度值均为100%;95%在眶回;92.6%在梭状回。无幻觉和视幻觉患者在额叶的程度值分别为41.2%和54.3% (p = 0.02),在前额内侧回的程度值分别为33.3%和51.0% (p = 0.02)。经年龄调整的多变量分析显示,额叶的范围值与视幻觉有关(优势比:1.09,95%可信区间1.00-1.18,p = 0.04)。结论:上述结果表明,脑血流在大脑皮层的几个区域减少,提示新发DLB患者额叶血流量减少与视觉幻觉的出现之间存在关联。
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引用次数: 1
Myocardial perfusion imaging using single-photon emission computed tomography with cadmium-zinc-telluride technology. 采用碲化镉锌技术的单光子发射计算机断层扫描心肌灌注成像。
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 Epub Date: 2022-07-18 DOI: 10.5603/NMR.a2022.0025
Sonia J Konsek-Komorowska, Mariola Peczkowska, Jaroslaw B Cwikła

Myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is a well-established diagnostic approach for patients with suspected or confirmed coronary artery disease (CAD). In the present century, nuclear cardiology has benefited immensely from advances in imaging instrumentation and technology. Dedicated cardiac SPECT cameras incorporating novel, highly efficient cadmium-zinc-telluride (CZT) detectors, collimators, and system designs have evolved as a result of the expansion of nuclear cardiology. A vast amount of evidence is emerging, demonstrating the new technology's advantages over the traditional gamma cameras. Myocardial perfusion imaging (MPI) using gamma-cameras with CZT detectors may be performed with the limited injected activity of radiotracer and recorded times. The use of CZT's dynamic acquisition of myocardial perfusion imaging in clinical practice may help cardiologists in detecting hemodynamically significant CAD. In this article, we present the current state of knowledge on cardiac CZT-SPECT scanners, a summary of the literature published on validation studies, radiation dose reduction, and dynamic acquisition, as well as a comparison of conventional myocardial perfusion imaging with invasive coronary angiography.

单光子发射计算机断层扫描(SPECT)心肌灌注成像(MPI)是一种公认的诊断疑似或确诊冠状动脉疾病(CAD)的方法。在本世纪,核心脏病学从成像仪器和技术的进步中受益匪浅。专用心脏SPECT相机结合新颖,高效的镉锌碲化(CZT)探测器,准直器和系统设计已经演变为核心脏病学的扩展的结果。大量的证据正在出现,证明了新技术比传统伽马相机的优势。心肌灌注成像(MPI)可以用带有CZT检测器的伽马照相机在有限的放射性示踪剂注入活度和记录时间下进行。在临床实践中使用CZT的动态获取心肌灌注成像可以帮助心脏病学家检测血液动力学上显著的CAD。在这篇文章中,我们介绍了心脏CZT-SPECT扫描仪的现状,对验证研究、辐射剂量降低和动态采集方面发表的文献进行了总结,并对传统心肌灌注成像和有创冠状动脉造影进行了比较。
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引用次数: 0
Efficacy of long-term ultrasonography in follow-up of patients with papillary thyroid carcinoma: a case of neck metastasis developed 19 years following primary treatment. 长期超声检查在甲状腺乳头状癌患者随访中的疗效:1例初次治疗后19年发生颈部转移。
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0011
Vlatka Jozanovic, Sanja Kusacic Kuna, Marija Despot, Tatjana Samardzic, Drazen Huic

The cases of relapse in papillary thyroid cancer patients who were initially considered low-risk and for many years were without signs of the disease are extremely rare, but exist. This is supported by the clinical case of a patient who underwent a total thyroidectomy due to papillary thyroid cancer and 19 years later metastasis with extracapsular spreading in a presumed thyroid place was revealed. Due to such cases, the importance of long-term ultrasound monitoring is emphasized.

甲状腺乳头状癌患者最初被认为是低风险的,多年来没有疾病迹象的复发病例极为罕见,但确实存在。这一观点得到了一个临床病例的支持,该患者因乳头状甲状腺癌接受了全甲状腺切除术,19年后发现转移并在假定的甲状腺部位发生囊外扩散。由于这些病例,强调了长期超声监测的重要性。
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引用次数: 0
Different glucose metabolism behavior relating to histotypes in synchronous breast cancers evaluated by [18F]FDG PET-CT. [18F]FDG PET-CT评估同步型乳腺癌不同糖代谢行为与组织型的关系。
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0012
Pietro Bellini, Domenico Albano, Francesco Dondi, Francesco Bertagna, Raffaele Giubbini

Glucose metabolism is increased in most aggressive tumors and it is commonly evaluated by positron emission tomography-computed tomography (PET-CT) with 18F-fluorodeoxyglucose ([18F]FDG), measuring the Maximum Standardized Uptake Value (SUVmax) for the assessment. Particularly, it is known that breast cancer expresses different glucose metabolism inrelation to estrogen receptor (ER), progesterone receptor (PR), Ki67 score, tumor grading, tumor size, and Human Epidermal Growth Factor Receptor 2 (HER2). We present an interesting case of a woman with two different, synchronous breast cancers characterized by different glucose metabolism, according to literature knowledge.

