Pub Date : 2022-07-05DOI: 10.1007/s40497-022-00315-3
K. Parthiban, C. C. Fernandaz, S. Selvanayaki
{"title":"Agroforestry Business Incubator—an innovative institution for leveraging technology-based business opportunities in forestry","authors":"K. Parthiban, C. C. Fernandaz, S. Selvanayaki","doi":"10.1007/s40497-022-00315-3","DOIUrl":"https://doi.org/10.1007/s40497-022-00315-3","url":null,"abstract":"","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"12 1","pages":"97 - 105"},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45431670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumor angiogenesis is closely associated with the metastasis and progression of non-small cell lung cancer (NSCLC), a highly vascularized solid tumor. However, novel therapeutics are lacking for the treatment of this cancer. Here, we developed a series of 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazol analogs (6a-6x) as tubulin colchicine-binding site inhibitors, aiming to find a novel promising drug candidate for NSCLC treatment. We first identified 2-(2-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)-5-(3-hydroxyazetidin-1-yl)-2H-1,2,3-triazole (6h) as a hit compound, which inhibited angiogenesis induced by NSCLC cells both in vivo and in vitro. In addition, our data showed that 6h could tightly bind to the colchicine-binding site of tubulin and inhibit tubulin polymerization. We also found that 6h could effectively induce G2/M cell cycle arrest of A549 and H460 cells, inhibit cell proliferation, and induce apoptosis. Furthermore, we showed 6h had the potential to inhibit the migration and invasion of NSCLC cells, two basic characteristics of tumor metastasis. Finally, we found 6h could effectively inhibit tumor progression in A549 xenograft mouse models with minimal toxicity. Taken together, these findings provide strong evidence for the development of 6h as a promising microtubule colchicine-binding site inhibitor for NSCLC treatment.
{"title":"A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non-small cell lung cancers.","authors":"Zi Liu, Liancheng Huang, Tianhao Zhou, Xing Chang, Yuying Yang, Yani Shi, Mingjing Hao, Zengqiang Li, Yingliang Wu, Qi Guan, Weige Zhang, Daiying Zuo","doi":"10.1016/j.jbc.2022.102063","DOIUrl":"10.1016/j.jbc.2022.102063","url":null,"abstract":"<p><p>Tumor angiogenesis is closely associated with the metastasis and progression of non-small cell lung cancer (NSCLC), a highly vascularized solid tumor. However, novel therapeutics are lacking for the treatment of this cancer. Here, we developed a series of 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazol analogs (6a-6x) as tubulin colchicine-binding site inhibitors, aiming to find a novel promising drug candidate for NSCLC treatment. We first identified 2-(2-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)-5-(3-hydroxyazetidin-1-yl)-2H-1,2,3-triazole (6h) as a hit compound, which inhibited angiogenesis induced by NSCLC cells both in vivo and in vitro. In addition, our data showed that 6h could tightly bind to the colchicine-binding site of tubulin and inhibit tubulin polymerization. We also found that 6h could effectively induce G2/M cell cycle arrest of A549 and H460 cells, inhibit cell proliferation, and induce apoptosis. Furthermore, we showed 6h had the potential to inhibit the migration and invasion of NSCLC cells, two basic characteristics of tumor metastasis. Finally, we found 6h could effectively inhibit tumor progression in A549 xenograft mouse models with minimal toxicity. Taken together, these findings provide strong evidence for the development of 6h as a promising microtubule colchicine-binding site inhibitor for NSCLC treatment.</p>","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"7 1","pages":"102063"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74024388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-28DOI: 10.1007/s40497-022-00310-8
H. Alamineh
{"title":"A Comparative Study on Influencing Factors of University and Technical and Vocational Education and Training (TVET) Graduate Students Intentions Toward Entrepreneurship: Evidence from Addis Ababa City, Ethiopia","authors":"H. Alamineh","doi":"10.1007/s40497-022-00310-8","DOIUrl":"https://doi.org/10.1007/s40497-022-00310-8","url":null,"abstract":"","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"12 1","pages":"83 - 96"},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48106985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-22DOI: 10.1007/s40497-022-00313-5
Vandana Pareek, M. Yadav, Neeraj Singh
{"title":"Unearthing the character of microfinance in self-employment generation for bridging the gaps of disparity: a case study","authors":"Vandana Pareek, M. Yadav, Neeraj Singh","doi":"10.1007/s40497-022-00313-5","DOIUrl":"https://doi.org/10.1007/s40497-022-00313-5","url":null,"abstract":"","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"12 1","pages":"71 - 81"},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44175934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.1007/s40497-022-00314-4
E. Yendaw
{"title":"Driving factors and sources of capital for immigrant entrepreneurs in Ghana","authors":"E. Yendaw","doi":"10.1007/s40497-022-00314-4","DOIUrl":"https://doi.org/10.1007/s40497-022-00314-4","url":null,"abstract":"","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"12 1","pages":"53 - 69"},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44677670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-25DOI: 10.1007/s40497-022-00311-7
Samaneh Bahrololoum, Mojtaba Mahmood Molaei Kermani, F. Koohzadi
{"title":"Ecopreneurs and agricultural waste management","authors":"Samaneh Bahrololoum, Mojtaba Mahmood Molaei Kermani, F. Koohzadi","doi":"10.1007/s40497-022-00311-7","DOIUrl":"https://doi.org/10.1007/s40497-022-00311-7","url":null,"abstract":"","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"1 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44327391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1007/s40497-022-00305-5
R. Khan, A. Mahmood, Mohammad Ghanim Ahmad, Makwan Jamil Mustafa, Mohammad Khamis Alshamsi, Qaisar Iqbal, Yashar Salamzadeh
{"title":"Correction to: Impact of network structure on sustainable competitive performance among Pakistani small and medium enterprises: does government financial support matter?","authors":"R. Khan, A. Mahmood, Mohammad Ghanim Ahmad, Makwan Jamil Mustafa, Mohammad Khamis Alshamsi, Qaisar Iqbal, Yashar Salamzadeh","doi":"10.1007/s40497-022-00305-5","DOIUrl":"https://doi.org/10.1007/s40497-022-00305-5","url":null,"abstract":"","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"12 1","pages":"45 - 45"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44377979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-29DOI: 10.1007/s40497-022-00309-1
Blesilda P. Badoc-Gonzales, M. B. Mandigma, Jackson J. Tan
{"title":"SME resilience as a catalyst for tourism destinations: a literature review","authors":"Blesilda P. Badoc-Gonzales, M. B. Mandigma, Jackson J. Tan","doi":"10.1007/s40497-022-00309-1","DOIUrl":"https://doi.org/10.1007/s40497-022-00309-1","url":null,"abstract":"","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"12 1","pages":"23 - 44"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43787952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-23DOI: 10.1007/s40497-022-00307-3
Haifa Asif
{"title":"Management skills enhancement improves women entrepreneurship: a study of the informal sector in Lahore","authors":"Haifa Asif","doi":"10.1007/s40497-022-00307-3","DOIUrl":"https://doi.org/10.1007/s40497-022-00307-3","url":null,"abstract":"","PeriodicalId":45024,"journal":{"name":"Journal of Global Entrepreneurship Research","volume":"1 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44629040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号