Clinica e Investigacion en Arteriosclerosis最新文献_第6页

Tratamiento de la hipertrigliceridemia para la reducción del riesgo cardiovascular 治疗高甘油三酯以降低心血管风险

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-06-01 DOI: 10.1016/j.arteri.2025.500816

Carlos Guijarro Herráiz

引用次数: 0

Environmental pollution and cardiovascular health. Challenges and new perspectives. 环境污染与心血管健康。挑战和新视角。

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-05-08 DOI: 10.1016/j.arteri.2025.500802

Francisco Gomez-Delgado, Manuel Raya-Cruz, Juan L Romero-Cabrera, Pablo Perez-Martinez

Environmental pollution is a key factor in cardiovascular disease (CVD) development. Several evidences support its impact at the pathophysiology of arteriosclerosis, highlighting the role of the "exposome", a concept that encompasses all environmental factors such as air pollution, water pollution, climate change and noise and light pollution. These factors are associated with an increased risk of ischemic heart disease (IHD), stroke, high blood pressure (HBP), heart failure (HF) and atrial fibrillation (AF). Currently, air pollution is the main environmental factor related to CVD. Components such as particulates matter (PM_0.1, PM_2.5, PM₁₀), sulfur dioxide (SO₂), nitrogen oxide and dioxide (NO_x), carbon monoxide (CO) and ozone (O₃) have a high capacity to penetrate the body and trigger both local and systemic inflammatory processes. These effects promote a proinflammatory, procoagulant state and an increase in oxidative stress. Similarly, aquatic pollution exposes the body to pollutants such as heavy metals, pesticides and microplastics, both through direct contact and via the food chain, thus contributing to the phenomena mentioned above. On the other hand, factors such as noise and light pollution, together with effects caused from climate change (extreme temperatures, wildfires, desertification, among others), have been closely linked to pathophysiological processes that favour the development and progression of atherosclerosis. These mechanisms include sympathetic nervous system (SNS) activation, stress hormones release such as cortisol and catecholamines, as well as chronodisruption. This review analyses the role of factors related to the exposome (air pollution, water pollution, noise and light pollution and phenomena associated with climate change) in atherosclerosis progression, as well as their involvement in the incidence, prevalence and prognosis of CVD. Physicians should promote awareness of environmental pollution impact on cardiovascular health, integrating the assessment of environmental factors into their clinical practice, advocating for sustainable policies to prevent diseases and protect present and future health.

环境污染是心血管疾病（CVD）发展的关键因素。一些证据支持其对动脉硬化病理生理的影响，强调了“暴露”的作用，这一概念包括所有环境因素，如空气污染、水污染、气候变化、噪音和光污染。这些因素与缺血性心脏病（IHD）、中风、高血压（HBP）、心力衰竭（HF）和心房颤动（AF）的风险增加有关。目前，大气污染是与心血管疾病相关的主要环境因素。颗粒物（PM0.1、PM2.5、PM10）、二氧化硫（SO2）、氮氧化物和二氧化氮（NOx）、一氧化碳（CO）和臭氧（O3）等成分具有很高的穿透身体并引发局部和全身炎症过程的能力。这些作用促进了促炎、促凝状态和氧化应激的增加。同样，水生污染通过直接接触和通过食物链使人体暴露于重金属、农药和微塑料等污染物中，从而导致上述现象。另一方面，噪音和光污染等因素，以及气候变化（极端温度、野火、荒漠化等）造成的影响，与有利于动脉粥样硬化发展和进展的病理生理过程密切相关。这些机制包括交感神经系统（SNS）的激活，皮质醇和儿茶酚胺等应激激素的释放，以及时间紊乱。本文就空气污染、水污染、噪声、光污染、气候变化等环境暴露相关因素在动脉粥样硬化发展中的作用及其与心血管疾病发病率、患病率和预后的关系进行综述。医生应提高对环境污染对心血管健康影响的认识，将环境因素的评估纳入其临床实践，倡导可持续的政策，以预防疾病，保护现在和未来的健康。

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引用次数: 0

Association between sociodemographic variables, lifestyle factors, and stress with lipoprotein ratio values. 社会人口学变量、生活方式因素和压力与脂蛋白比值值之间的关系。