在大多数侵袭性肿瘤中,葡萄糖代谢增加,通常通过正电子发射断层扫描-计算机断层扫描(PET-CT)与18F-氟脱氧葡萄糖([18F]FDG)进行评估,测量最大标准化摄取值(SUVmax)进行评估。特别是,已知乳腺癌表达不同的糖代谢与雌激素受体(ER)、孕激素受体(PR)、Ki67评分、肿瘤分级、肿瘤大小和人表皮生长因子受体2 (HER2)有关。我们提出一个有趣的情况下,一名妇女与两种不同的,同步乳腺癌的特点是不同的葡萄糖代谢,根据文献知识。
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引用次数: 1
Detection of a second primary cancer in a 18F-fluorocholine PET/CT - multicentre retrospective analysis on a group of 1345 prostate cancer patients. 18f -氟胆碱PET/CT对1345例前列腺癌患者的多中心回顾性分析发现第二原发癌
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0006
Paulina Cegla, Katarzyna Scibisz-Dziedzic, Kamila Witkowska, Anna Kubiak, Ewa Wierzchoslawska, Witold Kycler, Beata Chrapko, Rafał Czepczyński

Background: Aim of this study was to evaluate the rate of incidental detection of second primary cancer (SPC) at 18F-fluorocholine ([18F]FCH) positron emission tomography/computed tomography (PET/CT) performed in prostate cancer patients.

Material and methods: A retrospective analysis was performed on a group of 1345 prostate cancer patients, who underwent [18F]FCH PET/CT study because of suspicion of recurrence (n = 937) or for initial staging (n = 408). Images were acquired after intravenous injection [18F]FCH with a mean activity of 200 ± 75 MBq (5.4 ± 2 mCi), from the top of the head to the half of the thigh. The confirmation of second primary cancer was obtained from the cancer registry.

Results: Based on the [18F]FCH PET/CT scans, a second primary cancer was suspected in 89 patients (6.6%). Of these, a malignancy was histologically confirmed in 26 patients (29% of all suspected findings and 1.9% of the complete cohort). Lung cancer (including adenocarcinoma, neuroendocrine cancer) was diagnosed in 13 patients (50%) and hematologic neoplasm (including chronic lymphocytic leukemia, Hodgkin lymphoma, follicular lymphoma, and multiple myeloma) in 5 patients (19%). 18F-fluorocholine PET/CT also revealed esophageal cancer, mesothelioma, testicular, renal, bladder, and colorectal cancer inindividual patients, non-keratinizing squamous cell carcinoma (SCC) of the skin as well as head and neck SCC with unknown primary.

Conclusion: We conclude that incidental detection of a second primary cancer in prostate cancer patients using [18F]FCH PET/CT is not very common and that lung cancer and hematologic malignancies are most frequently detected.

背景:本研究旨在评价18F-氟胆碱([18F]FCH)正电子发射断层扫描/计算机断层扫描(PET/CT)对前列腺癌患者第二原发癌(SPC)的意外检出率。材料与方法:回顾性分析1345例因怀疑复发(n = 937)或因初步分期(n = 408)接受FCH PET/CT检查的前列腺癌患者[18F]。静脉注射[18F]FCH后获得图像,平均活度为200±75 MBq(5.4±2 mCi),从头顶到大腿一半。第二原发癌的确认来自癌症登记。结果:根据[18F]FCH PET/CT扫描,89例(6.6%)患者怀疑第二原发癌。其中,26例患者经组织学证实为恶性肿瘤(占所有疑似病例的29%,占整个队列的1.9%)。肺癌(包括腺癌、神经内分泌癌)13例(50%),血液肿瘤(包括慢性淋巴细胞白血病、霍奇金淋巴瘤、滤泡性淋巴瘤、多发性骨髓瘤)5例(19%)。18f -氟胆碱PET/CT还可在个别患者中发现食管癌、间皮瘤、睾丸癌、肾癌、膀胱癌和结直肠癌,皮肤非角化鳞状细胞癌(SCC)以及原发不明的头颈部鳞状细胞癌。结论:我们得出结论,使用[18F]FCH PET/CT在前列腺癌患者中偶然发现第二原发癌的情况并不常见,肺癌和血液系统恶性肿瘤是最常见的。
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引用次数: 1
Optimal timing of SPECT/CT to demonstrate parathyroid adenomas in 99mTc-sestamibi scintigraphy. 99mTc-sestamibi显像中显示甲状旁腺瘤的SPECT/CT最佳时机。
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0020
Kate Hunter, Niamh Gavin, Colin McQuade, Brendan Hogan, John Feeney

