Pub Date : 2020-04-27DOI: 10.19080/jocct.2020.16.555933
R. Aikawa
Background: We have recently reported that polaprezinc which is a zinc delivery has an anti-inflammatory effect and improves cardiac function after acute myocardial infarction (AMI). As a secondary analysis, the aim of the present study was to evaluate if zinc concentration in blood affects anti-inflammatory effect and cardiac function after AMI. Methods: The primary study population included 50 patients with AMI. We equally divided the patients into two groups between the high group (H) and the low group (L) by blood concentration of zinc without relating to polaprezinc medication. The two groups were analyzed about cardiac function, cardiac enzymes, and the levels of the inflammation marker interleukin-6 (IL-6) as similar to the primary study. Results: The urine zinc levels of the H group were prominently higher than those of the L group at 8 days after PCI. The mean IL-6 level was strongly reduced in the H group (44.7(7.15-107.7) pg/mL vs. 130(19.6-384.25) pg/mL, respectively; p<0.05). As for the days of decline of both CRP and WBC, there were significant differences between the two groups (Figure 2). In addition, echocardiography indicated that the EF of the H group was clearly increased between day 3 and 9 months post-MI (54.5(50.5-59.75)% vs. 62(55-70)%, respectively; p<0.01). Conclusions: The present study suggests that high concentration of zinc has an anti-inflammatory effect and improves cardiac function after AMI.
背景：最近，我们报道了一种锌给药 polaprezinc 具有抗炎作用，并能改善急性心肌梗塞（AMI）后的心脏功能。作为辅助分析，本研究旨在评估血液中的锌浓度是否会影响抗炎效果和急性心肌梗死后的心脏功能。研究方法主要研究对象包括 50 名急性心肌梗死患者。我们按血液中锌浓度将患者平均分为两组，即高浓度组（H）和低浓度组（L），与多拉普锌药物无关。对两组患者的心功能、心肌酶和炎症标志物白细胞介素-6（IL-6）水平进行了分析，分析结果与初选研究结果相似。结果显示PCI术后8天，H组的尿锌水平明显高于L组。H组的平均IL-6水平显著降低（分别为44.7（7.15-107.7）pg/mL vs. 130（19.6-384.25）pg/mL；P<0.05）。至于 CRP 和 WBC 的下降天数，两组之间存在显著差异（图 2）。此外，超声心动图显示，在心肌梗死后第 3 天至 9 个月期间，H 组的 EF 明显增加（分别为 54.5(50.5-59.75)% vs. 62(55-70)%；P<0.01）。结论：本研究表明，高浓度锌具有抗炎作用，并能改善急性心肌梗死后的心脏功能。
{"title":"Augmentation of Zinc Concentration in Blood has a Favorable Effect on Cardiac Function Post-Myocardial Infarction","authors":"R. Aikawa","doi":"10.19080/jocct.2020.16.555933","DOIUrl":"https://doi.org/10.19080/jocct.2020.16.555933","url":null,"abstract":"Background: We have recently reported that polaprezinc which is a zinc delivery has an anti-inflammatory effect and improves cardiac function after acute myocardial infarction (AMI). As a secondary analysis, the aim of the present study was to evaluate if zinc concentration in blood affects anti-inflammatory effect and cardiac function after AMI. Methods: The primary study population included 50 patients with AMI. We equally divided the patients into two groups between the high group (H) and the low group (L) by blood concentration of zinc without relating to polaprezinc medication. The two groups were analyzed about cardiac function, cardiac enzymes, and the levels of the inflammation marker interleukin-6 (IL-6) as similar to the primary study. Results: The urine zinc levels of the H group were prominently higher than those of the L group at 8 days after PCI. The mean IL-6 level was strongly reduced in the H group (44.7(7.15-107.7) pg/mL vs. 130(19.6-384.25) pg/mL, respectively; p<0.05). As for the days of decline of both CRP and WBC, there were significant differences between the two groups (Figure 2). In addition, echocardiography indicated that the EF of the H group was clearly increased between day 3 and 9 months post-MI (54.5(50.5-59.75)% vs. 62(55-70)%, respectively; p<0.01). Conclusions: The present study suggests that high concentration of zinc has an anti-inflammatory effect and improves cardiac function after AMI.","PeriodicalId":447476,"journal":{"name":"Journal of Cardiology & Cardiovascular Therapy","volume":"140 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141209823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-02DOI: 10.19080/jocct.2020.16.555931