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-05-02 DOI: 10.1016/j.arteri.2025.500803

Ángel Arturo López-González, José Ignacio Ramírez-Manent, Emilio Martínez-Almoyna Rifá, Hernán Paublini Oliveira, Cristina Martorell Sánchez, Pedro Juan Tárraga López

Introduction: Atherosclerosis is a multifactorial process underlying major cardiovascular diseases (CVDs). Among the associated risk factors, lipoprotein ratios have been identified as key indicators of atherogenic risk. However, the influence of sociodemographic variables, lifestyle factors, and stress levels on lipoprotein ratios remains underexplored.

Objective: To analyze the relationship between sociodemographic variables, healthy lifestyle habits, and stress levels with lipoprotein ratios and atherogenic risk in a large cohort of Spanish workers.

Materials and methods: A cross-sectional study was conducted in 24,244 Spanish workers. The association between age, gender, socioeconomic status, tobacco and alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress levels with atherogenic risk scales, including atherogenic dyslipidemia (AD) and atherogenic índices, was evaluated.

Results: A significant association was found between all analyzed variables and lipoprotein ratios. The strongest associations were observed with age and gender, followed by occupational status, tobacco and alcohol consumption, physical activity, diet, and stress levels. Men exhibited a higher atherogenic risk compared to women (OR 2.36; 95% CI 2.18-2.55). The risk increased significantly with age, peaking in the 50-69 age group (OR 5.00; 95% CI 3.70-6.31). Manual workers had a higher prevalence of atherogenic dyslipidemia compared to non-manual workers (OR 1.35; 95% CI 1.27-1.41). Furthermore, smoking (OR 1.84; 95% CI 1.71-1.97) and alcohol consumption (OR 1.45; 95% CI 1.36-1.55), physical inactivity (OR 1.90; 95% CI 1.76-2.05), and low adherence to the Mediterranean diet (OR 1.72; 95% CI 1.60-1.84) were associated with higher atherogenic index values.

Conclusions: The presence of an adverse lipoprotein profile is strongly influenced by sociodemographic factors, lifestyle habits, and stress. Identifying these determinants may enable the implementation of preventive strategies aimed at reducing atherogenic risk and improving cardiovascular health in working populations.

动脉粥样硬化是一个多因素的过程，是主要心血管疾病（cvd）的基础。在相关的危险因素中，脂蛋白比率已被确定为动脉粥样硬化风险的关键指标。然而，社会人口变量、生活方式因素和压力水平对脂蛋白比率的影响仍未得到充分探讨。目的：分析西班牙一大群工人的社会人口学变量、健康生活习惯和压力水平与脂蛋白比率和动脉粥样硬化风险之间的关系。材料和方法：对24,244名西班牙工人进行了横断面研究。评估了年龄、性别、社会经济地位、烟酒消费、体育活动、地中海饮食依从性和压力水平与动脉粥样硬化风险量表（包括动脉粥样硬化性血脂异常（AD）和动脉粥样硬化índices）之间的关系。结果：所有分析变量与脂蛋白比值之间存在显著相关性。年龄和性别的相关性最强，其次是职业状况、烟酒消费、体育活动、饮食和压力水平。与女性相比，男性表现出更高的动脉粥样硬化风险(OR 2.36；95% ci 2.18-2.55)。随着年龄的增长，风险显著增加，在50-69岁年龄组达到高峰(OR 5.00；95% ci 3.70-6.31)。体力劳动者患动脉粥样硬化性血脂异常的比例高于非体力劳动者(OR 1.35；95% ci 1.27-1.41)。此外，吸烟(OR 1.84；95% CI 1.71-1.97)和饮酒(OR 1.45；95% CI 1.36-1.55)，缺乏身体活动(OR 1.90；95% CI 1.76-2.05)，地中海饮食依从性低(OR 1.72；95% CI 1.60-1.84)与较高的动脉粥样硬化指数值相关。结论：不良脂蛋白谱的存在受到社会人口因素、生活习惯和压力的强烈影响。确定这些决定因素可能有助于实施旨在减少动脉粥样硬化风险和改善工作人群心血管健康的预防战略。

