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Environmentally Persistent Free Radical Promotes Lung Cancer Progression by Regulating the Expression Profile of miRNAs. 环境持久性自由基通过调控 miRNAs 的表达谱促进肺癌进展
IF 2.4 2区 哲学 Q1 HISTORY Pub Date : 2024-10-01 Epub Date: 2022-05-17 DOI: 10.1089/cbr.2021.0378
Xiaomin Liu, Binshu Chai, Xianyi Wang, Zong Wu, Heng Zou, Yangyang Liu, Saijing Zheng, Guangren Qian, Zhongliang Ma, Jie Lu

Background: Environmentally persistent free radicals (EPFRs) are generated in the combustion processes of solid waste and can cause adverse influences on human health, especially lung diseases. Lung cancer is one of the most serious malignancies in recent years, which the global deaths rate is about 1.6 million every year. Methods and Results: In this study, we verified that ZnO/MCB EPFRs promote cell proliferation and migration, impedes cell apoptosis in lung cancer. Furthermore, we found that ZnO/MCB could influence the expression of miRNAs (miR-18a and miR-34a). In vivo, ZnO/MCB and ZnO EPFRs can reduce the weight and survival rate of BALB/c male mice more than that of BALB/c female mice. In the ZnO/MCB exposed group, male mice lung became even smaller, while the female mice the lung increased significantly. Taken together, our results provide evidence for assessing the potential health risks of persistent free radicals on fine particles. Conclusions: This study linked toxicity of EPFRs with miRNAs revealed the potential health hazard to human lung cancer.

背景:固体废物在燃烧过程中会产生环境持久性自由基(EPFRs),这些自由基会对人体健康造成不良影响,尤其是肺部疾病。肺癌是近年来最严重的恶性肿瘤之一,全球每年约有 160 万人死于肺癌。方法与结果本研究验证了 ZnO/MCB EPFRs 可促进肺癌细胞的增殖和迁移,阻碍细胞凋亡。此外,我们还发现 ZnO/MCB 可影响 miRNA(miR-18a 和 miR-34a)的表达。在体内,ZnO/MCB 和 ZnO EPFRs 比 BALB/c 雌性小鼠更能减轻 BALB/c 雄性小鼠的体重并降低其存活率。在 ZnO/MCB 暴露组中,雄性小鼠的肺变得更小,而雌性小鼠的肺则明显增大。综上所述,我们的研究结果为评估细颗粒上的持久性自由基对健康的潜在危害提供了证据。结论这项研究将 EPFRs 的毒性与 miRNAs 联系起来,揭示了其对人类肺癌的潜在健康危害。
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引用次数: 0
Monastic Authority and Legitimizing Religio-Political Activism: Buddhist Nationalist Monks in Myanmar 佛教权威与宗教政治活动合法化——缅甸佛教民族主义僧侣
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231705
Niklas Foxeus
The Buddhist nationalist movements that emerged during the political and economic liberalization of the second parliamentarian period (2011–2021) in Burma/Myanmar provide unique material for the study of monastic authority. The aim of this article is to examine two overlapping dynamics regarding how monastic authority is established and undermined. As for the first dynamic, the article examines three strategies in Buddhist nationalist sermons aiming to provide legitimacy for the nationalist monks. The second dynamic is a political outgroup criticism that became more common during the period in question. The article makes a distinction between generic monastic authority, which is the fundamental one, and nationalist monastic authority, as they are legitimized and established in different ways. Finally, the article argues that recognition of monastic authority by laypeople is based not merely on trust and respect but tends to be a more complex process.
缅甸第二次议会时期(2011-2021)政治和经济自由化期间出现的佛教民族主义运动为研究寺院权威提供了独特的材料。这篇文章的目的是研究关于寺院权威如何建立和破坏的两个重叠的动态。对于第一种动力,本文考察了佛教民族主义布道中的三种策略,旨在为民族主义僧侣提供合法性。第二种动态是政治外群体批评,这种批评在这一时期变得更为普遍。本文对作为基础的一般寺院权威和民族寺院权威进行了区分,因为它们的合法化和建立方式不同。最后,本文认为俗人对寺院权威的认可不仅仅是基于信任和尊重,而且往往是一个更复杂的过程。
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引用次数: 0
Crystal Shops and Shopping for Crystals in Estonia: Materiality and Experience as Sources of Value 爱沙尼亚的水晶店和水晶购物:物质性和经验作为价值来源
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231704
Tenno Teidearu
This article concentrates on crystal shops and shopping for crystals in Estonia. Consumption and commerce are inherent parts of New Spirituality. Crystals became the most salient commodities in esoteric shops during the 2010s, most of the shops having become “crystal shops” in Estonia. The aim of this article is to analyze the meaning-making potential of the materiality of crystals in shopping, and the material and sensuous aspects of crystal shops. From the perspective of material culture and consumption studies, this case study proposes that crystals are valuable in shopping primarily because of their materiality as a source of meaning and experience. In choosing crystals, people follow their material form and material qualities instead of a textual description of their supportive effects. Crystal shops are generally described as therapeutic places, however as an “experiencescape” they are strictly sensuous and material places.