TY Tang
{"title":"Intravascular Ultrasound (IVUS) for Deep Venous Work - Want or Need?","authors":"TY Tang","doi":"10.19080/jocct.2020.16.555931","DOIUrl":"https://doi.org/10.19080/jocct.2020.16.555931","url":null,"abstract":"","PeriodicalId":447476,"journal":{"name":"Journal of Cardiology & Cardiovascular Therapy","volume":"111 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141216672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-30DOI: 10.19080/jocct.2020.15.555929
Cielito C Reyes Gibby
Background: The Emergency Department (ED) is the safety net for unanticipated or undertreated health needs. Patients with cancer have been reported to be substantial users of ED resources, to be of higher acuity than others, and to have a longer length of stay. Patients with head and neck cancer live longer than patients with other types of cancer. Therefore, we assessed the extent to which epidemiological, behavioral, and clinical factors collected prior to treatment were associated with eventual ED visits in patients with head and neck cancer. Methods: Questionnaires were administered at baseline, prior to cancer treatment. ED data were abstracted for up to 5 years follow up period from initial diagnosis and treatment of patients newly diagnosed with squamous cell carcinoma of the head and neck (HNSCC). Results: Our sample comprised 969 patients. The earliest ED visit occurred within 1 week of diagnosis. As many as 513 patients had ≥1 ED visit and the mean time to first ED visit was 27 weeks (SD=2.3 weeks). The most frequent chief complaints were: pain (n=181; 35.3% [abdominal pain=16.3%, chest pain=7.5%]); fever (n=107; 20.9%); nausea/vomiting (n=64; 12.5%); weakness/fatigue (n=45; 8.8%). Multivariate logistic regression indicated that hypertension (OR=1.43, 95% CI=1.02–2.03; P=0.039), T-stage (OR=2.05, 95% CI=1.45–2.92; P<0.0001), and N-stage (OR=1.47, 95% CI=1.17–1.86; P<0.001) were significantly associated with ED visits. Conclusion: To our knowledge, our study is the first to find a specific association between hypertension and ED visits in patients with HNSCC. Further research is needed to investigate possible reasons for the association between comorbidities such as hypertension and the need for emergent care, as well as to determine whether aggressive management of comborbid conditions during and after cancer therapy might reduce the likelihood of ED visits.
背景：急诊科（ED）是满足意外或治疗不足的健康需求的安全网。据报道，癌症患者占用了大量急诊室资源，他们的病情比其他人更严重，住院时间也更长。与其他类型的癌症患者相比，头颈部癌症患者的寿命更长。因此，我们评估了治疗前收集的流行病学、行为和临床因素与头颈部癌症患者最终去急诊室就诊的关联程度。研究方法在癌症治疗前进行基线问卷调查。对新诊断为头颈部鳞状细胞癌（HNSCC）的患者从初次诊断到治疗的长达 5 年的随访期间的 ED 数据进行摘要。结果我们的样本包括 969 名患者。最早的急诊就诊时间为确诊后 1 周内。多达 513 名患者的 ED 就诊次数≥1 次，首次就诊的平均时间为 27 周（SD=2.3 周）。最常见的主诉为：疼痛（181 人；35.3% [腹痛=16.3%，胸痛=7.5%]）；发热（107 人；20.9%）；恶心/呕吐（64 人；12.5%）；虚弱/疲劳（45 人；8.8%）。多变量逻辑回归表明，高血压（OR=1.43，95% CI=1.02-2.03；P=0.039）、T 期（OR=2.05，95% CI=1.45-2.92；P<0.0001）和 N 期（OR=1.47，95% CI=1.17-1.86；P<0.001）与急诊就诊显著相关。结论据我们所知，我们的研究首次发现高血压与 HNSCC 患者的急诊就诊之间存在特定关联。我们需要进一步研究高血压等合并症与急诊就诊需求之间可能存在关联的原因，并确定在癌症治疗期间和之后积极控制合并症是否可以降低急诊就诊的可能性。
{"title":"Hypertension and Emergency Department Visits by Patients with Head and Neck Cancer","authors":"Cielito C Reyes Gibby","doi":"10.19080/jocct.2020.15.555929","DOIUrl":"https://doi.org/10.19080/jocct.2020.15.555929","url":null,"abstract":"Background: The Emergency Department (ED) is the safety net for unanticipated or undertreated health needs. Patients with cancer have been reported to be substantial users of ED resources, to be of higher acuity than others, and to have a longer length of stay. Patients with head and neck cancer live longer than patients with other types of cancer. Therefore, we assessed the extent to which epidemiological, behavioral, and clinical factors collected prior to treatment were associated with eventual ED