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引用次数: 0

Eficiencia de las combinaciones a dosis fija de estatina y ezetimiba en el tratamiento de la hipercolesterolemia 他汀与依折替米贝固定剂量联合治疗高胆固醇血症的疗效观察。

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-05-01 DOI: 10.1016/j.arteri.2024.500753

Carlos Guijarro , Angel Diaz , Eva Moreno , Paula Gamonal , Maria Soler , Neus Vidal-Vilar , Maria Rosa Fernandez

Objective

To estimate the clinical and economic benefits derived from increasing the use of fixed-dose combinations of high-intensity statins and ezetimibe in patients at high/very high cardiovascular risk, from the perspective of the Spanish National Health System (SNS).

Methods

A baseline scenario (current market shares) was compared with scenarios that increased the use of fixed-dose combinations (alternative: 30% increase; optimized: 69% increase). The potential annual increase in the number of controlled patients, cardiovascular events avoided and the associated savings in direct medical costs were estimated, including the cost of pharmacological treatment, follow-up, and managing cardiovascular events over a three-year time horizon.

Results

Over the three years of the study, the baseline scenario estimated a total of 1,552,686 controlled patients and 39,449 cardiovascular events, with a total cost to the SNS of €1,841,057,122. In the alternative scenario, controlled patients would increase by 36.1%, and 139 cardiovascular events would be avoided, resulting in savings for the SNS of €36,116,631. In the optimized scenario, there would be a 64% increase in controlled patients and 250 cardiovascular events would be avoided, leading to savings of €56,415,300 for the SNS.

Conclusion

Increased use of high-intensity statin and ezetimibe fixed-dose combinations in patients with high/very high cardiovascular risk may increase the number of controlled patients, reduce cardiovascular events and produce economic savings from an SNS perspective.

目的：从西班牙国家卫生系统（SNS）的角度，评估在高/极高心血管风险患者中增加使用高强度他汀类药物和依zetimibe固定剂量组合所带来的临床和经济效益。方法：将基线情景（当前市场份额）与增加固定剂量联合使用的情景(替代方案：增加30%；优化后：增加69%)。对控制患者数量的潜在年度增长、心血管事件的避免以及相关的直接医疗费用节约进行了估计，包括三年时间内药物治疗、随访和心血管事件管理的费用。结果：在三年的研究中，基线情景估计总共有1,552,686名对照患者和39,449例心血管事件，SNS的总成本为1,841,057,122欧元。在另一种情况下，对照患者将增加36.1%，139例心血管事件将避免，从而节省€36,116,631的SNS。在优化的情况下，对照患者将增加64%，避免250例心血管事件，从而为SNS节省56,415,300欧元。结论：从SNS的角度来看，高/极高心血管风险患者增加高强度他汀和依zetimibe固定剂量组合的使用可能会增加对照患者的数量，减少心血管事件并节省经济。

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引用次数: 0

Plasma expression of a microRNA panel is differentially associated with 1H-NMR lipoprotein profile in rheumatoid arthritis patients 类风湿关节炎患者血浆中microRNA的表达与1H-NMR脂蛋白谱存在差异。

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-05-01 DOI: 10.1016/j.arteri.2025.500759

Dídac Llop , Silvia Paredes , Roser Rosales , Josep Ribalta , Joan-Carles Vallvé

Introduction

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disorder that leads to cartilage and bone deterioration. This inflammatory activity causes extra-articular manifestations, including the acceleration of the atherosclerotic process. However, the exact causes of this accelerated process are under investigation. In this study, we compared the advanced lipid profile between patients with RA, patients with metabolic disorders, and controls. We also explored how microRNAs previously associated with subclinical atherosclerosis in RA are linked to these lipid subfractions in RA.

Methods

The study included 219 patients with RA, 82 with metabolic disorders and 64 controls. Clinical evaluations were performed, and blood samples were collected. Quantification of microRNAs (Let7a, 24, 96, 103, 125a, 125b, 132, 146, 191, 223, 425, 451) and measurement of the advanced lipid profile using nuclear magnetic resonance (NMR) were carried out. Kruskal–Wallis tests and multivariate linear models were applied.