Background: Accurate preoperative localisation of the parathyroid adenoma is essential to achieve a minimally invasive parathyroidectomy. The purpose of this study was to validate and improve our single-isotope dual-phase parathyroid imaging protocol utilising 99mTechnetium-Sestamibi ([99mTc]MIBI). There has been no accepted gold standard evidence-based protocol regarding timing of single-photon emission computed tomography/computed tomography (SPECT/CT) acquisition in parathyroid imaging with resultant variation between centres. We sought to determine the optimum timing of SPECT/CT post administration of [99mTc]MIBI in the identification of parathyroid adenomas. We aimed to evaluate the efficacy of early and late SPECT/CT and to establish whether SPECT/CT demonstrates increased sensitivity over planar imaging.

Material and methods: A sample of 36 patients with primary hyperparathyroidism underwent planar and SPECT/CT acquisition 15 minutes (early) and two hours (late) post [99mTc]MIBI administration. Two radionuclide radiologists reviewed the images and Fisher's exact Chi-squared statistic was used to evaluate the diagnostic performances of early versus late SPECT/CT acquisition and SPECT/CT versus planar imaging.

Results: Twenty-one likely parathyroid adenomas were identified with a statistically superior diagnosis rate in the late SPECT/CT acquisition compared with both early SPECT/CT and planar imaging (p < 0.05). All adenomas diagnosed on early SPECT/CT acquisition were also identified on late SPECT/CT images.

Conclusions: Single late phase SPECT/CT is significantly superior to early SPECT/CT in the identification of parathyroid adenomas. Late SPECT/CT improves diagnostic accuracy over planar acquisition. Imaging protocols should be revised to include late SPECT/CT acquisition. Early SPECT/CT acquisition can be eliminated from scan protocols with associated implications regarding reduced scan time and increased patient throughput.

背景:准确的术前定位甲状旁腺瘤是实现微创甲状旁腺切除术的必要条件。本研究的目的是验证和改进我们使用99mTechnetium-Sestamibi ([99mTc]MIBI)的单同位素双相甲状旁腺成像方案。关于甲状旁腺成像中单光子发射计算机断层扫描/计算机断层扫描(SPECT/CT)采集的时间,由于中心之间的差异,目前还没有公认的金标准循证方案。我们试图确定在诊断甲状旁腺瘤时使用[99mTc]MIBI后SPECT/CT的最佳时机。我们的目的是评估早期和晚期SPECT/CT的疗效,并确定SPECT/CT是否比平面成像更敏感。材料和方法:36例原发性甲状旁腺功能亢进患者在服用[99mTc]MIBI后15分钟(早)和2小时(晚)行平面和SPECT/CT采集。两名放射性核素放射科医生检查了图像,并使用Fisher精确卡方统计量来评估早期与晚期SPECT/CT采集和SPECT/CT与平面成像的诊断性能。结果:21例疑似甲状旁腺瘤在SPECT/CT晚期显像的诊断率高于早期SPECT/CT和平面显像(p < 0.05)。所有早期SPECT/CT图像诊断的腺瘤也在晚期SPECT/CT图像中被发现。结论:单次晚期SPECT/CT诊断甲状旁腺瘤明显优于早期SPECT/CT。晚期SPECT/CT比平面采集提高了诊断准确性。成像方案应修订,以包括后期SPECT/CT采集。早期SPECT/CT采集可以从扫描方案中消除,从而减少扫描时间并增加患者吞吐量。
{"title":"Optimal timing of SPECT/CT to demonstrate parathyroid adenomas in 99mTc-sestamibi scintigraphy.","authors":"Kate Hunter,&nbsp;Niamh Gavin,&nbsp;Colin McQuade,&nbsp;Brendan Hogan,&nbsp;John Feeney","doi":"10.5603/NMR.a2022.0020","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0020","url":null,"abstract":"<p><strong>Background: </strong>Accurate preoperative localisation of the parathyroid adenoma is essential to achieve a minimally invasive parathyroidectomy. The purpose of this study was to validate and improve our single-isotope dual-phase parathyroid imaging protocol utilising 99mTechnetium-Sestamibi ([99mTc]MIBI). There has been no accepted gold standard evidence-based protocol regarding timing of single-photon emission computed tomography/computed tomography (SPECT/CT) acquisition in parathyroid imaging with resultant variation between centres. We sought to determine the optimum timing of SPECT/CT post administration of [99mTc]MIBI in the identification of parathyroid adenomas. We aimed to evaluate the efficacy of early and late SPECT/CT and to establish whether SPECT/CT demonstrates increased sensitivity over planar imaging.</p><p><strong>Material and methods: </strong>A sample of 36 patients with primary hyperparathyroidism underwent planar and SPECT/CT acquisition 15 minutes (early) and two hours (late) post [99mTc]MIBI administration. Two radionuclide radiologists reviewed the images and Fisher's exact Chi-squared statistic was used to evaluate the diagnostic performances of early versus late SPECT/CT acquisition and SPECT/CT versus planar imaging.</p><p><strong>Results: </strong>Twenty-one likely parathyroid adenomas were identified with a statistically superior diagnosis rate in the late SPECT/CT acquisition compared with both early SPECT/CT and planar imaging (p < 0.05). All adenomas diagnosed on early SPECT/CT acquisition were also identified on late SPECT/CT images.</p><p><strong>Conclusions: </strong>Single late phase SPECT/CT is significantly superior to early SPECT/CT in the identification of parathyroid adenomas. Late SPECT/CT improves diagnostic accuracy over planar acquisition. Imaging protocols should be revised to include late SPECT/CT acquisition. Early SPECT/CT acquisition can be eliminated from scan protocols with associated implications regarding reduced scan time and increased patient throughput.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40335191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A crying liver: a scan pattern mimicking spontaneous perforation of the biliary ducts. 哭泣的肝脏:一种模拟自发胆管穿孔的扫描模式。
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0028
Somaye Barashki, Hadis Mohammadzadeh Kosari, Emran Askari, Zahra Bakhshi Golestani, Mehran Hiradfar, Ramin Sadeghi