visits in patients with head and neck cancer. Methods: Questionnaires were administered at baseline, prior to cancer treatment. ED data were abstracted for up to 5 years follow up period from initial diagnosis and treatment of patients newly diagnosed with squamous cell carcinoma of the head and neck (HNSCC). Results: Our sample comprised 969 patients. The earliest ED visit occurred within 1 week of diagnosis. As many as 513 patients had ≥1 ED visit and the mean time to first ED visit was 27 weeks (SD=2.3 weeks). The most frequent chief complaints were: pain (n=181; 35.3% [abdominal pain=16.3%, chest pain=7.5%]); fever (n=107; 20.9%); nausea/vomiting (n=64; 12.5%); weakness/fatigue (n=45; 8.8%). Multivariate logistic regression indicated that hypertension (OR=1.43, 95% CI=1.02–2.03; P=0.039), T-stage (OR=2.05, 95% CI=1.45–2.92; P<0.0001), and N-stage (OR=1.47, 95% CI=1.17–1.86; P<0.001) were significantly associated with ED visits. Conclusion: To our knowledge, our study is the first to find a specific association between hypertension and ED visits in patients with HNSCC. Further research is needed to investigate possible reasons for the association between comorbidities such as hypertension and the need for emergent care, as well as to determine whether aggressive management of comborbid conditions during and after cancer therapy might reduce the likelihood of ED visits.","PeriodicalId":447476,"journal":{"name":"Journal of Cardiology & Cardiovascular Therapy","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141220023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-30DOI: 10.19080/jocct.2020.16.555930
Hind Tahri
The occurrence of pericardial effusion during a hypothyroid state is frequent. This clinical evolution justifies the realization of an echocardiographic exam at diagnosis and during follow-up in the management of patient with hypothyroid disease. The pejorative clinical signs of pericardial effusion are relatively rare; the evolution into a pericardial tamponade is not frequently reported. This retrospective report covers the clinical evolution of 3 cases of pericardial tamponade commonly demonstrating a primary hypothyroidy. The echocardiogram allowed for immediate diagnosis of the tamponade; supported by the clinical aspect and the diagnosis of hypothyroidy confirmed biologically. The treatment approach was based on pericardiocentesis of the pericardial effusion associated with progressive hormonotherapy resulting in a favorable clinical outcome and the elimination of the pericardial effusion.
{"title":"Cardiac Tamponade Due to Primary Hypothyroidism: A Rare Presentation","authors":"Hind Tahri","doi":"10.19080/jocct.2020.16.555930","DOIUrl":"https://doi.org/10.19080/jocct.2020.16.555930","url":null,"abstract":"The occurrence of pericardial effusion during a hypothyroid state is frequent. This clinical evolution justifies the realization of an echocardiographic exam at diagnosis and during follow-up in the management of patient with hypothyroid disease. The pejorative clinical signs of pericardial effusion are relatively rare; the evolution into a pericardial tamponade is not frequently reported. This retrospective report covers the clinical evolution of 3 cases of pericardial tamponade commonly demonstrating a primary hypothyroidy. The echocardiogram allowed for immediate diagnosis of the tamponade; supported by the clinical aspect and the diagnosis of hypothyroidy confirmed biologically. The treatment approach was based on pericardiocentesis of the pericardial effusion associated with progressive hormonotherapy resulting in a favorable clinical outcome and the elimination of the pericardial effusion.","PeriodicalId":447476,"journal":{"name":"Journal of Cardiology & Cardiovascular Therapy","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141219968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：