Results

Patients with RA exhibited elevated total, large, medium, and small VLDL particles compared to controls. Their LDL subfractions were decreased compared to patients with metabolic disorders, with differences with controls. Patients with RA had fewer and smaller HDL particles than both groups. MicroRNA-125a was associated with VLDL subfractions and small LDL particles. Other microRNAs (96, 132, 191, 451) showed associations with certain LDL subfractions.

Conclusions

In patients with RA, elevated levels of VLDL particles have been observed, while LDL levels remain similar to controls. The notable association of microRNA-125a with the metabolism of both VLDL and LDL in RA patients suggests its involvement in lipid regulation. This could point to microRNA-125a as a promising therapeutic target to address the increased cardiovascular risks of RA.

类风湿关节炎（RA）是一种自身免疫和炎症性疾病，导致软骨和骨骼恶化。这种炎症活动引起关节外表现，包括动脉粥样硬化过程的加速。然而，这一加速进程的确切原因正在调查中。在这项研究中，我们比较了RA患者、代谢紊乱患者和对照组之间的晚期脂质谱。我们还探讨了先前与类风湿性关节炎亚临床动脉粥样硬化相关的microrna如何与类风湿性关节炎的这些脂质亚组分相关联。方法：219例RA患者，82例代谢紊乱患者和64例对照组。进行临床评估，并采集血样。采用核磁共振（NMR）技术对microrna （Let7a, 24, 96, 103, 125a, 125b, 132, 146, 191, 223, 425, 451）进行定量分析，并测定其高级脂质谱。采用Kruskal-Wallis检验和多元线性模型。结果：与对照组相比，RA患者表现出总、大、中、小VLDL颗粒升高。与代谢紊乱患者相比，他们的低密度脂蛋白亚组分降低，与对照组存在差异。与两组相比，RA患者的HDL颗粒更少、更小。MicroRNA-125a与VLDL亚组分和小LDL颗粒相关。其他microrna（96、132、191、451）显示与某些LDL亚组分相关。结论：在RA患者中，观察到VLDL颗粒水平升高，而LDL水平与对照组相似。microRNA-125a与RA患者VLDL和LDL代谢的显著相关性提示其参与脂质调节。这可能表明microRNA-125a是解决RA心血管风险增加的有希望的治疗靶点。

{"title":"Plasma expression of a microRNA panel is differentially associated with 1H-NMR lipoprotein profile in rheumatoid arthritis patients","authors":"Dídac Llop , Silvia Paredes , Roser Rosales , Josep Ribalta , Joan-Carles Vallvé","doi":"10.1016/j.arteri.2025.500759","DOIUrl":"10.1016/j.arteri.2025.500759","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis (RA) is an autoimmune and inflammatory disorder that leads to cartilage and bone deterioration. This inflammatory activity causes extra-articular manifestations, including the acceleration of the atherosclerotic process. However, the exact causes of this accelerated process are under investigation. In this study, we compared the advanced lipid profile between patients with RA, patients with metabolic disorders, and controls. We also explored how microRNAs previously associated with subclinical atherosclerosis in RA are linked to these lipid subfractions in RA.</div></div><div><h3>Methods</h3><div>The study included 219 patients with RA, 82 with metabolic disorders and 64 controls. Clinical evaluations were performed, and blood samples were collected. Quantification of microRNAs (Let7a, 24, 96, 103, 125a, 125b, 132, 146, 191, 223, 425, 451) and measurement of the advanced lipid profile using nuclear magnetic resonance (NMR) were carried out. Kruskal–Wallis tests and multivariate linear models were applied.</div></div><div><h3>Results</h3><div>Patients with RA exhibited elevated total, large, medium, and small VLDL particles compared to controls. Their LDL subfractions were decreased compared to patients with metabolic disorders, with differences with controls. Patients with RA had fewer and smaller HDL particles than both groups. MicroRNA-125a was associated with VLDL subfractions and small LDL particles. Other microRNAs (96, 132, 191, 451) showed associations with certain LDL subfractions.</div></div><div><h3>Conclusions</h3><div>In patients with RA, elevated levels of VLDL particles have been observed, while LDL levels remain similar to controls. The notable association of microRNA-125a with the metabolism of both VLDL and LDL in RA patients suggests its involvement in lipid regulation. This could point to microRNA-125a as a promising therapeutic target to address the increased cardiovascular risks of RA.</div></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":"37 3","pages":"Article 500759"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