A 2-month-old infant was referred for hepatobiliary scintigraphy due to ascites of unknown cause. The top differential diagnosis was spontaneous perforation of the biliary ducts. Delayed images up to 4 hours were against this diagnosis showing normal distribution of the radiotracer throughout the bowel. However, on delayed images, the scan showed mild tracer retention in the ascites confirmed by SPECT/CT images. Surprisingly, the exploratory abdominal surgery revealed an intact hepatobiliary system, pointing toward other possible etiologies. Second-review surgery was performed due to uncontrolled progressive ascites showing congestive hepatopathy and biliary leak from the hepatic surface suggestive of the "crying liver".

一个2个月大的婴儿因不明原因的腹水而接受肝胆造影检查。最重要的鉴别诊断是自发性胆管穿孔。延迟4小时的图像显示放射性示踪剂在整个肠道内的正常分布与此诊断相反。然而,在延迟图像上,扫描显示SPECT/CT图像证实腹水中有轻微的示踪剂潴留。令人惊讶的是,腹部探查手术显示一个完整的肝胆系统,指向其他可能的病因。由于无法控制的进展性腹水显示充血性肝病和肝表面胆道泄漏提示“哭泣的肝”,进行了二次复查手术。
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引用次数: 0
Editorial Note. 编辑的注意。
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.2022.0016
Grzegorz Kamiński
{"title":"Editorial Note.","authors":"Grzegorz Kamiński","doi":"10.5603/NMR.2022.0016","DOIUrl":"https://doi.org/10.5603/NMR.2022.0016","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40417922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocardial perfusion imaging single photon emission computed tomography may detect silent myocardial ischemia in patient with epilepsy. 心肌灌注成像单光子发射计算机断层扫描可检测癫痫患者无症状心肌缺血。
IF 0.9 Q3 Medicine Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0023
Sofia Markoula, Afroditi Tsoumani, Chainti Antonella Votti, Maria Beltsiou, Lampros Lakkas, Konstantinos Pappas, Ioannis Iakovou, Andreas Fotopoulos, Athanassios P Kyritsis, Chrissa Sioka

Background: The aim of the present study was to compare the myocardial perfusion imaging (MPI) with [99mTc]tetrofosmin stress - rest single-photon emission computer tomography (SPECT) of patients with epilepsy with matched control individuals.