这篇文章集中在水晶店和购买水晶在爱沙尼亚。消费和商业是新灵性的固有部分。在2010年代,水晶成为了神秘商店中最引人注目的商品,爱沙尼亚的大多数商店都变成了“水晶店”。本文的目的是分析水晶在购物中的物质性的意义制造潜力,以及水晶店的物质和感官方面。从物质文化和消费研究的角度来看,本案例研究提出水晶在购物中的价值主要是因为它们作为意义和体验来源的物质性。在选择晶体时,人们遵循它们的物质形式和物质质量,而不是文本描述它们的支持效果。水晶店通常被描述为治疗场所,然而作为一个“体验之地”,它们是严格意义上的感官和物质场所。
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引用次数: 0
Applying Heterarchy Theory to Ancient Mesopotamian Religions 将层次理论应用于古代美索不达米亚宗教
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231707
Shana Zaia
Heterarchy theory is a valuable tool for analyzing complex and changing relationships between elements in a system. It has been employed in anthropology, archaeology, and recently in religious studies. Its utility has not yet been exploited for religions that are studied through textual evidence, such as Mesopotamian religions. As Mesopotamian religions were polytheistic and the texts represent multiple genres from a broad timeframe, relationships between system actors such as gods, temples, and cities defy static and lineal arrangements. Heterarchies are well suited for untangling these relationships, showing how they change depending on the measuring criteria. Using the case of the city of Assur, which housed many deities and was both the religious center and a political capital, heterarchy theory shows how the same elements – temples and cities – reveal different rankings that coexisted simultaneously. Heterarchies productively complicate our understanding of these religious relationships and expose the multimodality of each element in the system.
层次理论是分析系统中元素之间复杂和变化的关系的一个有价值的工具。它已被用于人类学、考古学和最近的宗教研究。它的效用还没有被用于通过文本证据研究的宗教,比如美索不达米亚宗教。由于美索不达米亚的宗教是多神教,并且文本代表了广泛时间框架内的多种流派,因此系统参与者(如神、寺庙和城市)之间的关系违背了静态和线性安排。层次结构非常适合解开这些关系,显示它们如何根据度量标准而变化。以亚述尔城为例,它既是宗教中心又是政治首都,它展示了同样的元素——寺庙和城市——如何揭示了同时共存的不同等级。层次结构有效地使我们对这些宗教关系的理解复杂化,并暴露了系统中每个元素的多模态。
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引用次数: 0
Ritual: How Seemingly Senseless Acts Make Life Worth Living, written by Dimitris Xygalatas 仪式:看似无意义的行为如何让生活变得有价值,迪米特里斯·西加拉塔斯著
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231709
Sarah Demmrich
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引用次数: 5
The Glory Jest and Riddle: Jonathan Z. Smith and an Aesthetic of Impossibles 荣耀的玩笑和谜语:乔纳森·史密斯与不可能的审美
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231702
Sam Gill
The late Jonathan Z. Smith was a central influence in the development of a study of religion on a par with the social and even natural sciences. This article reexamines Smith’s legacy for the inspiration to build a proper academic study of religion. It looks to Smith’s common use of jokes and riddles, grounded in his early studies of Frazer’s The Golden Bough, in order to tease out not simply stylistic or methodological concerns, but fundamental philosophical shapings of religion theory. I develop a presentation of this position in what is termed an aesthetic of impossibles, the distinctively human capacity of considering things as equal or identical knowing full well that they are not and doing so without any necessity for reconciliation. This aesthetic is examined and illustrated in a consideration of Smith’s views of comparison and mapping. In an extended discussion, it is also considered in terms of human self-moving as the marker of vitality, established in both philosophy and biology.
