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SGLT 2 Inhibitors and Hypertension: Mild but Effective. What can we expect ? sglt2抑制剂与高血压:温和但有效。我们能期待什么?
Pub Date : 2022-12-13 DOI: 10.19080/jocct.2022.18.555977
B. Ivanović
Sodium-glucose co-transporter-2 (SGLT2) inhibitors are a new class of medications used for the treatment of diabetes mellitus (DM). It has been shown that, in addition to a favorable metabolic effect, they significantly reduce atherosclerotic events, cardiovascular and total mortality, hospitalization duration in patients with heart failure and have a significant effect on reducing the progression of chronic kidney disease. It has been observed that in patients with diabetes mellitus, they lead to a reduction of blood pressure (BP). The aim of this article is to evaluate current knowledge about mechanisms of antihypertensive action and clinical benefits of SGLT2 inhibitors in reducing arterial blood pressure in patients with diabetes mellitus and arterial hypertension.
钠-葡萄糖共转运蛋白-2 (SGLT2)抑制剂是一类用于治疗糖尿病(DM)的新型药物。研究表明,它们除了具有良好的代谢作用外,还能显著减少心力衰竭患者的动脉粥样硬化事件、心血管和总死亡率、住院时间,并对减少慢性肾脏疾病的进展有显著作用。据观察,在糖尿病患者中,它们会导致血压(BP)的降低。本文的目的是评估目前关于SGLT2抑制剂在降低糖尿病和动脉高血压患者动脉血压方面的降压作用机制和临床益处。
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引用次数: 0
Constrictive Pericarditis Secondary to Tuberculosis Infection: Literature Review 结核感染继发的缩窄性心包炎:文献综述
Pub Date : 2022-12-12 DOI: 10.19080/jocct.2022.18.555976
Maria Isabel Gomez Coral
Tuberculous pericarditis is produced by Mycobacterium tuberculosis, accounting for 1% of all forms of tuberculosis. Its prevalence varies according to coinfection with HIV. Mortality varies between 17 and 40%. In the US, the prevalence is low compared to developing countries. This article aims to review the literature on pericarditis caused by tuberculosis (TBP), its prevalence in the US, clinical manifestations, diagnosis, and treatment. Among the most frequent clinical manifestations are dyspnea, fever, chest pain, and cough. TBP should be suspected in patients at high risk of exposure to tuberculosis. There are multiple lab tests for diagnosis, and its primary treatment is triple therapy with isoniazid, rifampin, and streptomycin or ethambutol. In case of persistent elevation of systemic venous pressure, surgical intervention is indicated. The clinical presentation was found to be variable.
结核性心包炎是由结核分枝杆菌引起的,占所有结核形式的1%。其流行程度因合并感染艾滋病毒而异。死亡率在17%到40%之间。与发展中国家相比,美国的患病率较低。本文旨在回顾有关结核性心包炎(TBP)的文献,其在美国的患病率,临床表现,诊断和治疗。最常见的临床表现是呼吸困难、发热、胸痛和咳嗽。暴露于结核病的高危患者应怀疑有TBP。诊断有多种实验室检查,其主要治疗方法是异烟肼、利福平、链霉素或乙胺丁醇三联治疗。如果持续升高的全身静脉压,手术干预是指。临床表现是可变的。
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引用次数: 0
Active Bleeding after Valve Surgery under Extracorporeal Circulation: Incidence and Risk Factors? Prospective Observational Study on 59 Patients in a West African Country 体外循环下瓣膜手术后活动性出血:发生率和危险因素?西非国家59例患者的前瞻性观察研究
Pub Date : 2022-12-07 DOI: 10.19080/jocct.2022.17.555975
E. Boubacar Ba
Active bleeding after cardiac surgery is defined as blood loss > 1.5 ml / kg / h for 6 consecutive hours within the first 24 hours or in case of re-operation for haemostasis within the first 12 hours postoperatively. The aim of our work was to assess the incidence and risk factors for the occurrence of active bleeding in postoperative valve surgery with extracorporeal circulation.