¿Cómo alcanzar los objetivos en colesterol LDL con los criterios de financiación de los nuevos fármacos hipolipemiantes? 如何在新的降脂药物的资助标准下实现LDL胆固醇目标？

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-05-01 DOI: 10.1016/j.arteri.2024.500752

Antón González-Guerrero , Elisenda Climent , David Benaiges , Juan PedroBotet

Given the apparent inconsistency of having potent lipid-lowering drugs and the unacceptable rate of achievement of therapeutic goals in LDL cholesterol, it is imperative to define new strategies. In this regard, it is appropriate to detail the key points in planning to start lipid-lowering therapy, emphasizing relevant clinical aspects such as the considerable individual variability in the response to statin therapy, positioning in relation to high-potency statins versus statin + ezetimibe combination therapy, and the order of choice of lipid-lowering drugs in the therapeutic strategy. An algorithm is then proposed that ensures a personalized approach to lipid-lowering drug treatment in patients with cardiovascular disease and/or familial hypercholesterolemia with the aim of achieving the therapeutic goal in the shortest possible time, taking into account the patient's previous treatment, the funding criteria for new drugs, and the individualized goal of LDL cholesterol reduction.

鉴于有效降脂药物的明显不一致性和低密度脂蛋白胆固醇治疗目标的不可接受的实现率，必须确定新的策略。在这方面，有必要详细说明计划开始降脂治疗的关键点，强调相关的临床方面，如对他汀类药物治疗反应的相当大的个体差异，高效他汀类药物与他汀类药物+依折替米贝联合治疗的定位，以及在治疗策略中选择降脂药物的顺序。然后提出了一种算法，确保在考虑患者既往治疗、新药资助标准和降低LDL胆固醇的个体化目标的情况下，在尽可能短的时间内实现心血管疾病和/或家族性高胆固醇血症患者降脂药物治疗的个性化方法。

引用次数: 0

La complejidad del riesgo cardiovascular en las mujeres. Revisión descriptiva 女性心血管风险的复杂性。描述性综述。

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-05-01 DOI: 10.1016/j.arteri.2024.08.005

J. Ildefonzo Arocha Rodulfo , Gestne Aure Fariñez

Objectives

Cardiovascular diseases (CVD) are the greatest threat to the health of women and is the leading cause of death amongst women globally; however, cardiovascular disease in women remains understudied, under-recognized, underdiagnosed, and undertreated. The aim of this descriptive review is to summarize the existing problem and to identify the knowledge gaps in cardiovascular disease research, prevention, treatment, and access to care for women.

Material and methods

This is a descriptive review of the literature based on numerous articles published in peer-reviewed journals since the beginning of this century related to the spectrum of cardiovascular disease in women.

Results

There are several obstacles to improve cardiovascular disease outcomes in women. One of them is the lack of reliable, effective screening modalities since her participation in clinical trial is quite low. Other concern is the complexity of the female organism with several hormonal changes during her life and the hemodynamics stress during pregnancy. Moreover, in the last stage of their life several cardiometabolic risk factor may appear, most of them not recognized by the health team in primary care attention.

Discussion

Effective strategies are required to address inequalities in the diagnosis, treatment and prevention of heart disease in women; to advance innovative solutions for early detection and oriented management; to clarify the underlying biological mechanisms that contribute to sex-specific differences in outcomes; and finally, reduce the global burden of cardiovascular disease in women.