已故的乔纳森·z·史密斯(Jonathan Z. Smith)对宗教研究的发展产生了核心影响,其影响力与社会科学甚至自然科学不相上下。本文重新审视了史密斯的遗产,以启发我们建立一个适当的宗教学术研究。它着眼于史密斯在早期对弗雷泽的《金枝》的研究中常用的笑话和谜语,不仅是为了梳理出风格或方法上的问题,而且是为了梳理出宗教理论的基本哲学形态。我用所谓的“不可能的美学”来阐述这一立场,这是人类特有的一种能力,即认为事物是平等或相同的,完全知道它们不是平等或相同的,而且这样做不需要任何和解。这种美学在考虑史密斯的比较和映射观点时得到了检验和说明。在进一步的讨论中,它也被认为是人类自我运动作为活力的标志,在哲学和生物学中都有确立。
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引用次数: 0
Egyptian Hieroglyphs in the Late Antique Imagination, written by Jennifer Taylor Westerfeld 《古埃及晚期象形文字》,作者詹妮弗·泰勒·韦斯特菲尔德
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231708
Christian H. Bull
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引用次数: 0
Interdisciplinarity in Nondisciplines: Archive and Academe in the Study of Religion 非学科的跨学科性:宗教研究中的档案与学术
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231703
Rafal K. Stepien
This article reveals, criticizes, and attempts to overcome the systemic divides between the ideals of an interdisciplinarily employed archive and the realities of a disciplinarily deployed academy. Following an initial section on “Parameters and Proposals” in which I frame the ambit and arguments to follow, in “Religious Studies as Nondiscipline” I argue against the view that religious studies constitutes a discrete discipline. In “Interdisciplinarity and Nondisciplines” I theorize interdisciplinarity and argue for a conceptual relationship between it and the study of religion. Subsequent sections on “Interdisciplinarity in the Practice” and “An Interdisciplinarity in Practice” relate the practical consequences of my account for university-based professional religious studies, and provide an exemplary case study of the alternative approach advanced. Finally, in “Archive and Academe” I draw on contemporary theorizations of the archive to propose the study of religion, as here conceived, to be preeminently located to enact long overdue structural change in academe.
本文揭示、批评并试图克服跨学科使用档案的理想与学科部署学院的现实之间的系统性分歧。在“参数和建议”的第一节中,我阐述了要遵循的范围和论点,在“宗教研究作为非学科”中,我反对宗教研究构成一个离散学科的观点。在《跨学科与非学科》一书中,我将跨学科理论化,并主张它与宗教研究之间存在概念关系。随后关于“实践中的跨学科性”和“实践的跨学科”的章节讲述了我对大学专业宗教研究的描述的实际后果,并提供了一个关于所提出的替代方法的示例性案例研究。最后,在《档案与学术》一书中,我借鉴了档案的当代理论,提出了对宗教的研究,正如这里所设想的那样,处于卓越的位置,以实现学术界早该发生的结构变革。
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引用次数: 0
Turn to Traditions – Calls for Change: Negotiations over Liturgy in the Synagogues of Finland 转向传统-呼吁改变:芬兰犹太教堂礼拜仪式的谈判
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231706
Simo Muir, R. Illman, Riikka Tuori
This article explores how Jews in Finland relate to the musical traditions of their synagogues and the changes that have occurred in the customs over time and as the result of various cultural and spiritual influences. Based on ethnographic data, it focuses on rituals, liturgy, and music as contexts for negotiating relationships between the institution and the individual, memory practices, and contemporary innovation – being and doing Jewish, to use concepts from the vernacular religion framework. The article outlines the historical development of Minhag Finland, the vernacular liturgical customs. It concludes that the “turn to traditions” should be stated in the plural, as several Jewish customs, cultures, and context are engaged in the negotiations around liturgy. This is not just a way to freeze time and preserve the status quo. Instead, seeking for meaningful models in the past paves the way for change – especially when turning toward a broad range of traditions.
本文探讨了芬兰的犹太人如何与他们犹太教堂的音乐传统以及随着时间的推移以及各种文化和精神影响而发生的习俗变化联系在一起。基于人种学数据,它将仪式、礼拜仪式和音乐作为协商机构与个人之间关系的背景,记忆实践和当代创新——作为犹太人和做犹太人,使用当地宗教框架中的概念。本文概述了芬兰民哈格的历史发展、当地的礼仪习俗。它的结论是,“转向传统”应该用复数形式表述,因为在围绕礼拜仪式的谈判中,有几种犹太习俗、文化和背景。这不仅仅是一种冻结时间和维持现状的方式。相反,在过去寻找有意义的模式为变革铺平了道路——尤其是在转向广泛的传统时。
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引用次数: 0
Kritische Gesamtausgabe (KGA), written by Ernst Troeltsch 评论完整版(KGA),Ernst Troeltsch著
IF 1.1 2区 哲学 Q1 HISTORY Pub Date : 2023-09-04 DOI: 10.1163/15685276-20231710
Christoph Auffarth
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引用次数: 0
期刊
NUMEN-INTERNATIONAL REVIEW FOR THE HISTORY OF RELIGIONS
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