心脏手术后活动性出血定义为术后24小时内连续6小时失血量> 1.5 ml / kg / h或术后12小时内再次手术止血。我们的研究目的是评估体外循环瓣膜手术后活动性出血的发生率和危险因素。
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引用次数: 0
Chylopericardium In a Young Woman Revealing A Mediastinal Cystic Lymphangioma: A Case Report 年轻女性纵隔囊性淋巴管瘤乳糜心包1例报告
Pub Date : 2022-12-01 DOI: 10.19080/jocct.2022.17.555974
I. Tlohi
Isolated chylopericardium due to mediastinal cystic lymphangioma is a rare entity. We report a case of asymptomatic chylopericardium in an 18 years old female with no history of trauma, thoracic surgery, malignancy, infection, or tuberculosis sand who presented with cardiomegaly noticed on chest x-ray before surgery of mandibular subluxation. Echocardiography showed a large number of pericardial effusions and pericardiocentesis yielded 1.25 L of milky-colored fluid which showed a triglyceride level of 4.82 g/L and cholesterol of 0.29 g/L with a cholesterol to triglyceride ratio of <1, characteristic of the chylous fluid. Chest computed tomography showed a huge mediastinal cystic lymphangioma. The patient successfully responded to continuous pericardial drainage and a medium-chain triglyceride diet then she was referred to the thoracic department for surgery. This type of case risks being misdiagnosed as tuberculosis, especially in countries where tuberculosis is endemic. Therefore, assessing pericardial fluid for chyle is crucial.
摘要纵隔囊性淋巴管瘤引起的孤立性乳糜心包是一种罕见的疾病。我们报告一例无症状乳糜包心膜患者,年龄18岁,无外伤、胸外科手术、恶性肿瘤、感染或结核病史,在下颌骨半脱位手术前胸部x线检查发现心脏肿大。超声心动图显示大量心包积液,心包穿刺检出1.25 L乳白色液体,甘油三酯4.82 g/L,胆固醇0.29 g/L,胆固醇/甘油三酯比值<1,为乳糜液特征。胸部电脑断层显示一巨大纵隔囊性淋巴管瘤。患者成功响应持续心包引流和中链甘油三酯饮食,然后她被转到胸外科手术。这类病例有被误诊为结核病的风险,特别是在结核病流行的国家。因此,评估心包积液是否有乳糜泻是至关重要的。
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引用次数: 0
Heparin-Induced Venous and Arterial Thromboembolic Disease: Case Report and Literature Data 肝素诱发的静脉和动脉血栓栓塞性疾病:病例报告和文献资料
Pub Date : 2022-11-30 DOI: 10.19080/jocct.2022.17.555973
N. Mahoungou-Mackonia
HIT results from the development of F4P-specific IgG antibodies. It usually begins 5-14 days after initiation of heparin therapy with a drop in platelet count of more than 50% from a pretreatment value, associated in one in two patients with venous and/or arterial thrombotic complications. This is a rarer problem that occurs in 1-5% with UFH and 0.1-0.2% with LMWH and requires prompt management. Forty-seven-year-old patient, alcoholic at 3g/d for 10 years, hospitalized for APO complicating an ethylic CMD, LVEF 33% in tachy ACFA at 150batt/min. The patient was treated with furosemide and risordan. Injectable Cordarone was administered and LMWH in curative dose for 7 days. The evolution was marked by a resumption of sinus rhythm, disappearance of crepitus rales, after one week, but an installation of thrombenia at 22000/mm3, a pulmonary embolism, left popliteal DVT and thrombosis of the iliac and then left femoral arteries. The diagnosis of HIT type 2 was confirmed by the presence of anti-PF4 antibodies in association with the platelet activation test. LMWH was stopped, the patient received Fondaparinux 7.5mg/d until platelets normalized after 10 days and then substituted with rivaroxaban for 6 months after clinical improvement and normalization of arteriovenous Doppler ultrasound and chest angioscan.
HIT源于f4p特异性IgG抗体的产生。它通常在开始肝素治疗后5-14天开始,血小板计数比预处理值下降50%以上,与两名静脉和/或动脉血栓形成并发症患者中有一名相关。这是一种罕见的问题,发生在1-5%的UFH和0.1-0.2%的低分子肝素中,需要及时治疗。47岁患者,每日3克酒精摄入10年,因APO合并乙基性CMD住院,150次/分钟ACFA过速LVEF 33%。患者给予速尿和利索当治疗。注射可达酮和低分子肝素(治疗剂量),连续7天。发展的标志是窦性心律恢复,一周后耳鸣消失,但血栓形成22000/mm3,肺栓塞,左腘窝DVT和髂动脉血栓形成,然后是左股动脉血栓形成。抗pf4抗体与血小板活化试验相结合,证实了HIT 2型的诊断。停用低分子肝素,10天后给予Fondaparinux 7.5mg/d至血小板恢复正常,待临床改善,动静脉多普勒超声及胸部血管检查恢复正常后,改用利伐沙班治疗6个月。
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引用次数: 0
Catheter Ablation of The Posterior-Septal Accessory Pathway in Patients with Wolf-Parkinson-White Syndrome Initially Present in Aberrant Atrial Fibrillation 最初表现为异常房颤的Wolf-Parkinson-White综合征患者后-间隔副通路的导管消融
Pub Date : 2022-09-08 DOI: 10.19080/jocct.2022.17.555972
M. Tushar
A 50-year-old man with no prior medical history went to the emergency department complaining of persistent palpitations, pressure in his chest, and shortness of breath with an EKG that revealed atrial fibrillation with aberrancy. Patient became hemodynamically unstable and was cardiovert. Post cardioversion EKG showed diffuse ST depressions and he was sent to the cath lab, The patient’s post-catheterization ekg displayed a short PR interval and a delta wave compatible with Wolff Parkinson White syndrome. Patient was treated with postero-septal catheter ablation. After his symptoms subsided, the patient was sent home.