目标：心血管疾病（CVD）是对妇女健康的最大威胁，也是全球妇女死亡的主要原因；然而，对妇女心血管疾病的研究、认识、诊断和治疗仍然不足。这篇描述性综述的目的是总结现有问题，找出在心血管疾病研究、预防、治疗和妇女获得护理方面存在的知识差距：这是一篇描述性的文献综述，以本世纪初以来在同行评审期刊上发表的与女性心血管疾病相关的大量文章为基础：在改善女性心血管疾病治疗效果方面存在一些障碍。其中一个障碍是缺乏可靠、有效的筛查方法，因为女性参与临床试验的比例很低。另一个令人担忧的问题是女性机体的复杂性，在其一生中荷尔蒙会发生数次变化，而且在怀孕期间血液动力学会产生压力。此外，在她们生命的最后阶段，可能会出现一些心脏代谢风险因素，而其中大多数并没有被初级保健医疗团队所认识到：讨论：需要制定有效的战略，以解决妇女在诊断、治疗和预防心脏病方面的不平等问题；推进早期检测和定向管理的创新解决方案；阐明导致性别差异结果的潜在生物机制；并最终减轻全球妇女心血管疾病的负担。

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引用次数: 0

Asociación entre variables sociodemográficas, hábitos saludables y estrés con diabesidad 社会人口变量、健康习惯和压力与糖尿病之间的关系。

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-05-01 DOI: 10.1016/j.arteri.2024.500754

Ángel Arturo López-González , Emilio Martínez-Almoyna Rifá , Hernán Paublini Oliveira , Cristina Martorell Sánchez , Pedro Juan Tárraga López , José Ignacio Ramírez-Manent

Introduction

Diabesity is a pathological condition that combines obesity and type 2 diabetes in the same individual. Due to the current rise in both conditions, the prevalence of diabesity is increasing worldwide. Its etiology is known to be multifactorial; therefore, the aim of this study is to understand how diabesity is associated with various sociodemographic variables, healthy habits, and stress.

Materials and Methods

A descriptive, cross-sectional study was conducted on 24,224 Spanish workers to evaluate the association between diabesity and various factors such as age, gender, socioeconomic status, smoking, alcohol consumption, physical activity, adherence to the Mediterranean diet, and stress. The criteria used to define diabesity included body mass index (BMI), body fat (BF), and visceral fat (VF).

Results

All the aforementioned variables were found to be associated with diabesity. The highest odds ratios (OR) were observed for age, with values ranging from 5.57 (95% CI: 4.48-6.67) when BF was used as the diabesity criterion to 6.89 (95% CI: 5.60-8.19) when VF was the criterion. Similarly, elevated ORs were observed for male gender, with ORs of 6.77 (95% CI: 5.31-8.24) for VF and 3.34 (95% CI: 2.77-3.94) for BF.

Conclusions

In our study, the profile of a person at highest risk of diabesity is a man over 50 years old from a lower socioeconomic status, who is a smoker, regular alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high stress levels.

简介：糖尿病是一种在同一个体中合并肥胖和2型糖尿病的病理状态。由于目前这两种情况的增加，全世界的糖尿病患病率正在增加。其病因已知是多因素的；因此，本研究的目的是了解糖尿病与各种社会人口变量、健康习惯和压力之间的关系。材料和方法：对24,224名西班牙工人进行了一项描述性横断面研究，以评估糖尿病与各种因素（如年龄、性别、社会经济地位、吸烟、饮酒、体育活动、坚持地中海饮食和压力）之间的关系。用于定义糖尿病的标准包括身体质量指数（BMI）、体脂（BF）和内脏脂肪（VF）。结果：上述变量均与糖尿病相关。年龄的比值比（OR）最高，当以BF作为糖尿病标准时，比值比为5.57 (95% CI: 4.48-6.67)，当以VF作为标准时，比值比为6.89 （95% CI: 5.60-8.19）。同样，男性的or值升高，VF的or值为6.77 (95% CI: 5.31-8.24)， BF的or值为3.34 （95% CI: 2.77-3.94）。结论：在我们的研究中，糖尿病风险最高的人群是50岁以上、社会经济地位较低、吸烟、经常饮酒、久坐不动、地中海饮食依从性低、压力大的男性。

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引用次数: 0

MicroARNs asociados a partículas lipídicas con potencial para prevenir o reducir el desarrollo de arteriosclerosis en pacientes con Artritis Reumatoide 与具有预防或减少类风湿性关节炎患者动脉粥样硬化发展潜力的脂质颗粒相关联的微RNA