Material and methods: All 29 adult epileptic patients were receiving antiepileptic drugs (AEDs) for epilepsy. Thirty-two individuals matched for gender and age consisted of the control group. MPIs SPECT were performed, and myocardial summed scores were obtained during stress (SSS) and rest (SRS) images. Abnormal MPI was considered when SSS was ≥ 4. In addition, the difference (SDS) between SSS and SRS was also assessed, which represents a rate of reversibility after stress.

Results: Twenty of 29 (68.97%) patients with epilepsy had abnormal MPI and 14/32 (43.75%) of the controls (p = 0.04). Among males, 18/23 patients and 11/25 controls had abnormal MPI (p = 0.01), with quite a significant difference for mean SSS between male patients and controls (p = 0.002). Furthermore, SDS comparison showed that irreversible abnormalities were more common in patients than in control individuals. A difference of inadequately compensated myocardial ischemia between patients treated with enzyme inducing AEDs and patients treated with valproic acid was also detected.

Conclusions: Single-photon emission computer tomography (SPECT) may detect increased risk for coronary artery disease and further cardiovascular events in patients with epilepsy. Our findings favor the conclusion that SPECT could be used for the early identification of cardiovascular comorbidity in epilepsy.

背景:本研究的目的是比较癫痫患者与对照组的心肌灌注显像(MPI)与[99mTc]tetrofosmin应激休止单光子发射计算机断层扫描(SPECT)。材料与方法:29例成人癫痫患者均接受抗癫痫药物治疗。32名性别和年龄相匹配的人组成了对照组。行MPIs SPECT,分别在应激(SSS)和静息(SRS)图像中获取心肌总评分。当SSS≥4时认为MPI异常。此外,还评估了SSS和SRS之间的差异(SDS),这代表了应激后的可逆性。结果:29例癫痫患者中有20例(68.97%)MPI异常,对照组中有14例(43.75%)MPI异常(p = 0.04)。男性患者有18/23例MPI异常,对照组有11/25例MPI异常(p = 0.01),男性患者与对照组的平均SSS差异有统计学意义(p = 0.002)。此外,SDS比较显示,不可逆异常在患者中比在对照组中更常见。观察酶诱导aed治疗组与丙戊酸治疗组的代偿性心肌缺血的差异。结论:单光子发射计算机断层扫描(SPECT)可以检测癫痫患者冠状动脉疾病和进一步心血管事件的风险增加。我们的研究结果支持SPECT可用于癫痫患者心血管合并症的早期识别的结论。
{"title":"Myocardial perfusion imaging single photon emission computed tomography may detect silent myocardial ischemia in patient with epilepsy.","authors":"Sofia Markoula,&nbsp;Afroditi Tsoumani,&nbsp;Chainti Antonella Votti,&nbsp;Maria Beltsiou,&nbsp;Lampros Lakkas,&nbsp;Konstantinos Pappas,&nbsp;Ioannis Iakovou,&nbsp;Andreas Fotopoulos,&nbsp;Athanassios P Kyritsis,&nbsp;Chrissa Sioka","doi":"10.5603/NMR.a2022.0023","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0023","url":null,"abstract":"<p><strong>Background: </strong>The aim of the present study was to compare the myocardial perfusion imaging (MPI) with [99mTc]tetrofosmin stress - rest single-photon emission computer tomography (SPECT) of patients with epilepsy with matched control individuals.</p><p><strong>Material and methods: </strong>All 29 adult epileptic patients were receiving antiepileptic drugs (AEDs) for epilepsy. Thirty-two individuals matched for gender and age consisted of the control group. MPIs SPECT were performed, and myocardial summed scores were obtained during stress (SSS) and rest (SRS) images. Abnormal MPI was considered when SSS was ≥ 4. In addition, the difference (SDS) between SSS and SRS was also assessed, which represents a rate of reversibility after stress.</p><p><strong>Results: </strong>Twenty of 29 (68.97%) patients with epilepsy had abnormal MPI and 14/32 (43.75%) of the controls (p = 0.04). Among males, 18/23 patients and 11/25 controls had abnormal MPI (p = 0.01), with quite a significant difference for mean SSS between male patients and controls (p = 0.002). Furthermore, SDS comparison showed that irreversible abnormalities were more common in patients than in control individuals. A difference of inadequately compensated myocardial ischemia between patients treated with enzyme inducing AEDs and patients treated with valproic acid was also detected.</p><p><strong>Conclusions: </strong>Single-photon emission computer tomography (SPECT) may detect increased risk for coronary artery disease and further cardiovascular events in patients with epilepsy. Our findings favor the conclusion that SPECT could be used for the early identification of cardiovascular comorbidity in epilepsy.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40672310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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NUCLEAR MEDICINE REVIEW
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