一名50岁男性,无既往病史,就诊于急诊科,主诉持续性心悸、胸压、呼吸短促,心电图显示房颤异常。患者血流动力学不稳定,心脏转导。心电转复后心电图显示弥漫性ST段压抑,被送至导管室。置管后心电图显示PR间期短,δ波与Wolff - Parkinson - White综合征相符。患者接受后间隔导管消融治疗。症状消退后,病人被送回家。
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引用次数: 0
Cardiovascular Manifestations of COVID-19: An Update COVID-19的心血管表现:最新进展
Pub Date : 2022-09-07 DOI: 10.19080/jocct.2022.17.555971
K. Roy
Higher mortality rates are linked to COVID-19 cardiovascular problems. Cardiac damage may result from a variety of factors, including combinations of cytokine storm, myocarditis, extremely high levels of physical and mental stress, ischemic injury, hyper-coagulopathy, right heart strain, and corpulmonale. Prognostic information is provided by echocardiography, c-TN, D-dimer, and NT-proBNP values. There is no particular therapy for COVID-19-related cardiac damage other from percutaneous coronary intervention for STEMI, and care is mostly supportive. It remains to be known if antiviral treatments given early in the course of the illness would stop the severe illness and cardiovascular consequences linked to COVID-19.SAIDs: Non-steroidal Anti-inflammatory Drugs; NO: Nitric Oxide; cGMP: cyclic Guanosine Monophosphate; LDL: Low-density Lipoprotein
更高的死亡率与COVID-19心血管问题有关。心脏损伤可能由多种因素引起,包括细胞因子风暴、心肌炎、极高水平的身体和精神压力、缺血性损伤、高凝血病、右心劳损和肺脏病。预后信息由超声心动图、c-TN、d -二聚体和NT-proBNP值提供。除经皮冠状动脉介入治疗外,对STEMI的covid -19相关心脏损伤没有特别的治疗方法,护理主要是支持性的。在病程早期给予抗病毒治疗是否能阻止与COVID-19相关的严重疾病和心血管后果仍有待观察。非甾体抗炎药;NO:一氧化氮;cGMP:环鸟苷单磷酸;LDL:低密度脂蛋白
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引用次数: 0
Heart Failure Management, including Recently Approved Therapeutic Options: An Overview 心力衰竭管理,包括最近批准的治疗方案:概述
Pub Date : 2022-08-22 DOI: 10.19080/jocct.2022.17.555970
G. B. Benitez Lopez
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引用次数: 0
Social Determinants of Health on Cardiovascular Disease Prevention in Special Populations: An Overview 特殊人群心血管疾病预防的社会健康决定因素综述
Pub Date : 2022-08-09 DOI: 10.19080/jocct.2022.17.555969
Guillermo Andrés Moreno Cortes
Social determinants of health interfere significantly in the health-disease process. This article examines the impact of these determinants on the main pathologies addressed by the internist and the family doctor in medical care. The World Health Organization defines social determinants of health (SDH) as the circumstances in which people are born, grow, work, live and age, including the broader set of forces and systems that influence conditions of daily life. These forces and systems include economic policies and systems, development programs, social norms and policies, and political systems. The above conditions can be very different for various subgroups of a population and can lead to differences in health outcomes. It may be unavoidable that some of these conditions are different, which is considered inequalities. These social determinants influence and modify the development and course of the disease. In the pathologies exposed in this review, we found that adequate management involves a sizeable non-pharmacological component that refers to intervention in eating habits, healthy living, management of traditional cardiovascular risk factors, and monitoring disease activity. In support of the evidence, we review several meta-analyses of observational studies that allow us to infer what is the significant impact of the social determinants of health in the control or exacerbation of the pathologies described and how we can positively interfere in their evolution and outcome of disease through increasingly effective comprehensive interventions according to the current evidence described.