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-05-01 DOI: 10.1016/j.arteri.2025.500825

Oriol Alberto Rangel-Zúñiga

引用次数: 0

sICAM-1 concentrations are associated with inflammation in contralateral carotid plaque in patients with ischemic stroke sICAM-1 浓度与缺血性中风患者对侧颈动脉斑块的炎症有关。

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis

Pub Date : 2025-03-01 DOI: 10.1016/j.arteri.2024.07.002

Núria Puig , Pol Camps-Renom , Eduardo Garcia , Aleyda Benítez-Amaro , Ana Aguilera-Simón , Alejandro Fernández-León , Jose Luis Sanchez Quesada , Vicenta Llorente-Cortés , Sonia Benitez

Background

Atherosclerotic plaques in the internal carotid artery are responsible for more than 15% of ischemic strokes. Carotid ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) detects plaque inflammation. Plasma ICAM-1 and LRP1 concentrations have been associated with inflammation in ipsilateral carotid plaque. The aim of the present study was to test the association between the soluble (s) form of these biomarkers and contralateral carotid plaques.

Methods

Prospective study conducted in 53 patients with a recent ischemic stroke and at least one atherosclerotic plaque in both carotid arteries. All of the patients underwent an early carotid ¹⁸F-FDG PET, and a blood sample was obtained at 7 ± 1 days. Several plasma inflammatory markers were evaluated by Multiplex and sLRP1 levels were measured by commercial ELISA. Bivariate and multivariable linear regression was used to assess the association between inflammatory markers and the clinical variables, including contralateral maximum standardized uptake value (SUVmax) and mean SUVmax (mean of contralateral and ipsilateral SUVmax) of ¹⁸F-FDG uptake. Hazard ratio (HR) was estimated with Cox models adjusted for potential confounding factors to evaluate recurrence.

Results

Multivariable linear regression analysis showed an independent association between sICAM-1 and sVCAM-1 and mean SUVmax (CI = −0.064–0.325, p = 0.004; CI = 0.079–0.554, p = 0.010). In addition, in bivariate regression analysis, sICAM-1 was associated with contralateral SUVmax (CI = 0.049–0.382, p = 0.012). Cox regression showed that mean SUVmax was associated with stroke recurrence (HR = 5.604, p = 0.044).

Conclusions

sICAM-1 was independently associated with mean carotid plaque inflammation and with inflammation in contralateral plaque. sICAM-1 could be an indicator of plaque inflammation even in asymptomatic plaques.

背景：超过15%的缺血性中风是颈内动脉粥样硬化斑块引起的。颈动脉 18F- 氟脱氧葡萄糖正电子发射断层扫描（18F-FDG PET）可检测斑块炎症。血浆 ICAM-1 和 LRP1 的浓度与同侧颈动脉斑块的炎症有关。本研究旨在检测这些生物标志物的可溶性（s）形式与对侧颈动脉斑块之间的关联：方法：对 53 名近期发生缺血性脑卒中且双侧颈动脉至少有一个动脉粥样硬化斑块的患者进行前瞻性研究。所有患者均接受了早期颈动脉18F-FDG PET检查，并在7±1天时采集了血液样本。采用 Multiplex 方法评估了几种血浆炎症标记物，并采用商用 ELISA 方法测量了 sLRP1 的水平。采用双变量和多变量线性回归评估炎症标志物与临床变量（包括对侧最大标准化摄取值（SUVmax）和18F-FDG摄取的平均SUVmax（对侧和同侧SUVmax的平均值））之间的关系。在评估复发情况时，采用Cox模型对潜在的混杂因素进行了调整，从而估算出危险比（HR）：多变量线性回归分析显示，sICAM-1和sVCAM-1与平均SUVmax之间存在独立关联（CI=-0.064-0.325，P=0.004；CI=0.079-0.554，P=0.010）。此外，在双变量回归分析中，sICAM-1与对侧SUVmax相关（CI=0.049-0.382，P=0.012）。Cox回归显示，平均SUVmax与中风复发有关（HR=5.604，P=0.044）。结论：sICAM-1与平均颈动脉斑块炎症和对侧斑块炎症独立相关。

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引用次数: 0