健康的社会决定因素在健康-疾病过程中有显著的干扰作用。本文探讨了这些决定因素对内科医生和家庭医生在医疗保健中处理的主要病理的影响。世界卫生组织将健康的社会决定因素定义为人们出生、成长、工作、生活和衰老所处的环境,包括影响日常生活条件的一系列更广泛的力量和制度。这些力量和系统包括经济政策和制度、发展计划、社会规范和政策以及政治制度。上述情况对于人口的不同亚组可能非常不同,并可能导致健康结果的差异。这些条件中的一些是不同的,这可能是不可避免的,这被认为是不平等。这些社会决定因素影响和改变疾病的发展和过程。在本综述中暴露的病理中,我们发现适当的管理涉及相当大的非药物成分,即干预饮食习惯、健康生活、管理传统心血管危险因素和监测疾病活动。为了支持这些证据,我们回顾了几项观察性研究的荟萃分析,这些研究使我们能够推断出健康的社会决定因素在控制或加剧所描述的病理方面的重大影响,以及我们如何根据目前所描述的证据,通过日益有效的综合干预,积极干预它们的演变和疾病的结果。
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引用次数: 0
Catheter Ablation of Premature Ventricular Complexes Exclusively by a Pace-Mapping Software Technique: Feasibility of a Registry Study 完全通过起搏图软件技术对室性早搏进行导管消融:登记研究的可行性
Pub Date : 2020-04-27 DOI: 10.19080/jocct.2020.16.555932
Fabricio Sarmento Vassallo
Introduction/Objective: Ablation of premature ventricular complexes a challenge in routine electrophysiology because results, depend on factors such as location, tools and technologies used. Aim of study was analyze exclusive use of pace-mapping technique with module of Score Map Software of Ensite Velocity/Precision and compare with success procedure, 7- and 30-days post-ablation. Methods/Results: Retrospectively analyzed 50 procedures in 47 symptomatic patients between January 2018 and February 2020. Ablation with irrigated tip catheter, power 40Watts, pump flow 30ml/min. Mapping with Duodecapolar in 40(80%) and HDGrid catheter in 10(20%). Female was 25 (53.19%), mean age 53.5years (19-78), hypertension 27 (57.45%), 7 (14.91%) coronary disease, 4 (8.51%) myocarditis, 2 (4.26%) Diabetes and 2 (4.26%) patients with an implanted defibrillator. Mean ejection fraction 63.17%. Average radiofrequency time was 580.58 seconds and mean XRay time 7.74min. Median SM was 93.92% and only 8 (16%) ablations were considered unsuccessful due to maintenance of extrasystoles or do not show a marked reduction on PVC at the end of the procedure. At 7- and 30-days follow up 9 (18%) and 7 (14%) patients had unsuccessful ablation. All patients had a Score <95%, underwent ablation with conscious sedation, majority female, most PVCs located in left ventricle and had more extensive ablation. Conclusion: Score Map is useful as exclusive technique for ablation of premature ventricular complexes with very good acute success and low complications. Score Map more than 95% had high success. Failure is related to conscious sedation, female gender, left ventricle ablation and longer radiofrequency time.
导言/目的:室性早搏消融是常规电生理学中的一项挑战,因为消融结果取决于所使用的位置、工具和技术等因素。本研究旨在分析使用 Ensite Velocity/Precision 的 Score Map 软件模块的起搏图绘制技术,并比较消融后 7 天和 30 天的成功率。方法/结果:回顾性分析了2018年1月至2020年2月期间47名症状患者的50例手术。使用灌注尖端导管进行消融,功率 40 瓦,泵流量 30 毫升/分钟。40例(80%)使用十二极导管,10例(20%)使用HDGrid导管。女性 25 人(53.19%),平均年龄 53.5 岁(19-78 岁),高血压 27 人(57.45%),冠心病 7 人(14.91%),心肌炎 4 人(8.51%),糖尿病 2 人(4.26%),植入除颤器 2 人(4.26%)。平均射血分数为 63.17%。平均射频时间为 580.58 秒,平均 X 光时间为 7.74 分钟。中位 SM 值为 93.92%,只有 8 例(16%)消融因维持期外收缩或手术结束时 PVC 未明显减少而被视为不成功。在 7 天和 30 天的随访中,分别有 9 名(18%)和 7 名(14%)患者消融不成功。所有患者的评分均小于 95%,均在有意识镇静的情况下接受了消融术,大多数患者为女性,大多数 PVC 位于左心室,消融范围更广。结论:Score Map 是消融室性早搏的专用技术,急性成功率高,并发症少。Score Map 的成功率超过 95%。失败与有意识镇静、女性、左心室消融和射频时间较长有关。
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引用次数: 0
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Journal of Cardiology &amp; Cardiovascular Therapy
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